{"id":"https://openalex.org/W7127057360","doi":"https://doi.org/10.1016/j.jcoa.2026.100310","title":"Sustainable methods for flavonoid determination: Applications with modern green analytical techniques","display_name":"Sustainable methods for flavonoid determination: Applications with modern green analytical techniques","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127057360","doi":"https://doi.org/10.1016/j.jcoa.2026.100310"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcoa.2026.100310","doi":"https://doi.org/10.1016/j.jcoa.2026.100310","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcoa.2026.100310","pdf_url":null,"source":{"id":"https://openalex.org/S4210211886","display_name":"Journal of Chromatography Open","issn_l":"2772-3917","issn":["2772-3917"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jcoa.2026.100310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Seyda Yayla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seyda Yayla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064784474","display_name":"Ahmet \u00c7etinkaya","orcid":"https://orcid.org/0000-0001-5014-0907","observed_orcids":["https://orcid.org/0000-0001-5014-0907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmet Cetinkaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057930394","display_name":"Muhammed Mesud H\u00dcRKUL","orcid":"https://orcid.org/0000-0002-9241-2496","observed_orcids":["https://orcid.org/0000-0002-9241-2496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Mesud Hurkul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5124706523","display_name":"Sibel A. OZKAN","orcid":"https://orcid.org/0000-0001-7494-3077","observed_orcids":["https://orcid.org/0000-0001-7494-3077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sibel A. Ozkan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7494-3077","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2360,"currency":"USD","value_usd":2360},"apc_paid":{"value":2360,"currency":"USD","value_usd":2360},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04845495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"100310","last_page":"100310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.41990000009536743,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/green-analytical-chemistry","display_name":"green analytical chemistry","score":0.9869999885559082},{"id":"https://openalex.org/keywords/supercritical-fluid-chromatography","display_name":"supercritical fluid chromatography","score":0.8429999947547913},{"id":"https://openalex.org/keywords/microextraction","display_name":"microextraction","score":0.9269999861717224},{"id":"https://openalex.org/keywords/capillary-electrophoresis","display_name":"capillary electrophoresis","score":0.996999979019165},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.7630000114440918},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lc-ms-ms","display_name":"LC-MS/MS","score":0.902999997138977},{"id":"https://openalex.org/keywords/flavonoid-quantification","display_name":"flavonoid quantification","score":0.7580000162124634},{"id":"https://openalex.org/keywords/natural-product-analysis","display_name":"natural product analysis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/green-chemistry","display_name":"green chemistry","score":0.39899998903274536},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.6668000221252441},{"id":"https://openalex.org/C66204764","wikidata":"https://www.wikidata.org/wiki/Q219416","display_name":"Sustainability","level":2,"score":0.47290000319480896},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.44130000472068787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42899999022483826},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4027999937534332},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.39629998803138733},{"id":"https://openalex.org/C2988629283","wikidata":"https://www.wikidata.org/wiki/Q44337","display_name":"Complex matrix","level":2,"score":0.3950999975204468},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3944000005722046},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.38530001044273376},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33309999108314514},{"id":"https://openalex.org/C91558341","wikidata":"https://www.wikidata.org/wiki/Q725361","display_name":"Green chemistry","level":4,"score":0.3292999863624573},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3285999894142151},{"id":"https://openalex.org/C3020792226","wikidata":"https://www.wikidata.org/wiki/Q1331083","display_name":"Human use","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C170814935","wikidata":"https://www.wikidata.org/wiki/Q4751159","display_name":"Analytical technique","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3149999976158142},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C176503865","wikidata":"https://www.wikidata.org/wiki/Q5381220","display_name":"Environmental engineering science","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C3018256011","wikidata":"https://www.wikidata.org/wiki/Q898987","display_name":"Separation method","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C2987718291","wikidata":"https://www.wikidata.org/wiki/Q2095","display_name":"Food products","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C552854447","wikidata":"https://www.wikidata.org/wiki/Q131201","display_name":"Sustainable development","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.26570001244544983},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.2630000114440918},{"id":"https://openalex.org/C3019207227","wikidata":"https://www.wikidata.org/wiki/Q10883614","display_name":"Human life","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C18276189","wikidata":"https://www.wikidata.org/wiki/Q2138286","display_name":"Environmental analysis","level":2,"score":0.2529999911785126}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jcoa.2026.100310","doi":"https://doi.org/10.1016/j.jcoa.2026.100310","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcoa.2026.100310","pdf_url":null,"source":{"id":"https://openalex.org/S4210211886","display_name":"Journal of Chromatography Open","issn_l":"2772-3917","issn":["2772-3917"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography Open","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:efa3a2b8ef3b4b22a08f6c6e3293a655","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/efa3a2b8ef3b4b22a08f6c6e3293a655","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chromatography Open, Vol 9, Iss , Pp 100310- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jcoa.2026.100310","doi":"https://doi.org/10.1016/j.jcoa.2026.100310","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcoa.2026.100310","pdf_url":null,"source":{"id":"https://openalex.org/S4210211886","display_name":"Journal of Chromatography Open","issn_l":"2772-3917","issn":["2772-3917"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography Open","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.42037490010261536,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W596920516","https://openalex.org/W1914622032","https://openalex.org/W1946684142","https://openalex.org/W1976051515","https://openalex.org/W2001376656","https://openalex.org/W2015466408","https://openalex.org/W2026523033","https://openalex.org/W2049540027","https://openalex.org/W2060488109","https://openalex.org/W2071049635","https://openalex.org/W2082142840","https://openalex.org/W2084229951","https://openalex.org/W2088673175","https://openalex.org/W2095404602","https://openalex.org/W2139196828","https://openalex.org/W2166470563","https://openalex.org/W2211774112","https://openalex.org/W2507344435","https://openalex.org/W2558513992","https://openalex.org/W2565383127","https://openalex.org/W2736285103","https://openalex.org/W2789815678","https://openalex.org/W2801172935","https://openalex.org/W2887218638","https://openalex.org/W2892193414","https://openalex.org/W2930520995","https://openalex.org/W3087709740","https://openalex.org/W3132104108","https://openalex.org/W3138388644","https://openalex.org/W3147713116","https://openalex.org/W3148626141","https://openalex.org/W3149181705","https://openalex.org/W3165499556","https://openalex.org/W3198669059","https://openalex.org/W3202155886","https://openalex.org/W3215700118","https://openalex.org/W4205645806","https://openalex.org/W4212828208","https://openalex.org/W4213146499","https://openalex.org/W4213417312","https://openalex.org/W4224253174","https://openalex.org/W4281677075","https://openalex.org/W4302013369","https://openalex.org/W4303644866","https://openalex.org/W4312226049","https://openalex.org/W4385212906","https://openalex.org/W4388221667","https://openalex.org/W4390640352","https://openalex.org/W4391490429","https://openalex.org/W4391774196","https://openalex.org/W4394824121","https://openalex.org/W4394982185","https://openalex.org/W4399009666","https://openalex.org/W4402087014","https://openalex.org/W4403532496","https://openalex.org/W4407275041","https://openalex.org/W4407731119","https://openalex.org/W4410499979","https://openalex.org/W4411377706","https://openalex.org/W4412702432","https://openalex.org/W4415815068","https://openalex.org/W4416025895"],"related_works":[],"abstract_inverted_index":{"Flavonoids":[0],"are":[1,9,171,312],"a":[2,21,39,74,106,276],"diverse":[3],"group":[4],"of":[5,42,103,210,231,250,271,279,305,332],"polyphenolic":[6],"compounds.":[7],"They":[8,19],"ubiquitously":[10],"found":[11],"in":[12,24,63,77,121,282,336],"fruits,":[13],"vegetables,":[14],"tea,":[15],"and":[16,28,50,66,83,94,101,118,143,158,175,222,243,261,290,320],"medicinal":[17],"plants.":[18],"play":[20],"pivotal":[22,330],"role":[23,331],"both":[25,172],"plant":[26],"physiology":[27],"human":[29],"health.":[30],"Numerous":[31],"studies":[32,183],"have":[33,197],"demonstrated":[34],"that":[35,73,170,311],"these":[36,61,211,296],"compounds":[37,62],"exhibit":[38],"wide":[40],"range":[41],"biological":[43],"activities,":[44],"including":[45,88],"antioxidant,":[46],"anti-inflammatory,":[47],"cardioprotective,":[48],"neuroprotective,":[49],"anticancer":[51],"properties.":[52],"Accordingly,":[53],"significant":[54],"research":[55],"attention":[56],"has":[57,263],"been":[58],"directed":[59],"toward":[60],"nutraceutical,":[64],"pharmaceutical,":[65],"food":[67],"science":[68],"research.":[69],"Evidence":[70],"is":[71,110],"growing":[72],"diet":[75],"rich":[76],"flavonoids":[78,104],"can":[79],"help":[80],"to":[81,112,137,151,164,200,301],"prevent":[82],"manage":[84],"several":[85],"chronic":[86],"diseases,":[87,93],"cardiovascular":[89],"disorders,":[90],"diabetes,":[91],"neurodegenerative":[92],"certain":[95],"cancers.":[96],"However,":[97],"the":[98,144,162,186,229,248,298,302,329],"accurate":[99],"quantification":[100],"characterisation":[102],"remain":[105],"scientific":[107],"challenge.":[108],"This":[109,273],"due":[111,136],"their":[113,131,138,287],"structural":[114],"diversity,":[115],"low":[116],"stability,":[117],"matrix":[119],"complexity":[120],"natural":[122,306],"samples.":[123],"Conventional":[124],"analytical":[125,168,195,207,284,334,338],"approaches,":[126],"while":[127,340],"widely":[128],"used":[129],"for":[130,267],"effectiveness,":[132],"raise":[133],"environmental":[134,324],"concerns":[135],"reliance":[139],"on":[140,182],"toxic":[141],"solvents":[142],"resulting":[145],"hazardous":[146],"waste,":[147],"which":[148],"runs":[149],"counter":[150],"sustainable":[152,316],"chemistry":[153],"principles.":[154],"The":[155,178],"escalating":[156],"ecological":[157,342],"regulatory":[159],"demands":[160],"underscore":[161],"imperative":[163],"promptly":[165],"implement":[166],"green":[167,194,283,333],"methodologies":[169,335],"analytically":[173],"robust":[174],"ecologically":[176],"compatible.":[177],"present":[179],"review":[180,274],"focuses":[181],"published":[184],"within":[185],"past":[187],"five":[188],"years.":[189],"In":[190],"recent":[191,280],"years,":[192],"modern":[193],"techniques":[196,212],"reshaped":[198],"approaches":[199,310],"phytochemical":[201],"analysis":[202,241],"by":[203,236],"prioritizing":[204],"sustainability":[205],"alongside":[206],"performance.":[208],"Examples":[209],"include":[213],"supercritical":[214],"fluid":[215],"chromatography":[216],"(SFC),":[217],"microextraction":[218],"techniques,":[219,285],"capillary":[220],"electrophoresis,":[221],"miniaturised":[223],"spectrometric":[224],"systems.":[225],"These":[226],"methods":[227,252],"follow":[228],"principles":[230],"Green":[232],"Analytical":[233],"Chemistry":[234],"(GAC)":[235],"using":[237],"fewer":[238],"reagents,":[239],"reducing":[240],"time,":[242],"consuming":[244],"less":[245],"energy.":[246],"Also,":[247],"use":[249],"combined":[251],"(e.g.,":[253],"LC-MS/MS,":[254],"GC\u2013MS,":[255],"or":[256],"HPLC-DAD)":[257],"with":[258,322],"microfluidic":[259],"systems":[260],"biosensors":[262],"created":[264],"new":[265],"possibilities":[266],"fast,":[268],"portable":[269],"measurement":[270],"flavonoids.":[272],"provides":[275],"comprehensive":[277],"examination":[278],"advances":[281],"emphasizing":[286],"methodological":[288],"innovations":[289],"practical":[291],"applications.":[292],"By":[293],"critically":[294],"evaluating":[295],"developments,":[297],"work":[299],"contributes":[300],"ongoing":[303],"transformation":[304],"product":[307],"analysis,":[308],"fostering":[309],"not":[313],"only":[314],"more":[315],"but":[317],"also":[318],"resource-efficient":[319],"aligned":[321],"contemporary":[323],"imperatives.":[325],"Moreover,":[326],"it":[327],"underscores":[328],"improving":[337],"performance":[339],"minimising":[341],"impact.":[343]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-03T00:00:00"}
