{"id":"https://openalex.org/W7127055263","doi":"https://doi.org/10.3389/fcell.2026.1762891","title":"Decoding the brain\u2019s ATG8 paralog code: LC3\u2013GABARAP specialization at synapses and the astrocyte\u2013neuron interface","display_name":"Decoding the brain\u2019s ATG8 paralog code: LC3\u2013GABARAP specialization at synapses and the astrocyte\u2013neuron interface","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127055263","doi":"https://doi.org/10.3389/fcell.2026.1762891","pmid":"https://pubmed.ncbi.nlm.nih.gov/41705110","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12907385"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1762891","doi":"https://doi.org/10.3389/fcell.2026.1762891","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1762891","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1762891/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1762891/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018518022","display_name":"Haneul Choi","orcid":"https://orcid.org/0009-0006-6629-2212","observed_orcids":["https://orcid.org/0009-0006-6629-2212"]},"institutions":[{"id":"https://openalex.org/I112728665","display_name":"Hannam University","ror":"https://ror.org/01cwbae71","country_code":"KR","type":"education","lineage":["https://openalex.org/I112728665"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Haneul Choi","raw_affiliation_strings":["Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University","institution_ids":["https://openalex.org/I112728665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124701490","display_name":"Seung-Min Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112728665","display_name":"Hannam University","ror":"https://ror.org/01cwbae71","country_code":"KR","type":"education","lineage":["https://openalex.org/I112728665"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Min Lee","raw_affiliation_strings":["Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University","institution_ids":["https://openalex.org/I112728665"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124725515","display_name":"Jin-A. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112728665","display_name":"Hannam University","ror":"https://ror.org/01cwbae71","country_code":"KR","type":"education","lineage":["https://openalex.org/I112728665"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin-A. Lee","raw_affiliation_strings":["Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University","institution_ids":["https://openalex.org/I112728665"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5124725515"],"corresponding_institution_ids":["https://openalex.org/I112728665"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"1762891","last_page":"1762891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.949999988079071},{"id":"https://openalex.org/keywords/gabarap","display_name":"GABARAP","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/synapses","display_name":"synapses","score":0.5320000052452087},{"id":"https://openalex.org/keywords/receptor-turnover","display_name":"receptor turnover","score":0.8309999704360962},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lysosome-fusion","display_name":"lysosome fusion","score":0.753000020980835},{"id":"https://openalex.org/keywords/amyloid-beta-clearance","display_name":"amyloid-beta clearance","score":0.718999981880188},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8560000061988831},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.921999990940094},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.7509999871253967},{"id":"https://openalex.org/keywords/selective-autophagy","display_name":"selective autophagy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.910099983215332},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7318999767303467},{"id":"https://openalex.org/C2780042272","wikidata":"https://www.wikidata.org/wiki/Q27548992","display_name":"ATG8","level":4,"score":0.7195000052452087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6717000007629395},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.550599992275238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5324000120162964},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.46880000829696655},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.4609000086784363},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4302999973297119},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.40720000863075256},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.38100001215934753},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.3573000133037567},{"id":"https://openalex.org/C2777969728","wikidata":"https://www.wikidata.org/wiki/Q1270676","display_name":"Gephyrin","level":5,"score":0.3253999948501587},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.3131999969482422},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.2976999878883362},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.27880001068115234},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C2776104650","wikidata":"https://www.wikidata.org/wiki/Q2113512","display_name":"Proteotoxicity","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.2549999952316284}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2026.1762891","doi":"https://doi.org/10.3389/fcell.2026.1762891","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1762891","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1762891/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:41705110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41705110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12907385","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12907385/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b4d9a52e9029496e8337e0763edd393b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4d9a52e9029496e8337e0763edd393b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1762891","doi":"https://doi.org/10.3389/fcell.2026.1762891","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1762891","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1762891/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3417719126","display_name":null,"funder_award_id":"RS-2025-00508237","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G3812690899","display_name":null,"funder_award_id":"RS-2023","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G4460937405","display_name":null,"funder_award_id":"2025-RISE-06-013","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4844161418","display_name":null,"funder_award_id":"RS-2025-02217131","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G487934837","display_name":null,"funder_award_id":"RS-2025-00508237","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5748685320","display_name":null,"funder_award_id":"RS\u20102020\u2010NR049540","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7241089269","display_name":null,"funder_award_id":"RS-2023-NR077176","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7881291310","display_name":null,"funder_award_id":"RS-2025-02262991","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G8022801985","display_name":null,"funder_award_id":"RS-2025-02262991","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127055263.pdf","grobid_xml":"https://content.openalex.org/works/W7127055263.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W1919353","https://openalex.org/W1806909159","https://openalex.org/W1884727057","https://openalex.org/W1964057486","https://openalex.org/W1968444524","https://openalex.org/W1971898834","https://openalex.org/W1985706328","https://openalex.org/W1988855682","https://openalex.org/W1990749189","https://openalex.org/W1993201929","https://openalex.org/W1994423882","https://openalex.org/W1999522052","https://openalex.org/W2001045944","https://openalex.org/W2003407164","https://openalex.org/W2006001960","https://openalex.org/W2014413787","https://openalex.org/W2022812113","https://openalex.org/W2025060864","https://openalex.org/W2026531845","https://openalex.org/W2051629075","https://openalex.org/W2053282493","https://openalex.org/W2057539652","https://openalex.org/W2063761428","https://openalex.org/W2076930147","https://openalex.org/W2079378641","https://openalex.org/W2079733146","https://openalex.org/W2080967954","https://openalex.org/W2089180401","https://openalex.org/W2093642622","https://openalex.org/W2111567059","https://openalex.org/W2112001589","https://openalex.org/W2125236750","https://openalex.org/W2128101513","https://openalex.org/W2128537698","https://openalex.org/W2129447571","https://openalex.org/W2133470905","https://openalex.org/W2137686667","https://openalex.org/W2155015733","https://openalex.org/W2156356581","https://openalex.org/W2164945122","https://openalex.org/W2275148408","https://openalex.org/W2291070922","https://openalex.org/W2319002174","https://openalex.org/W2467513012","https://openalex.org/W2522769221","https://openalex.org/W2540740602","https://openalex.org/W2555734739","https://openalex.org/W2556818673","https://openalex.org/W2558947326","https://openalex.org/W2577326796","https://openalex.org/W2588921039","https://openalex.org/W2591498991","https://openalex.org/W2592067246","https://openalex.org/W2601754404","https://openalex.org/W2624682934","https://openalex.org/W2732951987","https://openalex.org/W2744221619","https://openalex.org/W2748821417","https://openalex.org/W2755399567","https://openalex.org/W2765408167","https://openalex.org/W2769290777","https://openalex.org/W2775851379","https://openalex.org/W2777237974","https://openalex.org/W2783503227","https://openalex.org/W2799473901","https://openalex.org/W2887384294","https://openalex.org/W2908623237","https://openalex.org/W2908742504","https://openalex.org/W2933052407","https://openalex.org/W2936367852","https://openalex.org/W2958740406","https://openalex.org/W2960967248","https://openalex.org/W2963539474","https://openalex.org/W2991916794","https://openalex.org/W3015125846","https://openalex.org/W3034595692","https://openalex.org/W3094964773","https://openalex.org/W3096224945","https://openalex.org/W3106606650","https://openalex.org/W3118485760","https://openalex.org/W3136781934","https://openalex.org/W3151202750","https://openalex.org/W3151636199","https://openalex.org/W3169315007","https://openalex.org/W3171786035","https://openalex.org/W4200463812","https://openalex.org/W4210598731","https://openalex.org/W4210681189","https://openalex.org/W4212763273","https://openalex.org/W4220988819","https://openalex.org/W4280532218","https://openalex.org/W4280536568","https://openalex.org/W4283365472","https://openalex.org/W4294266935","https://openalex.org/W4294992789","https://openalex.org/W4312186441","https://openalex.org/W4321601542","https://openalex.org/W4321613221","https://openalex.org/W4379768271","https://openalex.org/W4391384277","https://openalex.org/W4393196586","https://openalex.org/W4394689401","https://openalex.org/W4395030581","https://openalex.org/W4400916244","https://openalex.org/W4403129766","https://openalex.org/W4403158461","https://openalex.org/W4406390197","https://openalex.org/W4407911464","https://openalex.org/W4409628240","https://openalex.org/W4409866361","https://openalex.org/W4410454133","https://openalex.org/W4410706323","https://openalex.org/W4411371197","https://openalex.org/W4412522673","https://openalex.org/W4413831266","https://openalex.org/W4414414810","https://openalex.org/W4415629512"],"related_works":["https://openalex.org/W2921989942","https://openalex.org/W2789664360","https://openalex.org/W2994886188","https://openalex.org/W2799305762","https://openalex.org/W4413831266","https://openalex.org/W7106533586","https://openalex.org/W7045760823","https://openalex.org/W2514651144","https://openalex.org/W4402217412","https://openalex.org/W4405265911"],"abstract_inverted_index":{"Macroautophagy":[0],"is":[1],"essential":[2],"for":[3,128,205],"the":[4,12,41,53],"long-term":[5],"health":[6],"of":[7,31,66,133,147],"neurons":[8,95],"and":[9,23,52,73,82,85,104,112,120,131,157,165,179,187,192,201],"astrocytes":[10],"in":[11,40,94,177],"central":[13],"nervous":[14],"system":[15],"(CNS).":[16],"The":[17],"six":[18],"mammalian":[19],"ATG8":[20],"paralogs":[21],"(LC3A/B/C":[22],"GABARAP/GABARAPL1/L2)":[24],"exhibit":[25],"an":[26],"emerging":[27,184],"\u201cATG8":[28],"code\u201d\u2014a":[29],"division":[30],"labor":[32],"among":[33],"these":[34,87,148],"proteins":[35],"that":[36],"assigns":[37],"specialized":[38,198],"roles":[39],"autophagy":[42,67,100,107,116,127,142,169,199],"pathway":[43],"to":[44,161,190],"each":[45],"paralog,":[46],"enabling":[47],"fine-tuned":[48],"proteostasis":[49],"at":[50,171],"synapses":[51,172],"astrocyte\u2013neuron":[54],"interface.":[55],"This":[56],"review":[57],"synthesizes":[58],"how":[59,86],"LC3":[60],"versus":[61,96],"GABARAP":[62,77],"mediate":[63],"distinct":[64],"steps":[65],"(LC3":[68],"primarily":[69],"governs":[70],"cargo":[71],"recruitment":[72],"phagophore":[74],"expansion,":[75],"whereas":[76,167],"drives":[78],"autophagosome":[79],"maturation,":[80],"transport,":[81],"lysosomal":[83],"fusion)":[84],"molecular":[88],"distinctions":[89],"translate":[90],"into":[91],"functional":[92],"differences":[93],"astrocytes.":[97],"Neurons":[98],"coordinate":[99],"across":[101],"long":[102],"axons":[103],"synapses:":[105],"presynaptic":[106],"clears":[108],"aging":[109],"synaptic":[110,121],"vesicles":[111],"organelles,":[113],"while":[114],"postsynaptic":[115],"modulates":[117],"receptor":[118],"turnover":[119],"plasticity.":[122],"Astrocytes,":[123],"by":[124],"contrast,":[125],"leverage":[126],"metabolic":[129],"support":[130],"clearance":[132,159],"extracellular":[134],"debris":[135],"(e.g.,":[136],"amyloid-\u03b2":[137],"plaques),":[138],"interfacing":[139],"with":[140],"neuronal":[141],"via":[143],"transcellular":[144],"mechanisms.":[145],"Dysregulation":[146],"processes":[149],"underlies":[150],"diverse":[151],"CNS":[152],"disorders:":[153],"impaired":[154],"autophagic":[155],"flux":[156],"aggregate":[158],"contribute":[160],"neurodegenerative":[162],"diseases":[163],"(Alzheimer\u2019s":[164],"Parkinson\u2019s),":[166],"selective":[168],"deficits":[170],"disrupt":[173],"circuit":[174],"homeostasis":[175],"(implicated":[176],"epilepsy":[178],"autism).":[180],"Finally,":[181],"we":[182],"highlight":[183],"methodologies\u2014from":[185],"multi-omics":[186],"live":[188],"imaging":[189],"optogenetics":[191],"targeted":[193],"therapeutics\u2014that":[194],"are":[195],"illuminating":[196],"this":[197],"network":[200],"opening":[202],"novel":[203],"avenues":[204],"intervention.":[206]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-03T00:00:00"}