{"id":"https://openalex.org/W7127050034","doi":"https://doi.org/10.1186/s12964-026-02701-w","title":"MSCs-derived CRABP2 regulates Treg/CXCL1 to ameliorate alcohol-induced liver injury","display_name":"MSCs-derived CRABP2 regulates Treg/CXCL1 to ameliorate alcohol-induced liver injury","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127050034","doi":"https://doi.org/10.1186/s12964-026-02701-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41629950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12954987"},"language":"en","primary_location":{"id":"doi:10.1186/s12964-026-02701-w","doi":"https://doi.org/10.1186/s12964-026-02701-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-02701-w","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12964-026-02701-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101104165","display_name":"Chongjun Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongjun Xiao","raw_affiliation_strings":["Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124743919","display_name":"Huiling Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiling Liu","raw_affiliation_strings":["Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124694881","display_name":"Jie Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Jiang","raw_affiliation_strings":["Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124744635","display_name":"Jianning Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianning Chen","raw_affiliation_strings":["Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124723714","display_name":"Yunwei Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunwei Guo","raw_affiliation_strings":["Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101939466","display_name":"Qiuli Liu","orcid":"https://orcid.org/0000-0002-8090-8718","observed_orcids":["https://orcid.org/0000-0002-8090-8718"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiuli Liu","raw_affiliation_strings":["Biotherapy Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. liuqli3@mail.sysu.edu.cn","Cell-Gene Therapy Center (CGTC), Institute for Frontier Interdisciplinary Research in Health Sciences and Technology, Sun Yat-Sen University, Guangzhou, 510080, China. liuqli3@mail.sysu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. liuqli3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Cell-Gene Therapy Center (CGTC), Institute for Frontier Interdisciplinary Research in Health Sciences and Technology, Sun Yat-Sen University, Guangzhou, 510080, China. liuqli3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124728579","display_name":"Bin Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Wu","raw_affiliation_strings":["Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. wubin6@mail.sysu.edu.cn","Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. wubin6@mail.sysu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcoholic Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. wubin6@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I4210146956"]},{"raw_affiliation_string":"Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. wubin6@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I4210146956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101939466","https://openalex.org/A5124728579"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146956"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05255958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.3215000033378601,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/crabp2","display_name":"CRABP2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.7900000214576721},{"id":"https://openalex.org/keywords/alcoholic-hepatitis","display_name":"alcoholic hepatitis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alcohol-induced-liver-injury","display_name":"alcohol-induced liver injury","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hepatocyte-inflammation","display_name":"hepatocyte inflammation","score":0.527999997138977},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8050000071525574},{"id":"https://openalex.org/keywords/treg-depletion","display_name":"Treg depletion","score":0.625},{"id":"https://openalex.org/keywords/msc-therapy","display_name":"MSC-based therapy","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7390999794006348},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5866000056266785},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5555999875068665},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.527899980545044},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5051000118255615},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.48919999599456787},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.47620001435279846},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4717000126838684},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.335099995136261},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30320000648498535},{"id":"https://openalex.org/C2779919695","wikidata":"https://www.wikidata.org/wiki/Q4201963","display_name":"CD11c","level":4,"score":0.30149999260902405},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.2906999886035919},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.2782000005245209},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.25940001010894775},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006519","descriptor_name":"Hepatitis, Alcoholic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006519","descriptor_name":"Hepatitis, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12964-026-02701-w","doi":"https://doi.org/10.1186/s12964-026-02701-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-02701-w","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmid:41629950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41629950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication and signaling : CCS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12954987","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12954987/pdf/12964_2026_Article_2701.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Commun Signal","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0e16034790a34a688078056009966ce7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0e16034790a34a688078056009966ce7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Communication and Signaling, Vol 24, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12964-026-02701-w","doi":"https://doi.org/10.1186/s12964-026-02701-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-02701-w","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1636423811","display_name":null,"funder_award_id":"82370629","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1882414500","display_name":null,"funder_award_id":"82170604","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4264819298","display_name":null,"funder_award_id":"82070574","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1619337631","https://openalex.org/W2001288327","https://openalex.org/W2009835065","https://openalex.org/W2024933805","https://openalex.org/W2041911908","https://openalex.org/W2044227292","https://openalex.org/W2058681367","https://openalex.org/W2059714773","https://openalex.org/W2061495263","https://openalex.org/W2067740038","https://openalex.org/W2087401044","https://openalex.org/W2097053532","https://openalex.org/W2128675314","https://openalex.org/W2152084270","https://openalex.org/W2181249084","https://openalex.org/W2207804031","https://openalex.org/W2238141562","https://openalex.org/W2337861353","https://openalex.org/W2469725217","https://openalex.org/W2519292031","https://openalex.org/W2522728319","https://openalex.org/W2526341307","https://openalex.org/W2533320009","https://openalex.org/W2578174210","https://openalex.org/W2590668924","https://openalex.org/W2754195997","https://openalex.org/W2784039673","https://openalex.org/W2791304132","https://openalex.org/W2800637473","https://openalex.org/W2808158796","https://openalex.org/W2808825101","https://openalex.org/W2908494584","https://openalex.org/W2910709942","https://openalex.org/W2923662776","https://openalex.org/W2949476004","https://openalex.org/W2982252373","https://openalex.org/W3015515669","https://openalex.org/W3016176323","https://openalex.org/W3045201025","https://openalex.org/W3112001494","https://openalex.org/W3133624176","https://openalex.org/W3135621139","https://openalex.org/W3179750506","https://openalex.org/W3186731637","https://openalex.org/W3192292169","https://openalex.org/W4205759455","https://openalex.org/W4205973639","https://openalex.org/W4210980460","https://openalex.org/W4214517857","https://openalex.org/W4220760557","https://openalex.org/W4223505166","https://openalex.org/W4237588511","https://openalex.org/W4281898206","https://openalex.org/W4313475670","https://openalex.org/W4317435345","https://openalex.org/W4366352037","https://openalex.org/W4375946084","https://openalex.org/W4382020862","https://openalex.org/W4385989420"],"related_works":["https://openalex.org/W2790965559","https://openalex.org/W3006220411","https://openalex.org/W2097227226","https://openalex.org/W2910292443","https://openalex.org/W7097215093","https://openalex.org/W3008262226","https://openalex.org/W7124442643","https://openalex.org/W2969876915","https://openalex.org/W2612651702","https://openalex.org/W3005633690"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alcoholic":[1],"hepatitis":[2],"(AH)":[3],"is":[4],"an":[5,50],"inflammatory":[6,33,159,195],"disease":[7],"associated":[8],"with":[9,119,151],"high":[10],"mortality.":[11],"Mesenchymal":[12],"stromal":[13],"cells":[14,63],"(MSCs)":[15],"are":[16,163],"promising":[17,189],"immune":[18],"regulators":[19,166],"in":[20,132],"modulating":[21],"acute":[22,168],"or":[23,140],"chronic":[24],"inflammation.":[25],"However,":[26],"the":[27,31,83,97,124,152,193],"specific":[28],"mechanism":[29],"mediating":[30],"persistent":[32,194],"response":[34,196],"during":[35,167,197],"AH":[36,144],"and":[37,72,95,123,156],"therapeutic":[38],"potential":[39],"of":[40,53,60,85,99,154],"MSCs":[41,47,71,90,139],"remains":[42],"unclear.":[43],"METHODS:":[44],"We":[45],"performed":[46,76],"infusion":[48],"on":[49,77],"animal":[51],"model":[52],"acute-on-chronic":[54],"alcohol-induced":[55,169,179],"liver":[56,93,170,180],"injury.":[57,171],"Inducible":[58],"depletion":[59],"regulatory":[61],"T":[62],"(Treg)":[64],"was":[65],"achieved":[66],"using":[67],"Foxp3-DTR/EGFP":[68],"transgenic":[69],"mice.":[70],"anti-CXCL1":[73,141],"treatments":[74],"were":[75],"Treg-depleted":[78,133],"mice":[79,134],"to":[80,177],"further":[81],"elucidate":[82],"mechanisms":[84],"Treg-mediated":[86],"neutrophil":[87,114,130],"infiltration.":[88],"RESULTS:":[89],"therapy":[91],"ameliorated":[92],"damage,":[94],"elevated":[96,120],"proportion":[98,176],"Treg":[100,110,149,162,175],"by":[101,138],"secreting":[102],"cellular":[103],"retinoic":[104],"acid":[105],"binding":[106],"protein":[107],"2":[108],"(CRABP2).":[109],"deficiency":[111],"exacerbated":[112],"hepatic":[113,155],"infiltration":[115,131],"upon":[116],"alcohol":[117],"stimulation,":[118],"serum":[121],"TNF\u03b1":[122],"subsequent":[125],"hepatocellular":[126],"CXCL1":[127],"expression.":[128],"Hepatic":[129],"cannot":[135],"be":[136],"reduced":[137],"treatment.":[142],"Consistently,":[143],"patients":[145],"had":[146],"decreased":[147],"peripheral":[148,157],"proportion,":[150],"activation":[153],"CXCL1-neutrophil":[158],"axis.":[160],"CONCLUSIONS:":[161],"critical":[164],"protective":[165],"MSCs-derived":[172],"CRABP2":[173],"increases":[174],"ameliorate":[178],"injury":[181],"through":[182],"regulating":[183],"CXCL1/neutrophil":[184],"axis,":[185],"appearing":[186],"as":[187],"a":[188],"strategy":[190],"for":[191],"limiting":[192],"severe":[198],"AH.":[199]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-02-03T00:00:00"}
