{"id":"https://openalex.org/W7127048082","doi":"https://doi.org/10.4251/wjgo.v18.i2.115401","title":"Advancing precision medicine in human epidermal growth factor receptor 2 negative gastric cancer: Insights from a novel nomogram for immunochemotherapy prognosis","display_name":"Advancing precision medicine in human epidermal growth factor receptor 2 negative gastric cancer: Insights from a novel nomogram for immunochemotherapy prognosis","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127048082","doi":"https://doi.org/10.4251/wjgo.v18.i2.115401","pmid":"https://pubmed.ncbi.nlm.nih.gov/41695938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12898011"},"language":"en","primary_location":{"id":"doi:10.4251/wjgo.v18.i2.115401","doi":"https://doi.org/10.4251/wjgo.v18.i2.115401","is_oa":true,"landing_page_url":"https://doi.org/10.4251/wjgo.v18.i2.115401","pdf_url":null,"source":{"id":"https://openalex.org/S75576204","display_name":"World Journal of Gastrointestinal Oncology","issn_l":"1948-5204","issn":["1948-5204"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4251/wjgo.v18.i2.115401","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121757247","display_name":"Abinash Nayak","orcid":"https://orcid.org/0009-0007-9351-9803","observed_orcids":["https://orcid.org/0009-0007-9351-9803"]},"institutions":[{"id":"https://openalex.org/I70699430","display_name":"Utkal University","ror":"https://ror.org/0034eez47","country_code":"IN","type":"education","lineage":["https://openalex.org/I70699430"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abinash Nayak","raw_affiliation_strings":["Department of Zoology, Utkal University, Bhubaneshwar 751004, Odisha, India. abinashnayakzoology@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Utkal University, Bhubaneshwar 751004, Odisha, India. abinashnayakzoology@gmail.com","institution_ids":["https://openalex.org/I70699430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124702749","display_name":"Gunanidhi Sahoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70699430","display_name":"Utkal University","ror":"https://ror.org/0034eez47","country_code":"IN","type":"education","lineage":["https://openalex.org/I70699430"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gunanidhi Sahoo","raw_affiliation_strings":["Department of Zoology, Utkal University, Bhubaneshwar 751004, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Utkal University, Bhubaneshwar 751004, Odisha, India","institution_ids":["https://openalex.org/I70699430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012236247","display_name":"Sudhansu Sekhar Nishank","orcid":"https://orcid.org/0000-0003-4508-3914","observed_orcids":["https://orcid.org/0000-0003-4508-3914","https://orcid.org/0009-0003-0517-3103"]},"institutions":[{"id":"https://openalex.org/I70699430","display_name":"Utkal University","ror":"https://ror.org/0034eez47","country_code":"IN","type":"education","lineage":["https://openalex.org/I70699430"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudhansu Sekhar Nishank","raw_affiliation_strings":["Department of Zoology, Utkal University, Bhubaneshwar 751004, Odisha, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Utkal University, Bhubaneshwar 751004, Odisha, India","institution_ids":["https://openalex.org/I70699430"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I70699430"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"2","first_page":"115401","last_page":"115401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-negative-gastric-cancer","display_name":"HER2-negative gastric cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8759999871253967},{"id":"https://openalex.org/keywords/microsatellite-status","display_name":"microsatellite status","score":0.953000009059906},{"id":"https://openalex.org/keywords/tnm-stage","display_name":"TNM stage","score":0.8500000238418579},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.953000009059906},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-reactive-protein-albumin-lymphocyte-index","display_name":"C-reactive protein-albumin-lymphocyte index","score":0.8989999890327454},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9779999852180481},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9333999752998352},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.8928999900817871},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.801800012588501},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5573999881744385},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5231000185012817},{"id":"https://openalex.org/C2908728163","wikidata":"https://www.wikidata.org/wiki/Q415271","display_name":"Human Epidermal Growth Factor Receptor 2","level":4,"score":0.5126000046730042},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5088000297546387},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.477400004863739},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3871000111103058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3864000141620636},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35199999809265137},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33809998631477356},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3192000091075897},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.25049999356269836}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4251/wjgo.v18.i2.115401","doi":"https://doi.org/10.4251/wjgo.v18.i2.115401","is_oa":true,"landing_page_url":"https://doi.org/10.4251/wjgo.v18.i2.115401","pdf_url":null,"source":{"id":"https://openalex.org/S75576204","display_name":"World Journal of Gastrointestinal Oncology","issn_l":"1948-5204","issn":["1948-5204"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11711428","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12898011","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12898011/pdf/wjgo-18-2-115401.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41695938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41695938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastrointestinal oncology","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:12898011","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12898011/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastrointest Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4251/wjgo.v18.i2.115401","doi":"https://doi.org/10.4251/wjgo.v18.i2.115401","is_oa":true,"landing_page_url":"https://doi.org/10.4251/wjgo.v18.i2.115401","pdf_url":null,"source":{"id":"https://openalex.org/S75576204","display_name":"World Journal of Gastrointestinal Oncology","issn_l":"1948-5204","issn":["1948-5204"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127048082.pdf","grobid_xml":"https://content.openalex.org/works/W7127048082.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W3020886383","https://openalex.org/W3128646645","https://openalex.org/W3157626213","https://openalex.org/W4210990885","https://openalex.org/W4288734447","https://openalex.org/W4290079455","https://openalex.org/W4366290186","https://openalex.org/W4385429828","https://openalex.org/W4387743600","https://openalex.org/W4400040002","https://openalex.org/W4400963625","https://openalex.org/W4403341030","https://openalex.org/W4408076804","https://openalex.org/W4408350199","https://openalex.org/W4409738033","https://openalex.org/W4410208838","https://openalex.org/W4410404940","https://openalex.org/W4410741973","https://openalex.org/W4413302401","https://openalex.org/W4416126445"],"related_works":["https://openalex.org/W7163130652","https://openalex.org/W4416126445","https://openalex.org/W7161039612","https://openalex.org/W4413939840","https://openalex.org/W2566282962","https://openalex.org/W4399898675","https://openalex.org/W4392143451","https://openalex.org/W2772766969","https://openalex.org/W3081716951","https://openalex.org/W7161291334"],"abstract_inverted_index":{"Gastric":[0],"cancer":[1],"poses":[2],"a":[3,34],"significant":[4],"global":[5],"health":[6],"burden,":[7],"particularly":[8],"in":[9,24,74],"advanced":[10],"human":[11],"epidermal":[12],"growth":[13],"factor":[14],"receptor":[15],"2-negative":[16],"cases":[17],"where":[18],"prognosis":[19],"remains":[20],"poor":[21],"despite":[22],"advances":[23],"immunochemotherapy.":[25],"The":[26],"recent":[27,72],"study":[28],"by":[29],"Yao":[30],"et":[31],"al":[32],"introduces":[33],"nomogram":[35],"model":[36],"integrating":[37],"programmed":[38],"death":[39],"ligand":[40],"1":[41],"expression,":[42],"microsatellite":[43],"status,":[44],"tumor-node-metastasis":[45],"stage,":[46],"tumor":[47],"differentiation,":[48],"neutrophil-to-lymphocyte":[49],"ratio,":[50],"and":[51,58,68,76],"C-reactive":[52],"protein-albumin-lymphocyte":[53],"index":[54],"to":[55],"predict":[56],"progression-free":[57],"overall":[59],"survival.":[60],"This":[61],"letter":[62],"discusses":[63],"the":[64],"model\u2019s":[65],"strengths,":[66],"limitations,":[67],"its":[69,79],"alignment":[70],"with":[71],"developments":[73],"biomarkers":[75],"therapies,":[77],"emphasizing":[78],"potential":[80],"for":[81],"personalized":[82],"medicine.":[83]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-03T00:00:00"}