{"id":"https://openalex.org/W7127045962","doi":"https://doi.org/10.64898/2026.01.28.702357","title":"Illuminating the renal response to pH stress with single-nucleus RNA sequencing","display_name":"Illuminating the renal response to pH stress with single-nucleus RNA sequencing","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127045962","doi":"https://doi.org/10.64898/2026.01.28.702357","pmid":"https://pubmed.ncbi.nlm.nih.gov/41659579"},"language":"en","primary_location":{"id":"doi:10.64898/2026.01.28.702357","doi":"https://doi.org/10.64898/2026.01.28.702357","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.01.28.702357","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041014294","display_name":"Jianxiang Xue","orcid":"https://orcid.org/0000-0001-8847-0581","observed_orcids":["https://orcid.org/0000-0001-8847-0581"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianxiang Xue","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024233566","display_name":"Krystin Eaton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystin Eaton","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124720766","display_name":"Omar Rachidi Alaoui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Rachidi Alaoui","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016293625","display_name":"Olga Ponomarova","orcid":"https://orcid.org/0000-0001-6331-9949","observed_orcids":["https://orcid.org/0000-0001-6331-9949"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Ponomarova","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States"],"raw_orcid":"https://orcid.org/0000-0001-6331-9949","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013851126","display_name":"Kathryn J. Brayer","orcid":"https://orcid.org/0000-0002-1098-941X","observed_orcids":["https://orcid.org/0000-0002-1098-941X"]},"institutions":[{"id":"https://openalex.org/I4390039284","display_name":"UNM Comprehensive Cancer Center","ror":"https://ror.org/05kx2e072","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I169521973","https://openalex.org/I4390039284"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Kathryn J Brayer","raw_affiliation_strings":["University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I4390039284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086877801","display_name":"Nathan A. Zaidman","orcid":"https://orcid.org/0000-0003-3864-6029","observed_orcids":["https://orcid.org/0000-0003-3864-6029"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4390039284","display_name":"UNM Comprehensive Cancer Center","ror":"https://ror.org/05kx2e072","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I169521973","https://openalex.org/I4390039284"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathan A. Zaidman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States","University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States"],"raw_orcid":"https://orcid.org/0000-0003-3864-6029","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States","institution_ids":["https://openalex.org/I4390039284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086877801"],"corresponding_institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4390039284"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/alkalosis","display_name":"alkalosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8069999814033508},{"id":"https://openalex.org/keywords/single-nucleus-rna-sequencing","display_name":"single-nucleus RNA sequencing","score":0.8500000238418579},{"id":"https://openalex.org/keywords/kidney-transcriptome","display_name":"kidney transcriptome","score":0.5720000267028809},{"id":"https://openalex.org/keywords/proximal-straight-tubule","display_name":"proximal straight tubule","score":0.7839999794960022},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6579999923706055},{"id":"https://openalex.org/keywords/ammoniagenesis","display_name":"ammoniagenesis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/nephron-segments","display_name":"nephron segments","score":0.5440000295639038},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.7958999872207642},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6876999735832214},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6764000058174133},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.6729999780654907},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.6642000079154968},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6399000287055969},{"id":"https://openalex.org/C2776777027","wikidata":"https://www.wikidata.org/wiki/Q2914731","display_name":"Distal convoluted tubule","level":4,"score":0.5317000150680542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5098999738693237},{"id":"https://openalex.org/C2779403450","wikidata":"https://www.wikidata.org/wiki/Q178623","display_name":"Kidney stones","level":2,"score":0.4957999885082245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48910000920295715},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.48179998993873596},{"id":"https://openalex.org/C2779010597","wikidata":"https://www.wikidata.org/wiki/Q5166601","display_name":"Convoluted tubule","level":3,"score":0.44119998812675476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.396699994802475},{"id":"https://openalex.org/C2780498532","wikidata":"https://www.wikidata.org/wiki/Q7850941","display_name":"Tubule","level":3,"score":0.3953000009059906},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.3874000012874603},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.3862000107765198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36820000410079956},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3562000095844269},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3361000120639801},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3337000012397766},{"id":"https://openalex.org/C2781079508","wikidata":"https://www.wikidata.org/wiki/Q1516211","display_name":"Renal tubular acidosis","level":3,"score":0.31630000472068787},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2833000123500824},{"id":"https://openalex.org/C2777068682","wikidata":"https://www.wikidata.org/wiki/Q512654","display_name":"Alkalosis","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C134746045","wikidata":"https://www.wikidata.org/wiki/Q3275718","display_name":"Acid\u2013base homeostasis","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.01.28.702357","doi":"https://doi.org/10.64898/2026.01.28.702357","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.01.28.702357","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41659579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41659579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6542501449584961,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000005190","display_name":null,"funder_award_id":"P30\u2010CA118100","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000086230","display_name":null,"funder_award_id":"P20 GM130422","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000171184","display_name":null,"funder_award_id":"R00DK127215","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000887737","display_name":"Minority Institutional Research Training Program (T32)","funder_award_id":"T32HL007736","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W89068342","https://openalex.org/W135762540","https://openalex.org/W1537461545","https://openalex.org/W1940626095","https://openalex.org/W1973666679","https://openalex.org/W1978232207","https://openalex.org/W1986278462","https://openalex.org/W1990460736","https://openalex.org/W1994174181","https://openalex.org/W2010457001","https://openalex.org/W2027931280","https://openalex.org/W2035618305","https://openalex.org/W2036619231","https://openalex.org/W2039312335","https://openalex.org/W2042188046","https://openalex.org/W2049340875","https://openalex.org/W2056111746","https://openalex.org/W2057851452","https://openalex.org/W2059418104","https://openalex.org/W2069089843","https://openalex.org/W2115257346","https://openalex.org/W2120285739","https://openalex.org/W2130410032","https://openalex.org/W2163073102","https://openalex.org/W2164860876","https://openalex.org/W2168347174","https://openalex.org/W2187361792","https://openalex.org/W2214074259","https://openalex.org/W2217738232","https://openalex.org/W2228514233","https://openalex.org/W2248284212","https://openalex.org/W2513742702","https://openalex.org/W2584082995","https://openalex.org/W2902647266","https://openalex.org/W2916020270","https://openalex.org/W2945322608","https://openalex.org/W2949177718","https://openalex.org/W2951506174","https://openalex.org/W2956683312","https://openalex.org/W2972604213","https://openalex.org/W2978446784","https://openalex.org/W2997280954","https://openalex.org/W3003235058","https://openalex.org/W3036487861","https://openalex.org/W3048025734","https://openalex.org/W3126892323","https://openalex.org/W3185630056","https://openalex.org/W4205300000","https://openalex.org/W4220663642","https://openalex.org/W4229032525","https://openalex.org/W4282982919","https://openalex.org/W4285820285","https://openalex.org/W4292749511","https://openalex.org/W4297359106","https://openalex.org/W4317608131","https://openalex.org/W4362593114","https://openalex.org/W4379600655","https://openalex.org/W4386002673","https://openalex.org/W4386707745","https://openalex.org/W4388042143","https://openalex.org/W4388451846","https://openalex.org/W4388796353","https://openalex.org/W4391033742","https://openalex.org/W4391882838","https://openalex.org/W4394979394","https://openalex.org/W4400651595","https://openalex.org/W4400729501","https://openalex.org/W4400956442","https://openalex.org/W4403419477"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Maintenance":[1],"of":[2,51,63,85,105,117,130,153,167,189,204,286],"whole-body":[3,81],"pH":[4,18,43,56,69,106,217,275],"is":[5,136,142,249],"essential":[6],"for":[7,266],"human":[8],"health.":[9],"The":[10,115,202],"kidneys":[11],"play":[12],"a":[13,46,137,143,220],"crucial":[14],"role":[15],"in":[16,24,119,146],"defending":[17],"homeostasis":[19],"by":[20,213],"excreting":[21],"excess":[22],"acid":[23],"the":[25,32,100,109,120,127,133,150,154,164,174,208,214,264,270,284],"urine":[26],"and":[27,39,48,76,93,102,126,171,183,233,243,283],"returning":[28],"alkali":[29],"buffers":[30],"to":[31,60,68,72,79,95,124,157,162,216,274,280],"blood.":[33],"Consequently,":[34],"renal":[35,91,272,281],"insufficiency":[36,282],"causes":[37],"serious":[38,47],"harmful":[40],"effects":[41,104],"on":[42,108,173,181],"balance.":[44],"While":[45],"common":[49],"complication":[50],"chronic":[52,103],"kidney":[53,64,97,111,215],"disease":[54],"(CKD),":[55],"imbalances":[57,70],"themselves":[58],"appear":[59],"be":[61],"catalysts":[62],"injury.":[65,98,260],"Renal":[66],"adaptations":[67,273],"contribute":[71],"compensated":[73],"acid-base":[74,190],"disorders":[75],"are":[77,112],"vital":[78],"correcting":[80],"pH.":[82],"However,":[83,140],"overstimulation":[84],"these":[86,237],"adaptive":[87],"processes":[88],"can":[89],"cause":[90],"inflammation":[92],"lead":[94,279],"long-term":[96,271],"Surprisingly,":[99],"acute":[101],"challenges":[107,276],"whole":[110],"poorly":[113],"defined.":[114],"upregulation":[116],"ammoniagenesis":[118],"proximal":[121,221,238],"tubule":[122,223,239],"due":[123],"acidosis,":[125],"coordinated":[128],"secretion":[129],"protons":[131],"from":[132,251,258],"collecting":[134],"ducts":[135],"well-documented":[138],"phenomenon.":[139],"there":[141],"significant":[144],"gap":[145],"knowledge":[147],"regarding":[148],"how":[149],"other":[151,252],"segments":[152],"nephron":[155],"respond":[156],"acidosis":[158,170,232],"or":[159],"alkalosis.":[160,234],"Therefore,":[161],"determine":[163],"cell-specific":[165],"impact":[166],"overt":[168],"metabolic":[169],"alkalosis":[172],"kidney,":[175],"we":[176],"performed":[177],"single-nucleus":[178],"RNA":[179],"sequencing":[180],"male":[182],"female":[184],"WT":[185],"mice":[186],"following":[187,230],"48-hours":[188],"challenge":[191],"(280mM":[192],"NH4Cl":[193],"(acid),":[194],"280mM":[195,198],"NaHCO3":[196],"(alkali),":[197],"NaCl":[199],"(isosmotic":[200],"control)).":[201],"results":[203],"our":[205],"studies":[206,262],"reveal":[207],"sex-specific":[209],"single-cell":[210],"transcriptional":[211,247],"response":[212],"imbalances,":[218],"including":[219],"straight":[222],"cell":[224],"cluster":[225],"that":[226,245,256,277],"arises":[227],"de":[228],"novo":[229],"both":[231],"We":[235],"label":[236],"cells":[240,255],"PT":[241,254],"S3a":[242],"demonstrate":[244],"their":[246],"profile":[248],"distinct":[250],"injured":[253],"arise":[257],"ischemic":[259],"These":[261],"lay":[263],"foundation":[265],"future":[267],"research":[268],"into":[269],"may":[278],"development":[285],"CKD.":[287]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-02-03T00:00:00"}