{"id":"https://openalex.org/W7127045446","doi":"https://doi.org/10.21203/rs.3.rs-8418969/v1","title":"Targeting extracellular matrix deposition from tumour cells reactivates T cell infiltration and anti-PD1 response in immune-excluded triple-negative breast cancer","display_name":"Targeting extracellular matrix deposition from tumour cells reactivates T cell infiltration and anti-PD1 response in immune-excluded triple-negative breast cancer","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127045446","doi":"https://doi.org/10.21203/rs.3.rs-8418969/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-8418969/v1","doi":"https://doi.org/10.21203/rs.3.rs-8418969/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8418969/v1","pdf_url":"https://www.researchsquare.com/article/rs-8418969/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W7127045446"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-8418969/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018077287","display_name":"Oliver M.T. Pearce","orcid":"https://orcid.org/0000-0003-3953-1629","observed_orcids":["https://orcid.org/0000-0003-3953-1629"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Oliver Pearce","raw_affiliation_strings":["Barts Cancer Institute, Queen Mary University of London"],"raw_orcid":"https://orcid.org/0000-0003-3953-1629","affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088886466","display_name":"Valentine Gauthier","orcid":"https://orcid.org/0000-0001-7360-4305","observed_orcids":["https://orcid.org/0000-0001-7360-4305"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valentine Gauthier","raw_affiliation_strings":["Barts Cancer Institute, Queen Mary University of London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057647644","display_name":"Eleanor J. Tyler","orcid":"https://orcid.org/0000-0001-8945-4823","observed_orcids":["https://orcid.org/0000-0001-8945-4823"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eleanor Tyler","raw_affiliation_strings":["Queen Mary University of London"],"raw_orcid":"https://orcid.org/0000-0001-8945-4823","affiliations":[{"raw_affiliation_string":"Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124727572","display_name":"Ying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Barts Cancer Institute, Queen Mary University of London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000345935","display_name":"Eleni Maniati","orcid":"https://orcid.org/0000-0001-6993-9890","observed_orcids":["https://orcid.org/0000-0001-6993-9890"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eleni Maniati","raw_affiliation_strings":["Queen Mary University of London"],"raw_orcid":"https://orcid.org/0000-0001-6993-9890","affiliations":[{"raw_affiliation_string":"Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086748320","display_name":"Jaume Barcelo","orcid":"https://orcid.org/0000-0001-8577-1020","observed_orcids":["https://orcid.org/0000-0001-8577-1020"]},"institutions":[{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jaume Barcelo","raw_affiliation_strings":["Barts Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute","institution_ids":["https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052563437","display_name":"Nat\u00e1lia Rodrigues Mantuano","orcid":"https://orcid.org/0000-0002-1302-7013","observed_orcids":["https://orcid.org/0000-0002-1302-7013"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Natalia Rodrigues Mantuano","raw_affiliation_strings":["University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003363425","display_name":"Isabelle V. M. Siqueira","orcid":"https://orcid.org/0000-0001-9561-1610","observed_orcids":["https://orcid.org/0000-0001-9561-1610"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Isabelle Vasconcelos Menegoy Siqueira","raw_affiliation_strings":["University of Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717482","display_name":"David Marc Davies","orcid":"https://orcid.org/0000-0001-8690-6986","observed_orcids":["https://orcid.org/0000-0001-8690-6986"]},"institutions":[{"id":"https://openalex.org/I4405272435","display_name":"Leucid Bio (United Kingdom)","ror":"https://ror.org/045pe3119","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405272435"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Marc Davies","raw_affiliation_strings":["Leucid Bio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leucid Bio","institution_ids":["https://openalex.org/I4405272435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023442852","display_name":"Daniel Larcombe-Young","orcid":"https://orcid.org/0000-0002-3579-8695","observed_orcids":["https://orcid.org/0000-0002-3579-8695"]},"institutions":[{"id":"https://openalex.org/I4405272435","display_name":"Leucid Bio (United Kingdom)","ror":"https://ror.org/045pe3119","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405272435"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Larcombe-Young","raw_affiliation_strings":["Leucid Bio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leucid Bio","institution_ids":["https://openalex.org/I4405272435"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052560631","display_name":"Vinothini Rajeeve","orcid":"https://orcid.org/0000-0002-6361-4291","observed_orcids":["https://orcid.org/0000-0002-6361-4291"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vinothini Rajeeve","raw_affiliation_strings":["Barts Cancer Institute - Queen Mary University of London"],"raw_orcid":"https://orcid.org/0000-0002-6361-4291","affiliations":[{"raw_affiliation_string":"Barts Cancer Institute - Queen Mary University of London","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046510449","display_name":"Pedro R. Cutillas","orcid":"https://orcid.org/0000-0002-3426-2274","observed_orcids":["https://orcid.org/0000-0002-3426-2274","https://orcid.org/0000-0002-4207-9349"]},"institutions":[{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pedro R. Cutillas","raw_affiliation_strings":["Barts Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute","institution_ids":["https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324469","display_name":"Paul Grevitt","orcid":"https://orcid.org/0000-0001-8224-1315","observed_orcids":["https://orcid.org/0000-0001-8224-1315"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Grevitt","raw_affiliation_strings":["The Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078730275","display_name":"Jacqueline R. McDermott","orcid":"https://orcid.org/0000-0001-8052-7133","observed_orcids":["https://orcid.org/0000-0001-8052-7133"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacqueline McDermott","raw_affiliation_strings":["University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124712036","display_name":"John Maher","orcid":"https://orcid.org/0000-0001-8275-8488","observed_orcids":["https://orcid.org/0000-0001-8275-8488"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Maher","raw_affiliation_strings":["King's College London"],"raw_orcid":"https://orcid.org/0000-0001-8275-8488","affiliations":[{"raw_affiliation_string":"King's College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054532306","display_name":"\u00d3scar Maiques","orcid":"https://orcid.org/0000-0002-2172-4388","observed_orcids":["https://orcid.org/0000-0002-2172-4388"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oscar Maiques","raw_affiliation_strings":["Barts Cancer Institute , Queen Mary University of London , London , United Kingdom","College London"],"raw_orcid":"https://orcid.org/0000-0002-2172-4388","affiliations":[{"raw_affiliation_string":"Barts Cancer Institute , Queen Mary University of London , London , United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]},{"raw_affiliation_string":"College London","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013884482","display_name":"Tyson V. Sharp","orcid":"https://orcid.org/0000-0003-1861-7984","observed_orcids":["https://orcid.org/0000-0003-1861-7984"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tyson Sharp","raw_affiliation_strings":["Queen Mary University of London"],"raw_orcid":"https://orcid.org/0000-0003-1861-7984","affiliations":[{"raw_affiliation_string":"Queen Mary University of London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057625517","display_name":"Victoria Sanz\u2010Moreno","orcid":"https://orcid.org/0000-0002-5096-9456","observed_orcids":["https://orcid.org/0000-0002-5096-9456"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210090991","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76","country_code":"CA","type":"facility","lineage":["https://openalex.org/I176337269","https://openalex.org/I4210090991"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Victoria Sanz-Moreno","raw_affiliation_strings":["The Institute of Cancer Research"],"raw_orcid":"https://orcid.org/0000-0002-5096-9456","affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210090991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124720330","display_name":"J Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Jones","raw_affiliation_strings":["Barts Cancer Institute - CRUK Centre of Excellence"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute - CRUK Centre of Excellence","institution_ids":["https://openalex.org/I4405264518"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034706637","display_name":"Heinz Philipp Laubli","orcid":"https://orcid.org/0000-0002-8910-5620","observed_orcids":["https://orcid.org/0000-0002-8910-5620"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Heinz L\u00e4ubli","raw_affiliation_strings":["University of Basel"],"raw_orcid":"https://orcid.org/0000-0002-8910-5620","affiliations":[{"raw_affiliation_string":"University of Basel","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018077287"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9179999828338623},{"id":"https://openalex.org/keywords/immune-exclusion","display_name":"immune exclusion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.8930000066757202},{"id":"https://openalex.org/keywords/anti-pd-1-response","display_name":"anti-PD-1 response","score":0.8029999732971191},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.8379999995231628},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tumor-fibrosis","display_name":"tumor fibrosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7200000286102295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.671500027179718},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6255999803543091},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6062999963760376},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5536999702453613},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5297999978065491},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4754999876022339},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.47360000014305115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4542999863624573},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4487000107765198},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.42750000953674316},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C2781005279","wikidata":"https://www.wikidata.org/wiki/Q5264825","display_name":"Desmoplasia","level":4,"score":0.39899998903274536},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.38679999113082886},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3682999908924103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3531000018119812},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3395000100135803},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33410000801086426},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.3059000074863434},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.303600013256073},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.27869999408721924},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.2784999907016754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2736999988555908},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2705000042915344},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-8418969/v1","doi":"https://doi.org/10.21203/rs.3.rs-8418969/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8418969/v1","pdf_url":"https://www.researchsquare.com/article/rs-8418969/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-8418969/v1","doi":"https://doi.org/10.21203/rs.3.rs-8418969/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8418969/v1","pdf_url":"https://www.researchsquare.com/article/rs-8418969/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2198857803","display_name":null,"funder_award_id":"CTRQQR-2021\\100004","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3001951048","display_name":null,"funder_award_id":"C33043/A24478","funder_id":"https://openalex.org/F4320311061","funder_display_name":"Queen Mary University of London"},{"id":"https://openalex.org/G5071531949","display_name":null,"funder_award_id":"A27947","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6552948620","display_name":null,"funder_award_id":"C33043 / A24478","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320311061","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846"},{"id":"https://openalex.org/F4320315977","display_name":"Barts Charity","ror":"https://ror.org/0513pp416"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127045446.pdf","grobid_xml":"https://content.openalex.org/works/W7127045446.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4385684564"],"related_works":["https://openalex.org/W4379983368","https://openalex.org/W7056394646","https://openalex.org/W6982598906","https://openalex.org/W4362594269","https://openalex.org/W4207039407","https://openalex.org/W4206385491","https://openalex.org/W4220875103","https://openalex.org/W2739086840","https://openalex.org/W4404064109","https://openalex.org/W4393085468"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"growing":[2],"body":[3],"of":[4,31,85,130],"evidence":[5],"supports":[6],"that":[7],"targeting":[8,107],"the":[9],"tumour":[10,99,118],"extracellular":[11],"matrix":[12],"(ECM)":[13],"in":[14,25,44,77,86,98,111,124,132,137],"solid":[15],"cancers":[16],"holds":[17],"great":[18],"promises":[19],"to":[20,72,81],"reactivate":[21],"T":[22,53,143],"cell":[23,54,68,104],"migration":[24],"immune-excluded":[26,46,138],"patients.":[27],"By":[28],"matrisome":[29],"profiling":[30],"triple-negative":[32],"breast":[33,89],"cancer":[34,67,90,133],"(TNBC)":[35],"patients,":[36],"we":[37],"identified":[38],"two":[39,75],"core":[40],"ECM":[41,100],"proteins":[42,76],"enriched":[43],"fibrotic":[45,127],"tumours":[47,139],"and":[48,59,65,93,102,109,145],"associated":[49],"with":[50],"reduced":[51],"CD8+":[52],"stromal":[55],"infiltration,":[56],"versican":[57],"(VCAN)":[58],"fibronectin":[60],"(FN1).":[61],"Both":[62],"cancer-associated":[63],"fibroblasts":[64],"aggressive":[66],"lines":[69],"were":[70],"found":[71],"deposit":[73],"these":[74],"vitro,":[78],"conferring":[79],"resistance":[80],"T-cell-mediating":[82],"cytotoxicity.":[83],"Characterisation":[84],"vivo":[87],"murine":[88],"models":[91,113],"4T1":[92],"EMT6":[94],"revealed":[95],"significant":[96],"differences":[97],"deposition":[101],"immune":[103],"composition.":[105],"Accordingly,":[106],"Fn1":[108,131],"Vcan":[110],"both":[112],"induced":[114],"opposite":[115],"effects":[116],"on":[117],"growth.":[119],"While":[120],"it":[121],"appeared":[122],"unfavourable":[123],"inflamed":[125],"non":[126],"tumours,":[128],"deletion":[129],"cells":[134,144],"was":[135],"beneficial":[136],"by":[140],"promoting":[141],"TCF7+":[142],"restoring":[146],"anti-PD1":[147],"response.":[148]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-02-03T00:00:00"}