{"id":"https://openalex.org/W7127045263","doi":"https://doi.org/10.1002/ange.202518911","title":"Light\u2010Driven Competitive Selection in a Protein\u2010Catalyzed Dissipative Peptide Replication","display_name":"Light\u2010Driven Competitive Selection in a Protein\u2010Catalyzed Dissipative Peptide Replication","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127045263","doi":"https://doi.org/10.1002/ange.202518911"},"language":"en","primary_location":{"id":"doi:10.1002/ange.202518911","doi":"https://doi.org/10.1002/ange.202518911","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ange.202518911","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/ange.202518911","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038198053","display_name":"\u00c9va Bartus","orcid":"https://orcid.org/0000-0001-9976-6978","observed_orcids":["https://orcid.org/0000-0001-9976-6978"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c9va Bartus","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078133458","display_name":"Edit W\u00e9ber","orcid":"https://orcid.org/0000-0002-5904-0619","observed_orcids":["https://orcid.org/0000-0002-5904-0619"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Edit W\u00e9ber","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary","HUN\u2010REN\u2010SZTE Biomimetic Systems Research Group University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]},{"raw_affiliation_string":"HUN\u2010REN\u2010SZTE Biomimetic Systems Research Group University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021240690","display_name":"Attila T\u00f6k\u00f6li","orcid":"https://orcid.org/0000-0001-8413-3182","observed_orcids":["https://orcid.org/0000-0001-8413-3182"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","HU"],"is_corresponding":false,"raw_author_name":"Attila T\u00f6k\u00f6li","raw_affiliation_strings":["Department of Biochemistry University of Cambridge  Cambridge UK","Department of Medical Chemistry University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry University of Cambridge  Cambridge UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018541223","display_name":"Ferenc Bog\u00e1r","orcid":"https://orcid.org/0000-0002-0611-1452","observed_orcids":["https://orcid.org/0000-0002-0611-1452"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Ferenc Bog\u00e1r","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary","HUN\u2010REN\u2010SZTE Biomimetic Systems Research Group University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]},{"raw_affiliation_string":"HUN\u2010REN\u2010SZTE Biomimetic Systems Research Group University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124736675","display_name":"Momen R. F. Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG","HU"],"is_corresponding":false,"raw_author_name":"Momen R. F. Mohamed","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary","Department of Medicinal Chemistry Faculty of Pharmacy Minia University  Minia Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]},{"raw_affiliation_string":"Department of Medicinal Chemistry Faculty of Pharmacy Minia University  Minia Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010438676","display_name":"G\u00e1bor Kecskem\u00e9ti","orcid":"https://orcid.org/0000-0002-5584-6869","observed_orcids":["https://orcid.org/0000-0002-5584-6869"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor Kecskem\u00e9ti","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123664061","display_name":"Zoltan Szabo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Szab\u00f3","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074343449","display_name":"Zolt\u00e1n Kele","orcid":"https://orcid.org/0000-0002-4401-0302","observed_orcids":["https://orcid.org/0000-0002-4401-0302"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Kele","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124720693","display_name":"Andr\u00e1s Perczel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Andr\u00e1s Perczel","raw_affiliation_strings":["HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","HUN\u2010REN\u2010ELTE Protein Modeling Research Group, Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary","Laboratory of Structural Chemistry and Biology Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","institution_ids":["https://openalex.org/I80251312"]},{"raw_affiliation_string":"HUN\u2010REN\u2010ELTE Protein Modeling Research Group, Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary","institution_ids":["https://openalex.org/I106118109"]},{"raw_affiliation_string":"Laboratory of Structural Chemistry and Biology Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary","institution_ids":["https://openalex.org/I106118109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092559989","display_name":"M\u00e1rton Gadanecz","orcid":"https://orcid.org/0009-0009-8076-7597","observed_orcids":["https://orcid.org/0009-0009-8076-7597"]},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M\u00e1rton Gadanecz","raw_affiliation_strings":["HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","Hevesy Gy\u00f6rgy PhD School of Chemistry Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary","Laboratory of Structural Chemistry and Biology Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","institution_ids":["https://openalex.org/I80251312"]},{"raw_affiliation_string":"Hevesy Gy\u00f6rgy PhD School of Chemistry Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary","institution_ids":["https://openalex.org/I106118109"]},{"raw_affiliation_string":"Laboratory of Structural Chemistry and Biology Institute of Chemistry E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary","institution_ids":["https://openalex.org/I106118109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063702078","display_name":"Zolt\u00e1n Orgov\u00e1n","orcid":"https://orcid.org/0000-0002-8002-3047","observed_orcids":["https://orcid.org/0000-0002-8002-3047"]},"institutions":[{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Orgov\u00e1n","raw_affiliation_strings":["HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","Medicinal Chemistry Research Group HUN\u2010REN Research Centre For Natural Sciences  Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","institution_ids":["https://openalex.org/I80251312"]},{"raw_affiliation_string":"Medicinal Chemistry Research Group HUN\u2010REN Research Centre For Natural Sciences  Budapest Hungary","institution_ids":["https://openalex.org/I80251312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124695920","display_name":"Gy\u00f6rgy Mikl\u00f3s Keser\u0171","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29770179","display_name":"Budapest University of Technology and Economics","ror":"https://ror.org/02w42ss30","country_code":"HU","type":"education","lineage":["https://openalex.org/I29770179"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gy\u00f6rgy M. Keser\u0171","raw_affiliation_strings":["Department of Organic Chemistry and Technology Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics  Budapest Hungary","HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","Medicinal Chemistry Research Group HUN\u2010REN Research Centre For Natural Sciences  Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry and Technology Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics  Budapest Hungary","institution_ids":["https://openalex.org/I29770179"]},{"raw_affiliation_string":"HUN\u2010REN Research Centre For Natural Sciences Drug Innovation Centre and National Drug Discovery and Development Laboratory  Budapest Hungary","institution_ids":["https://openalex.org/I80251312"]},{"raw_affiliation_string":"Medicinal Chemistry Research Group HUN\u2010REN Research Centre For Natural Sciences  Budapest Hungary","institution_ids":["https://openalex.org/I80251312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084188691","display_name":"Tam\u00e1s A. Martinek","orcid":"https://orcid.org/0000-0003-3168-8066","observed_orcids":["https://orcid.org/0000-0003-3168-8066"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Tam\u00e1s A. Martinek","raw_affiliation_strings":["Department of Medical Chemistry University of Szeged  Szeged Hungary","HUN\u2010REN\u2010SZTE Biomimetic Systems Research Group University of Szeged  Szeged Hungary"],"raw_orcid":"https://orcid.org/0000-0003-3168-8066","affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]},{"raw_affiliation_string":"HUN\u2010REN\u2010SZTE Biomimetic Systems Research Group University of Szeged  Szeged Hungary","institution_ids":["https://openalex.org/I227486990"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":{"value":5790,"currency":"USD","value_usd":5790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09503368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"138","issue":"18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prebiotic-evolution","display_name":"prebiotic evolution","score":0.7879999876022339},{"id":"https://openalex.org/keywords/dissipative-systems","display_name":"dissipative systems","score":0.621999979019165},{"id":"https://openalex.org/keywords/protein-catalysis","display_name":"protein catalysis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/helical-foldamers","display_name":"helical foldamers","score":0.8650000095367432},{"id":"https://openalex.org/keywords/competitive-selection","display_name":"competitive selection","score":0.8610000014305115},{"id":"https://openalex.org/keywords/uva-radiation","display_name":"UVA","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C37263863","wikidata":"https://www.wikidata.org/wiki/Q786897","display_name":"Autocatalysis","level":3,"score":0.7692999839782715},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.5831000208854675},{"id":"https://openalex.org/C99692599","wikidata":"https://www.wikidata.org/wiki/Q596577","display_name":"Dissipative system","level":2,"score":0.5478000044822693},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.47269999980926514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45879998803138733},{"id":"https://openalex.org/C50318809","wikidata":"https://www.wikidata.org/wiki/Q2145081","display_name":"Replicator equation","level":3,"score":0.43950000405311584},{"id":"https://openalex.org/C95514000","wikidata":"https://www.wikidata.org/wiki/Q786897","display_name":"Autocatalytic reaction","level":2,"score":0.38989999890327454},{"id":"https://openalex.org/C155242204","wikidata":"https://www.wikidata.org/wiki/Q407525","display_name":"RNA world hypothesis","level":5,"score":0.3573000133037567},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C190161988","wikidata":"https://www.wikidata.org/wiki/Q231218","display_name":"Abiogenesis","level":2,"score":0.3431999981403351},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3174999952316284},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.3066999912261963},{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28279998898506165},{"id":"https://openalex.org/C3019856697","wikidata":"https://www.wikidata.org/wiki/Q912894","display_name":"Competitive binding","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C2988562018","wikidata":"https://www.wikidata.org/wiki/Q1063","display_name":"Biological evolution","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26919999718666077},{"id":"https://openalex.org/C2908542902","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed Molecular Evolution","level":5,"score":0.2612999975681305},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.202518911","doi":"https://doi.org/10.1002/ange.202518911","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ange.202518911","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/ange.202518911","doi":"https://doi.org/10.1002/ange.202518911","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ange.202518911","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1965061544","https://openalex.org/W1977643725","https://openalex.org/W1985405860","https://openalex.org/W1993444065","https://openalex.org/W2003194010","https://openalex.org/W2010087060","https://openalex.org/W2046230274","https://openalex.org/W2058598267","https://openalex.org/W2095498131","https://openalex.org/W2097868325","https://openalex.org/W2120520995","https://openalex.org/W2141233921","https://openalex.org/W2162557527","https://openalex.org/W2172112589","https://openalex.org/W2263385165","https://openalex.org/W2268742660","https://openalex.org/W2334348545","https://openalex.org/W2605925461","https://openalex.org/W2790340711","https://openalex.org/W2903779493","https://openalex.org/W2974978457","https://openalex.org/W3003257820","https://openalex.org/W3005500265","https://openalex.org/W3048675459","https://openalex.org/W3084197714","https://openalex.org/W3092450103","https://openalex.org/W4212805291","https://openalex.org/W4213238690","https://openalex.org/W4232501942","https://openalex.org/W4379741666","https://openalex.org/W4388251328","https://openalex.org/W4398171466","https://openalex.org/W4400018501","https://openalex.org/W4402925910","https://openalex.org/W4403434111","https://openalex.org/W4404741627"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Theoretical":[1],"models":[2],"of":[3,30],"prebiotic":[4],"evolution":[5],"propose":[6],"that":[7,17,50,114],"catalytic":[8],"modulation":[9],"can":[10,124],"influence":[11],"autocatalytic":[12,75],"replication":[13,29,61],"cycles.":[14],"We":[15],"hypothesized":[16],"a":[18,23,44,51,63,106],"protein":[19,69],"catalyst":[20,43],"could":[21],"create":[22],"favorable":[24],"environment":[25],"for":[26,92],"proximity\u2010controlled,":[27],"dissipative":[28,128],"primitive":[31,132],"peptides.":[32],"This":[33,99],"setup,":[34],"in":[35,62,120,130],"principle,":[36],"allows":[37],"competitive":[38,87],"selection":[39,103],"by":[40],"making":[41],"the":[42,80,97,115],"limited":[45],"resource.":[46],"Here,":[47],"we":[48],"show":[49],"structurally":[52],"flexible":[53],"and":[54,74],"promiscuous":[55],"protein,":[56],"calmodulin,":[57],"catalyzes":[58],"UVA":[59],"light\u2010driven":[60],"helical":[64],"foldamer\u2010based":[65],"replicator":[66,108,133],"system.":[67],"The":[68,83],"accelerates":[70],"both":[71],"non\u2010autocatalytic":[72],"synthesis":[73],"replication,":[76],"with":[77],"autocatalysis":[78],"being":[79],"dominant":[81],"pathway.":[82],"system":[84],"demonstrates":[85],"light\u2010intensity\u2010dependent":[86],"selection,":[88],"where":[89],"replicators":[90],"compete":[91],"scarce":[93],"binding":[94],"sites":[95],"on":[96],"catalyst.":[98],"mechanism":[100],"enables":[101],"efficient":[102],"even":[104],"within":[105],"large":[107],"pool.":[109],"Our":[110],"results":[111],"provide":[112],"evidence":[113],"specific":[116],"catalyst\u2013replicator":[117],"interactions":[118],"envisioned":[119],"Eigen's":[121],"hypercycle":[122],"model":[123],"be":[125],"approximated":[126],"under":[127],"conditions":[129],"catalyzed":[131],"systems.":[134]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-02-03T00:00:00"}