{"id":"https://openalex.org/W7127044724","doi":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","title":"Treatment Outcome of West Syndrome with Low-Dose ACTH Therapy in A Tertiary Care Center in Bangladesh","display_name":"Treatment Outcome of West Syndrome with Low-Dose ACTH Therapy in A Tertiary Care Center in Bangladesh","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127044724","doi":"https://doi.org/10.3329/cmoshmcj.v24i1.82519"},"language":"en","primary_location":{"id":"doi:10.3329/cmoshmcj.v24i1.82519","doi":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","is_oa":true,"landing_page_url":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","pdf_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/82519/56857","source":{"id":"https://openalex.org/S2764821823","display_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","issn_l":"2305-7890","issn":["2305-7890","2306-4919"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/82519/56857","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111685155","display_name":"Dhananjoy Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098085","display_name":"Chattagram Maa-O-Shishu Hospital Medical College","ror":"https://ror.org/00y8zcm61","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210098085"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Dhananjoy Das","raw_affiliation_strings":["Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh","institution_ids":["https://openalex.org/I4210098085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088762677","display_name":"Fahim Hasan Reza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098085","display_name":"Chattagram Maa-O-Shishu Hospital Medical College","ror":"https://ror.org/00y8zcm61","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210098085"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Fahim Hasan Reza","raw_affiliation_strings":["Department of Paediatric Critical Care Medicine (PCCM) Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Critical Care Medicine (PCCM) Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh","institution_ids":["https://openalex.org/I4210098085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071930670","display_name":"Rehena Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098085","display_name":"Chattagram Maa-O-Shishu Hospital Medical College","ror":"https://ror.org/00y8zcm61","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210098085"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Rehena Ahmed","raw_affiliation_strings":["Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh","institution_ids":["https://openalex.org/I4210098085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092540086","display_name":"Wahida Akther","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098085","display_name":"Chattagram Maa-O-Shishu Hospital Medical College","ror":"https://ror.org/00y8zcm61","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210098085"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Wahida Akther","raw_affiliation_strings":["Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh","institution_ids":["https://openalex.org/I4210098085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085792603","display_name":"Mahmood Ahmed Chowdhury","orcid":"https://orcid.org/0000-0003-0252-4900","observed_orcids":["https://orcid.org/0000-0003-0252-4900"]},"institutions":[{"id":"https://openalex.org/I4210098085","display_name":"Chattagram Maa-O-Shishu Hospital Medical College","ror":"https://ror.org/00y8zcm61","country_code":"BD","type":"education","lineage":["https://openalex.org/I4210098085"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mahmood A Chowdhury","raw_affiliation_strings":["Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatric Neurology and Development Chattagram Maa-O-Shishu Hospital Medical College Chattogram, Bangladesh","institution_ids":["https://openalex.org/I4210098085"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210098085"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":"87","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11097","display_name":"Cerebral Palsy and Movement Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/west-syndrome","display_name":"West syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8999999761581421},{"id":"https://openalex.org/keywords/epileptic-spasms","display_name":"epileptic spasms","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hypsarrhythmia","display_name":"hypsarrhythmia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6190000176429749},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.8420000076293945},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4090000092983246},{"id":"https://openalex.org/keywords/vigabatrin","display_name":"vigabatrin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9760000109672546},{"id":"https://openalex.org/keywords/eeg-responses","display_name":"EEG responses","score":0.6110000014305115},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.5149999856948853},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bangladesh","display_name":"Bangladesh","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.904699981212616},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6765000224113464},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5234000086784363},{"id":"https://openalex.org/C2991842025","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Tertiary care","level":2,"score":0.49790000915527344},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4593000113964081},{"id":"https://openalex.org/C2910479173","wikidata":"https://www.wikidata.org/wiki/Q1041258","display_name":"West Syndrome","level":3,"score":0.44679999351501465},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.4390999972820282},{"id":"https://openalex.org/C2779888125","wikidata":"https://www.wikidata.org/wiki/Q467590","display_name":"Hypsarrhythmia","level":3,"score":0.429500013589859},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4034000039100647},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3880999982357025},{"id":"https://openalex.org/C2908795159","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotrophic hormone","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C2778734009","wikidata":"https://www.wikidata.org/wiki/Q55785625","display_name":"Epilepsy syndromes","level":3,"score":0.2754000127315521},{"id":"https://openalex.org/C2780837902","wikidata":"https://www.wikidata.org/wiki/Q421663","display_name":"Vigabatrin","level":4,"score":0.27469998598098755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3329/cmoshmcj.v24i1.82519","doi":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","is_oa":true,"landing_page_url":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","pdf_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/82519/56857","source":{"id":"https://openalex.org/S2764821823","display_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","issn_l":"2305-7890","issn":["2305-7890","2306-4919"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3329/cmoshmcj.v24i1.82519","doi":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","is_oa":true,"landing_page_url":"https://doi.org/10.3329/cmoshmcj.v24i1.82519","pdf_url":"https://www.banglajol.info/index.php/CMOSHMCJ/article/download/82519/56857","source":{"id":"https://openalex.org/S2764821823","display_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","issn_l":"2305-7890","issn":["2305-7890","2306-4919"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chattagram Maa-O-Shishu Hospital Medical College Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127044724.pdf","grobid_xml":"https://content.openalex.org/works/W7127044724.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4210682239","https://openalex.org/W2136811990","https://openalex.org/W2134910395","https://openalex.org/W299889543","https://openalex.org/W2026543005","https://openalex.org/W4386822692","https://openalex.org/W2391178155","https://openalex.org/W2461260014","https://openalex.org/W7100759640","https://openalex.org/W2104381022"],"abstract_inverted_index":{"Background:":[0],"Corticosteroids,":[1],"Adrenocorticotrophic":[2],"Hormone":[3],"(ACTH)":[4],"and":[5,59,86,111,113,121,137,150,160,169,194,199,213,218,237,245,267],"vigabatrin":[6],"are":[7,22],"considered":[8],"to":[9,39,46,81,94],"be":[10],"the":[11,15,26,48,54,68,100,130,154,157,180,225],"first-line":[12],"drug":[13],"for":[14],"treatment":[16,33,55],"of":[17,32,34,50,56,70,73,129,145,147,156,183,187,205,224,265,269],"West":[18],"Syndrome":[19],"(WS).":[20],"There":[21],"little":[23],"consensus":[24],"regarding":[25],"definitive":[27],"dose,":[28],"efficacy":[29],"or":[30],"duration":[31],"these":[35],"agents":[36],"in":[37,53,67,99,192,207,211,241,254,263,271],"comparison":[38],"each":[40],"other.":[41],"So":[42],"this":[43],"study":[44,64,101],"aimed":[45],"assess":[47],"effectiveness":[49],"low-dose":[51],"ACTH":[52,109,162,260],"WS.":[57,274],"Materials":[58],"methods:":[60],"A":[61],"prospective":[62],"observational":[63],"was":[65,104,132,164,179,190,209,239,252,261],"conducted":[66],"Department":[69],"Child":[71],"neurology":[72],"Chattagram":[74],"Maa":[75,276],"Shishu-O-General":[76],"Hospital":[77],"from":[78],"January":[79],"2021":[80],"December":[82],"2022.":[83],"One":[84],"hundered":[85],"five":[87],"children":[88,273],"with":[89,106,272],"WS":[90],"aged":[91],"two":[92,95,120,198,217],"months":[93,136],"years":[96],"old":[97],"enrolled":[98],"population.":[102],"Treatment":[103],"initiated":[105],"low":[107],"dose":[108,259],"(20IU-40IU/day)":[110],"clinical":[112],"Electroencephalographic":[114],"(EEG)":[115],"responses":[116],"were":[117,139],"assessed":[118],"at":[119,165,197,216],"four":[122,200,219,250],"weeks.":[123],"Results:":[124],"The":[125,141],"mean":[126,142],"\u00b1SD":[127,143],"age":[128,144],"patients":[131,196,215,226],"11.21":[133],"\u00b1":[134,167,171],"7.86":[135],"74.28%":[138],"male.":[140],"onset":[146,155],"epileptic":[148,158,176,188],"spasm":[149,159,177,189,266],"time":[151],"interval":[152],"between":[153],"initiating":[161],"therapy":[163],"6.00":[166],"5.01":[168],"5.26":[170],"4.36":[172],"months,":[173],"respectively.":[174,203,221],"Symptomatic":[175],"76(72%)":[178],"major":[181],"category":[182],"spasm.":[184],"Clinical":[185],"cessation":[186,264],"found":[191,240,253],"55(52.38%)":[193],"71(67.61%)":[195],"weeks":[201,251],"follow-up,":[202],"Cessation":[204],"hypsarrythmia":[206],"EEG":[208],"noticed":[210],"24(27%)":[212],"66(62.8%)":[214],"weeks,":[220],"Majority":[222],"(65.71%)":[223],"did":[227],"not":[228],"have":[229],"any":[230],"adverse":[231],"effect.":[232],"Irritability,":[233],"sleep":[234],"disturbance,":[235],"infection":[236],"hypertension":[238],"21(20%),":[242],"7(6.6%),":[243],"5(4.7%)":[244],"3(2.8%)":[246],"patients.":[247],"Relapse":[248],"after":[249],"12":[255],"(11.4%).":[256],"Conclusion:":[257],"Low":[258],"effective":[262],"resolution":[268],"hypsarrhythmia":[270],"Chatt":[275],"Shi":[277],"Hosp":[278],"Med":[279],"Coll":[280],"J;":[281],"Vol.24":[282],"(1);":[283],"Jan":[284],"2025;":[285],"Page":[286],"87-90":[287]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-03T00:00:00"}
