{"id":"https://openalex.org/W7127044179","doi":"https://doi.org/10.4251/wjgo.v18.i2.113673","title":"Serum protein induced by vitamin K absence or antagonist-II predicts aggressive tumor biology in alpha-fetoprotein-normal hepatocellular carcinoma","display_name":"Serum protein induced by vitamin K absence or antagonist-II predicts aggressive tumor biology in alpha-fetoprotein-normal hepatocellular carcinoma","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127044179","doi":"https://doi.org/10.4251/wjgo.v18.i2.113673","pmid":"https://pubmed.ncbi.nlm.nih.gov/41695928","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12898172"},"language":"en","primary_location":{"id":"doi:10.4251/wjgo.v18.i2.113673","doi":"https://doi.org/10.4251/wjgo.v18.i2.113673","is_oa":true,"landing_page_url":"https://doi.org/10.4251/wjgo.v18.i2.113673","pdf_url":"https://rcastoragev2.blob.core.windows.net/6a44675a2da3de0c9aaf18587f3b7545/PMC7111028.pdf","source":{"id":"https://openalex.org/S75576204","display_name":"World Journal of Gastrointestinal Oncology","issn_l":"1948-5204","issn":["1948-5204"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7127044179"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rcastoragev2.blob.core.windows.net/6a44675a2da3de0c9aaf18587f3b7545/PMC7111028.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124716717","display_name":"Zaigham Abbas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140751","display_name":"Ziauddin Hospital","ror":"https://ror.org/041g86f21","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210140751"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zaigham Abbas","raw_affiliation_strings":["Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan. drzabbas@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan. drzabbas@gmail.com","institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093879529","display_name":"Darayus Percy Gazder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140751","display_name":"Ziauddin Hospital","ror":"https://ror.org/041g86f21","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210140751"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Darayus P Gazder","raw_affiliation_strings":["Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan","institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056609574","display_name":"Zeeshan Hyder","orcid":"https://orcid.org/0000-0002-1081-1849","observed_orcids":["https://orcid.org/0000-0002-1081-1849"]},"institutions":[{"id":"https://openalex.org/I4210140751","display_name":"Ziauddin Hospital","ror":"https://ror.org/041g86f21","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210140751"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zeeshan Hyder","raw_affiliation_strings":["Department of Hepatobiliary Surgery and Liver Transplantation, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery and Liver Transplantation, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan","institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085336212","display_name":"Muhammad Ali Qadeer","orcid":"https://orcid.org/0000-0003-3811-9579","observed_orcids":["https://orcid.org/0000-0003-3811-9579"]},"institutions":[{"id":"https://openalex.org/I4210140751","display_name":"Ziauddin Hospital","ror":"https://ror.org/041g86f21","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210140751"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Ali Qadeer","raw_affiliation_strings":["Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan","institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088486505","display_name":"Minaam Abbas","orcid":"https://orcid.org/0000-0002-0271-9292","observed_orcids":["https://orcid.org/0000-0002-0271-9292"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210140751","display_name":"Ziauddin Hospital","ror":"https://ror.org/041g86f21","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210140751"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["GB","PK"],"is_corresponding":false,"raw_author_name":"Minaam Abbas","raw_affiliation_strings":["Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan","Department of Medicine, University of Cambridge, Cambridge CB2 1QN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi 75600, Sindh, Pakistan","institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"]},{"raw_affiliation_string":"Department of Medicine, University of Cambridge, Cambridge CB2 1QN, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.8009,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92349419,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"18","issue":"2","first_page":"113673","last_page":"113673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/des-gamma-carboxy-prothrombin","display_name":"PIVKA-II","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alpha-fetoprotein-negative","display_name":"alpha-fetoprotein-negative","score":0.7570000290870667},{"id":"https://openalex.org/keywords/portal-vein-tumor-thrombus","display_name":"portal vein tumor thrombus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/milan-criteria","display_name":"Milan criteria","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-aggressiveness-prediction","display_name":"tumor aggressiveness prediction","score":0.5580000281333923},{"id":"https://openalex.org/keywords/liver-transplantation-eligibility","display_name":"liver transplantation eligibility","score":0.4390000104904175},{"id":"https://openalex.org/keywords/decompensated-cirrhosis","display_name":"decompensated cirrhosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prognostic-cutoff-values","display_name":"prognostic cutoff values","score":0.5809999704360962},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7533000111579895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7457000017166138},{"id":"https://openalex.org/C2993590494","wikidata":"https://www.wikidata.org/wiki/Q182338","display_name":"Vitamin k","level":2,"score":0.6517999768257141},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5425000190734863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3928000032901764},{"id":"https://openalex.org/C3020081911","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Serum concentration","level":2,"score":0.3873000144958496},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30820000171661377},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.296999990940094},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29089999198913574},{"id":"https://openalex.org/C2994136372","wikidata":"https://www.wikidata.org/wiki/Q110084","display_name":"Blood serum","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28529998660087585},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4251/wjgo.v18.i2.113673","doi":"https://doi.org/10.4251/wjgo.v18.i2.113673","is_oa":true,"landing_page_url":"https://doi.org/10.4251/wjgo.v18.i2.113673","pdf_url":"https://rcastoragev2.blob.core.windows.net/6a44675a2da3de0c9aaf18587f3b7545/PMC7111028.pdf","source":{"id":"https://openalex.org/S75576204","display_name":"World Journal of Gastrointestinal Oncology","issn_l":"1948-5204","issn":["1948-5204"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12898172","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12898172/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12898172/pdf/wjgo-18-2-113673.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastrointest Oncol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11711434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12898172","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41695928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41695928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastrointestinal oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4251/wjgo.v18.i2.113673","doi":"https://doi.org/10.4251/wjgo.v18.i2.113673","is_oa":true,"landing_page_url":"https://doi.org/10.4251/wjgo.v18.i2.113673","pdf_url":"https://rcastoragev2.blob.core.windows.net/6a44675a2da3de0c9aaf18587f3b7545/PMC7111028.pdf","source":{"id":"https://openalex.org/S75576204","display_name":"World Journal of Gastrointestinal Oncology","issn_l":"1948-5204","issn":["1948-5204"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127044179.pdf","grobid_xml":"https://content.openalex.org/works/W7127044179.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1525360702","https://openalex.org/W2045556691","https://openalex.org/W2059665962","https://openalex.org/W2181910904","https://openalex.org/W2315027248","https://openalex.org/W2330134488","https://openalex.org/W2582878252","https://openalex.org/W2618341908","https://openalex.org/W2895565245","https://openalex.org/W2969846817","https://openalex.org/W3006445783","https://openalex.org/W3107429779","https://openalex.org/W3162270595","https://openalex.org/W3173274954","https://openalex.org/W4306759100","https://openalex.org/W4313327002","https://openalex.org/W4321459779","https://openalex.org/W4389951754","https://openalex.org/W4394683035","https://openalex.org/W4411863665"],"related_works":["https://openalex.org/W4415412111","https://openalex.org/W3173274954","https://openalex.org/W7161003306","https://openalex.org/W3030449887","https://openalex.org/W2055499437","https://openalex.org/W2401761015","https://openalex.org/W2890926168","https://openalex.org/W2045952978","https://openalex.org/W6995868001","https://openalex.org/W7122832741"],"abstract_inverted_index":{"BACKGROUND":[0],"Patients":[1],"with":[2,11,42,72,125,203,219],"hepatocellular":[3],"carcinoma":[4],"(HCC)":[5],"beyond":[6,85],"the":[7,20,36,57,216,225,265],"Milan":[8,86],"criteria":[9],"or":[10,77],"portal":[12,88],"vein":[13,89],"tumor":[14,90,205],"thrombosis":[15,91],"are":[16],"often":[17],"excluded":[18],"from":[19],"transplant":[21],"list":[22],"owing":[23],"to":[24],"aggressive":[25,132,164,204,226,241],"biology":[26],"and":[27,75,115,187,250],"recurrence":[28],"risk.":[29],"While":[30],"high":[31],"alpha-fetoprotein":[32],"(AFP)":[33],"signals":[34],"aggressiveness,":[35],"behavior":[37],"of":[38,60,69,181,245,267],"normal":[39,63,73,76,236],"AFP":[40,64,74,237],"HCC":[41,165],"elevated":[43,78],"protein":[44],"induced":[45],"by":[46],"vitamin":[47],"K":[48],"absence/antagonist-II":[49],"(PIVKA-II)":[50],"is":[51],"less":[52],"defined.":[53],"AIM":[54],"To":[55],"assess":[56],"prognostic":[58],"value":[59,175],"PIVKA-II":[61,107,128,196,239,268],"in":[62,131,224],"HCC.":[65],"METHODS":[66],"Retrospective":[67],"cohort":[68],"113":[70],"patients":[71,218],"PIVKA-II.":[79],"\u201cAggressive\u201d":[80],"tumors":[81],"were":[82,96,223,232],"defined":[83],"as":[84],"and/or":[87],"(n":[92,98],"=":[93,99,210,213],"63);":[94],"others":[95],"non-aggressive":[97],"50).":[100],"Receiver":[101],"operating":[102,152],"characteristic":[103,153],"curve":[104,154],"analysis":[105,193],"identified":[106],"cut-offs.":[108],"RESULTS":[109],"This":[110],"study":[111],"included":[112],"78":[113],"men":[114],"35":[116],"women;":[117],"mean":[118],"age":[119],"58.4":[120],"\u00b1":[121],"11.1":[122],"years;":[123],"62.8%":[124],"decompensated":[126],"cirrhosis.":[127],"was":[129,166,200],"higher":[130],"tumors:":[133],"Median":[134],"2785":[135],"mAU/mL":[136,142,168,183,199,222,247,253,258],"(interquartile":[137,143],"range:":[138,144],"222-8152)":[139],"vs":[140],"239":[141],"55-727),":[145],"P":[146,212],"<":[147],"0.001.":[148],"Area":[149],"under":[150],"receiver":[151],"0.756":[155],"(95%":[156],"confidence":[157],"interval:":[158],"0.669-0.844).":[159],"The":[160],"Youden-optimized":[161],"cut-off":[162,180,244],"for":[163],"1609.5":[167,246],"[sensitivity:":[169],"0.54,":[170],"specificity:":[171],"0.94;":[172],"positive":[173],"predictive":[174],"(PPV):":[176],"0.919].":[177],"A":[178,243],"sensitivity-oriented":[179],"400":[182,198,252],"gave":[184],"sensitivity":[185,249],"0.69":[186],"specificity":[188],"0.64":[189],"(PPV:":[190,228],"0.71).":[191],"Regression":[192],"showed":[194],"that":[195],">":[197],"strongly":[201],"associated":[202],"phenotype":[206],"(adjusted":[207],"odds":[208],"ratio":[209],"5.16,":[211],"0.001).":[214],"All":[215,230],"29":[217],"\u2265":[220,256],"4000":[221,257],"group":[227],"1.0).":[229],"thresholds":[231],"dataset-derived.":[233],"CONCLUSION":[234],"In":[235],"HCC,":[238],"discriminates":[240],"biology.":[242],"balances":[248],"specificity;":[251],"favors":[254],"sensitivity;":[255],"delineates":[259],"an":[260],"ultra-high-risk":[261],"subgroup.":[262],"Findings":[263],"support":[264],"incorporation":[266],"into":[269],"risk":[270],"stratification.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-02-03T00:00:00"}
