{"id":"https://openalex.org/W7127043240","doi":"https://doi.org/10.1177/10815589261422248","title":"A review of the literature: Tuberculosis among HTLV-1-infected individuals in Latin America","display_name":"A review of the literature: Tuberculosis among HTLV-1-infected individuals in Latin America","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127043240","doi":"https://doi.org/10.1177/10815589261422248","pmid":"https://pubmed.ncbi.nlm.nih.gov/41622183"},"language":"en","primary_location":{"id":"doi:10.1177/10815589261422248","doi":"https://doi.org/10.1177/10815589261422248","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10815589261422248","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021846007","display_name":"Jorge C. F. Nakazaki","orcid":"https://orcid.org/0009-0009-8104-4307","observed_orcids":["https://orcid.org/0009-0009-8104-4307"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jorge C. Nakazaki","raw_affiliation_strings":["Department of Medicine, Internal Medicine, University of Alabama at Birmingham, USA"],"raw_orcid":"https://orcid.org/0009-0009-8104-4307","affiliations":[{"raw_affiliation_string":"Department of Medicine, Internal Medicine, University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012131517","display_name":"Angela I. Cotera-Ram\u00f3n","orcid":"https://orcid.org/0000-0002-4338-5225","observed_orcids":["https://orcid.org/0000-0002-4338-5225"]},"institutions":[{"id":"https://openalex.org/I197097402","display_name":"Universidad Peruana Cayetano Heredia","ror":"https://ror.org/03yczjf25","country_code":"PE","type":"education","lineage":["https://openalex.org/I197097402"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Angela I. Cotera-Ram\u00f3n","raw_affiliation_strings":["Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa","institution_ids":["https://openalex.org/I197097402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113291906","display_name":"Rodrigo G. Medina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197097402","display_name":"Universidad Peruana Cayetano Heredia","ror":"https://ror.org/03yczjf25","country_code":"PE","type":"education","lineage":["https://openalex.org/I197097402"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Rodrigo G. Medina","raw_affiliation_strings":["Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa","institution_ids":["https://openalex.org/I197097402"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088674868","display_name":"Germ\u00e1n Henostroza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"German Henostroza","raw_affiliation_strings":["Division of Infectious Diseases, University of Alabama at Birmingham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Alabama at Birmingham, USA","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021846007"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":2.3869,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82710134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"10815589261422248","last_page":"10815589261422248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.921999990940094},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tuberculosis-mortality","display_name":"tuberculosis mortality","score":0.9139999747276306},{"id":"https://openalex.org/keywords/latin-america","display_name":"Latin America","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tuberculosis-diagnosis","display_name":"tuberculosis diagnosis","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C158886217","wikidata":"https://www.wikidata.org/wiki/Q16799549","display_name":"Latin Americans","level":2,"score":0.9136999845504761},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7037000060081482},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6100000143051147},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.5716999769210815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42399999499320984},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.40070000290870667},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3287999927997589},{"id":"https://openalex.org/C2909991059","wikidata":"https://www.wikidata.org/wiki/Q821775","display_name":"Epidemiologic Surveillance","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.3012000024318695},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.2948000133037567},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.29280000925064087},{"id":"https://openalex.org/C2910825464","wikidata":"https://www.wikidata.org/wiki/Q506680","display_name":"Endemic diseases","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C45355965","wikidata":"https://www.wikidata.org/wiki/Q1643441","display_name":"Socioeconomics","level":1,"score":0.25679999589920044}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/10815589261422248","doi":"https://doi.org/10.1177/10815589261422248","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10815589261422248","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},{"id":"pmid:41622183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41622183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8354547619819641,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1992575936","https://openalex.org/W2000539332","https://openalex.org/W2037865875","https://openalex.org/W2054368420","https://openalex.org/W2093838623","https://openalex.org/W2107333881","https://openalex.org/W2112614127","https://openalex.org/W2146375628","https://openalex.org/W2167125339","https://openalex.org/W2327514593","https://openalex.org/W2522957439","https://openalex.org/W2763200999","https://openalex.org/W3132328277","https://openalex.org/W4205791358","https://openalex.org/W4220673194","https://openalex.org/W4410029822","https://openalex.org/W4410519674"],"related_works":[],"abstract_inverted_index":{"Human":[0],"T-cell":[1,55],"lymphotropic":[2],"virus":[3,53],"type":[4],"1":[5],"(HTLV-1)":[6],"is":[7,17,49,58],"a":[8,75,128],"retrovirus":[9],"that":[10,51],"predominantly":[11],"targets":[12],"CD4+":[13],"T":[14],"lymphocytes":[15],"and":[16,23,82,109,115,145,174,216,230],"transmitted":[18],"via":[19],"breastfeeding,":[20],"sexual":[21],"contact,":[22],"blood":[24],"transfusions.":[25],"Endemic":[26],"regions":[27],"of":[28,35,71,131,198,207,218],"HTLV-1":[29,41,108,157,190],"infection":[30],"often":[31],"overlap":[32],"with":[33,124,188],"those":[34],"tuberculosis":[36],"(TB).":[37],"The":[38],"mechanisms":[39,228],"linking":[40],"to":[42,90,135,179,183,224,233],"increased":[43,181],"TB":[44,133,138,184,199],"susceptibility":[45,182],"remain":[46],"unclear;":[47],"it":[48],"hypothesized":[50],"the":[52,68,79,105,122,180,195,205,214,226],"impairs":[54],"function,":[56],"which":[57],"crucial":[59],"for":[60],"immune":[61,167,227],"defense":[62],"against":[63],"Mycobacterium":[64],"TB,":[65,110],"thereby":[66],"influencing":[67],"clinical":[69],"progression":[70],"TB.":[72],"We":[73],"conducted":[74],"literature":[76],"review":[77],"using":[78],"Medline,":[80],"OVID,":[81],"Scielo":[83],"databases,":[84],"encompassing":[85],"publications":[86],"from":[87,98],"January":[88],"2000":[89],"July":[91],"2024.":[92],"Eight":[93],"studies":[94,221],"involving":[95],"6901":[96],"participants":[97],"Latin":[99,235],"America":[100],"were":[101,140],"included.":[102],"They":[103],"examined":[104],"relationship":[106],"between":[107,143],"focusing":[111],"on":[112],"demographic,":[113],"clinical,":[114],"mortality":[116,154],"data.":[117],"Coinfection":[118],"rates":[119,155],"varied":[120],"across":[121],"studies,":[123],"HTLV-1-positive":[125,144],"individuals":[126,186],"showing":[127],"higher":[129,153],"risk":[130],"developing":[132],"compared":[134],"uninfected":[136],"groups.":[137],"symptoms":[139],"generally":[141],"similar":[142],"seronegative":[146],"patients.":[147],"While":[148],"one":[149],"Peruvian":[150],"study":[151],"reported":[152],"in":[156,172,185,201],"co-infected":[158],"patients,":[159],"other":[160,234],"analyses":[161],"found":[162],"no":[163],"significant":[164],"differences.":[165],"Altered":[166],"responses,":[168],"such":[169],"as":[170],"changes":[171],"TNF-\u03b1":[173],"IL-17":[175],"levels,":[176],"may":[177],"contribute":[178],"infected":[187],"HTLV-1.":[189],"should":[191,212],"be":[192],"considered":[193],"during":[194],"diagnostic":[196],"evaluation":[197],"cases":[200],"endemic":[202],"regions.":[203],"Given":[204],"under-recognition":[206],"HTLV-1,":[208],"public":[209],"health":[210],"initiatives":[211],"emphasize":[213],"identification":[215],"management":[217],"coinfections.":[219],"Further":[220],"are":[222],"necessary":[223],"clarify":[225],"involved":[229],"generalize":[231],"findings":[232],"American":[236],"populations.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-02-03T00:00:00"}