{"id":"https://openalex.org/W7127040762","doi":"https://doi.org/10.1021/acs.jafc.5c11368","title":"Dose Optimization of Tilmicosin against Pasteurella multocida in Swine by Physiologically Based Pharmacokinetic-Pharmacodynamic Model","display_name":"Dose Optimization of Tilmicosin against Pasteurella multocida in Swine by Physiologically Based Pharmacokinetic-Pharmacodynamic Model","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127040762","doi":"https://doi.org/10.1021/acs.jafc.5c11368","pmid":"https://pubmed.ncbi.nlm.nih.gov/41621077"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.5c11368","doi":"https://doi.org/10.1021/acs.jafc.5c11368","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jafc.5c11368","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.5c11368?ref=article_openPDF","source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.5c11368?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124711365","display_name":"Lei Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Sun","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University","Department of Veterinary Medicine Science","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Department of Veterinary Medicine Science","institution_ids":[]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124711242","display_name":"ChengYang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ChengYang Zhang","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University","Department of Veterinary Medicine Science","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Department of Veterinary Medicine Science","institution_ids":[]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080045896","display_name":"Kun Mi","orcid":"https://orcid.org/0000-0001-7058-1849","observed_orcids":["https://orcid.org/0000-0001-7058-1849"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Mi","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University","Department of Veterinary Medicine Science","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Department of Veterinary Medicine Science","institution_ids":[]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124718925","display_name":"Hanyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanyu Wang","raw_affiliation_strings":["MOA Key Laboratory for Detection of Veterinary Drug Residues","MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOA Key Laboratory for Detection of Veterinary Drug Residues","institution_ids":[]},{"raw_affiliation_string":"MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124694111","display_name":"Yuanhu Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanhu Pan","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University","Department of Veterinary Medicine Science","MOA Key Laboratory for Detection of Veterinary Drug Residues","MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Department of Veterinary Medicine Science","institution_ids":[]},{"raw_affiliation_string":"MOA Key Laboratory for Detection of Veterinary Drug Residues","institution_ids":[]},{"raw_affiliation_string":"MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124713936","display_name":"Yanfei Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfei Tao","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University","Department of Veterinary Medicine Science","MOA Key Laboratory for Detection of Veterinary Drug Residues","MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Department of Veterinary Medicine Science","institution_ids":[]},{"raw_affiliation_string":"MOA Key Laboratory for Detection of Veterinary Drug Residues","institution_ids":[]},{"raw_affiliation_string":"MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101560193","display_name":"Lingli Huang","orcid":"https://orcid.org/0009-0006-9055-5158","observed_orcids":["https://orcid.org/0009-0006-9055-5158","https://orcid.org/0000-0002-8780-1534"]},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingli Huang","raw_affiliation_strings":["College of Veterinary Medicine, Huazhong Agricultural University","Department of Veterinary Medicine Science","MOA Key Laboratory for Detection of Veterinary Drug Residues","MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","National Reference Laboratory of Veterinary Drug Residues (HZAU)"],"raw_orcid":"https://orcid.org/0009-0006-9055-5158","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Huazhong Agricultural University","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Department of Veterinary Medicine Science","institution_ids":[]},{"raw_affiliation_string":"MOA Key Laboratory for Detection of Veterinary Drug Residues","institution_ids":[]},{"raw_affiliation_string":"MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products","institution_ids":["https://openalex.org/I4210151987"]},{"raw_affiliation_string":"National Reference Laboratory of Veterinary Drug Residues (HZAU)","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101560193"],"corresponding_institution_ids":["https://openalex.org/I204823248","https://openalex.org/I4210151987"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06127094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"5","first_page":"4754","last_page":"4766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tilmicosin","display_name":"tilmicosin","score":1.0},{"id":"https://openalex.org/keywords/pasteurella-multocida","display_name":"Pasteurella multocida","score":1.0},{"id":"https://openalex.org/keywords/swine-respiratory-disease","display_name":"swine respiratory disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dosing-regimen-optimization","display_name":"dosing regimen optimization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bactericidal-efficacy","display_name":"bactericidal efficacy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/auc-mic","display_name":"AUC/MIC","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hollow-fiber-infection-model","display_name":"hollow-fiber infection model","score":0.9169999957084656},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5429999828338623},{"id":"https://openalex.org/keywords/lung-pharmacokinetics","display_name":"lung pharmacokinetics","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2776231263","wikidata":"https://www.wikidata.org/wiki/Q722387","display_name":"Tilmicosin","level":3,"score":0.972599983215332},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6935999989509583},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.6802999973297119},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6337000131607056},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5457000136375427},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.503000020980835},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.47350001335144043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4542999863624573},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.43630000948905945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39820000529289246},{"id":"https://openalex.org/C82085835","wikidata":"https://www.wikidata.org/wiki/Q16142045","display_name":"Aerosolization","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2955999970436096},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.272599995136261},{"id":"https://openalex.org/C2780861368","wikidata":"https://www.wikidata.org/wiki/Q343332","display_name":"Actinobacillus pleuropneumoniae","level":3,"score":0.2630999982357025}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010326","descriptor_name":"Pasteurella Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015645","descriptor_name":"Tylosin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016979","descriptor_name":"Pasteurella multocida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.jafc.5c11368","doi":"https://doi.org/10.1021/acs.jafc.5c11368","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jafc.5c11368","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.5c11368?ref=article_openPDF","source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:41621077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41621077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11710497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12903901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12903901","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12903901/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Agric Food Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jafc.5c11368","doi":"https://doi.org/10.1021/acs.jafc.5c11368","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jafc.5c11368","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.5c11368?ref=article_openPDF","source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4835094213485718,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1262482297","display_name":null,"funder_award_id":"2023YFD1800901","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127040762.pdf","grobid_xml":"https://content.openalex.org/works/W7127040762.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1503087732","https://openalex.org/W1922930888","https://openalex.org/W2009538750","https://openalex.org/W2011786693","https://openalex.org/W2042315357","https://openalex.org/W2050876696","https://openalex.org/W2084405960","https://openalex.org/W2135810831","https://openalex.org/W2152118216","https://openalex.org/W2161794813","https://openalex.org/W2190742848","https://openalex.org/W2321409638","https://openalex.org/W2540396308","https://openalex.org/W2568755489","https://openalex.org/W2578687907","https://openalex.org/W2617975382","https://openalex.org/W2628941350","https://openalex.org/W2772591596","https://openalex.org/W2794803601","https://openalex.org/W2811045118","https://openalex.org/W2915541151","https://openalex.org/W2916207143","https://openalex.org/W2922371767","https://openalex.org/W2940775977","https://openalex.org/W2949876655","https://openalex.org/W2952028961","https://openalex.org/W2957643531","https://openalex.org/W2995184520","https://openalex.org/W3000065815","https://openalex.org/W3016257431","https://openalex.org/W3036805388","https://openalex.org/W3041225049","https://openalex.org/W3043981739","https://openalex.org/W3110450501","https://openalex.org/W3136305460","https://openalex.org/W3197744882","https://openalex.org/W4200012195","https://openalex.org/W4220719620","https://openalex.org/W4220927584","https://openalex.org/W4281721368","https://openalex.org/W4317213662","https://openalex.org/W4323294409","https://openalex.org/W4385650173","https://openalex.org/W4385863650","https://openalex.org/W4386410446","https://openalex.org/W4387363004","https://openalex.org/W4391577241","https://openalex.org/W4405815071","https://openalex.org/W4406965823","https://openalex.org/W4408128531","https://openalex.org/W4410778815","https://openalex.org/W4410875807","https://openalex.org/W4411573072"],"related_works":[],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Rising":[7],"bacterial":[8],"resistance":[9,158],"leads":[10],"to":[11,27],"diminishing":[12],"clinical":[13],"efficacy":[14,139,155],"of":[15,32,127,145],"tilmicosin":[16,33,49],"against":[17,34],"Pasteurella":[18],"multocida":[19,36],"in":[20,62,81,118],"porcine":[21],"respiratory":[22],"disease.":[23],"This":[24],"study":[25],"aimed":[26],"optimize":[28],"the":[29,38,55,141,154],"dosing":[30,150],"regimen":[31,151],"P.":[35],"using":[37,52,92],"physiologically":[39],"based":[40],"pharmacokinetic-pharmacodynamic":[41],"model":[42,47,74],"(PBPK\u2013PD).":[43],"A":[44],"swine":[45],"PBPK":[46],"for":[48,100,132],"was":[50,75,90],"developed":[51],"microdialysis":[53],"and":[54,64,103,109,112,115,122,156],"literature":[56],"data.":[57],"It":[58],"accurately":[59],"predicted":[60],"pharmacokinetics":[61],"lung":[63],"edible":[65],"tissues,":[66],"though":[67],"it":[68],"overestimated":[69],"plasma":[70],"levels.":[71],"The":[72,87,96,125,148],"PBPK\u2013PD":[73],"integrated":[76],"with":[77,140],"dynamic":[78],"time-killing":[79],"studies":[80],"a":[82],"hollow":[83],"fiber":[84],"infection":[85],"model.":[86],"withdrawal":[88,143],"interval":[89,144],"projected":[91],"Monte":[93],"Carlo":[94],"analysis.":[95],"PK\u2013PD":[97],"parameters,":[98],"AUC/MIC,":[99],"bacteriostatic,":[101],"bactericidal,":[102],"elimination":[104],"effect":[105],"were":[106],"12.13,":[107],"28.48,":[108],"51.08":[110],"h":[111,117],"7.17,":[113],"46.54,":[114],"78.66":[116],"pulmonary":[119],"interstitial":[120],"fluid":[121],"plasma,":[123],"respectively.":[124],"dosage":[126],"40":[128],"mg/kg":[129],"once":[130],"daily":[131],"3":[133],"consecutive":[134],"days":[135],"could":[136],"achieve":[137],"bactericidal":[138],"estimated":[142],"8":[146],"days.":[147],"optimized":[149],"will":[152],"enhance":[153],"avoid":[157],"selection.":[159]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-02-03T00:00:00"}