{"id":"https://openalex.org/W7127040679","doi":"https://doi.org/10.1007/s00415-026-13639-x","title":"The interplay between GBA1 status and age of onset on cognitive, motor and non-motor outcomes in Parkinson\u2019s disease: multicenter cross-sectional study","display_name":"The interplay between GBA1 status and age of onset on cognitive, motor and non-motor outcomes in Parkinson\u2019s disease: multicenter cross-sectional study","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127040679","doi":"https://doi.org/10.1007/s00415-026-13639-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41621006"},"language":"en","primary_location":{"id":"doi:10.1007/s00415-026-13639-x","doi":"https://doi.org/10.1007/s00415-026-13639-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-026-13639-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-13639-x.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-13639-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087073377","display_name":"Claudia Ledda","orcid":"https://orcid.org/0000-0003-0839-932X","observed_orcids":["https://orcid.org/0000-0003-0839-932X"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudia Ledda","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy. claudia.ledda@unito.it","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy. claudia.ledda@unito.it"],"raw_orcid":"https://orcid.org/0000-0003-0839-932X","affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy. claudia.ledda@unito.it","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy. claudia.ledda@unito.it","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007871751","display_name":"Silvia Gallo","orcid":"https://orcid.org/0000-0001-7223-2060","observed_orcids":["https://orcid.org/0000-0001-7223-2060"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Gallo","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091396775","display_name":"Micol Avenali","orcid":"https://orcid.org/0000-0002-7880-9921","observed_orcids":["https://orcid.org/0000-0002-7880-9921"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Micol Avenali","raw_affiliation_strings":["Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy","IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081285710","display_name":"Carlo Alberto Artusi","orcid":"https://orcid.org/0000-0001-8579-3772","observed_orcids":["https://orcid.org/0000-0001-8579-3772"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Alberto Artusi","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068095271","display_name":"Gabriele Imbalzano","orcid":"https://orcid.org/0000-0002-4842-529X","observed_orcids":["https://orcid.org/0000-0002-4842-529X"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Imbalzano","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104975302","display_name":"Francesca Donetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Donetto","raw_affiliation_strings":["SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029696224","display_name":"Elisa Montanaro","orcid":"https://orcid.org/0000-0002-2254-9956","observed_orcids":["https://orcid.org/0000-0002-2254-9956"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Montanaro","raw_affiliation_strings":["SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003437267","display_name":"Alberto Romagnolo","orcid":"https://orcid.org/0000-0002-1312-1843","observed_orcids":["https://orcid.org/0000-0002-1312-1843"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Romagnolo","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093127061","display_name":"Pierfrancesco Mitrotti","orcid":"https://orcid.org/0000-0003-3574-1290","observed_orcids":["https://orcid.org/0000-0003-3574-1290"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierfrancesco Mitrotti","raw_affiliation_strings":["Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy","IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134008928","display_name":"Luca Gallo","orcid":"https://orcid.org/0009-0007-3693-0380","observed_orcids":["https://orcid.org/0009-0007-3693-0380"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Gallo","raw_affiliation_strings":["Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040701099","display_name":"Rosa De Micco","orcid":"https://orcid.org/0000-0002-6397-8888","observed_orcids":["https://orcid.org/0000-0002-6397-8888"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosa De Micco","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002460351","display_name":"Valeria Sant\u2019Elia","orcid":"https://orcid.org/0000-0002-5575-1835","observed_orcids":["https://orcid.org/0000-0002-5575-1835"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Sant\u2019Elia","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy","Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060318072","display_name":"Mattia Siciliano","orcid":"https://orcid.org/0000-0001-5246-2109","observed_orcids":["https://orcid.org/0000-0001-5246-2109"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mattia Siciliano","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004117859","display_name":"Alessandro Tessitore","orcid":"https://orcid.org/0000-0003-1740-8566","observed_orcids":["https://orcid.org/0000-0003-1740-8566","https://orcid.org/0000-0002-2913-6548"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Tessitore","raw_affiliation_strings":["Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical and Surgical Sciences, University of Campania \"Luigi Vanvitelli\", Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067832842","display_name":"Giovanna Calandra Buonaura","orcid":"https://orcid.org/0000-0002-9447-3532","observed_orcids":["https://orcid.org/0000-0002-9447-3532"]},"institutions":[{"id":"https://openalex.org/I4210123211","display_name":"Istituto delle Scienze Neurologiche di Bologna","ror":"https://ror.org/02mgzgr95","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210119117","https://openalex.org/I4210123211","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanna Calandra-Buonaura","raw_affiliation_strings":["Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy","IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210123211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074347972","display_name":"Giulia Giannini","orcid":"https://orcid.org/0000-0002-0499-3236","observed_orcids":["https://orcid.org/0000-0002-0499-3236"]},"institutions":[{"id":"https://openalex.org/I4210123211","display_name":"Istituto delle Scienze Neurologiche di Bologna","ror":"https://ror.org/02mgzgr95","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210119117","https://openalex.org/I4210123211","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Giannini","raw_affiliation_strings":["Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy","IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and NeuroMotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210123211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041266375","display_name":"Luisa Sambati","orcid":"https://orcid.org/0000-0002-5939-7933","observed_orcids":["https://orcid.org/0000-0002-5939-7933"]},"institutions":[{"id":"https://openalex.org/I4210123211","display_name":"Istituto delle Scienze Neurologiche di Bologna","ror":"https://ror.org/02mgzgr95","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210119117","https://openalex.org/I4210123211","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Sambati","raw_affiliation_strings":["IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210123211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052765423","display_name":"Leonardo Lopiano","orcid":"https://orcid.org/0000-0001-9098-387X","observed_orcids":["https://orcid.org/0000-0001-9098-387X"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonardo Lopiano","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068582387","display_name":"Enza Maria Valente","orcid":"https://orcid.org/0000-0002-0600-6820","observed_orcids":["https://orcid.org/0000-0002-0600-6820"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enza Maria Valente","raw_affiliation_strings":["Department of Molecular Medicine, University of Pavia, Pavia, Italy","IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"IRCCS Mondino Foundation, Pavia, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078205854","display_name":"Marco Bozzali","orcid":"https://orcid.org/0000-0002-0568-2026","observed_orcids":["https://orcid.org/0000-0002-0568-2026","https://orcid.org/0009-0001-8218-0708"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Bozzali","raw_affiliation_strings":["Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience \"Rita Levi Montalcini\", University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"SC Neurologia 2U, AOU Citt\u00e0 della Salute e della Scienza, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5087073377"],"corresponding_institution_ids":["https://openalex.org/I4210086903","https://openalex.org/I55143463"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":3.9521,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88557617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"273","issue":"2","first_page":"111","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7269999980926514},{"id":"https://openalex.org/keywords/motor-symptoms","display_name":"motor symptoms","score":0.699999988079071},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6610000133514404},{"id":"https://openalex.org/keywords/early-onset-parkinson-s-disease","display_name":"early-onset Parkinson's disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/late-onset-parkinson-s-disease","display_name":"late-onset Parkinson's disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/montreal-cognitive-assessment","display_name":"Montreal Cognitive Assessment","score":0.6069999933242798},{"id":"https://openalex.org/keywords/mds-updrs","display_name":"MDS-UPDRS","score":0.8259999752044678},{"id":"https://openalex.org/keywords/scopa-aut","display_name":"SCOPA-AUT","score":0.8080000281333923},{"id":"https://openalex.org/keywords/beck-depression-inventory","display_name":"Beck Depression Inventory","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6862999796867371},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5579000115394592},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5278000235557556},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.489300012588501},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.4878999888896942},{"id":"https://openalex.org/C2779889316","wikidata":"https://www.wikidata.org/wiki/Q642836","display_name":"Neuroradiology","level":3,"score":0.4609000086784363},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.42250001430511475},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.37279999256134033},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3698999881744385},{"id":"https://openalex.org/C112758219","wikidata":"https://www.wikidata.org/wiki/Q16038819","display_name":"Duration (music)","level":2,"score":0.3382999897003174},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.298799991607666},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C3018987647","wikidata":"https://www.wikidata.org/wiki/Q3221083","display_name":"Motor symptoms","level":4,"score":0.2768000066280365},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C2780824705","wikidata":"https://www.wikidata.org/wiki/Q1065413","display_name":"Institutional repository","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00415-026-13639-x","doi":"https://doi.org/10.1007/s00415-026-13639-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-026-13639-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-13639-x.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:41621006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41621006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/1062590","doi":null,"is_oa":true,"landing_page_url":"https://link.springer.com/article/10.1007/s00415-026-13639-x","pdf_url":"https://cris.unibo.it/bitstream/11585/1062590/1/unpaywall-bitstream--759973890.pdf","source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:11669607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12862001","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:iris.unito.it:2318/2128957","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2318/2128957","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00415-026-13639-x","doi":"https://doi.org/10.1007/s00415-026-13639-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00415-026-13639-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00415-026-13639-x.pdf","source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320324041","display_name":"Universit\u00e0 degli Studi di Torino","ror":"https://ror.org/048tbm396"},{"id":"https://openalex.org/F4320332585","display_name":"Allergan","ror":"https://ror.org/00wthd003"},{"id":"https://openalex.org/F4320333592","display_name":"Avid Radiopharmaceuticals","ror":"https://ror.org/00szax507"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127040679.pdf","grobid_xml":"https://content.openalex.org/works/W7127040679.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1909811863","https://openalex.org/W1975977835","https://openalex.org/W1982523487","https://openalex.org/W1991530575","https://openalex.org/W1994703428","https://openalex.org/W2005919985","https://openalex.org/W2007125560","https://openalex.org/W2044590002","https://openalex.org/W2049026824","https://openalex.org/W2053368008","https://openalex.org/W2068606962","https://openalex.org/W2074302943","https://openalex.org/W2090501435","https://openalex.org/W2095111193","https://openalex.org/W2096916909","https://openalex.org/W2100600161","https://openalex.org/W2106969548","https://openalex.org/W2108987128","https://openalex.org/W2112254680","https://openalex.org/W2112455323","https://openalex.org/W2117057382","https://openalex.org/W2140978740","https://openalex.org/W2146210116","https://openalex.org/W2163144163","https://openalex.org/W2170281382","https://openalex.org/W2272581670","https://openalex.org/W2275737843","https://openalex.org/W2509904505","https://openalex.org/W2523238466","https://openalex.org/W2559604477","https://openalex.org/W2806938337","https://openalex.org/W2913028043","https://openalex.org/W3034878543","https://openalex.org/W3043699812","https://openalex.org/W3113843096","https://openalex.org/W3144135002","https://openalex.org/W3175099911","https://openalex.org/W3183180288","https://openalex.org/W3203464896","https://openalex.org/W4205777611","https://openalex.org/W4206181210","https://openalex.org/W4224297855","https://openalex.org/W4243261038","https://openalex.org/W4288036685","https://openalex.org/W4295235556","https://openalex.org/W4372335396","https://openalex.org/W4385751164","https://openalex.org/W4386482891","https://openalex.org/W4386981044","https://openalex.org/W4387950047","https://openalex.org/W4391470686","https://openalex.org/W4401383018","https://openalex.org/W4408446589","https://openalex.org/W4410033315","https://openalex.org/W4415443146"],"related_works":[],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Age":[3,174],"at":[4,32],"onset":[5,33,65,70,75,176,253],"is":[6,242],"a":[7],"key":[8],"determinant":[9],"of":[10,51,83,116,118,175,238,249],"disease":[11,17],"course":[12],"in":[13,37,100,259],"the":[14,84,136,211,235],"general":[15],"Parkinson's":[16,88,101],"(PD)":[18],"population,":[19],"but":[20],"its":[21,262],"influence":[22,182,231],"among":[23],"GBA-PD":[24,38,44,143],"remains":[25],"undetermined.":[26],"This":[27],"study":[28],"investigates":[29],"whether":[30],"age":[31,50,117,244],"affects":[34],"cognitive":[35,240,257],"decline":[36,241],"patients":[39,60,151],"and":[40,45,73,81,105,122,144,169,177,193,198,203,225,245,266],"compares":[41],"symptoms":[42],"between":[43],"nonGBA-PD":[46,146],"groups,":[47],"stratified":[48,62],"by":[49],"onset.":[52],"METHODS:":[53],"In":[54,234],"this":[55],"multicentric":[56],"cross-sectional":[57],"study,":[58],"PD":[59,217],"were":[61,110,125],"into":[63],"early":[64],"(<":[66],"50":[67],"years),":[68,72],"intermediate":[69],"(50-60":[71],"late":[74],"(>":[76],"60":[77],"years).":[78],"Demographic-clinical":[79],"data":[80,134],"scores":[82,155,205,221],"Movement":[85],"Disorder":[86],"Society-Unified":[87],"Disease":[89],"Rating":[90],"Scale":[91],"(MDS-UPDRS),":[92],"Montreal":[93],"Cognitive":[94],"Assessment":[95],"(MoCA),":[96],"Scales":[97],"for":[98,264],"Outcomes":[99],"Disease-Autonomic":[102],"Dysfunction":[103],"(SCOPA-AUT),":[104],"Beck":[106],"Depression":[107],"Inventory":[108],"(BDI-II)":[109],"compared":[111],"using":[112,133],"ANCOVA.":[113],"The":[114],"effects":[115],"onset,":[119],"GBA1":[120,178,186,227,250],"status,":[121],"their":[123],"interaction":[124],"investigated.":[126],"External":[127],"validation":[128],"on":[129,210],"cognition":[130],"was":[131],"performed":[132],"from":[135],"PPMI":[137],"cohort.":[138],"RESULTS:":[139],"We":[140],"analyzed":[141],"80":[142],"236":[145],"patients.":[147],"Among":[148],"GBA-PD,":[149,260],"late-onset":[150,216],"exhibited":[152],"worse":[153],"axial":[154],"(p":[156,166,171,195,206,222],"=":[157,167,172,200,207],"0.037),":[158],"while":[159],"early-onset":[160],"had":[161,218],"more":[162],"severe":[163],"motor":[164],"complications":[165],"0.007)":[168],"dysautonomia":[170],"0.012).":[173],"status":[179,187,228],"did":[180,229],"not":[181,230,255],"MoCA":[183,220],"scores.":[184],"Conversely,":[185],"independently":[188],"affected":[189],"MDS-UPDRS":[190],"parts":[191],"I":[192],"II":[194],"<":[196,223],"0.001":[197],"p":[199],"0.019,":[201],"respectively)":[202],"BDI-II":[204],"0.002).":[208],"Analysis":[209],"external":[212],"dataset":[213],"(PPMI)":[214],"showed":[215],"lower":[219],"0.001)":[224],"confirmed":[226],"cognition.":[232],"DISCUSSION:":[233],"first":[236],"decade":[237],"PD,":[239],"mainly":[243],"duration":[246],"dependent,":[247],"irrespective":[248],"genotype.":[251],"Early":[252],"does":[254],"increase":[256],"risk":[258],"supporting":[261],"relevance":[263],"counseling":[265],"treatment":[267],"planning.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-02-03T00:00:00"}
