{"id":"https://openalex.org/W7127040033","doi":"https://doi.org/10.1158/0008-5472.31228800","title":"Supplementary Data 2 from Enozertinib Is a Selective, Brain-Penetrant EGFR Inhibitor for Treating Non\u2013Small Cell Lung Cancers with EGFR Exon 20 and Atypical Mutations","display_name":"Supplementary Data 2 from Enozertinib Is a Selective, Brain-Penetrant EGFR Inhibitor for Treating Non\u2013Small Cell Lung Cancers with EGFR Exon 20 and Atypical Mutations","publication_year":2026,"publication_date":"2026-02-02","ids":{"openalex":"https://openalex.org/W7127040033","doi":"https://doi.org/10.1158/0008-5472.31228800"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.31228800","doi":"https://doi.org/10.1158/0008-5472.31228800","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31228800","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.31228800","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040110214","display_name":"Melissa R. Junttila","orcid":"https://orcid.org/0000-0003-3538-1192","observed_orcids":["https://orcid.org/0000-0003-3538-1192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa R. Junttila","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3538-1192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003812416","display_name":"Claire E. Repellin","orcid":"https://orcid.org/0000-0002-6552-3318","observed_orcids":["https://orcid.org/0000-0002-6552-3318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire E. Repellin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6552-3318","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124819447","display_name":"Sumeet Salaniwal","orcid":"https://orcid.org/0009-0002-4744-5317","observed_orcids":["https://orcid.org/0009-0002-4744-5317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumeet Salaniwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-4744-5317","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051809645","display_name":"Robert L. Warne","orcid":"https://orcid.org/0009-0009-2738-3121","observed_orcids":["https://orcid.org/0009-0009-2738-3121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Warne","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-2738-3121","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101450441","display_name":"Younho Lee","orcid":"https://orcid.org/0000-0002-4235-1269","observed_orcids":["https://orcid.org/0000-0002-4235-1269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Younho Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4235-1269","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124811266","display_name":"Haelee Kim","orcid":"https://orcid.org/0000-0003-0569-7129","observed_orcids":["https://orcid.org/0000-0003-0569-7129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haelee Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0569-7129","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124697663","display_name":"Kyung Ah Seo","orcid":"https://orcid.org/0009-0009-4838-8992","observed_orcids":["https://orcid.org/0009-0009-4838-8992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyung Ah Seo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4838-8992","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124750318","display_name":"Youngyi Lee","orcid":"https://orcid.org/0000-0003-2293-1634","observed_orcids":["https://orcid.org/0000-0003-2293-1634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youngyi Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2293-1634","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124788886","display_name":"Hong-ryul Jung","orcid":"https://orcid.org/0000-0001-7969-5885","observed_orcids":["https://orcid.org/0000-0001-7969-5885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-ryul Jung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7969-5885","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124714607","display_name":"Jason Baik","orcid":"https://orcid.org/0009-0009-6901-8632","observed_orcids":["https://orcid.org/0009-0009-6901-8632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Baik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-6901-8632","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008934311","display_name":"Jae Hoon Chang","orcid":"https://orcid.org/0000-0003-3457-7695","observed_orcids":["https://orcid.org/0000-0003-3457-7695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae H. Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3457-7695","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124700014","display_name":"Gina Andreatta","orcid":"https://orcid.org/0009-0008-6211-7577","observed_orcids":["https://orcid.org/0009-0008-6211-7577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gina Andreatta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-6211-7577","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005115402","display_name":"Jason E. Long","orcid":"https://orcid.org/0000-0002-8229-0341","observed_orcids":["https://orcid.org/0000-0002-8229-0341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason E. Long","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8229-0341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124816892","display_name":"Jessica D. Sun","orcid":"https://orcid.org/0000-0002-9844-9767","observed_orcids":["https://orcid.org/0000-0002-9844-9767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica D. Sun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9844-9767","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124813365","display_name":"Stephanie W. Ni","orcid":"https://orcid.org/0000-0002-8821-7786","observed_orcids":["https://orcid.org/0000-0002-8821-7786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie W. Ni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8821-7786","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066497154","display_name":"Liliana Soroceanu","orcid":"https://orcid.org/0000-0001-8281-016X","observed_orcids":["https://orcid.org/0000-0001-8281-016X","https://orcid.org/0000-0002-4811-5099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liliana Soroceanu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4811-5099","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085226365","display_name":"Lidia C. Sambucetti","orcid":"https://orcid.org/0000-0001-9686-5444","observed_orcids":["https://orcid.org/0000-0001-9686-5444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lidia C. Sambucetti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9686-5444","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124741531","display_name":"Akash Kumar Das","orcid":"https://orcid.org/0009-0007-3193-3304","observed_orcids":["https://orcid.org/0009-0007-3193-3304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akash Das","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-3193-3304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124792260","display_name":"Brenda Chan","orcid":"https://orcid.org/0009-0004-8471-6723","observed_orcids":["https://orcid.org/0009-0004-8471-6723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda Chan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-8471-6723","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124857837","display_name":"Padmini Narayanan","orcid":"https://orcid.org/0000-0003-0163-9087","observed_orcids":["https://orcid.org/0000-0003-0163-9087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Padmini Narayanan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0163-9087","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124718436","display_name":"Ashley S. Pereira","orcid":"https://orcid.org/0000-0003-4871-0856","observed_orcids":["https://orcid.org/0000-0003-4871-0856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashley S. Pereira","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4871-0856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009723460","display_name":"Edna Chow Maneval","orcid":"https://orcid.org/0000-0001-8131-755X","observed_orcids":["https://orcid.org/0000-0001-8131-755X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edna Chow Maneval","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8131-755X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041698432","display_name":"Pratik S. Multani","orcid":"https://orcid.org/0000-0001-8358-3560","observed_orcids":["https://orcid.org/0000-0001-8358-3560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pratik S. Multani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8358-3560","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110838","display_name":"Rupal Patel","orcid":"https://orcid.org/0000-0003-4809-5494","observed_orcids":["https://orcid.org/0000-0003-4809-5494","https://orcid.org/0009-0005-5978-2179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupal Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5978-2179","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124726073","display_name":"Matt Panuwat","orcid":"https://orcid.org/0009-0002-6841-0236","observed_orcids":["https://orcid.org/0009-0002-6841-0236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt Panuwat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-6841-0236","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039528755","display_name":"Brian R. Blank","orcid":"https://orcid.org/0009-0003-4763-9856","observed_orcids":["https://orcid.org/0009-0003-4763-9856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian R. Blank","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-4763-9856","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124775978","display_name":"Chudi Ndubaku","orcid":"https://orcid.org/0000-0003-4183-0417","observed_orcids":["https://orcid.org/0000-0003-4183-0417"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chudi Ndubaku","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4183-0417","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124787920","display_name":"F. Anthony Romero","orcid":"https://orcid.org/0000-0001-7917-1459","observed_orcids":["https://orcid.org/0000-0001-7917-1459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Anthony Romero","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7917-1459","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022839853","display_name":"Anneleen Daemen","orcid":"https://orcid.org/0000-0001-6287-7105","observed_orcids":["https://orcid.org/0000-0001-6287-7105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anneleen Daemen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6287-7105","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044613951","display_name":"Alexander I. Spira","orcid":"https://orcid.org/0000-0003-1303-0447","observed_orcids":["https://orcid.org/0000-0003-1303-0447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander I. Spira","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1303-0447","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103054591","display_name":"Lori S. Friedman","orcid":"https://orcid.org/0000-0001-9127-9892","observed_orcids":["https://orcid.org/0000-0001-9127-9892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori S. Friedman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9127-9892","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/egfr-exon-20-mutations","display_name":"EGFR exon 20 mutations","score":0.9100000262260437},{"id":"https://openalex.org/keywords/brain-penetration","display_name":"brain penetration","score":0.7739999890327454},{"id":"https://openalex.org/keywords/variant-allele-frequency","display_name":"variant allele frequency","score":0.9309999942779541},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6966000199317932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6092000007629395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5594000220298767},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5070000290870667},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4422000050544739},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43549999594688416},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4147000014781952},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.3386000096797943},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2773999869823456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.25780001282691956}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.31228800","doi":"https://doi.org/10.1158/0008-5472.31228800","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31228800","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.31228800","doi":"https://doi.org/10.1158/0008-5472.31228800","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.31228800","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415962648","https://openalex.org/W7127054427","https://openalex.org/W7212249518","https://openalex.org/W7117002553","https://openalex.org/W7116935836","https://openalex.org/W7116961433","https://openalex.org/W3122878837","https://openalex.org/W4362546489","https://openalex.org/W4415711190","https://openalex.org/W4223521674"],"abstract_inverted_index":{"Supplementary":[0],"Data":[1],"2":[2],"shows":[3],"the":[4],"variant":[5],"allele":[6],"frequency":[7],"(VAF)":[8],"of":[9],"patient":[10]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-02-03T00:00:00"}
