{"id":"https://openalex.org/W7127038508","doi":"https://doi.org/10.1177/10815589261422249","title":"Influence of thrombocytosis on the prognosis of endometrial cancer: Results from propensity score matching","display_name":"Influence of thrombocytosis on the prognosis of endometrial cancer: Results from propensity score matching","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127038508","doi":"https://doi.org/10.1177/10815589261422249","pmid":"https://pubmed.ncbi.nlm.nih.gov/41622172"},"language":"en","primary_location":{"id":"doi:10.1177/10815589261422249","doi":"https://doi.org/10.1177/10815589261422249","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10815589261422249","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124718005","display_name":"Tung-Ying Wu","orcid":"https://orcid.org/0009-0008-3784-0034","observed_orcids":["https://orcid.org/0009-0008-3784-0034"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Ying Wu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0009-0008-3784-0034","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032384926","display_name":"Pei\u2010Ru Lin","orcid":"https://orcid.org/0009-0003-3888-7049","observed_orcids":["https://orcid.org/0009-0003-3888-7049"]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Ru Lin","raw_affiliation_strings":["Big Data and Digital Promotion Center, Changhua Christian Hospital, Taiwan"],"raw_orcid":"https://orcid.org/0009-0003-3888-7049","affiliations":[{"raw_affiliation_string":"Big Data and Digital Promotion Center, Changhua Christian Hospital, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067834950","display_name":"Chew\u2010Teng Kor","orcid":"https://orcid.org/0000-0002-5665-9635","observed_orcids":["https://orcid.org/0000-0002-5665-9635"]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chew-Teng Kor","raw_affiliation_strings":["Big Data and Digital Promotion Center, Changhua Christian Hospital, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-5665-9635","affiliations":[{"raw_affiliation_string":"Big Data and Digital Promotion Center, Changhua Christian Hospital, Taiwan","institution_ids":["https://openalex.org/I4210159511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000967603","display_name":"Ying\u2010Lin Hsu","orcid":"https://orcid.org/0000-0002-3551-0321","observed_orcids":["https://orcid.org/0000-0002-3551-0321"]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Lin Hsu","raw_affiliation_strings":["Department of Applied Mathematics and Institute of Statistics, National Chung Hsing University, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-3551-0321","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Institute of Statistics, National Chung Hsing University, Taichung, Taiwan","institution_ids":["https://openalex.org/I162838928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124732671","display_name":"Ming Ju Chen","orcid":"https://orcid.org/0009-0003-4802-0887","observed_orcids":["https://orcid.org/0009-0003-4802-0887"]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]},{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ming-Ju Chen","raw_affiliation_strings":["Big Data and Digital Promotion Center, Changhua Christian Hospital, Taiwan","Department of Applied Mathematics, National Chung Hsing University, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0009-0003-4802-0887","affiliations":[{"raw_affiliation_string":"Big Data and Digital Promotion Center, Changhua Christian Hospital, Taiwan","institution_ids":["https://openalex.org/I4210159511"]},{"raw_affiliation_string":"Department of Applied Mathematics, National Chung Hsing University, Taichung, Taiwan","institution_ids":["https://openalex.org/I162838928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5124732671"],"corresponding_institution_ids":["https://openalex.org/I162838928","https://openalex.org/I4210159511"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04982036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"10815589261422249","last_page":"10815589261422249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombocytosis","display_name":"thrombocytosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7369999885559082},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.996999979019165},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9021000266075134},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.8809000253677368},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.8454999923706055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7450000047683716},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.73580002784729},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.7001000046730042},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.5860000252723694},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5590000152587891},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49720001220703125},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4927000105381012},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42160001397132874},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.39329999685287476},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35269999504089355},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34860000014305115},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2531999945640564}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/10815589261422249","doi":"https://doi.org/10.1177/10815589261422249","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10815589261422249","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},{"id":"pmid:41622172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41622172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7658668756484985}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1605655296","https://openalex.org/W2000991311","https://openalex.org/W2012356282","https://openalex.org/W2031645898","https://openalex.org/W2036193982","https://openalex.org/W2057261749","https://openalex.org/W2064555706","https://openalex.org/W2108888241","https://openalex.org/W2130888089","https://openalex.org/W2334096321","https://openalex.org/W2342373729","https://openalex.org/W2439433741","https://openalex.org/W2554323113","https://openalex.org/W2560287982","https://openalex.org/W2606142897","https://openalex.org/W2622047259","https://openalex.org/W2729707472","https://openalex.org/W2797421660","https://openalex.org/W2900914993","https://openalex.org/W2912218228","https://openalex.org/W2972893864","https://openalex.org/W3007850211","https://openalex.org/W3044278080","https://openalex.org/W3080599072","https://openalex.org/W3089103945","https://openalex.org/W3165279291","https://openalex.org/W3210512371","https://openalex.org/W4221065058","https://openalex.org/W4286774870","https://openalex.org/W4308679222","https://openalex.org/W4309516558","https://openalex.org/W4318166979","https://openalex.org/W4319596801","https://openalex.org/W4372294517","https://openalex.org/W4381309093","https://openalex.org/W4382238504","https://openalex.org/W4387139386","https://openalex.org/W4403269386"],"related_works":[],"abstract_inverted_index":{"Thrombocytosis":[0],"has":[1],"been":[2],"implicated":[3],"as":[4,161],"a":[5,76,162],"potential":[6],"prognostic":[7,27,154],"biomarker":[8],"in":[9,15,35,75,156],"various":[10],"malignancies,":[11],"but":[12],"its":[13],"role":[14],"endometrial":[16],"cancer":[17],"(EC)":[18],"remains":[19],"unclear.":[20],"This":[21],"retrospective":[22],"cohort":[23],"study":[24],"evaluated":[25],"the":[26],"value":[28],"of":[29,41],"elevated":[30],"preoperative":[31],"platelet":[32],"count":[33],"(PLT)":[34],"patients":[36,43,104],"with":[37],"EC.":[38],"A":[39],"total":[40],"548":[42],"treated":[44],"at":[45],"Changhua":[46],"Christian":[47],"Hospital":[48],"between":[49],"2010":[50],"and":[51,65,69,87,96,123,142,158,168],"2021":[52],"were":[53,56,91,105,135],"included.":[54],"Patients":[55],"classified":[57],"into":[58],"high":[59,108,133],"(>400":[60],"\u00d7":[61],"10":[62],"9":[63],"/L)":[64],"normal":[66],"PLT":[67,109,134],"groups,":[68],"propensity":[70],"score":[71],"matching":[72],"was":[73],"applied":[74],"1:3":[77],"ratio":[78],"to":[79],"balance":[80],"baseline":[81],"characteristics.":[82],"Recurrence,":[83],"disease-free":[84],"survival":[85,89],"(DFS),":[86],"overall":[88],"(OS)":[90],"assessed":[92],"using":[93],"Kaplan\u2013Meier":[94],"analysis":[95],"Cox":[97],"proportional":[98],"hazards":[99],"modeling.":[100],"After":[101],"matching,":[102],"224":[103],"analyzed.":[106],"The":[107],"group":[110],"demonstrated":[111],"significantly":[112],"higher":[113],"recurrence":[114],"(37.5%":[115],"vs":[116,121,127],"26.8%),":[117],"shorter":[118],"DFS":[119],"(48.2%":[120],"67.3%),":[122],"reduced":[124],"OS":[125],"(71.4%":[126],"83.3%).":[128],"Adjusted":[129],"hazard":[130],"ratios":[131],"for":[132,137,140,144,165],"1.76":[136],"recurrence,":[138],"1.98":[139],"DFS,":[141],"2.11":[143],"OS.":[145],"These":[146],"findings":[147],"suggest":[148],"that":[149],"thrombocytosis":[150],"is":[151],"an":[152],"independent":[153],"factor":[155],"EC":[157],"may":[159],"serve":[160],"useful":[163],"tool":[164],"risk":[166],"stratification":[167],"treatment":[169],"planning.":[170]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-02-03T00:00:00"}