{"id":"https://openalex.org/W7127038401","doi":"https://doi.org/10.2147/jpr.s567567","title":"Molecular Mechanisms and Therapeutic Targets for Pain Following Osteoporotic Vertebral Fractures","display_name":"Molecular Mechanisms and Therapeutic Targets for Pain Following Osteoporotic Vertebral Fractures","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127038401","doi":"https://doi.org/10.2147/jpr.s567567","pmid":"https://pubmed.ncbi.nlm.nih.gov/41878085"},"language":"en","primary_location":{"id":"doi:10.2147/jpr.s567567","doi":"https://doi.org/10.2147/jpr.s567567","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jpr.s567567","pdf_url":null,"source":{"id":"https://openalex.org/S130650480","display_name":"Journal of Pain Research","issn_l":"1178-7090","issn":["1178-7090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/jpr.s567567","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043115703","display_name":"Huisheng Zhou","orcid":"https://orcid.org/0009-0002-1133-7891","observed_orcids":["https://orcid.org/0009-0002-1133-7891"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huisheng Zhou","raw_affiliation_strings":["Department of Orthopaedics, the First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124711247","display_name":"Kanglong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]},{"id":"https://openalex.org/I4210139237","display_name":"First Hospital of Jiaxing","ror":"https://ror.org/03q5hbn76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kanglong Wu","raw_affiliation_strings":["Department of Orthopaedics, the First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, the First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, People's Republic of China","institution_ids":["https://openalex.org/I4210092870","https://openalex.org/I4210139237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0607711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10776","display_name":"Spinal Fractures and Fixation Techniques","score":0.05829999968409538,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporotic-vertebral-fractures","display_name":"osteoporotic vertebral fractures","score":0.984000027179718},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6830000281333923},{"id":"https://openalex.org/keywords/molecular-mechanisms-of-pain","display_name":"molecular mechanisms of pain","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.7170000076293945},{"id":"https://openalex.org/keywords/osteoclast-activity","display_name":"osteoclast activity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.871999979019165},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.859000027179718},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8489999771118164},{"id":"https://openalex.org/keywords/trpa1","display_name":"TRPA1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/wwp1","display_name":"WWP1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/stk11","display_name":"STK11","score":1.0},{"id":"https://openalex.org/keywords/neural-pathways","display_name":"neural pathways","score":0.44600000977516174},{"id":"https://openalex.org/keywords/anti-osteoporotic-therapy","display_name":"anti-osteoporotic therapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9678999781608582},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5315999984741211},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4973999857902527},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.45159998536109924},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.43320000171661377},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.4092999994754791},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3720000088214874},{"id":"https://openalex.org/C2991742891","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain control","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C2776139714","wikidata":"https://www.wikidata.org/wiki/Q3480107","display_name":"Bone pain","level":2,"score":0.350600004196167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3325999975204468},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.33219999074935913},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C2776501849","wikidata":"https://www.wikidata.org/wiki/Q5781808","display_name":"Back pain","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2147/jpr.s567567","doi":"https://doi.org/10.2147/jpr.s567567","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jpr.s567567","pdf_url":null,"source":{"id":"https://openalex.org/S130650480","display_name":"Journal of Pain Research","issn_l":"1178-7090","issn":["1178-7090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain Research","raw_type":"journal-article"},{"id":"pmid:41878085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41878085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pain research","raw_type":"Journal Article"},{"id":"pmh:oai:dovepress.com/111540","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/molecular-mechanisms-and-therapeutic-targets-for-pain-following-osteop-peer-reviewed-fulltext-article-JPR","pdf_url":"https://www.dovepress.com/article/download/111540","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:13008118","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13008118/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13008118/pdf/JPR-19-567567.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Pain Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2147/jpr.s567567","doi":"https://doi.org/10.2147/jpr.s567567","is_oa":true,"landing_page_url":"https://doi.org/10.2147/jpr.s567567","pdf_url":null,"source":{"id":"https://openalex.org/S130650480","display_name":"Journal of Pain Research","issn_l":"1178-7090","issn":["1178-7090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pain Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W2056567602","https://openalex.org/W2093482229","https://openalex.org/W2559809466","https://openalex.org/W2971135861","https://openalex.org/W3006410442","https://openalex.org/W3027130245","https://openalex.org/W3087049586","https://openalex.org/W3088450528","https://openalex.org/W3092589286","https://openalex.org/W3106581765","https://openalex.org/W3129619386","https://openalex.org/W3133397451","https://openalex.org/W3134569922","https://openalex.org/W3157223134","https://openalex.org/W3165222669","https://openalex.org/W3176814188","https://openalex.org/W3186951593","https://openalex.org/W3189980693","https://openalex.org/W3201615287","https://openalex.org/W3207413163","https://openalex.org/W3210133982","https://openalex.org/W3212297893","https://openalex.org/W3212474907","https://openalex.org/W3217563678","https://openalex.org/W4200002803","https://openalex.org/W4200416873","https://openalex.org/W4220717341","https://openalex.org/W4225105821","https://openalex.org/W4280554536","https://openalex.org/W4280564381","https://openalex.org/W4280590277","https://openalex.org/W4282841155","https://openalex.org/W4289109730","https://openalex.org/W4292466653","https://openalex.org/W4293691859","https://openalex.org/W4296027776","https://openalex.org/W4297477899","https://openalex.org/W4312082827","https://openalex.org/W4312574985","https://openalex.org/W4318346748","https://openalex.org/W4321168652","https://openalex.org/W4321373878","https://openalex.org/W4327892883","https://openalex.org/W4360942145","https://openalex.org/W4379468289","https://openalex.org/W4382560321","https://openalex.org/W4387078927","https://openalex.org/W4387082125","https://openalex.org/W4387694306","https://openalex.org/W4388797145","https://openalex.org/W4390975058","https://openalex.org/W4390979923","https://openalex.org/W4391109255","https://openalex.org/W4391783120","https://openalex.org/W4392349358","https://openalex.org/W4392913247","https://openalex.org/W4394853504","https://openalex.org/W4396688538","https://openalex.org/W4401525477","https://openalex.org/W4401556143","https://openalex.org/W4401592410","https://openalex.org/W4401905374","https://openalex.org/W4402201808","https://openalex.org/W4402729577","https://openalex.org/W4404461494","https://openalex.org/W4405570810","https://openalex.org/W4405892235","https://openalex.org/W4406198006","https://openalex.org/W4407065204","https://openalex.org/W4408934839","https://openalex.org/W4408959824","https://openalex.org/W4409119234","https://openalex.org/W4412522198","https://openalex.org/W4414461890"],"related_works":[],"abstract_inverted_index":{"Osteoporotic":[0],"vertebral":[1],"fractures":[2,9,39],"(OVF)":[3],"are":[4,14,101],"among":[5],"the":[6,47,75],"most":[7],"common":[8],"in":[10,40,58,123],"older":[11],"adults.":[12],"They":[13],"strongly":[15],"linked":[16],"to":[17,104,143,148],"severe":[18],"pain,":[19,106],"disability,":[20],"and":[21,33,65,77,91,112,121,135,147,153,160],"a":[22],"reduced":[23],"quality":[24,161],"of":[25,50,79,162],"life.":[26,163],"Pain":[27],"from":[28,35],"OVFs":[29],"often":[30],"becomes":[31],"chronic":[32],"differs":[34],"pain":[36,81,119],"caused":[37],"by":[38],"normal":[41],"bone.":[42],"This":[43],"review":[44],"systematically":[45],"summarizes":[46],"molecular":[48,98],"mechanisms":[49,146],"OVF-related":[51],"pain.":[52],"It":[53],"focuses":[54],"on":[55],"how":[56],"changes":[57],"bone":[59],"metabolism,":[60],"inflammation,":[61],"non-coding":[62],"RNA":[63],"regulation,":[64],"neural":[66,136],"pathways":[67],"affect":[68],"each":[69],"other.":[70],"Major":[71],"factors":[72],"that":[73,100,157],"drive":[74],"onset":[76],"persistence":[78],"OVF":[80,105],"include":[82,128],"increased":[83],"osteoclast":[84],"activity,":[85],"abnormal":[86],"Wnt/\u03b2-catenin":[87],"signaling,":[88],"inflammatory":[89],"mediators,":[90],"neuropeptides.":[92],"Recent":[93],"studies":[94],"also":[95],"report":[96],"new":[97],"targets":[99],"closely":[102],"related":[103],"such":[107],"as":[108],"TRPA1,":[109],"WWP1,":[110],"STK11,":[111],"specific":[113],"microRNAs.":[114],"Targeted":[115],"treatments":[116,156],"may":[117],"improve":[118,158],"control":[120],"function":[122],"patients":[124],"with":[125],"OVF.":[126],"These":[127],"anti-neurosensitization":[129],"drugs,":[130],"anti-osteoporosis":[131],"therapies,":[132],"anti-inflammatory":[133],"treatments,":[134],"modulators.":[137],"More":[138],"research":[139],"is":[140],"still":[141],"needed":[142],"clarify":[144],"these":[145],"develop":[149],"safer,":[150],"more":[151,154],"effective,":[152],"personalized":[155],"outcomes":[159]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-02-03T00:00:00"}
