{"id":"https://openalex.org/W7127038267","doi":"https://doi.org/10.1002/ccr3.71984","title":"Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report","display_name":"Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127038267","doi":"https://doi.org/10.1002/ccr3.71984","pmid":"https://pubmed.ncbi.nlm.nih.gov/41635425"},"language":"en","primary_location":{"id":"doi:10.1002/ccr3.71984","doi":"https://doi.org/10.1002/ccr3.71984","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ccr3.71984","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ccr3.71984","source":{"id":"https://openalex.org/S2737168579","display_name":"Clinical Case Reports","issn_l":"2050-0904","issn":["2050-0904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ccr3.71984","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045115034","display_name":"Rahim Badrfam","orcid":"https://orcid.org/0000-0001-9808-1678","observed_orcids":["https://orcid.org/0000-0001-9808-1678"]},"institutions":[{"id":"https://openalex.org/I4387153077","display_name":"Alborz University of Medical Sciences","ror":"https://ror.org/03hh69c20","country_code":"IR","type":"education","lineage":["https://openalex.org/I4387153077"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Rahim Badrfam","raw_affiliation_strings":["Community Mental Health Center (CMHCs) Alborz University of Medical Sciences  Karaj Alborz Iran","Department of Psychosomatic Medicine, Shariati Hospital Alborz University of Medical Sciences  Karaj Alborz Iran","Non\u2010Communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Alborz Iran"],"raw_orcid":"https://orcid.org/0000-0001-9808-1678","affiliations":[{"raw_affiliation_string":"Community Mental Health Center (CMHCs) Alborz University of Medical Sciences  Karaj Alborz Iran","institution_ids":["https://openalex.org/I4387153077"]},{"raw_affiliation_string":"Department of Psychosomatic Medicine, Shariati Hospital Alborz University of Medical Sciences  Karaj Alborz Iran","institution_ids":["https://openalex.org/I4387153077"]},{"raw_affiliation_string":"Non\u2010Communicable Diseases Research Center Alborz University of Medical Sciences  Karaj Alborz Iran","institution_ids":["https://openalex.org/I4387153077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001224629","display_name":"Atefeh Zandifar","orcid":"https://orcid.org/0000-0002-4725-1734","observed_orcids":["https://orcid.org/0000-0002-4725-1734"]},"institutions":[{"id":"https://openalex.org/I4387153077","display_name":"Alborz University of Medical Sciences","ror":"https://ror.org/03hh69c20","country_code":"IR","type":"education","lineage":["https://openalex.org/I4387153077"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Atefeh Zandifar","raw_affiliation_strings":["Clinical Research Development Unit, Department of Psychiatry, Imam Hossein Medical Education Center Alborz University of Medical Sciences  Karaj Alborz Iran","Social Determinants of Health Research Center Alborz University of Medical Sciences  Karaj Alborz Iran"],"raw_orcid":"https://orcid.org/0000-0002-4725-1734","affiliations":[{"raw_affiliation_string":"Clinical Research Development Unit, Department of Psychiatry, Imam Hossein Medical Education Center Alborz University of Medical Sciences  Karaj Alborz Iran","institution_ids":["https://openalex.org/I4387153077"]},{"raw_affiliation_string":"Social Determinants of Health Research Center Alborz University of Medical Sciences  Karaj Alborz Iran","institution_ids":["https://openalex.org/I4387153077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001224629"],"corresponding_institution_ids":["https://openalex.org/I4387153077"],"apc_list":{"value":1820,"currency":"USD","value_usd":1820},"apc_paid":{"value":1820,"currency":"USD","value_usd":1820},"fwci":8.8513,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.97218397,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"14","issue":"2","first_page":"e71984","last_page":"e71984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/suicidal-ideation","display_name":"suicidal ideation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.7860000133514404},{"id":"https://openalex.org/keywords/insomnia","display_name":"insomnia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.6620000004768372},{"id":"https://openalex.org/keywords/melatonin-receptors","display_name":"melatonin receptors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/antidepressant-side-effects","display_name":"antidepressant side effects","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9538999795913696},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.7983999848365784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7576000094413757},{"id":"https://openalex.org/C2776641880","wikidata":"https://www.wikidata.org/wiki/Q944142","display_name":"Suicidal ideation","level":4,"score":0.717199981212616},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.6164000034332275},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.6111999750137329},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48539999127388},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.46779999136924744},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.45170000195503235},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4487999975681305},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.42820000648498535},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.40950000286102295},{"id":"https://openalex.org/C3020493615","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive mood","level":3,"score":0.4009000062942505},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3982999920845032},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.38499999046325684},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C3018449479","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressed mood","level":3,"score":0.34450000524520874},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.3179999887943268},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.3172000050544739},{"id":"https://openalex.org/C2780798758","wikidata":"https://www.wikidata.org/wiki/Q395229","display_name":"Agomelatine","level":4,"score":0.31439998745918274},{"id":"https://openalex.org/C88160501","wikidata":"https://www.wikidata.org/wiki/Q5223563","display_name":"Dark therapy","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.29429998993873596},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.28459998965263367},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2824000120162964},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C2778996325","wikidata":"https://www.wikidata.org/wiki/Q422201","display_name":"Actigraphy","level":3,"score":0.262800008058548}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/ccr3.71984","doi":"https://doi.org/10.1002/ccr3.71984","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ccr3.71984","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ccr3.71984","source":{"id":"https://openalex.org/S2737168579","display_name":"Clinical Case Reports","issn_l":"2050-0904","issn":["2050-0904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Case Reports","raw_type":"journal-article"},{"id":"pmid:41635425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41635425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical case reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11669867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12862267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2468640e52c743cab9dc228a43ad631d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2468640e52c743cab9dc228a43ad631d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Case Reports, Vol 14, Iss 2, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ccr3.71984","doi":"https://doi.org/10.1002/ccr3.71984","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ccr3.71984","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ccr3.71984","source":{"id":"https://openalex.org/S2737168579","display_name":"Clinical Case Reports","issn_l":"2050-0904","issn":["2050-0904"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6570991277694702,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327589","display_name":"Alborz University of Medical Sciences","ror":"https://ror.org/03hh69c20"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7127038267.pdf","grobid_xml":"https://content.openalex.org/works/W7127038267.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2094716109","https://openalex.org/W3104511921","https://openalex.org/W3167915831","https://openalex.org/W4200393284","https://openalex.org/W4284958197","https://openalex.org/W4294308467","https://openalex.org/W4310494045","https://openalex.org/W4319455609","https://openalex.org/W4360599471","https://openalex.org/W4391032989","https://openalex.org/W4392199329","https://openalex.org/W4399781578","https://openalex.org/W4411125562"],"related_works":[],"abstract_inverted_index":{"Melatonin":[0],"is":[1],"a":[2,51,55],"neurohormone":[3],"that":[4],"primarily":[5],"regulates":[6],"sleep":[7,60],"patterns":[8],"and":[9,18,58,62],"circadian":[10,22],"rhythms":[11,23],"by":[12],"interacting":[13],"with":[14,32,65,69],"melatonin":[15,40],"receptors":[16],"MT1":[17],"MT2.":[19],"Disruptions":[20],"in":[21],"may":[24],"contribute":[25],"to":[26,43],"mood":[27,57],"disorders;":[28],"for":[29],"example,":[30],"individuals":[31],"major":[33],"depressive":[34],"disorder":[35],"often":[36],"have":[37],"significantly":[38],"lower":[39],"levels":[41],"compared":[42],"healthy":[44],"individuals.":[45],"In":[46,67],"this":[47],"report,":[48],"we":[49],"present":[50],"patient":[52],"who":[53],"experienced":[54],"depressed":[56],"nighttime":[59],"disturbances":[61],"was":[63],"treated":[64],"melatonin.":[66],"patients":[68],"depression,":[70],"factors":[71],"such":[72],"as":[73],"insomnia":[74],"or":[75],"poor":[76],"psychosocial":[77],"conditions":[78],"can":[79],"increase":[80],"the":[81],"risk":[82],"of":[83],"suicidal":[84],"thoughts.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-02-03T00:00:00"}