{"id":"https://openalex.org/W7127038197","doi":"https://doi.org/10.1021/acsnano.5c20032","title":"Deciphering the Hepatic Cellular Interactions of PEGylated Iron Oxide Nanoparticles","display_name":"Deciphering the Hepatic Cellular Interactions of PEGylated Iron Oxide Nanoparticles","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127038197","doi":"https://doi.org/10.1021/acsnano.5c20032","pmid":"https://pubmed.ncbi.nlm.nih.gov/41620948"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.5c20032","doi":"https://doi.org/10.1021/acsnano.5c20032","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5c20032","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014785642","display_name":"Jianxian Ge","orcid":"https://orcid.org/0000-0002-4317-1083","observed_orcids":["https://orcid.org/0000-0002-4317-1083"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxian Ge","raw_affiliation_strings":["Institute of Biomedical Engineering, School of Life Sciences","Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","Suzhou Medical College of Soochow University"],"raw_orcid":"https://orcid.org/0000-0002-4317-1083","affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering, School of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124724180","display_name":"Jieya Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieya Chen","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124700637","display_name":"Ning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124697290","display_name":"Xiuqi Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuqi Hu","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124731906","display_name":"Dandan Zhou","orcid":"https://orcid.org/0000-0002-7054-4498","observed_orcids":["https://orcid.org/0000-0002-7054-4498"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Zhou","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":"https://orcid.org/0000-0002-7054-4498","affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124730926","display_name":"Yun Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Gao","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124696175","display_name":"Yi Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhou","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124718377","display_name":"Ruru Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruru Zhang","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124733810","display_name":"Zhe Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Yang","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124736261","display_name":"Can Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Can Chen","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030875855","display_name":"Lei Chen","orcid":"https://orcid.org/0000-0003-3016-1625","observed_orcids":["https://orcid.org/0000-0003-3016-1625"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Chen","raw_affiliation_strings":["Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017245032","display_name":"Jianfeng Zeng","orcid":"https://orcid.org/0000-0001-7654-8724","observed_orcids":["https://orcid.org/0000-0001-7654-8724"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianfeng Zeng","raw_affiliation_strings":["Biomedical Basic Research Center (BBRC) of Jiangsu Province","Department of Radiology","Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","The First Affiliated Hospital of Soochow University"],"raw_orcid":"https://orcid.org/0000-0001-7654-8724","affiliations":[{"raw_affiliation_string":"Biomedical Basic Research Center (BBRC) of Jiangsu Province","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]},{"raw_affiliation_string":"The First Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124704752","display_name":"Mingyuan Gao","orcid":"https://orcid.org/0000-0002-7360-3684","observed_orcids":["https://orcid.org/0000-0002-7360-3684"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4405271368","display_name":"State Key Laboratory of Radiation Medicine and Protection","ror":"https://ror.org/02av90z31","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271368"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingyuan Gao","raw_affiliation_strings":["Biomedical Basic Research Center (BBRC) of Jiangsu Province","Institute of Biomedical Engineering, School of Life Sciences","Soochow University","State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","Suzhou Medical College of Soochow University"],"raw_orcid":"https://orcid.org/0000-0002-7360-3684","affiliations":[{"raw_affiliation_string":"Biomedical Basic Research Center (BBRC) of Jiangsu Province","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedical Engineering, School of Life Sciences","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions","institution_ids":["https://openalex.org/I4405271368"]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017245032","https://openalex.org/A5124704752"],"corresponding_institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210153519","https://openalex.org/I4405271368"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.8979,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.87550984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"20","issue":"6","first_page":"5157","last_page":"5170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particle-size-effects","display_name":"particle size effects","score":0.6890000104904175},{"id":"https://openalex.org/keywords/peg-chain-length","display_name":"PEG chain length","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatocyte-uptake","display_name":"hepatocyte uptake","score":0.7540000081062317},{"id":"https://openalex.org/keywords/liver-sinusoidal-endothelial-cells","display_name":"liver sinusoidal endothelial cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanoparticle-clearance","display_name":"nanoparticle clearance","score":0.6930000185966492},{"id":"https://openalex.org/keywords/spect-ct-imaging","display_name":"SPECT/CT imaging","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nanomedicine-design","display_name":"nanomedicine design","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.7131999731063843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6032999753952026},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5881999731063843},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5508999824523926},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.4481000006198883},{"id":"https://openalex.org/C195521686","wikidata":"https://www.wikidata.org/wiki/Q17152676","display_name":"Liver cytology","level":3,"score":0.4478999972343445},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C2776165368","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Systemic circulation","level":2,"score":0.42329999804496765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41339999437332153},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3804999887943268},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.33149999380111694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.25440001487731934}],"mesh":[{"descriptor_ui":"D000072098","descriptor_name":"Single Photon Emission Computed Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072098","descriptor_name":"Single Photon Emission Computed Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072098","descriptor_name":"Single Photon Emission Computed Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072098","descriptor_name":"Single Photon Emission Computed Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082662","descriptor_name":"Magnetic Iron Oxide Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000082662","descriptor_name":"Magnetic Iron Oxide Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000082662","descriptor_name":"Magnetic Iron Oxide Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000082662","descriptor_name":"Magnetic Iron Oxide Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsnano.5c20032","doi":"https://doi.org/10.1021/acsnano.5c20032","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5c20032","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:41620948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41620948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1083336075","display_name":null,"funder_award_id":"BK20255001","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G2141878717","display_name":null,"funder_award_id":"82172003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3282968693","display_name":null,"funder_award_id":"82402458","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5081740801","display_name":null,"funder_award_id":"82572396","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6890253078","display_name":null,"funder_award_id":"82222033","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8663587304","display_name":null,"funder_award_id":"82130059","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1131581251","https://openalex.org/W1545032870","https://openalex.org/W1963890445","https://openalex.org/W1976952320","https://openalex.org/W1990796256","https://openalex.org/W2042275621","https://openalex.org/W2046258330","https://openalex.org/W2050886209","https://openalex.org/W2057775112","https://openalex.org/W2058841557","https://openalex.org/W2067038346","https://openalex.org/W2076779593","https://openalex.org/W2077576735","https://openalex.org/W2087757733","https://openalex.org/W2107910518","https://openalex.org/W2111288662","https://openalex.org/W2114797146","https://openalex.org/W2115782119","https://openalex.org/W2121170935","https://openalex.org/W2126564292","https://openalex.org/W2127236332","https://openalex.org/W2143743183","https://openalex.org/W2156938445","https://openalex.org/W2210403156","https://openalex.org/W2290495400","https://openalex.org/W2435972256","https://openalex.org/W2470906679","https://openalex.org/W2515394036","https://openalex.org/W2564043830","https://openalex.org/W2772471632","https://openalex.org/W2886620535","https://openalex.org/W2899456184","https://openalex.org/W2936176039","https://openalex.org/W2976606306","https://openalex.org/W3011522961","https://openalex.org/W3044368567","https://openalex.org/W3115905980","https://openalex.org/W3163583874","https://openalex.org/W3205549065","https://openalex.org/W4205729477","https://openalex.org/W4206212907","https://openalex.org/W4210888253","https://openalex.org/W4285588391","https://openalex.org/W4289942888","https://openalex.org/W4396867871","https://openalex.org/W4401715974","https://openalex.org/W4408075107","https://openalex.org/W4409096130"],"related_works":[],"abstract_inverted_index":{"The":[0],"hepatic":[1,58,97,108,118,139,194],"accumulation":[2,195,209],"of":[3,19,42,165,177,183,196,210,226],"nanoparticles":[4,37],"significantly":[5,146],"impedes":[6],"their":[7,57],"diagnostic":[8],"and":[9,45,48,54,81,95,117,138,151,189,219,242],"therapeutic":[10],"efficacy":[11],"in":[12,23,78,121,187,190,204,229],"biomedical":[13],"applications.":[14],"However,":[15],"the":[16,40,71,79,106,159,174,180,193,208,224],"precise":[17],"role":[18],"specific":[20],"physicochemical":[21],"properties":[22],"determining":[24],"nanoliver":[25,230],"interaction":[26],"remains":[27],"poorly":[28],"understood.":[29],"This":[30],"study":[31,160],"utilizes":[32],"99m":[33],"Tc-labeled":[34],"iron":[35],"oxide":[36],"to":[38,156,215,238],"elucidate":[39],"effect":[41],"size":[43,150],"(3.6":[44],"12.0":[46],"nm)":[47],"PEG":[49,89,104,152],"chain":[50,153],"length":[51],"(1K,":[52],"2K,":[53],"5K)":[55],"on":[56],"interactions.":[59],"In":[60],"vivo":[61,191],"SPECT/CT":[62],"imaging":[63],"reveals":[64],"that":[65],"small":[66,197],"particles":[67,75,100,198,212],"initially":[68],"clear":[69],"through":[70],"kidneys,":[72],"while":[73,207],"large":[74,211],"predominantly":[76],"accumulate":[77],"liver":[80,86,126,130],"spleen,":[82],"ultimately":[83],"showing":[84],"significant":[85],"uptake.":[87],"Longer":[88],"chains":[90],"generally":[91],"extend":[92],"circulation":[93,115],"time":[94,116],"slow":[96],"uptake,":[98],"with":[99,102,124,201,217],"coated":[101],"2K":[103],"exhibiting":[105],"lowest":[107],"accumulation,":[109],"suggesting":[110],"an":[111,162],"optimal":[112],"balance":[113],"between":[114],"sequestration.":[119],"Complementary":[120],"vitro":[122,188],"studies":[123],"primary":[125,181,205],"cells\u2500namely":[127],"hepatocytes":[128],"(HCs),":[129],"sinusoidal":[131],"endothelial":[132],"cells":[133,136,141],"(LSECs),":[134],"Kupffer":[135],"(KCs),":[137],"stellate":[140],"(HSCs)\u2500reveal":[142],"complex":[143],"uptake":[144,163,202],"behaviors":[145],"influenced":[147],"by":[148],"particle":[149],"length.":[154],"Contrary":[155],"conventional":[157],"wisdom,":[158],"identifies":[161],"trend":[164],"HCs":[166],"\u223c":[167],"HSCs":[168],">":[169,171],"LSECs":[170,218],"KCs,":[172],"challenging":[173],"prevailing":[175],"notion":[176],"KCs":[178],"as":[179],"mediators":[182],"nanoparticle":[184],"clearance.":[185],"Bridging":[186],"observations,":[192],"closely":[199],"correlates":[200],"patterns":[203],"HCs,":[206],"is":[213],"linked":[214],"interactions":[216],"KCs.":[220],"These":[221],"results":[222],"highlight":[223],"importance":[225],"cellular":[227],"microenvironments":[228],"interactions,":[231],"offering":[232],"design":[233],"guidance":[234],"for":[235],"optimizing":[236],"nanomedicines":[237],"achieve":[239],"enhanced":[240],"specificity":[241],"reduced":[243],"off-target":[244],"effects.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-02-03T00:00:00"}