{"id":"https://openalex.org/W7127037965","doi":"https://doi.org/10.1080/09205063.2026.2614052","title":"Evaluation of PLGA nanoparticle-based conjugate vaccines incorporating lipopolysaccharide and alginate for inducing immunity against P. aeruginosa : a rabbit model study","display_name":"Evaluation of PLGA nanoparticle-based conjugate vaccines incorporating lipopolysaccharide and alginate for inducing immunity against P. aeruginosa : a rabbit model study","publication_year":2026,"publication_date":"2026-02-01","ids":{"openalex":"https://openalex.org/W7127037965","doi":"https://doi.org/10.1080/09205063.2026.2614052","pmid":"https://pubmed.ncbi.nlm.nih.gov/41621065"},"language":"en","primary_location":{"id":"doi:10.1080/09205063.2026.2614052","doi":"https://doi.org/10.1080/09205063.2026.2614052","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09205063.2026.2614052","pdf_url":null,"source":{"id":"https://openalex.org/S150667925","display_name":"Journal of Biomaterials Science Polymer Edition","issn_l":"0920-5063","issn":["0920-5063","1568-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Science, Polymer Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124724007","display_name":"Mohammad Hossein Mosannani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Hossein Mosannani","raw_affiliation_strings":["Department of Microbiology, Faculty of Sciences, Young Researchers Club, Za. C.,, Islamic Azad University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Sciences, Young Researchers Club, Za. C.,, Islamic Azad University","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124700507","display_name":"Masoud Maleki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masoud Maleki","raw_affiliation_strings":["Nanobiotechnology Research Center, Za. C., Islamic Azad University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanobiotechnology Research Center, Za. C., Islamic Azad University","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084296757","display_name":"Mojtaba Salouti","orcid":"https://orcid.org/0000-0003-3287-0791","observed_orcids":["https://orcid.org/0000-0003-3287-0791"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mojtaba Salouti","raw_affiliation_strings":["Nanobiotechnology Research Center, Za. C., Islamic Azad University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanobiotechnology Research Center, Za. C., Islamic Azad University","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037743638","display_name":"Reza Shapouri","orcid":"https://orcid.org/0000-0003-1998-759X","observed_orcids":["https://orcid.org/0000-0003-1998-759X"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Reza Shapouri","raw_affiliation_strings":["Department of Microbiology, Faculty of Sciences, Za. C.,, Islamic Azad University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Sciences, Za. C.,, Islamic Azad University","institution_ids":["https://openalex.org/I110525433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084296757"],"corresponding_institution_ids":["https://openalex.org/I110525433"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06119066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.19859999418258667,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.19529999792575836,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9449999928474426},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.847000002861023},{"id":"https://openalex.org/keywords/nanovaccines","display_name":"nanovaccines","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alginate-capsules","display_name":"alginate capsules","score":0.765999972820282},{"id":"https://openalex.org/keywords/antigen-conjugation","display_name":"antigen conjugation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.7250000238418579},{"id":"https://openalex.org/keywords/intramuscular-vaccination","display_name":"intramuscular vaccination","score":0.9629999995231628},{"id":"https://openalex.org/keywords/antibody-titration","display_name":"antibody titration","score":0.6589999794960022},{"id":"https://openalex.org/keywords/opsonophagocytosis","display_name":"opsonophagocytosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6589999794960022},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.7373999953269958},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6984999775886536},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6682000160217285},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6643000245094299},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6575999855995178},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5460000038146973},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5412999987602234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49720001220703125},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.48539999127388},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.424699991941452},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41780000925064087},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4156999886035919},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4106999933719635},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4065000116825104},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38999998569488525},{"id":"https://openalex.org/C2776796551","wikidata":"https://www.wikidata.org/wiki/Q310656","display_name":"Pasteurella multocida","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2630000114440918},{"id":"https://openalex.org/C2779583294","wikidata":"https://www.wikidata.org/wiki/Q5161160","display_name":"Conjugate vaccine","level":4,"score":0.2574999928474426},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.25189998745918274}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/09205063.2026.2614052","doi":"https://doi.org/10.1080/09205063.2026.2614052","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09205063.2026.2614052","pdf_url":null,"source":{"id":"https://openalex.org/S150667925","display_name":"Journal of Biomaterials Science Polymer Edition","issn_l":"0920-5063","issn":["0920-5063","1568-5624"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Science, Polymer Edition","raw_type":"journal-article"},{"id":"pmid:41621065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41621065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomaterials science. Polymer edition","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44269901514053345,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1828116623","https://openalex.org/W1912209985","https://openalex.org/W1981732262","https://openalex.org/W1982335062","https://openalex.org/W2007753370","https://openalex.org/W2015561909","https://openalex.org/W2056187885","https://openalex.org/W2087136825","https://openalex.org/W2087336485","https://openalex.org/W2120151444","https://openalex.org/W2130907025","https://openalex.org/W2132807567","https://openalex.org/W2135878037","https://openalex.org/W2164347730","https://openalex.org/W2168260466","https://openalex.org/W2170284567","https://openalex.org/W2219109907","https://openalex.org/W2272680836","https://openalex.org/W2626082249","https://openalex.org/W2799456944","https://openalex.org/W2805031563","https://openalex.org/W2807161463","https://openalex.org/W2907444722","https://openalex.org/W2939347585","https://openalex.org/W2984211371","https://openalex.org/W2995167752","https://openalex.org/W3023796325","https://openalex.org/W3084654873","https://openalex.org/W3109746936","https://openalex.org/W3176575435","https://openalex.org/W3192110442","https://openalex.org/W4243380412","https://openalex.org/W4289645980","https://openalex.org/W4295129698","https://openalex.org/W4411516337"],"related_works":[],"abstract_inverted_index":{"A":[0],"common":[1],"Gram-negative":[2],"bacterium,":[3],"Pseudomonas":[4],"aeruginosa":[5,58],"poses":[6],"a":[7,80,154],"special":[8],"risk":[9],"to":[10,34,45,106,134,144,169,195],"people":[11,24],"with":[12,25,39,76],"compromised":[13],"immune":[14],"systems,":[15],"including":[16],"those":[17],"receiving":[18],"chemotherapy,":[19],"organ":[20],"transplant":[21],"recipients,":[22],"and":[23,42,61,74,86,104,140,174],"cystic":[26],"fibrosis.":[27],"The":[28,53,116],"purpose":[29],"of":[30,56,102,125,157,180],"this":[31],"study":[32],"was":[33,59,93,97,119,183],"use":[35],"PLGA":[36,77,175],"nanoparticles":[37],"conjugated":[38,75],"lipopolysaccharide":[40,63],"(LPS)":[41],"alginate":[43],"antigens":[44],"create":[46],"an":[47],"efficient":[48],"nanovaccine":[49],"against":[50],"P.":[51,57,158],"aeruginosa.":[52,159],"mass":[54],"culture":[55],"prepared":[60],"its":[62,67],"as":[64,66],"well":[65],"polysaccharide":[68],"capsule":[69],"(alginate)":[70],"were":[71,150],"extracted,":[72],"purified":[73],"NPs.":[78],"Using":[79],"zeta":[81],"sizer,":[82],"Fourier-transform":[83],"infrared":[84],"spectroscopy,":[85],"atomic":[87],"force":[88],"microscopy,":[89],"the":[90,126,131,137,146,148],"conjugation":[91],"process":[92],"verified.":[94],"Then,":[95,143],"vaccination":[96,187],"administered":[98],"in":[99,177],"two":[100,128],"ways":[101,179],"intramuscular":[103,189],"intranasal":[105,196],"48":[107],"New":[108],"Zealand":[109],"white":[110],"male":[111],"rabbits":[112,127,149],"(each":[113],"trial":[114],"24).":[115],"blood":[117],"sampling":[118],"performed":[120],"from":[121],"marginal":[122],"ear":[123],"vein":[124],"weeks":[129],"after":[130],"last":[132],"administration":[133],"carry":[135],"out":[136],"antibody":[138],"titration":[139],"opsonophagocytosis":[141],"assay.":[142],"check":[145],"immunogenicity,":[147],"challenged":[151],"by":[152,188],"injecting":[153],"direct":[155],"dose":[156],"In":[160],"general,":[161],"LPS-PLGA":[162],"conjugate":[163],"produced":[164],"significantly":[165],"higher":[166],"immunogenicity":[167],"compared":[168,194],"ALG-PLGA":[170],"conjugate,":[171],"pure":[172],"antigens,":[173],"NPs":[176],"both":[178],"administration.":[181],"It":[182],"also":[184],"found":[185],"that":[186],"injection":[190],"causes":[191],"better":[192],"immunity":[193],"vaccination.":[197]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-02-03T00:00:00"}