{"id":"https://openalex.org/W7126747283","doi":null,"title":"Oxidative stress is exacerbated in the aging cochlea of Alzheimer's disease mouse models","display_name":"Oxidative stress is exacerbated in the aging cochlea of Alzheimer's disease mouse models","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W7126747283"},"language":"en","primary_location":{"id":"pmh:oai:ruidera.uclm.es:10578/37587","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10578/37587","pdf_url":null,"source":{"id":"https://openalex.org/S4377196358","display_name":"RUIdeRA - Institutional University Repository (University of Castilla-La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu_repo/semantics/conferenceObject"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10578/37587","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124613244","display_name":"Jos\u00e9 Manuel Juiz G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juiz G\u00f3mez, Jos\u00e9 Manuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124624706","display_name":"Juan Carlos Alvarado Romero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alvarado Romero, Juan Carlos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124637959","display_name":"Thomas Lenarz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lenarz, Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095376519","display_name":"Zaskya Ben\u00edtez-Maic\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben\u00edtez Maican, Zaskya Chiquinquira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114574413","display_name":"Mar\u00eda Cruz Gabald\u00f3n Ull","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gablad\u00f3n Ull, Mar\u00eda C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8539999723434448},{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cochlea","display_name":"cochlea","score":0.9350000023841858},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7379999756813049},{"id":"https://openalex.org/keywords/auditory-receptors","display_name":"auditory receptors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6753000020980835},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.6355000138282776},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.607699990272522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5493999719619751},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5339999794960022},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5020999908447266},{"id":"https://openalex.org/C2779912225","wikidata":"https://www.wikidata.org/wiki/Q1756133","display_name":"Presbycusis","level":3,"score":0.5},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4912000000476837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4277999997138977},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C2777443451","wikidata":"https://www.wikidata.org/wiki/Q821413","display_name":"Auditory system","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3131999969482422},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.3127000033855438},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C2908709693","wikidata":"https://www.wikidata.org/wiki/Q821413","display_name":"Auditory pathways","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C23979983","wikidata":"https://www.wikidata.org/wiki/Q1165103","display_name":"Virtuous circle and vicious circle","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:ruidera.uclm.es:10578/37587","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10578/37587","pdf_url":null,"source":{"id":"https://openalex.org/S4377196358","display_name":"RUIdeRA - Institutional University Repository (University of Castilla-La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu_repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:ruidera.uclm.es:10578/37587","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10578/37587","pdf_url":null,"source":{"id":"https://openalex.org/S4377196358","display_name":"RUIdeRA - Institutional University Repository (University of Castilla-La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu_repo/semantics/conferenceObject"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162685637","https://openalex.org/W4415094574","https://openalex.org/W4380185425","https://openalex.org/W4404870368","https://openalex.org/W7135607358","https://openalex.org/W4392240411","https://openalex.org/W4283273580","https://openalex.org/W4309788001","https://openalex.org/W4294771861","https://openalex.org/W4210933524"],"abstract_inverted_index":{"Background:":[0],"Age-related":[1],"hearing":[2,50],"loss":[3],"(ARHL)":[4],"is":[5],"the":[6,26,29,36,43],"major":[7],"risk":[8],"factor":[9],"of":[10],"Alzheimer":[11],"disease":[12],"(AD)":[13],"in":[14,35],"midlife.":[15],"Neuropathogenic":[16],"interactions":[17],"between":[18,58],"ARHL":[19,59],"and":[20,60],"AD":[21,34],"are":[22],"unknown.":[23],"We":[24],"test":[25],"hypothesis":[27],"that":[28],"beta-amyloid":[30],"proteinopathy":[31],"linked":[32],"to":[33],"central":[37],"nervous":[38],"system":[39],"has":[40],"effects":[41],"on":[42],"auditory":[44],"receptor,":[45],"which":[46],"may":[47],"exacerbate":[48],"preexisting":[49],"loss,":[51],"thus":[52],"generating":[53],"an":[54],"unsuspected":[55],"vicious":[56],"circle":[57],"AD.":[61]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-02T00:00:00"}