{"id":"https://openalex.org/W7126730641","doi":null,"title":"Evaluation of the Immunogenicity of Novel HIV-1 gp160 Env mRNA Vaccines in Pre-clinical Mouse and Guinea Pig Models","display_name":"Evaluation of the Immunogenicity of Novel HIV-1 gp160 Env mRNA Vaccines in Pre-clinical Mouse and Guinea Pig Models","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W7126730641"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/42725339","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/42725339","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112699439","display_name":"Wenjin Jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiang, Wenjin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112699439"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-vaccine","display_name":"HIV-1 vaccine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mrna-vaccines","display_name":"mRNA vaccines","score":0.6800000071525574},{"id":"https://openalex.org/keywords/hiv-1-envelope-glycoprotein","display_name":"HIV-1 envelope glycoprotein","score":0.6549999713897705},{"id":"https://openalex.org/keywords/gp160","display_name":"gp160","score":0.9309999942779541},{"id":"https://openalex.org/keywords/sosip-trimers","display_name":"SOSIP trimers","score":0.5400000214576721},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.8510000109672546},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.9089999794960022},{"id":"https://openalex.org/keywords/fusion-peptide","display_name":"fusion peptide","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.901199996471405},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7315000295639038},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.644599974155426},{"id":"https://openalex.org/C2776258796","wikidata":"https://www.wikidata.org/wiki/Q5590520","display_name":"Gp41","level":4,"score":0.5695000290870667},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5618000030517578},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5552999973297119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5042999982833862},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4284999966621399},{"id":"https://openalex.org/C2909828532","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"AIDS Vaccines","level":4,"score":0.40939998626708984},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.3959999978542328},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3467000126838684},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.3458999991416931},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.3386000096797943},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.335999995470047},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.3174000084400177},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.30309998989105225},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.2766999900341034},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.2621000111103058},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.2621000111103058},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/42725339","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/42725339","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401546285","https://openalex.org/W4406674098","https://openalex.org/W7008515987","https://openalex.org/W4221095080","https://openalex.org/W2924788224","https://openalex.org/W7212045240","https://openalex.org/W3187225045","https://openalex.org/W3135919349","https://openalex.org/W7171516213","https://openalex.org/W3144367249"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1],"virus":[2],"(HIV)":[3],"is":[4,42,68],"one":[5],"of":[6,18,26,85,98,165,278,300,306,332,360,365],"the":[7,76,83,163,263,301,325,330,358],"biggest":[8],"healthcare":[9],"challenges":[10],"that":[11,202,238],"humans":[12],"have":[13],"ever":[14],"faced,":[15],"with":[16,21,47,132,270],"millions":[17],"people":[19],"living":[20],"HIV":[22,33,48,66,99,123,362],"and":[23,64,74,116,129,151,162,181,186,246,289,298,311,339,354],"new":[24,72],"cases":[25],"infections":[27,73],"each":[28],"year.":[29],"Despite":[30],"advances":[31],"in":[32,232,242,309,321,324],"treatments,":[34],"an":[35],"example":[36],"being":[37],"antiretroviral":[38],"therapies":[39],"(ART),":[40],"there":[41],"still":[43],"no":[44],"cure.":[45],"Individuals":[46],"are":[49,130],"required":[50],"to":[51,70,157,295,336],"take":[52],"lifelong":[53],"treatment":[54],"for":[55,178],"virologic":[56],"control.":[57],"As":[58],"a":[59,62,243,260],"result,":[60],"developing":[61],"safe":[63],"effective":[65],"vaccine":[67,104,334],"needed":[69],"reduce":[71],"protect":[75],"public.":[77],"In":[78],"this":[79],"study,":[80],"we":[81],"explored":[82],"immunogenicity":[84,231],"structure-based,":[86],"epitope-targeted":[87,351],"HIV-1":[88],"nanoparticle":[89],"enclosed":[90],"messenger":[91],"RNA":[92],"(mRNA)":[93],"vaccines":[94,316,363],"targeting":[95,247],"V2":[96],"apex":[97],"Envelope":[100],"(Env)":[101],"glycoprotein.":[102],"The":[103],"encodes":[105],"three":[106],"engineered":[107],"Env":[108,241],"glycoproteins":[109],"as":[110,141],"immunogens:":[111],"Wildtype":[112],"(WT),":[113],"Optimized":[114],"(OPT),":[115],"Alternative":[117],"(ALT).":[118],"All":[119],"immunogens":[120,171],"build":[121],"on":[122],"clade":[124],"C":[125],"serotype":[126],"459C":[127],"backbone":[128],"informed":[131],"broadly":[133,367],"neutralizing":[134,271,368],"antibody":[135,166,194,253,272,302],"(bNAb)":[136],"signatures.":[137],"Key":[138],"modifications":[139],"such":[140],"stabilizing":[142,239],"mutations,":[143,146,150],"glycan":[144],"hole":[145],"antigenic":[147],"diversity":[148],"set":[149],"cleavage":[152],"site":[153],"linkers":[154],"were":[155,184,188,196],"introduced":[156],"improve":[158,230],"trimer":[159],"stability,":[160],"immunogenicity,":[161],"breadth":[164,299],"responses.":[167,254,303],"mRNA":[168],"encoding":[169],"these":[170,307],"was":[172],"formulated":[173],"into":[174,225,350],"lipid":[175],"nanoparticles":[176],"(LNPs)":[177],"delivery.":[179],"Mice":[180],"Guinea":[182],"pigs":[183],"immunized,":[185],"sera":[187],"collected":[189,259],"at":[190],"regular":[191],"intervals.":[192],"Binding":[193],"responses":[195,342],"monitored":[197],"by":[198],"endpoint":[199],"ELISA,":[200],"demonstrating":[201],"SOSIP-stabilized":[203],"gp160":[204,213],"constructs":[205],"induce":[206],"significantly":[207],"higher":[208],"IgG":[209],"titers":[210],"than":[211],"non-SOSIP":[212],"or":[214],"SOSIP":[215],"gp140":[216],"constructs.":[217],"Moreover,":[218],"incorporating":[219],"fusion":[220],"peptide":[221],"(FP)":[222],"bNAb":[223],"signatures":[224],"V2-SET":[226],"designs":[227],"might":[228],"further":[229,356],"both":[233],"models.":[234],"These":[235],"findings":[236,346],"highlight":[237],"full-length":[240],"native-like":[244],"conformation":[245],"multiple":[248],"vulnerable":[249],"epitopes":[250],"enhances":[251],"vaccine-induced":[252],"For":[255],"future":[256],"studies,":[257],"serum":[258],"month":[261],"after":[262],"third":[264],"boosting":[265],"immunization":[266],"would":[267,317],"be":[268,293,319],"tested":[269,320],"(NAb)":[273],"assays":[274],"against":[275,343],"heterologous":[276],"panels":[277],"select":[279,314],"tier":[280],"2":[281],"V2-sensitive":[282],"and/or":[283],"FP-sensitive":[284],"HIV-Env":[285],"pseudoviruses.":[286],"Additional":[287],"boosts":[288],"longer-term":[290],"follow-ups":[291],"will":[292],"performed":[294],"evaluate":[296],"durability":[297],"After":[304],"completion":[305],"studies":[308],"mice":[310],"guinea":[312],"pigs,":[313],"candidate":[315],"finally":[318],"non-human":[322],"primates":[323],"future.":[326],"This":[327],"study":[328],"highlights":[329],"potential":[331],"mRNA-LNP":[333],"platforms":[335],"elicit":[337],"broad":[338],"robust":[340],"immune":[341],"HIV.":[344],"Our":[345],"provide":[347],"valuable":[348],"insights":[349],"immunogen":[352],"design":[353],"could":[355],"inform":[357],"development":[359],"next-generation":[361],"capable":[364],"inducing":[366],"antibodies.":[369]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2026-02-02T00:00:00"}