{"id":"https://openalex.org/W7126459307","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","title":"The role of FGF23 in cardiovascular disease: From pathophysiology to biomarker and therapeutic implications","display_name":"The role of FGF23 in cardiovascular disease: From pathophysiology to biomarker and therapeutic implications","publication_year":2026,"publication_date":"2026-01-31","ids":{"openalex":"https://openalex.org/W7126459307","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.4"},"language":"en","primary_location":{"id":"doi:10.21776/ub.hsj.2026.007.01.4","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","pdf_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20353/552","source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20353/552","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020656532","display_name":"Ary Bima Kurniawan","orcid":"https://orcid.org/0009-0006-6455-942X","observed_orcids":["https://orcid.org/0009-0006-6455-942X","https://orcid.org/0000-0001-8864-7770"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ary Kurniawan","raw_affiliation_strings":["Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia"],"raw_orcid":"https://orcid.org/0009-0006-6455-942X","affiliations":[{"raw_affiliation_string":"Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067526249","display_name":"Mohammad Saifur Rohman","orcid":"https://orcid.org/0000-0001-6461-2223","observed_orcids":["https://orcid.org/0000-0001-6461-2223","https://orcid.org/0009-0003-8194-8222"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]},{"id":"https://openalex.org/I4210130688","display_name":"RSUD Prof. Dr. Saiful Anwar Malang","ror":"https://ror.org/03qa48d48","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210130688"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mohammad Saifur Rohman","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia - Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia"],"raw_orcid":"https://orcid.org/0009-0003-8194-8222","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia - Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia","institution_ids":["https://openalex.org/I177055848","https://openalex.org/I4210130688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"17","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.890999972820282},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9139999747276306},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.968999981880188},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mineral-metabolism","display_name":"mineral metabolism","score":0.8420000076293945},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9810000061988831},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.953000009059906},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7089999914169312},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2776036575","wikidata":"https://www.wikidata.org/wiki/Q1641062","display_name":"Hyperphosphatemia","level":3,"score":0.7997000217437744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7652999758720398},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.7228000164031982},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6243000030517578},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5692999958992004},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5091000199317932},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4927999973297119},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.4864000082015991},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4796000123023987},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.41749998927116394},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3935000002384186},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.36010000109672546},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.33340001106262207},{"id":"https://openalex.org/C2781309322","wikidata":"https://www.wikidata.org/wiki/Q5038718","display_name":"Cardiorenal syndrome","level":3,"score":0.32829999923706055},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.31630000472068787},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21776/ub.hsj.2026.007.01.4","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","pdf_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20353/552","source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21776/ub.hsj.2026.007.01.4","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.hsj.2026.007.01.4","pdf_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20353/552","source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126459307.pdf","grobid_xml":"https://content.openalex.org/works/W7126459307.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1803609188","https://openalex.org/W1967604492","https://openalex.org/W1973870305","https://openalex.org/W1988422100","https://openalex.org/W1991297728","https://openalex.org/W2013057766","https://openalex.org/W2015668150","https://openalex.org/W2069321199","https://openalex.org/W2078730571","https://openalex.org/W2098935670","https://openalex.org/W2105125729","https://openalex.org/W2109411631","https://openalex.org/W2111361781","https://openalex.org/W2111614075","https://openalex.org/W2131843552","https://openalex.org/W2136001397","https://openalex.org/W2151714015","https://openalex.org/W2154225761","https://openalex.org/W2157448600","https://openalex.org/W2159532786","https://openalex.org/W2162615269","https://openalex.org/W2504981678","https://openalex.org/W2521550167","https://openalex.org/W2550881001","https://openalex.org/W2552829374","https://openalex.org/W2563417571","https://openalex.org/W2802752524","https://openalex.org/W2802871943","https://openalex.org/W2809961205","https://openalex.org/W2899773405","https://openalex.org/W2971576504","https://openalex.org/W2996912140","https://openalex.org/W3024268898","https://openalex.org/W3098263601","https://openalex.org/W3108795502","https://openalex.org/W3112831852","https://openalex.org/W3134804367","https://openalex.org/W3163339370","https://openalex.org/W3216696954","https://openalex.org/W4308419576","https://openalex.org/W4396556571","https://openalex.org/W4397011710"],"related_works":["https://openalex.org/W2763090493","https://openalex.org/W3134804367","https://openalex.org/W7128744787","https://openalex.org/W2023873704","https://openalex.org/W2071290793","https://openalex.org/W2809961205","https://openalex.org/W1967664222","https://openalex.org/W4414981301","https://openalex.org/W2508823587","https://openalex.org/W2616973692"],"abstract_inverted_index":{"Cardiovascular":[0,196],"disease":[1,66,182],"(CVD)":[2],"remains":[3],"a":[4,22,34,118,177,181],"leading":[5],"global":[6],"cause":[7],"of":[8],"mortality,":[9],"necessitating":[10],"deeper":[11],"insights":[12],"into":[13,184],"non-traditional":[14],"risk":[15,189],"factors.":[16],"Fibroblast":[17],"growth":[18],"factor":[19],"23":[20],"(FGF23),":[21],"hormone":[23,179],"central":[24],"to":[25,37,48,106,170],"phosphate":[26,143],"and":[27,59,68,82,97,132,159,180,191],"vitamin":[28],"D":[29],"regulation,":[30],"has":[31],"emerged":[32],"as":[33,117,175],"pivotal":[35],"contributor":[36],"CVD":[38,88,188],"pathogenesis.":[39],"This":[40],"review":[41],"synthesizes":[42],"evidence":[43],"linking":[44],"elevated":[45],"FGF23":[46,75,151],"levels":[47],"adverse":[49],"cardiovascular":[50,112],"outcomes,":[51],"including":[52],"left":[53],"ventricular":[54],"hypertrophy,":[55],"vascular":[56],"calcification,":[57],"hypertension,":[58],"atrial":[60],"fibrillation":[61],"in":[62,104,122],"both":[63,176],"chronic":[64],"kidney":[65],"(CKD)":[67],"individuals":[69],"with":[70],"preserved":[71],"renal":[72,130],"function.":[73],"Mechanistically,":[74],"exerts":[76],"direct":[77],"effects":[78,139],"on":[79],"cardiac":[80,154],"remodeling":[81],"calcium":[83],"handling":[84],"while":[85],"indirectly":[86],"promoting":[87],"via":[89],"dysregulated":[90],"mineral":[91],"metabolism,":[92],"renin-angiotensin-aldosterone":[93],"system":[94],"(RAAS)":[95],"activation,":[96],"inflammatory":[98],"pathways.":[99],"Paradoxically,":[100],"its":[101,115],"compensatory":[102,178],"rise":[103],"CKD":[105],"counteract":[107],"hyperphosphatemia":[108],"becomes":[109],"maladaptive,":[110],"accelerating":[111],"pathology.":[113],"Despite":[114],"potential":[116],"biomarker,":[119],"challenges":[120],"persist":[121],"establishing":[123],"causality,":[124],"disentangling":[125],"confounding":[126],"factors":[127],"(e.g.,":[128],"inflammation,":[129],"function),":[131],"developing":[133],"targeted":[134],"therapies":[135],"that":[136],"mitigate":[137],"pathological":[138],"without":[140],"disrupting":[141],"physiological":[142],"homeostasis.":[144],"Future":[145],"research":[146],"must":[147],"prioritize":[148],"defining":[149],"context-specific":[150],"thresholds,":[152],"elucidating":[153],"versus":[155],"systemic":[156],"signaling":[157],"mechanisms,":[158],"advancing":[160],"receptor-specific":[161],"interventions.":[162],"Bridging":[163],"these":[164],"gaps":[165],"will":[166],"require":[167],"multidisciplinary":[168],"collaboration":[169],"translate":[171],"FGF23\u2019s":[172],"dual":[173],"roles,":[174],"mediator":[183],"clinical":[185],"strategies":[186],"for":[187],"stratification":[190],"management.":[192],"Keyword":[193],":":[194],"Biomarker;":[195],"Disease;":[197],"FGF23;":[198],"Inflammation;":[199],"Mineral":[200],"Metabolism.":[201]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-02-02T00:00:00"}
