{"id":"https://openalex.org/W7126443299","doi":"https://doi.org/10.2169/internalmedicine.6293-25","title":"Successful Treatment of Synchronous Double Lung and Colon Cancers Using Immune Checkpoint Inhibitors","display_name":"Successful Treatment of Synchronous Double Lung and Colon Cancers Using Immune Checkpoint Inhibitors","publication_year":2026,"publication_date":"2026-01-31","ids":{"openalex":"https://openalex.org/W7126443299","doi":"https://doi.org/10.2169/internalmedicine.6293-25","pmid":"https://pubmed.ncbi.nlm.nih.gov/41621865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13627645"},"language":"en","primary_location":{"id":"doi:10.2169/internalmedicine.6293-25","doi":"https://doi.org/10.2169/internalmedicine.6293-25","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.6293-25","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6293-25/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6293-25/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026017066","display_name":"Shuichi Matsuoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129415","display_name":"Matsue Red Cross Hospital","ror":"https://ror.org/03nc3zw41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129415"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Matsuoka","raw_affiliation_strings":["Respiratory Medicine Division, Matsue Red Cross Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine Division, Matsue Red Cross Hospital, Japan","institution_ids":["https://openalex.org/I4210129415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008566571","display_name":"Hirokazu Tokuyasu","orcid":"https://orcid.org/0009-0008-1727-5285","observed_orcids":["https://orcid.org/0009-0008-1727-5285"]},"institutions":[{"id":"https://openalex.org/I4210129415","display_name":"Matsue Red Cross Hospital","ror":"https://ror.org/03nc3zw41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129415"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Tokuyasu","raw_affiliation_strings":["Respiratory Medicine Division, Matsue Red Cross Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine Division, Matsue Red Cross Hospital, Japan","institution_ids":["https://openalex.org/I4210129415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109576662","display_name":"Katsunori Arai","orcid":"https://orcid.org/0009-0002-4243-5531","observed_orcids":["https://orcid.org/0009-0002-4243-5531"]},"institutions":[{"id":"https://openalex.org/I4210129415","display_name":"Matsue Red Cross Hospital","ror":"https://ror.org/03nc3zw41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129415"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunori Arai","raw_affiliation_strings":["Respiratory Medicine Division, Matsue Red Cross Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine Division, Matsue Red Cross Hospital, Japan","institution_ids":["https://openalex.org/I4210129415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109382934","display_name":"Hiromitsu Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129415","display_name":"Matsue Red Cross Hospital","ror":"https://ror.org/03nc3zw41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129415"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Sakai","raw_affiliation_strings":["Respiratory Medicine Division, Matsue Red Cross Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Medicine Division, Matsue Red Cross Hospital, Japan","institution_ids":["https://openalex.org/I4210129415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093105510","display_name":"Chika Esumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129415","display_name":"Matsue Red Cross Hospital","ror":"https://ror.org/03nc3zw41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129415"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chika Esumi","raw_affiliation_strings":["Pathology Division, Matsue Red Cross Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Division, Matsue Red Cross Hospital, Japan","institution_ids":["https://openalex.org/I4210129415"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101570878","display_name":"Akira Yamasaki","orcid":"https://orcid.org/0000-0001-5175-2729","observed_orcids":["https://orcid.org/0000-0001-5175-2729"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Yamasaki","raw_affiliation_strings":["Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, School of Medicine, Faculty of Medicine, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"17","first_page":"2358","last_page":"2363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anti-ctla-4-antibody","display_name":"anti-CTLA-4 antibody","score":0.996999979019165},{"id":"https://openalex.org/keywords/microsatellite-instability-high","display_name":"microsatellite instability-high","score":0.6769999861717224},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9574999809265137},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6762999892234802},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6363000273704529},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6348000168800354},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.49939998984336853},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4887000024318695},{"id":"https://openalex.org/C2780833581","wikidata":"https://www.wikidata.org/wiki/Q2562556","display_name":"Ascending colon","level":2,"score":0.4683000147342682},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4523000121116638},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.44519999623298645},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4431999921798706},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35499998927116394},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3529999852180481},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34860000014305115},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C2993158029","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colon adenocarcinoma","level":4,"score":0.3156000077724457},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3131999969482422},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C2779563347","wikidata":"https://www.wikidata.org/wiki/Q843799","display_name":"Adenocarcinoma of the lung","level":4,"score":0.2799000144004822}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009378","descriptor_name":"Neoplasms, Multiple Primary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2169/internalmedicine.6293-25","doi":"https://doi.org/10.2169/internalmedicine.6293-25","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.6293-25","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6293-25/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},{"id":"pmid:41621865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41621865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal medicine (Tokyo, Japan)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13627645","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13627645/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intern Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2169/internalmedicine.6293-25","doi":"https://doi.org/10.2169/internalmedicine.6293-25","is_oa":true,"landing_page_url":"https://doi.org/10.2169/internalmedicine.6293-25","pdf_url":"https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_6293-25/_pdf","source":{"id":"https://openalex.org/S154471048","display_name":"Internal Medicine","issn_l":"0918-2918","issn":["0918-2918","1349-7235"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313351","host_organization_name":"The Japanese Society of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310313351"],"host_organization_lineage_names":["The Japanese Society of Internal Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126443299.pdf","grobid_xml":"https://content.openalex.org/works/W7126443299.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1759669640","https://openalex.org/W2014796448","https://openalex.org/W2107972234","https://openalex.org/W2111807726","https://openalex.org/W2114545185","https://openalex.org/W2164523473","https://openalex.org/W2228221433","https://openalex.org/W2610723832","https://openalex.org/W2767176099","https://openalex.org/W2801822890","https://openalex.org/W2914311090","https://openalex.org/W2946629069","https://openalex.org/W2984359187","https://openalex.org/W2986688781","https://openalex.org/W3110528877","https://openalex.org/W3204759452","https://openalex.org/W3211119032","https://openalex.org/W4212850558","https://openalex.org/W4212853769","https://openalex.org/W4304807333","https://openalex.org/W4308179948","https://openalex.org/W4388592608","https://openalex.org/W4392859371","https://openalex.org/W4398218166","https://openalex.org/W4402325058","https://openalex.org/W4404784379","https://openalex.org/W4404923724","https://openalex.org/W4404958494","https://openalex.org/W4406818361","https://openalex.org/W4411471356"],"related_works":["https://openalex.org/W2912120399","https://openalex.org/W4415539712","https://openalex.org/W4389244464","https://openalex.org/W4214729461","https://openalex.org/W2903653714","https://openalex.org/W4317910790","https://openalex.org/W2400886095","https://openalex.org/W4390239962","https://openalex.org/W3186656946","https://openalex.org/W3046968934"],"abstract_inverted_index":{"We":[0],"herein":[1],"report":[2],"a":[3,42],"case":[4],"of":[5,17,25,44,85,94],"successfully":[6],"treated":[7],"synchronous":[8],"advanced":[9],"cancers:":[10],"programmed":[11],"death-ligand1":[12],"(PD-L1)-negative":[13],"squamous":[14],"cell":[15],"carcinoma":[16],"the":[18,26,35,39,76,82,92],"left":[19],"upper":[20],"lung":[21,30,64,96],"lobe":[22],"and":[23,46,65,88,97],"adenocarcinoma":[24],"ascending":[27],"colon.":[28],"As":[29],"cancer":[31],"was":[32],"prioritized":[33],"as":[34],"primary":[36],"therapeutic":[37,83],"target,":[38],"patient":[40],"received":[41],"combination":[43],"anti-PD-L1":[45,87],"anti-cytotoxic":[47],"T-lymphocyte-associated":[48],"protein-4":[49],"(CTLA-4)":[50],"antibodies,":[51],"along":[52],"with":[53],"chemotherapy":[54],"(the":[55],"POSEIDON":[56],"regimen).":[57],"This":[58],"approach":[59],"proved":[60],"effective":[61],"against":[62],"both":[63],"colon":[66,77],"cancer.":[67,78],"Subsequent":[68],"testing":[69],"revealed":[70],"high-frequency":[71],"microsatellite":[72],"instability":[73],"(MSI-H)":[74],"in":[75,91],"These":[79],"findings":[80],"highlight":[81],"potential":[84],"combined":[86],"anti-CTLA-4":[89],"antibodies":[90],"treatment":[93],"PD-L1-negative":[95],"MSI-H":[98],"colorectal":[99],"cancers.":[100]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-02-02T00:00:00"}
