{"id":"https://openalex.org/W7126440933","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","title":"A case of cardiac myxoma with obstructive symptoms: Recognizing key early signs for improved diagnosis","display_name":"A case of cardiac myxoma with obstructive symptoms: Recognizing key early signs for improved diagnosis","publication_year":2026,"publication_date":"2026-01-31","ids":{"openalex":"https://openalex.org/W7126440933","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.21"},"language":"en","primary_location":{"id":"doi:10.21776/ub.hsj.2026.007.01.21","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","pdf_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20429/569","source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20429/569","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124523271","display_name":"Marco Filano","orcid":"https://orcid.org/0009-0001-4365-4907","observed_orcids":["https://orcid.org/0009-0001-4365-4907"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Marco Filano","raw_affiliation_strings":["Brawijaya Cardiovascular Research Centre, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia"],"raw_orcid":"https://orcid.org/0009-0001-4365-4907","affiliations":[{"raw_affiliation_string":"Brawijaya Cardiovascular Research Centre, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124471955","display_name":"Corinna Maria Kuhn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Corinna Maria Kuhn","raw_affiliation_strings":["Eberhard Karls Universit\u00e4t T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eberhard Karls Universit\u00e4t T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124490371","display_name":"Zihan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihan Zhao","raw_affiliation_strings":["Sichuan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124663691","display_name":"Noora Julia Laukkanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Noora Julia Laukkanen","raw_affiliation_strings":["University of Eastern Finland, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083598768","display_name":"Anna Fuji Rahimah","orcid":"https://orcid.org/0000-0002-4349-3744","observed_orcids":["https://orcid.org/0000-0002-4349-3744"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Anna Fuji Rahimah","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-4349-3744","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079435882","display_name":"Wella Karolina","orcid":"https://orcid.org/0009-0007-7569-0033","observed_orcids":["https://orcid.org/0009-0007-7569-0033"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wella Karolina","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia"],"raw_orcid":"https://orcid.org/0009-0007-7569-0033","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060712352","display_name":"Indra Prasetya","orcid":"https://orcid.org/0000-0003-0431-7411","observed_orcids":["https://orcid.org/0000-0003-0431-7411"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Indra Prasetya","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine , Faculty of Medicine , Universitas Brawijaya , Malang , Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-0431-7411","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine , Faculty of Medicine , Universitas Brawijaya , Malang , Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112965392","display_name":"M Luqman Fadli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"M. Luqman Fadli","raw_affiliation_strings":["Department of Pathology Anatomy , Faculty of Medicine , Universitas Brawijaya , Malang , Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Anatomy , Faculty of Medicine , Universitas Brawijaya , Malang , Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067526249","display_name":"Mohammad Saifur Rohman","orcid":"https://orcid.org/0000-0001-6461-2223","observed_orcids":["https://orcid.org/0000-0001-6461-2223","https://orcid.org/0009-0003-8194-8222"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mohammad Saifur Rohman","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia"],"raw_orcid":"https://orcid.org/0009-0003-8194-8222","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06272855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":"119","last_page":"123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12598","display_name":"Cardiac Structural Anomalies and Repair","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/left-atrial-myxoma","display_name":"left atrial myxoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/rheumatic-mitral-stenosis","display_name":"rheumatic mitral stenosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/primary-cardiac-tumor","display_name":"primary cardiac tumor","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.7409999966621399},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.746999979019165},{"id":"https://openalex.org/keywords/transthoracic-echocardiography","display_name":"transthoracic echocardiography","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitral-valve-area","display_name":"mitral valve area","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9049999713897705},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7728000283241272},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7652999758720398},{"id":"https://openalex.org/C2910622060","wikidata":"https://www.wikidata.org/wiki/Q4817544","display_name":"Left Atrial Myxoma","level":4,"score":0.6800000071525574},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.6662999987602234},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6509000062942505},{"id":"https://openalex.org/C2777542379","wikidata":"https://www.wikidata.org/wiki/Q589612","display_name":"Myxoma","level":2,"score":0.6309000253677368},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5443999767303467},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5307999849319458},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4846999943256378},{"id":"https://openalex.org/C114021368","wikidata":"https://www.wikidata.org/wiki/Q189265","display_name":"Atrium (architecture)","level":3,"score":0.3878999948501587},{"id":"https://openalex.org/C2780703314","wikidata":"https://www.wikidata.org/wiki/Q1140794","display_name":"Mitral valve stenosis","level":3,"score":0.37709999084472656},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3206999897956848},{"id":"https://openalex.org/C2777575523","wikidata":"https://www.wikidata.org/wiki/Q4817544","display_name":"Atrial myxoma","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C2775854548","wikidata":"https://www.wikidata.org/wiki/Q6882369","display_name":"Mitral valve replacement","level":3,"score":0.30079999566078186},{"id":"https://openalex.org/C2777274916","wikidata":"https://www.wikidata.org/wiki/Q1913658","display_name":"Papillary muscle","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27889999747276306},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C2777615863","wikidata":"https://www.wikidata.org/wiki/Q1074839","display_name":"Left atrium","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C2908602593","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral incompetence","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C2780346441","wikidata":"https://www.wikidata.org/wiki/Q55609890","display_name":"Doppler echocardiography","level":4,"score":0.259799987077713}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21776/ub.hsj.2026.007.01.21","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","pdf_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20429/569","source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.21776/ub.hsj.2026.007.01.21","doi":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","is_oa":true,"landing_page_url":"https://doi.org/10.21776/ub.hsj.2026.007.01.21","pdf_url":"https://heartscience.ub.ac.id/index.php/heartscience/article/download/20429/569","source":{"id":"https://openalex.org/S4210236341","display_name":"Heart Science Journal","issn_l":"2721-9976","issn":["2721-9976","2721-9984"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart Science Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126440933.pdf","grobid_xml":"https://content.openalex.org/works/W7126440933.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2566032678","https://openalex.org/W4384070893","https://openalex.org/W2082534874","https://openalex.org/W3177349170","https://openalex.org/W1538764509","https://openalex.org/W4412110072","https://openalex.org/W4393858489","https://openalex.org/W2276246443","https://openalex.org/W4396621944","https://openalex.org/W7202197517"],"abstract_inverted_index":{"Background:":[0],"LA":[1,182],"myxoma":[2,168],"is":[3,44,69,219],"the":[4,16,20,26,36,50,93,125,130,134,139,147,184,188,193,201,205,212,221,274],"most":[5],"common":[6],"primary":[7],"cardiac":[8,102,268,284],"tumor,":[9],"often":[10],"presenting":[11],"with":[12,83,112,243],"obstructive":[13,280],"symptoms":[14,172,245,281],"when":[15],"tumor":[17,142,185],"prolapses":[18],"into":[19,129,187],"mitral":[21,37,53,109,114,161,178,189],"valve":[22,115,162,190,223],"during":[23,133,192],"diastole.":[24],"On":[25],"other":[27],"hand,":[28],"rheumatic":[29,108],"MS":[30,218],"leads":[31],"to":[32,174,204,229],"fixed":[33],"obstruction":[34,158,176],"of":[35,41,52,58,177,252,277,283,288],"valve.":[38],"The":[39,156],"coexistence":[40],"both":[42],"conditions":[43,240],"extremely":[45],"rare":[46],"and":[47,66,73,96,146,164,208,214,233,257,262,299],"can":[48,292],"exacerbate":[49],"severity":[51],"inflow":[54],"obstruction.":[55],"Early":[56],"recognition":[57],"this":[59,226],"dual":[60,157],"pathology":[61],"through":[62],"careful":[63],"clinical":[64,290],"evaluation":[65,105],"echocardiographic":[67],"assessment":[68],"crucial":[70],"for":[71],"timely":[72],"effective":[74],"management.":[75],"Case":[76],"Presentations:":[77],"A":[78],"66-year-old":[79],"female":[80],"patient":[81,297],"presented":[82],"progressive":[84],"dyspnea.":[85],"Transthoracic":[86],"echocardiography":[87],"detected":[88],"a":[89,101,113,151,165],"mobile":[90],"mass":[91,126],"in":[92,170,211],"left":[94,131,152,166,202,206],"atrium":[95,203,213],"later":[97],"identified":[98],"it":[99],"as":[100,247],"myxoma.":[103,155,285],"Further":[104],"revealed":[106,150],"severe":[107,235],"stenosis":[110,163],"(MS)":[111],"area":[116],"(MVA)":[117],"measured":[118],"by":[119,160,266],"planimetry":[120],"at":[121],"1.23":[122],"cm\u00b2,":[123],"restricting":[124],"from":[127,200],"slipping":[128],"ventricle":[132,207],"diastolic":[135,175,260],"phase.":[136],"Based":[137],"on":[138],"conference":[140],"decision,":[141],"resection":[143],"was":[144],"performed,":[145],"histopathological":[148],"examination":[149],"atrial":[153,167,231],"(LA)":[154],"caused":[159,265],"resulted":[169],"life-threatening":[171],"due":[173],"inflow.":[179],"In":[180],"isolated":[181],"myxoma,":[183],"pushes":[186],"opening":[191],"heart's":[194],"relaxation":[195],"phase,":[196],"blocking":[197],"blood":[198],"flow":[199],"raising":[209],"pressure":[210,232],"lungs.":[215],"When":[216],"significant":[217],"present,":[220],"narrowed":[222],"further":[224],"worsens":[225],"obstruction,":[227],"leading":[228],"higher":[230],"more":[234],"heart":[236,253],"failure":[237,254],"symptoms.":[238],"Both":[239],"commonly":[241],"present":[242],"early":[244,279],"such":[246],"exertional":[248],"dyspnea,":[249],"palpitations,":[250],"signs":[251],"like":[255],"edema":[256],"pulmonary":[258],"crackles,":[259],"murmur,":[261],"sometimes":[263],"syncope":[264],"reduced":[267],"output.":[269],"Conclusions:":[270],"This":[271],"case":[272],"highlights":[273],"critical":[275],"importance":[276],"identifying":[278],"indicative":[282],"Timely":[286],"identification":[287],"these":[289],"manifestations":[291],"facilitate":[293],"earlier":[294],"diagnosis,":[295],"improve":[296],"outcomes,":[298],"prevent":[300],"potentially":[301],"fatal":[302],"complications.":[303],"Keyword":[304],":":[305],"Myxoma;":[306],"Mitral":[307],"Stenosis;":[308],"Obstructive":[309],"Symptoms.":[310]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-02-02T00:00:00"}