{"id":"https://openalex.org/W7126431329","doi":"https://doi.org/10.1016/b978-0-443-23908-3.00006-x","title":"Pancreatic cancer: Wnt signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives","display_name":"Pancreatic cancer: Wnt signaling dysregulation, potential proteomic techniques, therapeutic strategies, and future perspectives","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7126431329","doi":"https://doi.org/10.1016/b978-0-443-23908-3.00006-x"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-443-23908-3.00006-x","doi":"https://doi.org/10.1016/b978-0-443-23908-3.00006-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-443-23908-3.00006-x","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics: A Promising Approach for Cancer Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7126466931","display_name":"Proteomics: A Promising Approach for Cancer Research"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001605708","display_name":"Neelam Bhatti","orcid":"https://orcid.org/0000-0002-9863-0582","observed_orcids":["https://orcid.org/0000-0002-9863-0582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neelam Bhatti","raw_affiliation_strings":["Department of Sciences, KMS College of IT & Management, Dasuya, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sciences, KMS College of IT & Management, Dasuya, Punjab, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108904099","display_name":"Younis Ahmad Hajam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259092","display_name":"Sant Baba Bhag Singh University","ror":"https://ror.org/01qhmaj40","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405259092"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Younis Ahmad Hajam","raw_affiliation_strings":["Department of Life Sciences and Allied Health Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Allied Health Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab, India","institution_ids":["https://openalex.org/I4405259092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124621670","display_name":"Rohit Malhotra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259092","display_name":"Sant Baba Bhag Singh University","ror":"https://ror.org/01qhmaj40","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405259092"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rohit Malhotra","raw_affiliation_strings":["Department of Life Sciences and Allied Health Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences and Allied Health Sciences, Sant Baba Bhag Singh University, Jalandhar, Punjab, India","institution_ids":["https://openalex.org/I4405259092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"173","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.055399999022483826,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/canonical-wnt-beta-catenin-signaling","display_name":"canonical Wnt/\u03b2-catenin pathway","score":0.8769999742507935},{"id":"https://openalex.org/keywords/non-canonical-wnt-pathway","display_name":"non-canonical Wnt pathway","score":0.843999981880188},{"id":"https://openalex.org/keywords/rnf43","display_name":"RNF43","score":0.828000009059906},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.6060000061988831},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6840000152587891},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8849999904632568},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9649999737739563},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.6970000267028809},{"id":"https://openalex.org/keywords/single-cell-proteomics","display_name":"single-cell proteomics","score":0.9459999799728394},{"id":"https://openalex.org/keywords/phosphoproteomics","display_name":"phosphoproteomics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.746999979019165},{"id":"https://openalex.org/keywords/wnt-inhibitors","display_name":"Wnt inhibitors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ligand-trap","display_name":"ligand trap","score":0.7210000157356262},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9629999995231628},{"id":"https://openalex.org/keywords/metabolic-regulators","display_name":"metabolic modulators","score":0.7379999756813049},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8966000080108643},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6559000015258789},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6054999828338623},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5364999771118164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5092999935150146},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4884999990463257},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4595000147819519},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4196999967098236},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3203999996185303},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3018999993801117},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.26669999957084656},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.26440000534057617},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2603999972343445},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-443-23908-3.00006-x","doi":"https://doi.org/10.1016/b978-0-443-23908-3.00006-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-443-23908-3.00006-x","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics: A Promising Approach for Cancer Research","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1500925570","https://openalex.org/W1741548448","https://openalex.org/W1898960514","https://openalex.org/W1900557155","https://openalex.org/W1927662311","https://openalex.org/W1969433149","https://openalex.org/W1971085650","https://openalex.org/W1980383179","https://openalex.org/W1990742231","https://openalex.org/W1994029539","https://openalex.org/W1997467790","https://openalex.org/W2006419043","https://openalex.org/W2006621723","https://openalex.org/W2014344192","https://openalex.org/W2023139178","https://openalex.org/W2025542867","https://openalex.org/W2036001472","https://openalex.org/W2037339501","https://openalex.org/W2038463702","https://openalex.org/W2078060536","https://openalex.org/W2081239048","https://openalex.org/W2090789702","https://openalex.org/W2106639175","https://openalex.org/W2109389695","https://openalex.org/W2112603564","https://openalex.org/W2116201301","https://openalex.org/W2117994982","https://openalex.org/W2132591766","https://openalex.org/W2137549245","https://openalex.org/W2138182674","https://openalex.org/W2145767879","https://openalex.org/W2158021558","https://openalex.org/W2166178545","https://openalex.org/W2290845417","https://openalex.org/W2317854038","https://openalex.org/W2417500899","https://openalex.org/W2734646423","https://openalex.org/W2751788109","https://openalex.org/W2774426493","https://openalex.org/W2788841932","https://openalex.org/W2800557466","https://openalex.org/W2903740986","https://openalex.org/W2904840918","https://openalex.org/W2911366579","https://openalex.org/W3112837287","https://openalex.org/W3140857766","https://openalex.org/W4311074402","https://openalex.org/W4394883055"],"related_works":["https://openalex.org/W2970549798","https://openalex.org/W38473313","https://openalex.org/W2301072195","https://openalex.org/W2257230233","https://openalex.org/W2370203254","https://openalex.org/W2891811488","https://openalex.org/W2169456310","https://openalex.org/W2898583484","https://openalex.org/W4377139279","https://openalex.org/W2007598959"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2026-02-02T00:00:00"}