{"id":"https://openalex.org/W7126323409","doi":null,"title":"Unveiling a Novel Molecular Biotype of Depression - Effects of Dysregulated microRNA Biogenesis in Treatment Resistance Depression","display_name":"Unveiling a Novel Molecular Biotype of Depression - Effects of Dysregulated microRNA Biogenesis in Treatment Resistance Depression","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W7126323409"},"language":"en","primary_location":{"id":"pmh:oai:www.tdx.cat:10803/695334","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/695334","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.tdx.cat/bitstream/10803/695334/1/LORENZON_Nicola_Tesis_doctoral.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031156826","display_name":"Nicola Lorenz\u00f3n","orcid":"https://orcid.org/0000-0003-4128-011X","observed_orcids":["https://orcid.org/0000-0003-4128-011X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lorenzon, Nicola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031156826"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.9120000004768372},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.925000011920929},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mirna-dysregulation","display_name":"microRNA dysregulation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.6470000147819519},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.41100001335144043},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5669999718666077},{"id":"https://openalex.org/keywords/depression-biomarkers","display_name":"depression biomarkers","score":0.39100000262260437},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.39399999380111694},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.3499999940395355},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6898000240325928},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.659600019454956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5961999893188477},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.46480000019073486},{"id":"https://openalex.org/C2777342061","wikidata":"https://www.wikidata.org/wiki/Q7836891","display_name":"Treatment-resistant depression","level":4,"score":0.39320001006126404},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.387800008058548},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3456999957561493},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.29440000653266907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29249998927116394},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28600001335144043},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27639999985694885},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27379998564720154},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2660999894142151},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.tdx.cat:10803/695334","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/695334","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositori.upf.edu:10803/695334","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/695334","pdf_url":"https://www.tdx.cat/bitstream/10803/695334/1/LORENZON_Nicola_Tesis_doctoral.pdf","source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:repositori.upf.edu:10803/695334","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/695334","pdf_url":"https://www.tdx.cat/bitstream/10803/695334/1/LORENZON_Nicola_Tesis_doctoral.pdf","source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126323409.pdf","grobid_xml":"https://content.openalex.org/works/W7126323409.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1979712026","https://openalex.org/W1982818125","https://openalex.org/W1983773897","https://openalex.org/W1990793436","https://openalex.org/W2004874491","https://openalex.org/W2010763857","https://openalex.org/W2024063260","https://openalex.org/W2024861481","https://openalex.org/W2026088841","https://openalex.org/W2028260332","https://openalex.org/W2034101361","https://openalex.org/W2035015498","https://openalex.org/W2037316926","https://openalex.org/W2043335534","https://openalex.org/W2050613411","https://openalex.org/W2068831018","https://openalex.org/W2069090835","https://openalex.org/W2073079805","https://openalex.org/W2077611326","https://openalex.org/W2083099355","https://openalex.org/W2084213854","https://openalex.org/W2089693199","https://openalex.org/W2093274439","https://openalex.org/W2093962936","https://openalex.org/W2096796062","https://openalex.org/W2098048002","https://openalex.org/W2099749043","https://openalex.org/W2114897984","https://openalex.org/W2126525177","https://openalex.org/W2136812855","https://openalex.org/W2142827889","https://openalex.org/W2155807286","https://openalex.org/W2157607979","https://openalex.org/W2161633633","https://openalex.org/W2168088150","https://openalex.org/W2180062270","https://openalex.org/W2185623954","https://openalex.org/W2340620158","https://openalex.org/W2395114866","https://openalex.org/W2405624971","https://openalex.org/W2468924201","https://openalex.org/W2509397462","https://openalex.org/W2523390870","https://openalex.org/W2537623931","https://openalex.org/W2564988627","https://openalex.org/W2617341365","https://openalex.org/W2618672386","https://openalex.org/W2753281823","https://openalex.org/W2755184922","https://openalex.org/W2794134966","https://openalex.org/W2807457056","https://openalex.org/W2811212358","https://openalex.org/W2885738092","https://openalex.org/W2888674886","https://openalex.org/W2890450469","https://openalex.org/W2910919283","https://openalex.org/W2912143827","https://openalex.org/W2915941065","https://openalex.org/W2953159153","https://openalex.org/W2964643970","https://openalex.org/W2965225112","https://openalex.org/W2970480306","https://openalex.org/W2970623573","https://openalex.org/W2972836719","https://openalex.org/W2979424795","https://openalex.org/W2991106430","https://openalex.org/W2997131827","https://openalex.org/W3005886042","https://openalex.org/W3014640582","https://openalex.org/W3016968891","https://openalex.org/W3017901520","https://openalex.org/W3037718479","https://openalex.org/W3047170019","https://openalex.org/W3048095405","https://openalex.org/W3088236858","https://openalex.org/W3105171788","https://openalex.org/W3121993315","https://openalex.org/W3134803076","https://openalex.org/W3137375284","https://openalex.org/W3158141024","https://openalex.org/W3160304067","https://openalex.org/W3185277097","https://openalex.org/W3194870832","https://openalex.org/W3195285310","https://openalex.org/W3196641817","https://openalex.org/W3196783567","https://openalex.org/W3198357471","https://openalex.org/W3204457954","https://openalex.org/W3207292489","https://openalex.org/W3211397738","https://openalex.org/W4206386241","https://openalex.org/W4211178302","https://openalex.org/W4281492138","https://openalex.org/W4281689406","https://openalex.org/W4283272097","https://openalex.org/W4288080690","https://openalex.org/W4296101600","https://openalex.org/W4307223955","https://openalex.org/W4307233739","https://openalex.org/W4309474348","https://openalex.org/W4309659052","https://openalex.org/W4311513230","https://openalex.org/W4313326212","https://openalex.org/W4318066558","https://openalex.org/W4322619915","https://openalex.org/W4322761520","https://openalex.org/W4361298453","https://openalex.org/W4366548863","https://openalex.org/W4366989938","https://openalex.org/W4367187160","https://openalex.org/W4376279472","https://openalex.org/W4376503781","https://openalex.org/W4376955916","https://openalex.org/W4380085664","https://openalex.org/W4380421968","https://openalex.org/W4381893312","https://openalex.org/W4382400397","https://openalex.org/W4385303408","https://openalex.org/W4385422169","https://openalex.org/W4385454829","https://openalex.org/W4386705506","https://openalex.org/W4386765496","https://openalex.org/W4386941141","https://openalex.org/W4386982993","https://openalex.org/W4387502938","https://openalex.org/W4387949493","https://openalex.org/W4390909740","https://openalex.org/W4391406855","https://openalex.org/W4391722995","https://openalex.org/W4392731282","https://openalex.org/W4394740566","https://openalex.org/W4395071608","https://openalex.org/W4396799212","https://openalex.org/W4396933563","https://openalex.org/W4399042143","https://openalex.org/W4399746595","https://openalex.org/W4399797835","https://openalex.org/W4400729277","https://openalex.org/W4400952158","https://openalex.org/W4401382708","https://openalex.org/W4402414406","https://openalex.org/W4402439616","https://openalex.org/W4402506611","https://openalex.org/W4402604270","https://openalex.org/W4402761211","https://openalex.org/W4403454795","https://openalex.org/W4404458588","https://openalex.org/W4405444320","https://openalex.org/W4406115249","https://openalex.org/W4406471199","https://openalex.org/W4406591204","https://openalex.org/W4407955090"],"related_works":["https://openalex.org/W4413998488","https://openalex.org/W7065100948","https://openalex.org/W4396799212","https://openalex.org/W3194806452","https://openalex.org/W7017521483","https://openalex.org/W7197092192","https://openalex.org/W7162108672","https://openalex.org/W4293242151","https://openalex.org/W2743267029","https://openalex.org/W3205467760"],"abstract_inverted_index":{"El":[0],"Trastorno":[1],"Depresivo":[2],"Mayor":[3],"(TDM)":[4],"es":[5],"uno":[6],"de":[7,17,20,29,36,46,59,62,74,78,97,102,142,147,152,158,175,182,187,242,249,252,254,271,276,282,284,292,296,310,320,326,335],"los":[8,51,63,193,201,255,311,336],"trastornos":[9,224],"psiqui\u00e1tricos":[10],"m\u00e1s":[11,16,58,77,112],"frecuentes":[12],"e":[13],"invalidantes,":[14],"con":[15,43,66,85,169,179,301],"300":[18],"millones":[19],"personas":[21],"afectadas":[22],"en":[23,34,117,191,207,219,222,264,286,331],"todo":[24],"el":[25,180,324],"mundo.":[26],"Las":[27],"estrategias":[28,328],"tratamiento":[30],"actuales":[31],"se":[32,140,198,215,238],"basan":[33],"tratamientos":[35],"\"ensayo":[37],"y":[38,76,107,171,214,245,322],"error\",":[39],"siguiendo":[40],"directrices":[41],"universales":[42],"diferentes":[44,223],"grupos":[45],"medicamentos":[47],"que":[48,98,130,132,149,200,235,258],"act\u00faan":[49],"sobre":[50,109],"pocos":[52],"mecanismos":[53,100],"patog\u00e9nicos":[54],"conocidos.":[55],"En":[56,91],"consecuencia,":[57],"dos":[60],"tercios":[61],"pacientes":[64,168],"diagnosticados":[65],"TDM":[67,87],"no":[68],"responden":[69],"a":[70,82,156,173,184,240,246,290],"la":[71,95,124,153,208,228,236,250,306,333],"primera":[72],"l\u00ednea":[73],"tratamiento,":[75],"un":[79,86,143,176,185,204,280,287],"tercio":[80],"pasar\u00e1":[81],"ser":[83],"considerado":[84],"\"resistente":[88],"al":[89,137,230,269,308],"tratamiento\".":[90],"este":[92,103,259],"proyecto,":[93],"investigamos":[94],"hip\u00f3tesis":[96],"existen":[99],"etiopatog\u00e9nicos":[101],"trastorno":[104],"a\u00fan":[105],"inexplorados,":[106],"que,":[108],"todo,":[110],"van":[111],"all\u00e1":[113],"del":[114,210],"cl\u00e1sico":[115],"enfoque":[116],"neurotransmisi\u00f3n,":[118],"estr\u00e9s":[119],"o":[120,274],"inflamaci\u00f3n,":[121],"dictados":[122],"por":[123],"visi\u00f3n":[125],"reduccionista":[126],"actual.":[127],"Adem\u00e1s,":[128,278],"creemos":[129],"lo":[131],"com\u00fanmente":[133],"llamamos":[134],"\"depresi\u00f3n":[135],"resistente":[136],"tratamiento\"":[138],"(DRT)":[139],"trate":[141],"distinto":[144],"biotipo":[145],"molecular":[146,189],"depresi\u00f3n,":[148],"comparte":[150],"elementos":[151],"sintomatolog\u00eda":[154],"cl\u00ednica,":[155],"pesar":[157],"tener":[159],"otro":[160],"origen":[161],"etiopatol\u00f3gico.":[162],"Para":[163],"comprobar":[164],"esta":[165],"teor\u00eda,":[166],"comparamos":[167],"DRT":[170,237,321],"no-DRT":[172],"trav\u00e9s":[174,291],"m\u00e9todo":[177],"multi\u00f3mico,":[178],"objetivo":[181],"investigar":[183],"nivel":[186],"regulaci\u00f3n":[188,209],"inexplorado":[190],"psiquiatr\u00eda:":[192],"microRNAs":[194],"(miRNAs).":[195],"De":[196],"hecho,":[197],"sabe":[199],"miRNAs":[202,285,312],"juegan":[203],"papel":[205],"crucial":[206],"sistema":[211],"nervioso":[212],"central,":[213],"han":[216],"observado":[217],"cambios":[218],"sus":[220],"concentraciones":[221],"psiqui\u00e1tricos,":[225],"especialmente":[226],"seg\u00fan":[227],"respuesta":[229],"tratamiento.":[231],"Nuestros":[232,303],"resultados":[233],"demuestran":[234],"asocia":[239],"marcas":[241],"miRNA":[243],"espec\u00edficas":[244],"una":[247,293,317],"desregulaci\u00f3n":[248],"maquinaria":[251,334],"biog\u00e9nesis":[253],"miRNAs.":[256,337],"Creemos":[257],"fen\u00f3meno":[260],"desencadene":[261],"alteraciones":[262],"funcionales":[263],"varios":[265],"procesos":[266],"biol\u00f3gicos,":[267],"ayudando":[268],"desarrollo":[270,325],"fenotipo":[272],"depresivo,":[273],"incluso":[275],"DRT.":[277],"validamos":[279],"subgrupo":[281],"candidatos":[283],"modelo":[288],"murino":[289],"inyecci\u00f3n":[294],"intraventricular":[295],"antagomires,":[297],"obteniendo":[298],"fenotipos":[299],"compatibles":[300],"depresi\u00f3n.":[302],"descubrimientos":[304],"abren":[305],"puerta":[307],"uso":[309],"como":[313],"biomarcadores":[314],"predictivos":[315],"para":[316,323],"identificaci\u00f3n":[318],"precoz":[319],"nuevas":[327],"terap\u00e9uticas":[329],"enfocadas":[330],"restablecer":[332]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-02-01T00:00:00"}