{"id":"https://openalex.org/W7126207257","doi":"https://doi.org/10.1016/j.repc.2026.01.005","title":"Cardio-oncology meets pharmacoeconomics: Cardiovascular toxicity matters in CLL treatment decisions","display_name":"Cardio-oncology meets pharmacoeconomics: Cardiovascular toxicity matters in CLL treatment decisions","publication_year":2026,"publication_date":"2026-01-30","ids":{"openalex":"https://openalex.org/W7126207257","doi":"https://doi.org/10.1016/j.repc.2026.01.005","pmid":"https://pubmed.ncbi.nlm.nih.gov/41621708"},"language":"en","primary_location":{"id":"doi:10.1016/j.repc.2026.01.005","doi":"https://doi.org/10.1016/j.repc.2026.01.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.repc.2026.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S4210203548","display_name":"Revista Portuguesa de Cardiologia","issn_l":"0870-2551","issn":["0870-2551","2174-2030"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Portuguesa de Cardiologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.repc.2026.01.005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061626781","display_name":"J\u00falia Toste","orcid":"https://orcid.org/0000-0003-3386-2232","observed_orcids":["https://orcid.org/0000-0003-3386-2232"]},"institutions":[{"id":"https://openalex.org/I4210105254","display_name":"Sociedade Portuguesa de Cardiologia","ror":"https://ror.org/01ey0me92","country_code":"PT","type":"other","lineage":["https://openalex.org/I4210105254"]},{"id":"https://openalex.org/I4210128540","display_name":"Hospital da Luz","ror":"https://ror.org/03jpm9j23","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210128540"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"J\u00falia Cristina Toste","raw_affiliation_strings":["Grupo de Estudos de Cardio-Oncologia, Sociedade Portuguesa de Cardiologia, Lisbon, Portugal; Department of Cardiology, Hospital da Luz, Lisbon, Portugal; NOVA Medical School, Lisbon, Portugal. Electronic address: jctoste@hospitaldaluz.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Estudos de Cardio-Oncologia, Sociedade Portuguesa de Cardiologia, Lisbon, Portugal; Department of Cardiology, Hospital da Luz, Lisbon, Portugal; NOVA Medical School, Lisbon, Portugal. Electronic address: jctoste@hospitaldaluz.pt","institution_ids":["https://openalex.org/I4210105254","https://openalex.org/I4210128540","https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061626781"],"corresponding_institution_ids":["https://openalex.org/I4210105254","https://openalex.org/I4210128540","https://openalex.org/I83558840"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"3","first_page":"143","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cardio-oncology","display_name":"cardio-oncology","score":0.902999997138977},{"id":"https://openalex.org/keywords/pharmacoeconomics","display_name":"pharmacoeconomics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9449999928474426},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ischemic-events","display_name":"ischemic events","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.7160000205039978},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.7720000147819519},{"id":"https://openalex.org/keywords/economic-burden","display_name":"economic burden","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7540000081062317},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4553000032901764},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32100000977516174},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C2910163948","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiac toxicity","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.259799987077713}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.repc.2026.01.005","doi":"https://doi.org/10.1016/j.repc.2026.01.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.repc.2026.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S4210203548","display_name":"Revista Portuguesa de Cardiologia","issn_l":"0870-2551","issn":["0870-2551","2174-2030"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Portuguesa de Cardiologia","raw_type":"journal-article"},{"id":"pmid:41621708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41621708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:run.unl.pt:10362/201245","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/201245","pdf_url":"https://run.unl.pt/bitstreams/39dddf67-1f97-491b-b6f0-0f9ea57acb4a/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"other"}],"best_oa_location":{"id":"doi:10.1016/j.repc.2026.01.005","doi":"https://doi.org/10.1016/j.repc.2026.01.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.repc.2026.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S4210203548","display_name":"Revista Portuguesa de Cardiologia","issn_l":"0870-2551","issn":["0870-2551","2174-2030"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Portuguesa de Cardiologia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126207257.pdf","grobid_xml":"https://content.openalex.org/works/W7126207257.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2169428949","https://openalex.org/W3185756680","https://openalex.org/W4311293040","https://openalex.org/W4387710268","https://openalex.org/W4396573499","https://openalex.org/W4415375248","https://openalex.org/W7125778352"],"related_works":["https://openalex.org/W4388735720","https://openalex.org/W4285161847","https://openalex.org/W4413291263","https://openalex.org/W2809284029","https://openalex.org/W6960003068","https://openalex.org/W3029432504","https://openalex.org/W2895389827","https://openalex.org/W7152699324","https://openalex.org/W6948237616","https://openalex.org/W2402151622"],"abstract_inverted_index":{"Bruton's":[0],"tyrosine":[1],"kinase":[2],"inhibitors":[3,72],"(BTKis)":[4,73],"have":[5,21,61],"transformed":[6],"the":[7,99,116],"treatment":[8],"landscape":[9],"of":[10,66,98,102,121],"chronic":[11],"lymphocytic":[12],"leukemia":[13],"(CLL),":[14],"enabling":[15],"continuous,":[16],"oral,":[17],"chemotherapy-free":[18],"regimens":[19],"that":[20],"gradually":[22],"replaced":[23],"chemoimmunotherapy":[24],"in":[25,37,87],"both":[26,88],"frontline":[27],"and":[28,57,84,91,111,118],"relapsed":[29],"settings.1,2":[30],"This":[31],"shift":[32],"represents":[33],"a":[34,63],"paradigm":[35],"change":[36],"CLL":[38],"therapy,":[39],"moving":[40],"away":[41],"from":[42],"finite":[43],"cytotoxic":[44],"treatments":[45],"toward":[46],"targeted,":[47],"long-term":[48],"disease":[49],"management.1,2":[50],"Alongside":[51],"these":[52],"advances,":[53],"accumulated":[54],"clinical":[55,89,117],"experience":[56],"dedicated":[58],"cardio-oncology":[59],"research":[60],"revealed":[62],"consistent":[64],"pattern":[65],"cardiovascular":[67],"toxicities":[68],"associated":[69],"with":[70],"BTK":[71],"--including":[74],"atrial":[75],"fibrillation":[76],"(AF),":[77],"hypertension":[78],"(HTN),":[79],"heart":[80],"failure,":[81],"ischemic":[82],"events,":[83],"bleeding":[85],"---documented":[86],"trials":[90],"real-world":[92],"cohorts.":[93],"1":[94],"In":[95],"this":[96],"issue":[97],"Portuguese":[100],"Journal":[101],"Cardiology,":[103],"Figueira":[104],"et":[105],"al.":[106],"3":[107],"make":[108],"an":[109],"important":[110],"timely":[112],"contribution":[113],"by":[114],"examining":[115],"economic":[119],"consequences":[120]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-02-01T00:00:00"}
