{"id":"https://openalex.org/W7126080893","doi":"https://doi.org/10.1097/cad.0000000000001813","title":"APG-1252 enhances the anticancer role of paclitaxel in non-small-cell lung cancer cells by suppressing the extracellular regulated protein kinases/myeloid cell leukemia 1 pathway","display_name":"APG-1252 enhances the anticancer role of paclitaxel in non-small-cell lung cancer cells by suppressing the extracellular regulated protein kinases/myeloid cell leukemia 1 pathway","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7126080893","doi":"https://doi.org/10.1097/cad.0000000000001813","pmid":"https://pubmed.ncbi.nlm.nih.gov/41608859"},"language":"en","primary_location":{"id":"doi:10.1097/cad.0000000000001813","doi":"https://doi.org/10.1097/cad.0000000000001813","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cad.0000000000001813","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/cad.0000000000001813","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124265773","display_name":"Luxi Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luxi Qian","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zizhang Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zizhang Guo","raw_affiliation_strings":["Department of Thoracic Surgery, Jiangsu Province Hospital, Nanjing, Jiangsu Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Jiangsu Province Hospital, Nanjing, Jiangsu Province, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124175723","display_name":"Xiang Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiang Cao","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124212124","display_name":"Huanfeng Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanfeng Zhu","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jingshu Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingshu Xu","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101969087","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-1720-1226","observed_orcids":["https://orcid.org/0000-0002-1720-1226"]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057202069","display_name":"Dan Zong","orcid":"https://orcid.org/0000-0001-7927-5215","observed_orcids":["https://orcid.org/0000-0001-7927-5215"]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Zong","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083049654","display_name":"Xia He","orcid":"https://orcid.org/0000-0002-7314-1002","observed_orcids":["https://orcid.org/0000-0002-7314-1002"]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia He","raw_affiliation_strings":["Department of Radiation Oncology, Jiangsu Cancer Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Jiangsu Cancer Hospital","institution_ids":["https://openalex.org/I4210128482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5124175723","https://openalex.org/A5124265773"],"corresponding_institution_ids":["https://openalex.org/I4210128482","https://openalex.org/I4210152119"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04837622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"9","first_page":"536","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.16140000522136688,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9750000238418579},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.8980000019073486},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8130000233650208},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5419999957084656},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7360000014305115},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6514999866485596},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6514000296592712},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6086999773979187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5471000075340271},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5074999928474426},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.48399999737739563},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4812999963760376},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4629000127315521},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4596000015735626},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4397999942302704},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41670000553131104},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.38179999589920044},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3578000068664551},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3481999933719635},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.3260999917984009},{"id":"https://openalex.org/C2779177807","wikidata":"https://www.wikidata.org/wiki/Q3658562","display_name":"non-small cell lung cancer (NSCLC)","level":4,"score":0.2944999933242798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28600001335144043},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.271699994802475},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.2549000084400177}],"mesh":[{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/cad.0000000000001813","doi":"https://doi.org/10.1097/cad.0000000000001813","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cad.0000000000001813","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},{"id":"pmid:41608859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41608859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer drugs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13561098","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13561098/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13561098/pdf/acd-37-536.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anticancer Drugs","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/cad.0000000000001813","doi":"https://doi.org/10.1097/cad.0000000000001813","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cad.0000000000001813","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7109668254852295}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2131679403","display_name":null,"funder_award_id":"XHMS202408","funder_id":"https://openalex.org/F4320336297","funder_display_name":"Jiangsu Cancer Hospital"}],"funders":[{"id":"https://openalex.org/F4320336297","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1979328434","https://openalex.org/W2171625872","https://openalex.org/W2622149303","https://openalex.org/W2762933730","https://openalex.org/W3017437536","https://openalex.org/W3102922803","https://openalex.org/W3187443993","https://openalex.org/W3192493086","https://openalex.org/W3205774241","https://openalex.org/W3210249046","https://openalex.org/W3210893762","https://openalex.org/W4220757508","https://openalex.org/W4224298114","https://openalex.org/W4286241304","https://openalex.org/W4294710526","https://openalex.org/W4294740854","https://openalex.org/W4306318748","https://openalex.org/W4320879153","https://openalex.org/W4321781536","https://openalex.org/W4324133631","https://openalex.org/W4366351478","https://openalex.org/W4386944409","https://openalex.org/W4388729147","https://openalex.org/W4393318695","https://openalex.org/W4400646538","https://openalex.org/W4400856006","https://openalex.org/W4403136190","https://openalex.org/W4403191451","https://openalex.org/W4404725935","https://openalex.org/W4407798606"],"related_works":[],"abstract_inverted_index":{"The":[0,74,92,111],"efficacy":[1],"of":[2,53,94,114,159,169,186,200,203,211,219],"paclitaxel":[3],"(PTX),":[4],"an":[5,22,180],"important":[6],"chemotherapy":[7,37],"drug":[8],"in":[9,25,171,190,207,221],"non-small-cell":[10],"lung":[11],"cancer":[12,26],"(NSCLC)":[13],"cells,":[14],"is":[15],"limited":[16],"by":[17,55,127,224],"its":[18],"resistance.":[19],"APG-1252":[20,47,130,138,153,164,187,204,214,237],"has":[21],"inhibitory":[23],"role":[24,52,168,182,199,218],"and":[27,82,99,105,123,131,139,144,151,154,161],"can":[28],"inhibit":[29],"myeloid":[30],"cell":[31,70,75,142],"leukemia":[32],"1":[33],"(MCL-1)":[34],"to":[35,96,183],"enhance":[36,49],"drugs'":[38],"antitumor":[39],"effect.":[40],"Therefore,":[41],"this":[42],"research":[43],"further":[44],"investigated":[45],"whether":[46],"could":[48],"the":[50,69,134,146,157,166,184,197,201,208,216,226,232,236],"anticancer":[51,167,198,217],"PTX":[54,132,140,155,170,189,206,220],"regulating":[56],"MCL-1.":[57,162],"NSCLC":[58,135,172,191,212,222],"cells":[59,95,147,223],"were":[60,101,125],"treated":[61],"with":[62,188,205],"drugs.":[63],"Cell":[64],"viability":[65],"was":[66,77],"determined":[67],"using":[68,79,103],"counting":[71],"kit-8":[72],"assay.":[73],"apoptosis":[76,143],"examined":[78,102],"flow":[80],"cytometry":[81],"terminal":[83],"deoxynucleotidyl":[84],"transferase":[85],"deoxyuridine":[86],"triphosphate":[87],"nick":[88],"end":[89],"labeling":[90],"staining.":[91],"abilities":[93],"migrate,":[97],"invade,":[98],"proliferate":[100],"transwell":[104],"colony":[106],"formation":[107],"assays,":[108],"as":[109],"needed.":[110],"expression":[112,158],"levels":[113],"extracellular":[115],"regulated":[116],"protein":[117],"kinases":[118],"(ERK),":[119],"phosphorylated":[120],"ERK":[121],"(p-ERK),":[122],"MCL-1":[124],"quantified":[126],"Western":[128],"blot.":[129],"decreased":[133],"cells'":[136],"viability.":[137],"induced":[141],"inhibited":[145],"from":[148],"migrating,":[149],"proliferating,":[150],"invading.":[152],"suppressed":[156],"p-ERK":[160,177],"Besides,":[163],"enhanced":[165,215],"cells.":[173,192,213],"Ro":[174,194],"67-7476,":[175],"a":[176],"agonist,":[178],"had":[179],"opposite":[181],"combination":[185,202],"Additionally,":[193],"67-7476":[195],"abolished":[196],"biological":[209],"functions":[210],"suppressing":[225],"ERK/MCL-1":[227],"pathway.":[228],"This":[229],"work":[230],"provided":[231],"theoretical":[233],"basis":[234],"for":[235],"application.":[238]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-01-30T00:00:00"}