{"id":"https://openalex.org/W7126079863","doi":"https://doi.org/10.1016/j.ymthe.2026.01.028","title":"Enhancing adoptive T cell therapy by disrupting the SKI-SMAD2/3 axis to counteract TGF-\u03b2-mediated immunosuppression","display_name":"Enhancing adoptive T cell therapy by disrupting the SKI-SMAD2/3 axis to counteract TGF-\u03b2-mediated immunosuppression","publication_year":2026,"publication_date":"2026-01-29","ids":{"openalex":"https://openalex.org/W7126079863","doi":"https://doi.org/10.1016/j.ymthe.2026.01.028","pmid":"https://pubmed.ncbi.nlm.nih.gov/41612698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13154305"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2026.01.028","doi":"https://doi.org/10.1016/j.ymthe.2026.01.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.01.028","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13154305/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124278427","display_name":"Xiaohan Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Jin","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, China","institution_ids":["https://openalex.org/I105086349","https://openalex.org/I12411659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056366117","display_name":"Jinmei Yu","orcid":"https://orcid.org/0000-0002-3719-5601","observed_orcids":["https://orcid.org/0000-0002-3719-5601"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxuan Yu","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; Department of Immunology & State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; Department of Immunology & State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I105086349","https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124209280","display_name":"Xinyu Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Wu","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001002012","display_name":"Qingyong Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyong Hu","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124226758","display_name":"Xixi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xixi Chen","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051751803","display_name":"Wenbo Ma","orcid":"https://orcid.org/0000-0001-5569-639X","observed_orcids":["https://orcid.org/0000-0001-5569-639X"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Ma","raw_affiliation_strings":["School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102839155","display_name":"Yude Guan","orcid":"https://orcid.org/0009-0008-7478-2208","observed_orcids":["https://orcid.org/0009-0008-7478-2208"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yude Guan","raw_affiliation_strings":["Key Laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101428928","display_name":"Dongmei Guo","orcid":"https://orcid.org/0000-0001-7027-5884","observed_orcids":["https://orcid.org/0000-0001-7027-5884"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongmei Guo","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079013603","display_name":"Yulan Yang","orcid":"https://orcid.org/0000-0003-2463-158X","observed_orcids":["https://orcid.org/0000-0003-2463-158X"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulan Yang","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124217040","display_name":"Lingyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyu Wang","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124228535","display_name":"Guofei Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guofei Jin","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124175757","display_name":"Zhenglan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenglan Han","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034586695","display_name":"Shumin M. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shumin Zhang","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"last","author":{"id":null,"display_name":"Nianchao Zhang","orcid":"https://orcid.org/0009-0009-6827-0318","observed_orcids":["https://orcid.org/0009-0009-6827-0318"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nianchao Zhang","raw_affiliation_strings":["Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. Electronic address: nianchaoz@nsmc.edu.cn"],"raw_orcid":"https://orcid.org/0009-0009-6827-0318","affiliations":[{"raw_affiliation_string":"Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. Electronic address: nianchaoz@nsmc.edu.cn","institution_ids":["https://openalex.org/I105086349"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I105086349"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.9285,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86053569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"34","issue":"5","first_page":"2692","last_page":"2708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.75,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.75,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.16380000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skiing","display_name":"skiing","score":0.7450000047683716},{"id":"https://openalex.org/keywords/smad2-3","display_name":"Smad2/3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.699999988079071},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/t-cell-receptor-therapy","display_name":"T-cell receptor therapy","score":0.5730000138282776},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5673999786376953},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5357000231742859},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.4950000047683716},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4650999903678894},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4537000060081482},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43320000171661377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4284999966621399},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4235000014305115},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3855000138282776},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37700000405311584},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3765999972820282},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3743000030517578},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.37299999594688416},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.36559998989105225},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.3531999886035919},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.30000001192092896},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2858000099658966},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.2851000130176544},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.28450000286102295},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.2694999873638153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2687000036239624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2632000148296356},{"id":"https://openalex.org/C2780405999","wikidata":"https://www.wikidata.org/wiki/Q3483597","display_name":"Co-stimulation","level":5,"score":0.2556000053882599}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ymthe.2026.01.028","doi":"https://doi.org/10.1016/j.ymthe.2026.01.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.01.028","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmid:41612698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41612698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13154305","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13154305/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13154305","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13154305/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3187527026","display_name":null,"funder_award_id":"82504655","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6686502915","display_name":null,"funder_award_id":"32301072","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1767508090","https://openalex.org/W1842126375","https://openalex.org/W1971093570","https://openalex.org/W2006900588","https://openalex.org/W2009709218","https://openalex.org/W2040982194","https://openalex.org/W2049790267","https://openalex.org/W2066118264","https://openalex.org/W2074604431","https://openalex.org/W2104342221","https://openalex.org/W2133433819","https://openalex.org/W2515679023","https://openalex.org/W2766896536","https://openalex.org/W2801309958","https://openalex.org/W2805654943","https://openalex.org/W2886261984","https://openalex.org/W2922798588","https://openalex.org/W2931391344","https://openalex.org/W2937823726","https://openalex.org/W3003839508","https://openalex.org/W3016257110","https://openalex.org/W3044737312","https://openalex.org/W3119664087","https://openalex.org/W3198745106","https://openalex.org/W4224007350","https://openalex.org/W4293004820","https://openalex.org/W4309367684","https://openalex.org/W4386788919","https://openalex.org/W4390581196","https://openalex.org/W4391617619","https://openalex.org/W4394747404","https://openalex.org/W4399754190"],"related_works":["https://openalex.org/W4404052971","https://openalex.org/W2904742611","https://openalex.org/W2967440998","https://openalex.org/W7213227696","https://openalex.org/W2807108630","https://openalex.org/W1977258469","https://openalex.org/W3029545533","https://openalex.org/W2741049595","https://openalex.org/W2949381629","https://openalex.org/W1992909341"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-01-30T00:00:00"}