{"id":"https://openalex.org/W7126067326","doi":"https://doi.org/10.21037/jtd-2025-1-2503","title":"Flumonertinib after prior third-generation EGFR-tyrosine kinase inhibitor (TKI) therapy in patients with epidermal growth factor receptor-mutated non-small cell lung cancer after resistance to third-generation tyrosine kinase inhibitor treatment: a real-world study","display_name":"Flumonertinib after prior third-generation EGFR-tyrosine kinase inhibitor (TKI) therapy in patients with epidermal growth factor receptor-mutated non-small cell lung cancer after resistance to third-generation tyrosine kinase inhibitor treatment: a real-world study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7126067326","doi":"https://doi.org/10.21037/jtd-2025-1-2503","pmid":"https://pubmed.ncbi.nlm.nih.gov/41660441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12875795"},"language":"en","primary_location":{"id":"doi:10.21037/jtd-2025-1-2503","doi":"https://doi.org/10.21037/jtd-2025-1-2503","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jtd-2025-1-2503","pdf_url":null,"source":{"id":"https://openalex.org/S2754193772","display_name":"Journal of Thoracic Disease","issn_l":"2072-1439","issn":["2072-1439","2077-6624"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/jtd-2025-1-2503","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124233158","display_name":"Haoyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haoyu Wang","raw_affiliation_strings":["Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Jinan, China","Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Jinan, China","institution_ids":["https://openalex.org/I4210100830"]},{"raw_affiliation_string":"Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101640224","display_name":"Chenyue Zhang","orcid":"https://orcid.org/0000-0001-9130-8374","observed_orcids":["https://orcid.org/0000-0001-9130-8374"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyue Zhang","raw_affiliation_strings":["Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai Medical College, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Therapy, Fudan University Shanghai Cancer Center, Shanghai Medical College, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124243258","display_name":"Shanshan Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Du","raw_affiliation_strings":["Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Jinan, China","Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Jinan, China","institution_ids":["https://openalex.org/I4210100830"]},{"raw_affiliation_string":"Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101619547","display_name":"Haiyong Wang","orcid":"https://orcid.org/0000-0002-0658-4479","observed_orcids":["https://orcid.org/0000-0002-0658-4479","https://orcid.org/0009-0006-4732-9972"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiyong Wang","raw_affiliation_strings":["Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Jinan, China","Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Jinan, China","institution_ids":["https://openalex.org/I4210100830"]},{"raw_affiliation_string":"Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101619547","https://openalex.org/A5124233158"],"corresponding_institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0403315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"1","first_page":"37","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/third-generation-egfr-tyrosine-kinase-inhibitors","display_name":"third-generation EGFR tyrosine kinase inhibitors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-resistance","display_name":"tyrosine kinase inhibitor resistance","score":0.8069999814033508},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8759999871253967},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9909999966621399},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/treatment-timing","display_name":"treatment timing","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8751999735832214},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.704800009727478},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6757000088691711},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5760999917984009},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.569599986076355},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5245000123977661},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4799000024795532},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4634999930858612},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.42899999022483826},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3991999924182892},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.38600000739097595},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3537999987602234},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3488999903202057},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.2957000136375427},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.290800005197525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2897000014781952},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C2909867262","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Protein-Tyrosine Kinases","level":4,"score":0.28290000557899475},{"id":"https://openalex.org/C2778807442","wikidata":"https://www.wikidata.org/wiki/Q6152005","display_name":"Treatment of lung cancer","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.25189998745918274}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/jtd-2025-1-2503","doi":"https://doi.org/10.21037/jtd-2025-1-2503","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jtd-2025-1-2503","pdf_url":null,"source":{"id":"https://openalex.org/S2754193772","display_name":"Journal of Thoracic Disease","issn_l":"2072-1439","issn":["2072-1439","2077-6624"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11683473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12875795","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41660441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41660441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thoracic disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jtd-2025-1-2503","doi":"https://doi.org/10.21037/jtd-2025-1-2503","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jtd-2025-1-2503","pdf_url":null,"source":{"id":"https://openalex.org/S2754193772","display_name":"Journal of Thoracic Disease","issn_l":"2072-1439","issn":["2072-1439","2077-6624"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214589040","https://openalex.org/W4414371569","https://openalex.org/W4416812220","https://openalex.org/W4385856392","https://openalex.org/W2164207083","https://openalex.org/W4309212054","https://openalex.org/W3144671286","https://openalex.org/W4379345526","https://openalex.org/W4391055671","https://openalex.org/W3117619853"],"abstract_inverted_index":{"Background:":[0],")-mutated":[1],"non-small":[2],"cell":[3],"lung":[4],"cancer":[5],"(NSCLC)":[6],"due":[7],"to":[8,18,48,54,85,102,145,212],"their":[9],"exceptional":[10],"efficacy":[11],"and":[12,28,96,121,216],"favorable":[13],"safety":[14],"profile.":[15],"However,":[16],"resistance":[17,47,84],"third-generation":[19,43,49,80,87,136],"TKIs":[20],"is":[21,200,223],"inevitable.":[22],"Subsequent":[23],"treatment":[24,199,206],"options":[25],"are":[26],"limited":[27],"confer":[29],"only":[30],"modest":[31],"survival":[32,112,125,156,181,214],"benefit.":[33],"This":[34,66],"retrospective":[35,67],"study":[36,68],"examined":[37],"patients":[38,74,174],"receiving":[39,175],"flumonertinib":[40,77,133,176,195,208],"after":[41,78,134],"prior":[42,79,135,149],"EGFR-TKI":[44,81,137],"therapy":[45,82,138,147],"following":[46,83],"TKIs,":[50,194],"with":[51,207],"the":[52,115,122],"aim":[53],"assess":[55],"a":[56,70,179,201],"potential":[57],"therapeutic":[58,203],"approach":[59],"for":[60,114,190],"this":[61,221],"challenging":[62],"patient":[63,106],"population.":[64],"Methods:":[65],"included":[69],"cohort":[71,117],"of":[72,151,220],"40":[73],"who":[75,131],"received":[76,132],"other":[86],"TKIs.":[88],"Kaplan-Meier":[89],"analysis,":[90,95],"Cox":[91,97,168],"proportional":[92],"hazards":[93],"regression":[94],"subgroup":[98,169],"analysis":[99,170],"were":[100],"employed":[101],"examine":[103],"factors":[104],"influencing":[105],"survival.":[107],"Results:":[108],"The":[109],"median":[110,123],"progression-free":[111],"(PFS)":[113],"overall":[116,124],"was":[118,127],"8.95":[119],"months,":[120],"(OS)":[126],"18.03":[128],"months.":[129],"Patients":[130],"(80":[139],"or":[140],"160":[141],"mg)":[142],"as":[143],"first-":[144],"third-line":[146],"(\u22643":[148],"lines":[150],"therapy)":[152],"demonstrated":[153],"significantly":[154],"improved":[155],"outcomes":[157],"[hazard":[158],"ratio":[159],"(HR)":[160],"=0.43,":[161],"95%":[162,185],"confidence":[163],"interval":[164],"(CI):":[165],"0.20-0.89;":[166],"P=0.02].":[167],"further":[171,218],"revealed":[172],"that":[173],"monotherapy":[177,196],"derived":[178],"significant":[180],"benefit":[182],"(HR":[183],"=0.24,":[184],"CI:":[186],"0.07-0.85,":[187],"P=0.02;":[188],"P":[189],"interaction":[191],"=0.04).":[192],"Conclusions:":[193],"during":[197],"rechallenge":[198],"viable":[202],"option.":[204],"Initiating":[205],"earlier":[209],"may":[210],"lead":[211],"better":[213],"outcomes,":[215],"thus":[217],"investigation":[219],"strategy":[222],"warranted.":[224]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-01-30T00:00:00"}