{"id":"https://openalex.org/W7125968511","doi":"https://doi.org/10.21203/rs.3.rs-8604693/v1","title":"Itaconate-based nanoparticles induce immunometabolic reprogramming in macrophages and alleviate diet-induced obesity","display_name":"Itaconate-based nanoparticles induce immunometabolic reprogramming in macrophages and alleviate diet-induced obesity","publication_year":2026,"publication_date":"2026-01-28","ids":{"openalex":"https://openalex.org/W7125968511","doi":"https://doi.org/10.21203/rs.3.rs-8604693/v1","pmid":"https://pubmed.ncbi.nlm.nih.gov/41646330","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12869555"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-8604693/v1","doi":"https://doi.org/10.21203/rs.3.rs-8604693/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8604693/v1","pdf_url":"https://www.researchsquare.com/article/rs-8604693/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-8604693/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050939922","display_name":"Ryan M. Pearson","orcid":"https://orcid.org/0000-0002-7857-0973","observed_orcids":["https://orcid.org/0000-0002-7857-0973"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Pearson","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":"https://orcid.org/0000-0002-7857-0973","affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019486520","display_name":"Andrea L. Cottingham","orcid":"https://orcid.org/0000-0001-9067-2537","observed_orcids":["https://orcid.org/0000-0001-9067-2537"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Cottingham","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":"https://orcid.org/0000-0001-9067-2537","affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005960237","display_name":"Neda Mohaghegh","orcid":"https://orcid.org/0000-0002-2796-4315","observed_orcids":["https://orcid.org/0000-0002-2796-4315"]},"institutions":[{"id":"https://openalex.org/I4210097936","display_name":"Terasaki Foundation","ror":"https://ror.org/012381002","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097936"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Mohaghegh","raw_affiliation_strings":["Terasaki Institute for Biomedical Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Terasaki Institute for Biomedical Innovation","institution_ids":["https://openalex.org/I4210097936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115022761","display_name":"Sara Mangesh Kolhatkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Kolhatkar","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007082674","display_name":"Fanny Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fanny Xu","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044879059","display_name":"Shruti Dharmaraj","orcid":"https://orcid.org/0000-0003-4257-9439","observed_orcids":["https://orcid.org/0000-0003-4257-9439"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Dharmaraj","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090439397","display_name":"Jacob R. Shaw","orcid":"https://orcid.org/0000-0002-5885-1006","observed_orcids":["https://orcid.org/0000-0002-5885-1006"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Shaw","raw_affiliation_strings":["University of Maryland, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Baltimore","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056324813","display_name":"Sanmoy Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanmoy Pathak","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124111806","display_name":"Victor Andrade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Andrade","raw_affiliation_strings":["University of Maryland, Batimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Batimore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124106140","display_name":"Yan Shu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Shu","raw_affiliation_strings":["University of Maryland, Batimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, Batimore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059638560","display_name":"Abhinav P. Acharya","orcid":"https://orcid.org/0000-0002-9361-2764","observed_orcids":["https://orcid.org/0000-0002-9361-2764"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhinav Acharya","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007244623","display_name":"Alireza Hassani Najafabadi","orcid":"https://orcid.org/0000-0002-8215-4374","observed_orcids":["https://orcid.org/0000-0002-8215-4374"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alireza Najafabadi","raw_affiliation_strings":["University of Cincinnati"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cincinnati","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.2305999994277954,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-immunometabolism","display_name":"macrophage immunometabolism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.6800000071525574},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/brown-fat-activation","display_name":"brown fat activation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/adipose-tissue-browning","display_name":"adipose tissue browning","score":0.871999979019165},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/nanotherapy","display_name":"nanotherapy","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7307000160217285},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7282000184059143},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.669700026512146},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6567000150680542},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.6403999924659729},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.6107000112533569},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5654000043869019},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48350000381469727},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.47780001163482666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41609999537467957},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.39629998803138733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38519999384880066},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.36059999465942383},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3601999878883362},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.3573000133037567},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.31850001215934753},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2946000099182129},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2919999957084656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29100000858306885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2784000039100647},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27149999141693115},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.27059999108314514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2685000002384186},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2515000104904175},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.25},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.25}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21203/rs.3.rs-8604693/v1","doi":"https://doi.org/10.21203/rs.3.rs-8604693/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8604693/v1","pdf_url":"https://www.researchsquare.com/article/rs-8604693/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:41646330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41646330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11677382","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12869555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-8604693/v1","doi":"https://doi.org/10.21203/rs.3.rs-8604693/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8604693/v1","pdf_url":"https://www.researchsquare.com/article/rs-8604693/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000304207","display_name":"UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT","funder_award_id":"P30CA134274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000901377","display_name":"Polymeric nanoassemblies for precise tuning of immune responses","funder_award_id":"R35GM142752","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7125968511.pdf","grobid_xml":"https://content.openalex.org/works/W7125968511.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409194657","https://openalex.org/W4411533096","https://openalex.org/W7207799576","https://openalex.org/W7170050912","https://openalex.org/W7171823438","https://openalex.org/W3103728805","https://openalex.org/W4309214440","https://openalex.org/W7054885612","https://openalex.org/W4402959384","https://openalex.org/W3119185811"],"abstract_inverted_index":{"Abstract":[0],"Obesity":[1],"is":[2],"driven":[3],"by":[4,85],"chronic":[5],"adipose":[6,114],"tissue":[7,115],"inflammation":[8],"and":[9,29,43,49,60,89,117,121,141,144],"macrophage":[10,27,139],"dysfunction.":[11],"Here,":[12],"we":[13],"report":[14],"a":[15,39,45,76,94],"cargo-free":[16],"nanoparticle":[17],"(NP)":[18],"platform":[19],"derived":[20],"from":[21,53],"itaconate-based":[22],"polyesters":[23],"(pITA-NPs)":[24],"that":[25,136],"reprograms":[26],"immunometabolism":[28],"alleviates":[30],"diet-induced":[31],"obesity.":[32,149],"pITA-NPs":[33,74,130],"rapidly":[34],"induce":[35],"CD206":[36],"presentation":[37],"through":[38],"translationally":[40],"independent":[41],"mechanism":[42],"drive":[44],"non-canonical":[46,77],"M2-like":[47,78],"transcriptional":[48],"metabolic":[50,71,79,145],"state":[51,98],"distinct":[52],"IL-4/STAT6":[54],"polarization,":[55],"while":[56,92],"restraining":[57],"inflammatory":[58,124],"activation":[59],"macrophage-adipocyte":[61],"crosstalk":[62],"to":[63,147],"reduce":[64],"lipid":[65],"accumulation.":[66],"Bioenergetic":[67],"profiling":[68],"revealed":[69],"context-dependent":[70],"tuning,":[72],"with":[73],"promoting":[75],"transition":[80],"in":[81,99],"resting":[82],"macrophages":[83],"characterized":[84],"increased":[86],"mitochondrial":[87],"mass":[88],"oxidative":[90],"phosphorylation,":[91],"inducing":[93],"metabolically":[95],"restrained,":[96],"quiescent-like":[97],"M1-like":[100],"macrophages.":[101],"In":[102],"obese":[103],"mice,":[104],"subcutaneous":[105],"pITA-NP":[106],"treatment":[107],"suppresses":[108],"weight":[109],"gain,":[110],"reduces":[111],"adiposity,":[112],"promotes":[113],"beiging":[116],"brown":[118],"fat":[119],"activation,":[120],"mitigates":[122],"systemic":[123],"responses.":[125],"Together,":[126],"these":[127],"findings":[128],"establish":[129],"as":[131],"an":[132],"effective":[133],"immunometabolic":[134],"nanotherapy":[135],"leverages":[137],"materials-driven":[138],"reprogramming":[140],"coordinates":[142],"immune":[143],"regulation":[146],"treat":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-29T00:00:00"}
