{"id":"https://openalex.org/W7125711368","doi":"https://doi.org/10.31467/uluaricilik.1786679","title":"The Effects of Global Climate Change on Gene Expression in Honey Bees (Apis mellifera)","display_name":"The Effects of Global Climate Change on Gene Expression in Honey Bees (Apis mellifera)","publication_year":2026,"publication_date":"2026-01-22","ids":{"openalex":"https://openalex.org/W7125711368","doi":"https://doi.org/10.31467/uluaricilik.1786679"},"language":"en","primary_location":{"id":"doi:10.31467/uluaricilik.1786679","doi":"https://doi.org/10.31467/uluaricilik.1786679","is_oa":true,"landing_page_url":"https://doi.org/10.31467/uluaricilik.1786679","pdf_url":"https://dergipark.org.tr/en/download/article-file/5253856","source":{"id":"https://openalex.org/S4210234999","display_name":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi","issn_l":"1303-0248","issn":["1303-0248","2687-5594"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/5253856","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076788067","display_name":"Kemal Karaba\u011f","orcid":"https://orcid.org/0000-0002-4516-6480","observed_orcids":["https://orcid.org/0000-0002-4516-6480"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kemal Karaba\u011f","raw_affiliation_strings":["AKDEN\u0130Z \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0002-4516-6480","affiliations":[{"raw_affiliation_string":"AKDEN\u0130Z \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042610484","display_name":"Berkant \u0130smail Y\u0131ld\u0131z","orcid":"https://orcid.org/0000-0001-8965-6361","observed_orcids":["https://orcid.org/0000-0001-8965-6361"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berkant \u0130smail Y\u0131ld\u0131z","raw_affiliation_strings":["AKDEN\u0130Z \u00dcN\u0130VERS\u0130TES\u0130"],"raw_orcid":"https://orcid.org/0000-0001-8965-6361","affiliations":[{"raw_affiliation_string":"AKDEN\u0130Z \u00dcN\u0130VERS\u0130TES\u0130","institution_ids":["https://openalex.org/I197907453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I197907453"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03949297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"2026","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/climate-change","display_name":"climate change","score":0.7879999876022339},{"id":"https://openalex.org/keywords/apis-mellifera","display_name":"Apis mellifera","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cold-stress","display_name":"cold stress","score":0.9950000047683716},{"id":"https://openalex.org/keywords/elevated-co2","display_name":"elevated CO2","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drought","display_name":"drought","score":0.9430000185966492},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5989999771118164},{"id":"https://openalex.org/keywords/detoxification-genes","display_name":"detoxification genes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/vitellogenin","display_name":"vitellogenin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/defensin-1","display_name":"defensin-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.819100022315979},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6057999730110168},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5848000049591064},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5717999935150146},{"id":"https://openalex.org/C132215390","wikidata":"https://www.wikidata.org/wiki/Q461335","display_name":"Abiotic component","level":2,"score":0.5612999796867371},{"id":"https://openalex.org/C2777907900","wikidata":"https://www.wikidata.org/wiki/Q102857","display_name":"Honey bee","level":2,"score":0.5315999984741211},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48890000581741333},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4616999924182892},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.4366999864578247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4291999936103821},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.40059998631477356},{"id":"https://openalex.org/C2779078696","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenin","level":3,"score":0.39719998836517334},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.38600000739097595},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.38029998540878296},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36340001225471497},{"id":"https://openalex.org/C89519541","wikidata":"https://www.wikidata.org/wiki/Q4667893","display_name":"Abiotic stress","level":3,"score":0.3603000044822693},{"id":"https://openalex.org/C2780618852","wikidata":"https://www.wikidata.org/wiki/Q79932","display_name":"Pollen","level":2,"score":0.34540000557899475},{"id":"https://openalex.org/C132651083","wikidata":"https://www.wikidata.org/wiki/Q7942","display_name":"Climate change","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3188999891281128},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.3160000145435333},{"id":"https://openalex.org/C2775984649","wikidata":"https://www.wikidata.org/wiki/Q306939","display_name":"Apis cerana","level":3,"score":0.310699999332428},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.30219998955726624},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3001999855041504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2939999997615814},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.2799000144004822},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.2596000134944916},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.25380000472068787},{"id":"https://openalex.org/C2987418964","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Heat stress","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31467/uluaricilik.1786679","doi":"https://doi.org/10.31467/uluaricilik.1786679","is_oa":true,"landing_page_url":"https://doi.org/10.31467/uluaricilik.1786679","pdf_url":"https://dergipark.org.tr/en/download/article-file/5253856","source":{"id":"https://openalex.org/S4210234999","display_name":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi","issn_l":"1303-0248","issn":["1303-0248","2687-5594"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1786679","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/uluaricilik/article/1786679","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.31467/uluaricilik.1786679","doi":"https://doi.org/10.31467/uluaricilik.1786679","is_oa":true,"landing_page_url":"https://doi.org/10.31467/uluaricilik.1786679","pdf_url":"https://dergipark.org.tr/en/download/article-file/5253856","source":{"id":"https://openalex.org/S4210234999","display_name":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi","issn_l":"1303-0248","issn":["1303-0248","2687-5594"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uluda\u011f Ar\u0131c\u0131l\u0131k Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5365999937057495,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"sustainable_development_goals_aurora":[{"score":0.7201226353645325,"id":"https://metadata.un.org/sdg/13","display_name":"Climate action"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7125711368.pdf","grobid_xml":"https://content.openalex.org/works/W7125711368.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W578276104","https://openalex.org/W788982869","https://openalex.org/W1985141089","https://openalex.org/W2025433313","https://openalex.org/W2037145972","https://openalex.org/W2068780513","https://openalex.org/W2115511541","https://openalex.org/W2149598896","https://openalex.org/W2164008575","https://openalex.org/W2293487518","https://openalex.org/W2322648712","https://openalex.org/W2336522939","https://openalex.org/W2794439488","https://openalex.org/W2814614096","https://openalex.org/W2958513093","https://openalex.org/W2978011658","https://openalex.org/W2995888578","https://openalex.org/W3008411685","https://openalex.org/W3023444149","https://openalex.org/W3214138800","https://openalex.org/W4200138091","https://openalex.org/W4283325143","https://openalex.org/W4307555691","https://openalex.org/W4308631041","https://openalex.org/W4309327388","https://openalex.org/W4310682208","https://openalex.org/W4321498248","https://openalex.org/W4324088988","https://openalex.org/W4367598241","https://openalex.org/W4381617650","https://openalex.org/W4390814588","https://openalex.org/W4391559845","https://openalex.org/W4392553139","https://openalex.org/W4393081854","https://openalex.org/W4394915267","https://openalex.org/W4401339040","https://openalex.org/W4401992719","https://openalex.org/W4403130612","https://openalex.org/W4404726473","https://openalex.org/W4404776714","https://openalex.org/W4406002786","https://openalex.org/W4406217117","https://openalex.org/W4407635300","https://openalex.org/W4408116959","https://openalex.org/W4409571332","https://openalex.org/W4412943969","https://openalex.org/W4413427934","https://openalex.org/W4414017846","https://openalex.org/W4414299276","https://openalex.org/W4414716657"],"related_works":[],"abstract_inverted_index":{"Global":[0],"climate":[1],"change":[2],"is":[3],"reshaping":[4],"the":[5,26,29,60,74,86,105,160,166,183],"abiotic":[6],"environment":[7],"of":[8,35,62,76,107,162,175],"honey":[9],"bees":[10],"and":[11,19,54,69,88,102,109,115,153,178],"triggering":[12],"molecular":[13],"responses":[14,34],"that":[15,147],"underlie":[16],"colony":[17],"health":[18],"resilience.":[20],"This":[21],"review":[22],"synthesizes":[23],"research":[24,181],"from":[25],"2000s":[27],"to":[28,38,126],"present,":[30],"summarizing":[31],"gene":[32],"expression":[33,61,75,106],"Apis":[36],"mellifera":[37],"climate-related":[39],"stressors.":[40,189],"The":[41],"principal":[42],"drivers":[43],"include":[44],"temperature":[45],"extremes,":[46],"altered":[47],"seasonal":[48],"regimes,":[49],"elevated":[50],"atmospheric":[51],"CO\u2082,":[52],"drought,":[53],"their":[55,141],"interactions.":[56],"Heat":[57],"stress":[58,81],"induces":[59],"heat":[63],"shock":[64],"proteins":[65,78],"(HSP70/90),":[66],"antioxidant":[67],"defenses,":[68],"detoxification":[70],"genes,":[71],"while":[72],"suppressing":[73],"glandular":[77],"(MRJPs).":[79],"Cold":[80],"downregulates":[82],"genes":[83],"involved":[84],"in":[85,159],"peroxisomal":[87],"glutathione":[89],"pathways,":[90],"thereby":[91],"increasing":[92,137],"oxidative":[93],"damage.":[94],"Rising":[95],"CO\u2082":[96],"levels":[97],"reduce":[98],"pollen":[99],"protein":[100],"content":[101],"indirectly":[103],"alter":[104],"vitellogenin":[108],"immune":[110,119],"genes.":[111],"Drought,":[112],"nutritional":[113],"scarcity,":[114],"pathogen":[116],"pressure":[117],"reprogram":[118],"effectors":[120],"such":[121],"as":[122],"defensin-1.":[123],"Subspecies":[124],"adapted":[125],"hot":[127],"climates":[128],"(A.":[129],"m.":[130],"jemenetica)":[131],"exhibit":[132],"strong":[133],"HSP":[134],"responses,":[135],"although":[136],"extremes":[138],"may":[139],"exceed":[140],"adaptive":[142],"thresholds.":[143],"Recent":[144],"studies":[145],"suggest":[146],"epigenetic":[148],"mechanisms,":[149],"including":[150],"DNA":[151],"methylation":[152],"histone":[154],"modification,":[155],"play":[156],"a":[157],"role":[158],"persistence":[161],"these":[163],"responses.":[164],"Collectively,":[165],"findings":[167],"provide":[168],"an":[169],"integrative":[170],"framework":[171],"for":[172,179],"selective":[173],"breeding":[174],"stress-tolerant":[176],"colonies":[177],"omics-based":[180],"addressing":[182],"complex":[184],"interplay":[185],"among":[186],"multiple":[187],"climatic":[188]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-01-27T00:00:00"}