{"id":"https://openalex.org/W7125700391","doi":"https://doi.org/10.2174/0115672026430179251224095358","title":"Recent Progress in Hydrogen-mediated Neuroprotection via Modulation of Mitochondrial Quality Control Mechanisms in Brain Injury","display_name":"Recent Progress in Hydrogen-mediated Neuroprotection via Modulation of Mitochondrial Quality Control Mechanisms in Brain Injury","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W7125700391","doi":"https://doi.org/10.2174/0115672026430179251224095358","pmid":"https://pubmed.ncbi.nlm.nih.gov/41588594"},"language":"en","primary_location":{"id":"doi:10.2174/0115672026430179251224095358","doi":"https://doi.org/10.2174/0115672026430179251224095358","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115672026430179251224095358","pdf_url":null,"source":{"id":"https://openalex.org/S6525137","display_name":"Current Neurovascular Research","issn_l":"1567-2026","issn":["1567-2026","1875-5739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neurovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xue Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Jiang","raw_affiliation_strings":["College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045983868","display_name":"Chao Xia","orcid":"https://orcid.org/0009-0000-3658-7374","observed_orcids":["https://orcid.org/0009-0000-3658-7374","https://orcid.org/0000-0003-4403-2138"]},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Xia","raw_affiliation_strings":["College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040325425","display_name":"Ruping Zhao","orcid":"https://orcid.org/0000-0003-1096-6717","observed_orcids":["https://orcid.org/0000-0003-1096-6717","https://orcid.org/0009-0005-7940-4685"]},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruping Zhao","raw_affiliation_strings":["College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101295137","display_name":"Chenlu Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenlu Xiong","raw_affiliation_strings":["College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123868893","display_name":"Xinyuan Duan","orcid":"https://orcid.org/0009-0006-4777-3838","observed_orcids":["https://orcid.org/0009-0006-4777-3838"]},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyuan Duan","raw_affiliation_strings":["College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140477275","display_name":"Fei Xie","orcid":"https://orcid.org/0000-0002-6581-3964","observed_orcids":["https://orcid.org/0000-0002-6581-3964"]},"institutions":[{"id":"https://openalex.org/I37796252","display_name":"Beijing University of Technology","ror":"https://ror.org/037b1pp87","country_code":"CN","type":"education","lineage":["https://openalex.org/I37796252"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Xie","raw_affiliation_strings":["College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemistry and Life Science, Beijing University of Technology, Beijing, 100124, China","institution_ids":["https://openalex.org/I37796252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5140477275"],"corresponding_institution_ids":["https://openalex.org/I37796252"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60350797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"5","first_page":"347","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9679999947547913},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9829999804496765},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.8920000195503235},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/hypoxic-ischemic-encephalopathy","display_name":"hypoxic-ischemic encephalopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":1.0},{"id":"https://openalex.org/keywords/chronic-cerebral-hypoperfusion","display_name":"chronic cerebral hypoperfusion","score":0.9909999966621399},{"id":"https://openalex.org/keywords/toxic-encephalopathy","display_name":"toxic encephalopathy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6499999761581421},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mitochondria-targeted-therapy","display_name":"mitochondrial-targeted therapy","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9218999743461609},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7476999759674072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5335999727249146},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4799000024795532},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.45910000801086426},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4221999943256378},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.373199999332428},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3684000074863434},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.35899999737739563},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3264999985694885},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.32030001282691956},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C64348767","wikidata":"https://www.wikidata.org/wiki/Q3335079","display_name":"Neuroregeneration","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.27480000257492065},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2727000117301941},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.25459998846054077},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.25380000472068787},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/0115672026430179251224095358","doi":"https://doi.org/10.2174/0115672026430179251224095358","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0115672026430179251224095358","pdf_url":null,"source":{"id":"https://openalex.org/S6525137","display_name":"Current Neurovascular Research","issn_l":"1567-2026","issn":["1567-2026","1875-5739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neurovascular Research","raw_type":"journal-article"},{"id":"pmid:41588594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41588594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current neurovascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6778723001480103,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W1848144340","https://openalex.org/W2023468397","https://openalex.org/W2042353300","https://openalex.org/W2052723973","https://openalex.org/W2063802411","https://openalex.org/W2066391375","https://openalex.org/W2073441294","https://openalex.org/W2075720668","https://openalex.org/W2079370915","https://openalex.org/W2092876260","https://openalex.org/W2097133939","https://openalex.org/W2104873458","https://openalex.org/W2149239535","https://openalex.org/W2151706239","https://openalex.org/W2169657429","https://openalex.org/W2251567434","https://openalex.org/W2257748093","https://openalex.org/W2299896901","https://openalex.org/W2316084180","https://openalex.org/W2335342493","https://openalex.org/W2345777804","https://openalex.org/W2399895173","https://openalex.org/W2404128784","https://openalex.org/W2496283852","https://openalex.org/W2510013939","https://openalex.org/W2604919243","https://openalex.org/W2609166163","https://openalex.org/W2733994766","https://openalex.org/W2750534773","https://openalex.org/W2769413913","https://openalex.org/W2782887521","https://openalex.org/W2787276197","https://openalex.org/W2799431715","https://openalex.org/W2810504199","https://openalex.org/W2810886529","https://openalex.org/W2883222829","https://openalex.org/W2883833172","https://openalex.org/W2910355986","https://openalex.org/W2912592608","https://openalex.org/W2912920302","https://openalex.org/W2913863256","https://openalex.org/W2922431830","https://openalex.org/W2950046916","https://openalex.org/W2964546133","https://openalex.org/W2969377838","https://openalex.org/W2977879715","https://openalex.org/W2988046530","https://openalex.org/W2990376437","https://openalex.org/W2992227805","https://openalex.org/W2996457783","https://openalex.org/W3001334548","https://openalex.org/W3002853676","https://openalex.org/W3003394141","https://openalex.org/W3010589304","https://openalex.org/W3021188224","https://openalex.org/W3026321733","https://openalex.org/W3031963365","https://openalex.org/W3033179663","https://openalex.org/W3036949888","https://openalex.org/W3037526194","https://openalex.org/W3046617996","https://openalex.org/W3046954920","https://openalex.org/W3047181287","https://openalex.org/W3049178725","https://openalex.org/W3082470482","https://openalex.org/W3083233402","https://openalex.org/W3086673333","https://openalex.org/W3118356569","https://openalex.org/W3124548248","https://openalex.org/W3127354605","https://openalex.org/W3131453773","https://openalex.org/W3144323690","https://openalex.org/W3158489984","https://openalex.org/W3172480723","https://openalex.org/W3176772097","https://openalex.org/W3179001539","https://openalex.org/W3185755861","https://openalex.org/W3188063183","https://openalex.org/W3193018238","https://openalex.org/W3197468675","https://openalex.org/W3197785525","https://openalex.org/W3198007119","https://openalex.org/W3200436859","https://openalex.org/W3204493759","https://openalex.org/W3207190809","https://openalex.org/W3210991193","https://openalex.org/W4200389601","https://openalex.org/W4205319509","https://openalex.org/W4206555668","https://openalex.org/W4213237063","https://openalex.org/W4225376186","https://openalex.org/W4281390367","https://openalex.org/W4283321886","https://openalex.org/W4309531182","https://openalex.org/W4310011670","https://openalex.org/W4311348216","https://openalex.org/W4312083268","https://openalex.org/W4312188207","https://openalex.org/W4319081217","https://openalex.org/W4327614968","https://openalex.org/W4361288161","https://openalex.org/W4365482590","https://openalex.org/W4366778969","https://openalex.org/W4367834122","https://openalex.org/W4368362499","https://openalex.org/W4368617608","https://openalex.org/W4376639697","https://openalex.org/W4376875538","https://openalex.org/W4377100934","https://openalex.org/W4379209695","https://openalex.org/W4380084359","https://openalex.org/W4381085650","https://openalex.org/W4384297220","https://openalex.org/W4384925461","https://openalex.org/W4385583976","https://openalex.org/W4385619987","https://openalex.org/W4388459592","https://openalex.org/W4388785133","https://openalex.org/W4390838115","https://openalex.org/W4392509743","https://openalex.org/W4393156543","https://openalex.org/W4393188673","https://openalex.org/W4393282250","https://openalex.org/W4393851988","https://openalex.org/W4393972660","https://openalex.org/W4400027077","https://openalex.org/W4401092630","https://openalex.org/W4401424115","https://openalex.org/W4402441002","https://openalex.org/W4405661901","https://openalex.org/W4405747522","https://openalex.org/W4406459740","https://openalex.org/W4408070097","https://openalex.org/W4408134282","https://openalex.org/W4408160571","https://openalex.org/W4408588620","https://openalex.org/W4409452113","https://openalex.org/W4409517940","https://openalex.org/W4410599036","https://openalex.org/W4410767836","https://openalex.org/W4411438187","https://openalex.org/W4411441577","https://openalex.org/W4414159473"],"related_works":[],"abstract_inverted_index":{"Brain":[0],"injury":[1,55],"is":[2,104],"a":[3,30,177,188,194],"leading":[4],"cause":[5],"of":[6,53,82,121,124],"mortality":[7],"and":[8,21,67,78,99,127,134,147,166,197],"long-term":[9],"disability":[10],"worldwide,":[11],"characterized":[12],"by":[13],"energy":[14],"metabolism":[15],"dysfunction,":[16],"oxidative":[17],"stress,":[18],"inflammatory":[19],"responses,":[20],"programmed":[22],"cell":[23],"death,":[24],"with":[25],"mitochondrial":[26,111,125],"dysfunction":[27],"serving":[28],"as":[29,38,155,176],"central":[31],"pathological":[32],"nexus.":[33],"In":[34],"recent":[35],"years,":[36],"hydrogen,":[37],"an":[39],"emerging":[40],"gaseous":[41],"signaling":[42],"molecule,":[43],"has":[44,140],"demonstrated":[45],"remarkable":[46],"neuroprotective":[47,180],"effects":[48,77],"in":[49,84,205],"various":[50],"experimental":[51,163],"models":[52],"brain":[54,88,183],"owing":[56],"to":[57,109],"its":[58],"unique":[59],"biological":[60],"properties,":[61],"including":[62],"selective":[63],"antioxidant,":[64],"anti-inflammatory,":[65],"anti-apoptotic,":[66],"mitochondrial-":[68],"protective":[69,76],"activities.":[70],"This":[71],"review":[72,139],"comprehensively":[73],"summarizes":[74],"the":[75],"underlying":[79],"molecular":[80],"mechanisms":[81],"hydrogen":[83,172],"ischemic":[85],"stroke,":[86],"traumatic":[87],"injury,":[89,184],"hypoxic-ischemic":[90],"encephalopathy,":[91],"intracerebral":[92],"hemorrhage,":[93,95],"subarachnoid":[94],"chronic":[96],"cerebral":[97],"hypoperfusion,":[98],"toxic":[100],"encephalopathy.":[101],"Special":[102],"emphasis":[103],"placed":[105],"on":[106],"hydrogen's":[107],"ability":[108],"modulate":[110],"quality":[112],"control":[113],"networks,":[114],"encompassing":[115],"antioxidative":[116],"membrane":[117],"protection,":[118],"precise":[119,198],"regulation":[120],"mitophagy,":[122],"remodeling":[123],"dynamics,":[126],"metabolic":[128],"reprogramming,":[129],"thereby":[130],"improving":[131],"neuronal":[132],"survival":[133],"functional":[135],"recovery.":[136],"Moreover,":[137],"this":[138],"discussed":[141],"current":[142],"limitations,":[143],"unresolved":[144],"scientific":[145],"questions,":[146],"major":[148],"challenges,":[149],"while":[150],"proposing":[151],"future":[152,202],"directions,":[153],"such":[154],"multi-omics":[156],"integration,":[157],"advanced":[158],"structural":[159],"biology":[160],"investigations,":[161],"innovative":[162],"model":[164],"optimization,":[165],"systematic":[167],"clinical":[168,203],"translational":[169],"research.":[170],"Collectively,":[171],"holds":[173],"great":[174],"promise":[175],"novel":[178],"mitochondriatargeted":[179],"strategy":[181],"for":[182,201],"offering":[185],"not":[186],"only":[187],"solid":[189],"theoretical":[190],"foundation":[191],"but":[192],"also":[193],"potential":[195],"personalized":[196],"therapeutic":[199],"avenue":[200],"applications":[204],"neurological":[206],"disorders.":[207]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-01-27T00:00:00"}