{"id":"https://openalex.org/W7125675615","doi":"https://doi.org/10.1002/jbt.70704","title":"Histone Deacetylase 7 Exacerbates the Inflammatory Response by Inhibiting Nur77 Expression to Induce Lesions of Acute Respiratory Distress Syndrome","display_name":"Histone Deacetylase 7 Exacerbates the Inflammatory Response by Inhibiting Nur77 Expression to Induce Lesions of Acute Respiratory Distress Syndrome","publication_year":2026,"publication_date":"2026-01-26","ids":{"openalex":"https://openalex.org/W7125675615","doi":"https://doi.org/10.1002/jbt.70704","pmid":"https://pubmed.ncbi.nlm.nih.gov/41587382"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.70704","doi":"https://doi.org/10.1002/jbt.70704","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.70704","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.70704","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.70704","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123847977","display_name":"Dongdong Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongdong Yang","raw_affiliation_strings":["Department of Emergency Medicine The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101675104","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0001-6514-7503","observed_orcids":["https://orcid.org/0000-0001-6514-7503"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Zhou","raw_affiliation_strings":["First Clinical Medical College Zhejiang Chinese Medical University Hangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinical Medical College Zhejiang Chinese Medical University Hangzhou China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043718202","display_name":"Chenjuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenjuan Wang","raw_affiliation_strings":["Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123846815","display_name":"Mengyuan Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyuan Shen","raw_affiliation_strings":["Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123852592","display_name":"Zejiong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zejiong Li","raw_affiliation_strings":["Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123857781","display_name":"Yiheng Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiheng Fu","raw_affiliation_strings":["Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112392407","display_name":"Jiannong Wu","orcid":"https://orcid.org/0000-0003-0213-2456","observed_orcids":["https://orcid.org/0000-0003-0213-2456","https://orcid.org/0000-0002-2260-2067"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiannong Wu","raw_affiliation_strings":["Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China"],"raw_orcid":"https://orcid.org/0000-0002-2260-2067","affiliations":[{"raw_affiliation_string":"Department of ICU The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112392407"],"corresponding_institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04358911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"2","first_page":"e70704","last_page":"e70704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.24480000138282776,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac7","display_name":"HDAC7","score":0.9229999780654907},{"id":"https://openalex.org/keywords/nr4a1","display_name":"Nur77","score":0.9869999885559082},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8059999942779541},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.746999979019165},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.39399999380111694},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.8621000051498413},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5647000074386597},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5315999984741211},{"id":"https://openalex.org/C35552991","wikidata":"https://www.wikidata.org/wiki/Q12063746","display_name":"Nerve growth factor IB","level":5,"score":0.5249000191688538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4724999964237213},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.43369999527931213},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3691999912261963},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.35109999775886536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3375000059604645},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31200000643730164},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3089999854564667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2818000018596649},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.2741999924182892},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.25679999589920044}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.70704","doi":"https://doi.org/10.1002/jbt.70704","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.70704","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.70704","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:41587382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41587382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jbt.70704","doi":"https://doi.org/10.1002/jbt.70704","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.70704","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.70704","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5447193384170532}],"study_designs":[],"awards":[{"id":"https://openalex.org/G15765406","display_name":null,"funder_award_id":"82174178","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2633400589","display_name":null,"funder_award_id":"82104763","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G420254","display_name":null,"funder_award_id":"GD21H290001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7125675615.pdf","grobid_xml":"https://content.openalex.org/works/W7125675615.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1517180320","https://openalex.org/W2156952099","https://openalex.org/W2528853165","https://openalex.org/W2799645844","https://openalex.org/W2886496863","https://openalex.org/W2900150319","https://openalex.org/W2921521376","https://openalex.org/W2940456023","https://openalex.org/W2944962542","https://openalex.org/W2953178874","https://openalex.org/W2992691763","https://openalex.org/W2997313980","https://openalex.org/W3004624574","https://openalex.org/W3035218141","https://openalex.org/W3041738119","https://openalex.org/W3076128162","https://openalex.org/W3087169973","https://openalex.org/W3089518794","https://openalex.org/W3131011009","https://openalex.org/W3134351487","https://openalex.org/W3134940249","https://openalex.org/W3139181177","https://openalex.org/W3139367955","https://openalex.org/W3155789584","https://openalex.org/W3171793506","https://openalex.org/W3183279797","https://openalex.org/W3197272364","https://openalex.org/W3198987190","https://openalex.org/W4205735962","https://openalex.org/W4220659487","https://openalex.org/W4220662970","https://openalex.org/W4220755370","https://openalex.org/W4223567553","https://openalex.org/W4224989641","https://openalex.org/W4229456862","https://openalex.org/W4281251487","https://openalex.org/W4281693507","https://openalex.org/W4281898072","https://openalex.org/W4283790555","https://openalex.org/W4287009192","https://openalex.org/W4288702833","https://openalex.org/W4294767986","https://openalex.org/W4318263621","https://openalex.org/W4323038154","https://openalex.org/W4376599845","https://openalex.org/W4377245353","https://openalex.org/W4380078785","https://openalex.org/W4380264876","https://openalex.org/W4381546880","https://openalex.org/W4384029370","https://openalex.org/W4385778883","https://openalex.org/W4399360991","https://openalex.org/W4400150439","https://openalex.org/W4403243882","https://openalex.org/W4403334924","https://openalex.org/W4405887830","https://openalex.org/W4409338490"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Acute":[1],"respiratory":[2,9],"distress":[3],"syndrome":[4],"(ARDS)":[5],"is":[6],"an":[7],"acute":[8,27],"disease.":[10],"Nuclear":[11],"receptor":[12],"77":[13],"(Nur77)":[14],"shows":[15],"anti\u2010ARDS":[16],"activity.":[17],"Histone":[18],"deacetylase":[19],"7":[20],"(HDAC7)":[21],"knockdown":[22,142,217],"suppresses":[23],"inflammatory":[24,144,200],"response":[25,201],"in":[26,33,95,98,134,210],"lung":[28,49,65],"injury,":[29],"but":[30],"its":[31],"role":[32],"ARDS":[34,37,100,139,211,241,256],"remains":[35],"unclear.":[36],"mouse":[38],"models":[39],"were":[40,58,69,80,92],"established":[41],"by":[42,168,207,232,242],"cecum":[43],"ligation":[44],"and":[45,56,74,77,85,88,97,121,131,154,157,163,182,202,223,225,247,250],"puncture.":[46],"Assessment":[47],"of":[48,83,107,118,125,196],"function":[50,205],"indexes,":[51],"HE":[52],"staining,":[53],"immunohistochemistry,":[54],"ChIP,":[55],"proteomics":[57],"performed.":[59],"In":[60,138,213],"vitro,":[61],"human":[62],"non\u2010small":[63],"cell":[64,227],"cancer":[66],"A549":[67],"cells":[68],"treated":[70],"with":[71],"lipopolysaccharide":[72],"(LPS),":[73],"qRT\u2010PCR,":[75],"CCK8,":[76],"flow":[78],"cytometry":[79],"conducted.":[81],"Silencing":[82],"HDAC7":[84,141,155,184,208,216,235],"Nur77,":[86],"ELISA,":[87],"Western":[89],"blot":[90],"analysis":[91],"performed":[93],"both":[94],"vivo":[96],"vitro.":[99],"mice":[101],"exhibited":[102],"lower":[103],"pH,":[104],"partial":[105,123],"pressure":[106,124],"oxygen":[108,113],"(PaO":[109],"2":[110,116,129],"),":[111],"arterial":[112],"saturation,":[114],"PaO":[115],"/fraction":[117],"inspiration":[119],"oxygen,":[120],"higher":[122],"carbon":[126],"dioxide":[127],"(PaCO":[128],")":[130],"protein":[132],"levels":[133],"bronchoalveolar":[135],"lavage":[136],"fluid.":[137],"mice,":[140],"inhibited":[143],"infiltration,":[145],"reduced":[146,218],"tumor":[147],"necrosis":[148],"factor\u2010\u03b1":[149],"(TNF\u2010\u03b1),":[150],"interleukin":[151],"(IL)\u20101\u03b2,":[152],"IL\u20106,":[153],"levels,":[156,222],"enhanced":[158,192],"zonula":[159],"occludens\u20101,":[160],"Occludin,":[161],"Claudin\u20101,":[162],"Nur77":[164,169,187,197,233,238],"expression,":[165],"which":[166,229],"reversed":[167,231],"knockdown.":[170,234],"Moreover,":[171],"the":[172,193],"crucial":[173],"differentially":[174],"expressed":[175],"proteins":[176],"included":[177],"Igkv14\u2010126,":[178,244],"IGLC2,":[179,245],"Prss3b,":[180,246],"Ccdc50,":[181],"Chchd7.":[183],"bound":[185],"to":[186,239],"promoter.":[188],"Notably,":[189],"Ccdc50":[190,249],"over\u2010expression":[191,198,209],"mitigating":[194],"effect":[195],"on":[199],"impaired":[203],"barrier":[204],"aggravated":[206],"mice.":[212],"LPS\u2010treated":[214],"cells,":[215],"TNF\u2010\u03b1,":[219],"IL\u20101\u03b2,":[220],"IL\u20106":[221],"apoptosis,":[224],"increased":[226],"viability,":[228],"also":[230],"may":[236],"inhibit":[237],"exacerbate":[240],"upregulating":[243],"downregulating":[248],"Chchd7,":[251],"offering":[252],"new":[253],"targets":[254],"for":[255],"treatment.":[257]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-27T00:00:00"}
