{"id":"https://openalex.org/W7125589692","doi":"https://doi.org/10.1016/j.jvssci.2025.100347","title":"Abstract Tu0049: Leveraging a Transgenic Mouse Model to Study Endothelial Cell-Derived Extracellular Vesicles in Atherosclerosis","display_name":"Abstract Tu0049: Leveraging a Transgenic Mouse Model to Study Endothelial Cell-Derived Extracellular Vesicles in Atherosclerosis","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7125589692","doi":"https://doi.org/10.1016/j.jvssci.2025.100347"},"language":"en","primary_location":{"id":"doi:10.1016/j.jvssci.2025.100347","doi":"https://doi.org/10.1016/j.jvssci.2025.100347","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jvssci.2025.100347","pdf_url":null,"source":{"id":"https://openalex.org/S4210220199","display_name":"JVS Vascular Science","issn_l":"2666-3503","issn":["2666-3503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JVS-Vascular Science","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jvssci.2025.100347","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110981711","display_name":"Mandy Kunze Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mandy Kunze Guo","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003505348","display_name":"Corey A. Scipione","orcid":"https://orcid.org/0000-0002-0052-8038","observed_orcids":["https://orcid.org/0000-0002-0052-8038"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Corey Scipione","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006011295","display_name":"Leandro C. Breda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leandro Breda","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036027739","display_name":"Kamalben Prajapati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kamalben Prajapati","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016163505","display_name":"Sneha Raju","orcid":"https://orcid.org/0000-0001-9149-5907","observed_orcids":["https://orcid.org/0000-0001-9149-5907"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sneha Raju","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017152603","display_name":"Steven R. Botts","orcid":"https://orcid.org/0000-0002-2420-4679","observed_orcids":["https://orcid.org/0000-0002-2420-4679"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Steven Botts","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093653360","display_name":"Majed Abdul-Samad","orcid":"https://orcid.org/0009-0006-6007-3190","observed_orcids":["https://orcid.org/0009-0006-6007-3190"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Majed Abdul-Samad","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020817625","display_name":"Sarvatit Patel","orcid":"https://orcid.org/0000-0002-3101-8380","observed_orcids":["https://orcid.org/0000-0002-3101-8380"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sarvatit Patel","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111076283","display_name":"Garry Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Garry Yu","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084586982","display_name":"Andrew C. Dudley","orcid":"https://orcid.org/0000-0002-2663-1949","observed_orcids":["https://orcid.org/0000-0002-2663-1949"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Dudley","raw_affiliation_strings":["University of Virginia, Charlottesville, Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, Virginia, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078017816","display_name":"Jason E. Fish","orcid":"https://orcid.org/0000-0003-0640-7277","observed_orcids":["https://orcid.org/0000-0003-0640-7277"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jason Fish","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030997775","display_name":"Kathryn L. Howe","orcid":"https://orcid.org/0000-0002-6519-2280","observed_orcids":["https://orcid.org/0000-0002-6519-2280"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kathryn Howe","raw_affiliation_strings":["University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"100347","last_page":"100347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8619999885559082},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9539999961853027},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.953000009059906},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.6330000162124634},{"id":"https://openalex.org/keywords/lipoprotein-accumulation","display_name":"lipoprotein accumulation","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5942000150680542},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5860999822616577},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.484499990940094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4675000011920929},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3343000113964081},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.288100004196167}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jvssci.2025.100347","doi":"https://doi.org/10.1016/j.jvssci.2025.100347","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jvssci.2025.100347","pdf_url":null,"source":{"id":"https://openalex.org/S4210220199","display_name":"JVS Vascular Science","issn_l":"2666-3503","issn":["2666-3503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JVS-Vascular Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jvssci.2025.100347","doi":"https://doi.org/10.1016/j.jvssci.2025.100347","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jvssci.2025.100347","pdf_url":null,"source":{"id":"https://openalex.org/S4210220199","display_name":"JVS Vascular Science","issn_l":"2666-3503","issn":["2666-3503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JVS-Vascular Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4229445538","https://openalex.org/W2793710537","https://openalex.org/W4385224329","https://openalex.org/W4378471114","https://openalex.org/W3198317309","https://openalex.org/W2933572783","https://openalex.org/W4411397122","https://openalex.org/W2793404427","https://openalex.org/W4281842095","https://openalex.org/W4402840766"],"abstract_inverted_index":{"Atherosclerosis":[0],"is":[1],"characterized":[2],"by":[3],"the":[4,16,39],"accumulation":[5],"of":[6,38,50],"lipoproteins":[7],"and":[8,25,30,60,76],"immune":[9],"cells,":[10],"leading":[11],"to":[12],"unresolved":[13],"inflammation":[14],"in":[15,80,84],"arterial":[17],"wall.":[18],"Endothelial":[19],"cells":[20,79],"(EC)":[21],"form":[22],"a":[23,36],"barrier,":[24],"modulate":[26],"communication,":[27,52],"between":[28,70],"circulating":[29],"resident":[31],"vascular":[32],"cells.":[33],"EC":[34],"dysfunction,":[35],"hallmark":[37],"disease,":[40],"disrupts":[41],"healthy":[42],"communication.":[43],"Extracellular":[44],"vesicles":[45],"(EVs)":[46],"are":[47],"key":[48],"mediators":[49],"intercellular":[51],"carrying":[53],"bioactive":[54],"molecules":[55],"that":[56],"influence":[57],"cell":[58],"function":[59],"signal":[61],"disease":[62],"states.":[63],"While":[64],"our":[65],"group":[66],"previously":[67],"demonstrated":[68],"crosstalk":[69],"endothelial-derived":[71],"EVs":[72],"(EC-EVs)":[73],"with":[74],"monocytes":[75],"smooth":[77],"muscle":[78],"vitro,":[81],"their":[82],"role":[83],"vivo":[85],"remains":[86],"unclear.":[87]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-25T00:00:00"}