{"id":"https://openalex.org/W7125523916","doi":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","title":"An\u00e1lise prote\u00f4mica para detec\u00e7\u00e3o de potenciais biomarcadores de resist\u00eancia ao carrapato Rhipicephalus microplus em bovinos da ra\u00e7a Caracu","display_name":"An\u00e1lise prote\u00f4mica para detec\u00e7\u00e3o de potenciais biomarcadores de resist\u00eancia ao carrapato Rhipicephalus microplus em bovinos da ra\u00e7a Caracu","publication_year":2025,"publication_date":"2025-09-10","ids":{"openalex":"https://openalex.org/W7125523916","doi":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450"},"language":"pt","primary_location":{"id":"doi:10.11606/t.17.2025.tde-16012026-161450","doi":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","pdf_url":"http://www.teses.usp.br/teses/disponiveis/17/17135/tde-16012026-161450/publico/NATALYAGARDEZANIABDUCHsimples.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/17/17135/tde-16012026-161450/publico/NATALYAGARDEZANIABDUCHsimples.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073793054","display_name":"Natalya Gardezani Abduch","orcid":"https://orcid.org/0000-0002-2496-8046","observed_orcids":["https://orcid.org/0000-0002-2496-8046"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Natalya Gardezani Abduch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073793054"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhipicephalus-microplus","display_name":"Rhipicephalus microplus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tick-resistance","display_name":"tick resistance","score":0.8270000219345093},{"id":"https://openalex.org/keywords/caracu-cattle","display_name":"Caracu cattle","score":0.9670000076293945},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.656000018119812},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.609000027179718},{"id":"https://openalex.org/keywords/differentially-abundant-proteins","display_name":"differentially abundant proteins","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tick-infestation","display_name":"tick infestation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5877000093460083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5508000254631042},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.4097000062465668},{"id":"https://openalex.org/C2780505807","wikidata":"https://www.wikidata.org/wiki/Q1208989","display_name":"Beef cattle","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2727000117301941},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C194775826","wikidata":"https://www.wikidata.org/wiki/Q209542","display_name":"Herd","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2485000044107437},{"id":"https://openalex.org/C2778579951","wikidata":"https://www.wikidata.org/wiki/Q11353905","display_name":"Brucella abortus","level":3,"score":0.2460000067949295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2214999943971634}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.11606/t.17.2025.tde-16012026-161450","doi":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","pdf_url":"http://www.teses.usp.br/teses/disponiveis/17/17135/tde-16012026-161450/publico/NATALYAGARDEZANIABDUCHsimples.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:teses.usp.br:tde-16012026-161450","doi":null,"is_oa":false,"landing_page_url":"https://www.teses.usp.br/teses/disponiveis/17/17135/tde-16012026-161450/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tese (Doutorado)"}],"best_oa_location":{"id":"doi:10.11606/t.17.2025.tde-16012026-161450","doi":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.17.2025.tde-16012026-161450","pdf_url":"http://www.teses.usp.br/teses/disponiveis/17/17135/tde-16012026-161450/publico/NATALYAGARDEZANIABDUCHsimples.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.8409000039100647,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"},{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7125523916.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2903866083","https://openalex.org/W1674419345","https://openalex.org/W2754208578","https://openalex.org/W7120713789","https://openalex.org/W7057089384","https://openalex.org/W2784195216","https://openalex.org/W2768263480","https://openalex.org/W7120779139","https://openalex.org/W6981784351","https://openalex.org/W7120459778"],"abstract_inverted_index":{"O":[0],"carrapato":[1,25,222],"Rhipicephalus":[2],"microplus":[3],"provoca":[4],"grandes":[5],"preju\u00edzos":[6],"econ\u00f4micos":[7],"\u00e0":[8,22,102,221,246],"pecu\u00e1ria,":[9],"especialmente":[10],"em":[11,26,278],"regi\u00f5es":[12],"tropicais.":[13],"Conhecer":[14],"os":[15,175,207],"mecanismos":[16],"fenot\u00edpicos,":[17],"fisiol\u00f3gicos":[18],"e":[19,33,60,63,78,97,135,155,158,163,184,203,228,241,259,270,289],"gen\u00e9ticos":[20],"associados":[21],"resist\u00eancia":[23,48,220,266],"ao":[24,53],"bovinos":[27],"pode":[28],"favorecer":[29],"estrat\u00e9gias":[30],"de":[31,36,41,72,74,83,88,91,104,148,235,238,243,250,260,280,287],"sele\u00e7\u00e3o":[32],"manejo,":[34],"al\u00e9m":[35,82],"contribuir":[37,217],"para":[38,107],"a":[39,47,111,219,265],"identifica\u00e7\u00e3o":[40],"poss\u00edveis":[42],"biomarcadores.":[43],"Este":[44],"estudo":[45],"avaliou":[46],"da":[49,267],"ra\u00e7a":[50,268],"Caracu,":[51],"adaptada":[52],"clima":[54],"tropical,":[55],"utilizando":[56],"an\u00e1lises":[57],"fenot\u00edpicas,":[58],"hematol\u00f3gicas":[59],"prote\u00f4micas.":[61],"Vacas":[62],"novilhas":[64],"foram":[65,100],"avaliadas":[66],"por":[67],"18":[68],"meses,":[69],"com":[70,152,160,178,218],"registros":[71],"contagem":[73,147],"carrapatos,":[75],"colora\u00e7\u00e3o,":[76],"comprimento":[77,136],"espessura":[79,126],"do":[80,121,127,137],"pelame,":[81],"an\u00e1lise":[84,108,211],"hematol\u00f3gica.":[85],"Posteriormente,":[86],"amostras":[87],"plasma":[89],"sangu\u00edneo":[90],"16":[92],"animais":[93,182],"extremos":[94],"(8":[95],"resistentes":[96,183],"8":[98],"suscet\u00edveis)":[99],"submetidas":[101],"espectrometria":[103],"massas":[105],"(LC-MS/MS)":[106],"prote\u00f4mica.":[109],"Fenotipicamente,":[110],"infesta\u00e7\u00e3o":[112],"foi":[113],"influenciada":[114],"pela":[115],"idade":[116],"(vacas":[117],">":[118,124,131,142],"novilhas),":[119],"esta\u00e7\u00e3o":[120],"ano":[122],"(primavera/ver\u00e3o":[123],"outono/inverno),":[125],"pelame":[128,138],"(>1,5":[129],"mm":[130,141],"<":[132,143],"1.5":[133],"mm)":[134],"(>":[139],"6":[140,144],"mm).":[145],"A":[146,210,248],"carrapatos":[149],"correlacionou-se":[150],"negativamente":[151],"eritr\u00f3citos":[153],"(0.29)":[154],"hemat\u00f3crito":[156],"(0.24),":[157],"positivamente":[159],"HCM":[161],"(0.21)":[162],"CHCM":[164],"(0.25).":[165],"Foram":[166],"identificadas":[167],"14.034":[168],"prote\u00ednas,":[169],"sendo":[170],"152":[171],"diferencialmente":[172],"abundantes":[173],"entre":[174,206],"dois":[176],"grupos,":[177],"34":[179],"exclusivas":[180],"dos":[181,186],"172":[185],"suscet\u00edveis.":[187],"Genes":[188],"como":[189,223],"APOA4,":[190],"C4BPA,":[191],"HP,":[192],"KMT2B,":[193],"MAST2,":[194],"NOXO1,":[195],"PON1,":[196],"RNASE1,":[197],"RPS6KA5,":[198],"SETD1B,":[199],"SETD2,":[200],"TMEM63A,":[201],"TNS2,":[202],"ZNRF3":[204],"estiveram":[205],"mais":[208,293],"relevantes.":[209],"funcional":[212],"destacou":[213],"processos":[214],"que":[215,274],"podem":[216,275],"hemostasia,":[224],"endocitose,":[225],"fagocitose,":[226],"prolifera\u00e7\u00e3o":[227],"migra\u00e7\u00e3o":[229],"celular,":[230],"c\u00e1lcio,":[231],"actina,":[232],"lip\u00eddios,":[233],"receptores":[234],"elimina\u00e7\u00e3o,":[236],"per\u00f3xido":[237],"hidrog\u00eanio,":[239],"tirosina":[240],"fator":[242],"crescimento":[244],"semelhante":[245],"insulina.":[247],"rede":[249],"intera\u00e7\u00e3o":[251],"proteica":[252],"evidenciou":[253],"prote\u00ednas":[254],"centrais":[255],"nos":[256],"sistemas":[257],"imune":[258],"coagula\u00e7\u00e3o.":[261],"Os":[262],"resultados":[263],"refor\u00e7am":[264],"Caracu":[269],"indicam":[271],"potenciais":[272],"biomarcadores":[273],"ser":[276],"utilizados":[277],"programas":[279],"melhoramento":[281],"gen\u00e9tico,":[282],"visando":[283],"reduzir":[284],"o":[285],"uso":[286],"acaricidas":[288],"promover":[290],"uma":[291],"pecu\u00e1ria":[292],"sustent\u00e1vel.":[294]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-01-24T00:00:00"}