{"id":"https://openalex.org/W7125478804","doi":"https://doi.org/10.31020/mutftd.1749015","title":"In vitro Investigation of Wound Healing, Cytotoxic, Antioxidant Properties of Shed Snake Skin (Dolichophis caspius) Aqueous Extract","display_name":"In vitro Investigation of Wound Healing, Cytotoxic, Antioxidant Properties of Shed Snake Skin (Dolichophis caspius) Aqueous Extract","publication_year":2026,"publication_date":"2026-01-23","ids":{"openalex":"https://openalex.org/W7125478804","doi":"https://doi.org/10.31020/mutftd.1749015"},"language":"en","primary_location":{"id":"doi:10.31020/mutftd.1749015","doi":"https://doi.org/10.31020/mutftd.1749015","is_oa":true,"landing_page_url":"https://doi.org/10.31020/mutftd.1749015","pdf_url":"https://dergipark.org.tr/en/download/article-file/5082787","source":{"id":"https://openalex.org/S4210173265","display_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","issn_l":"1309-8004","issn":["1309-8004","1309-761X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318323","host_organization_name":"Mersin University School of Medicine","host_organization_lineage":["https://openalex.org/P4310318323"],"host_organization_lineage_names":["Mersin University School of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/5082787","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123695527","display_name":"Faruk Ba\u015fkurt","orcid":"https://orcid.org/0009-0005-0434-3910","observed_orcids":["https://orcid.org/0009-0005-0434-3910"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Faruk Ba\u015fkurt","raw_affiliation_strings":["Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering"],"raw_orcid":"https://orcid.org/0009-0005-0434-3910","affiliations":[{"raw_affiliation_string":"Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering","institution_ids":["https://openalex.org/I16748637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081625203","display_name":"Ay\u015feg\u00fcl \u0130nam","orcid":"https://orcid.org/0000-0002-9411-1232","observed_orcids":["https://orcid.org/0000-0002-9411-1232"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015feg\u00fcl \u0130nam","raw_affiliation_strings":["Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering"],"raw_orcid":"https://orcid.org/0000-0002-9411-1232","affiliations":[{"raw_affiliation_string":"Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering","institution_ids":["https://openalex.org/I16748637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033333016","display_name":"Furkan Ozan \u00c7\u00f6ven","orcid":"https://orcid.org/0000-0001-7696-3418","observed_orcids":["https://orcid.org/0000-0001-7696-3418"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Furkan Ozan \u00c7\u00f6ven","raw_affiliation_strings":["Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering"],"raw_orcid":"https://orcid.org/0000-0001-7696-3418","affiliations":[{"raw_affiliation_string":"Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering","institution_ids":["https://openalex.org/I16748637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011090314","display_name":"T\u00fclay \u00d6nc\u00fc \u00d6ner","orcid":"https://orcid.org/0000-0001-6180-5409","observed_orcids":["https://orcid.org/0000-0001-6180-5409"]},"institutions":[{"id":"https://openalex.org/I16748637","display_name":"Manisa Celal Bayar University","ror":"https://ror.org/053f2w588","country_code":"TR","type":"education","lineage":["https://openalex.org/I16748637"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"T\u00fclay \u00d6nc\u00fc \u00d6ner","raw_affiliation_strings":["Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering"],"raw_orcid":"https://orcid.org/0000-0001-6180-5409","affiliations":[{"raw_affiliation_string":"Manisa Celal Bayar University, Faculty of Engineering and Natural Sciences, Department of Bioengineering","institution_ids":["https://openalex.org/I16748637"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16748637"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":"244","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.6762999892234802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1421000063419342,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dolichophis-caspius","display_name":"Dolichophis caspius","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.7039999961853027},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.984000027179718},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":1.0},{"id":"https://openalex.org/keywords/total-phenolic-content","display_name":"total phenolic content","score":0.9760000109672546},{"id":"https://openalex.org/keywords/total-flavonoid-content","display_name":"total flavonoid content","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9700000286102295},{"id":"https://openalex.org/keywords/melanoma-cells","display_name":"melanoma cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7975000143051147},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.7311999797821045},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.722100019454956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6539999842643738},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.6510000228881836},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5580999851226807},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5311999917030334},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5249999761581421},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4569999873638153},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.4408999979496002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4334999918937683},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.4262000024318695},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.41339999437332153},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.412200003862381},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38940000534057617},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.3677000105381012},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3301999866962433},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.32510000467300415},{"id":"https://openalex.org/C2993873987","wikidata":"https://www.wikidata.org/wiki/Q184753","display_name":"Wound closure","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3068000078201294},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.2554999887943268}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31020/mutftd.1749015","doi":"https://doi.org/10.31020/mutftd.1749015","is_oa":true,"landing_page_url":"https://doi.org/10.31020/mutftd.1749015","pdf_url":"https://dergipark.org.tr/en/download/article-file/5082787","source":{"id":"https://openalex.org/S4210173265","display_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","issn_l":"1309-8004","issn":["1309-8004","1309-761X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318323","host_organization_name":"Mersin University School of Medicine","host_organization_lineage":["https://openalex.org/P4310318323"],"host_organization_lineage_names":["Mersin University School of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1749015","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/mutftd/article/1749015","pdf_url":null,"source":{"id":"https://openalex.org/S4210173265","display_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","issn_l":"1309-8004","issn":["1309-8004","1309-761X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318323","host_organization_name":"Mersin University School of Medicine","host_organization_lineage":["https://openalex.org/P4310318323"],"host_organization_lineage_names":["Mersin University School of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.31020/mutftd.1749015","doi":"https://doi.org/10.31020/mutftd.1749015","is_oa":true,"landing_page_url":"https://doi.org/10.31020/mutftd.1749015","pdf_url":"https://dergipark.org.tr/en/download/article-file/5082787","source":{"id":"https://openalex.org/S4210173265","display_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","issn_l":"1309-8004","issn":["1309-8004","1309-761X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4310318323","host_organization_name":"Mersin University School of Medicine","host_organization_lineage":["https://openalex.org/P4310318323"],"host_organization_lineage_names":["Mersin University School of Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mersin \u00dcniversitesi T\u0131p Fak\u00fcltesi Lokman Hekim T\u0131p Tarihi ve Folklorik T\u0131p Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1002539156","display_name":null,"funder_award_id":"TUBITAK 2209-A","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"},{"id":"https://openalex.org/G1321993874","display_name":null,"funder_award_id":"2209 - A","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"},{"id":"https://openalex.org/G4903128616","display_name":null,"funder_award_id":"TUBITAK-2209","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320318965","display_name":"Bursa Uluda\u011f \u00dcniversitesi","ror":null},{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7125478804.pdf","grobid_xml":"https://content.openalex.org/works/W7125478804.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W141599328","https://openalex.org/W193983472","https://openalex.org/W1986308133","https://openalex.org/W2013328140","https://openalex.org/W2043960873","https://openalex.org/W2100592123","https://openalex.org/W2112455718","https://openalex.org/W2319867926","https://openalex.org/W2323139754","https://openalex.org/W2340396355","https://openalex.org/W2548516545","https://openalex.org/W2808033049","https://openalex.org/W2941157941","https://openalex.org/W2965983472","https://openalex.org/W3004095135","https://openalex.org/W3021184934","https://openalex.org/W3047985389","https://openalex.org/W3096652613","https://openalex.org/W3110740831","https://openalex.org/W4224228443","https://openalex.org/W4321599175","https://openalex.org/W4385193438","https://openalex.org/W4385753725","https://openalex.org/W4400594728"],"related_works":["https://openalex.org/W7066016445","https://openalex.org/W7134031951","https://openalex.org/W2029819752","https://openalex.org/W4415715546","https://openalex.org/W2054740857","https://openalex.org/W2329294772","https://openalex.org/W7163051271","https://openalex.org/W3197733282","https://openalex.org/W4213289338","https://openalex.org/W4317607185"],"abstract_inverted_index":{"Purpose:":[0],"As":[1],"cold-blooded":[2],"reptiles,":[3],"snakes":[4],"seasonally":[5],"shed":[6,69,86,226],"dead":[7],"skin":[8,15,34,70],"cells":[9,181,187],"due":[10],"to":[11,47,72,196,240],"thickening":[12],"of":[13,38,43,62,66,76,153],"the":[14,39,49,59,63,74,95,99,104,110,113,118,131,154,197,204,207],"and":[16,52,71,81,103,117,130,150,165,175,185,235],"removing":[17],"harmful":[18],"parasites":[19],"during":[20],"growth.":[21],"Dolichophis":[22],"caspius":[23,68],"is":[24],"a":[25],"popularly":[26],"known":[27],"snake":[28,87,227],"in":[29,134,191,217,233],"T\u00fcrkiye":[30],"that":[31,203,225],"sheds":[32],"its":[33],"at":[35,206],"certain":[36],"times":[37],"year.":[40],"The":[41,85,122],"focus":[42],"this":[44],"study":[45],"was":[46,125,138,201],"determine":[48],"total":[50,53,96,100,147],"phenolic":[51,97,145],"flavonoid":[54,101,148],"contents,":[55,98,102],"as":[56,58,158,172],"well":[57],"antioxidant":[60,105,151],"activity,":[61],"aqueous":[64],"extracts":[65,78,205],"D.":[67],"investigate":[73],"effects":[75],"these":[77],"on":[79,133],"cytotoxicity":[80,234],"wound":[82,136,214,236],"healing.":[83],"Method:":[84],"skins":[88,228],"were":[89,107,156,170],"extracted":[90],"using":[91],"distilled":[92],"water.":[93],"Then,":[94],"activity":[106,124,152],"evaluated":[108],"through":[109],"Folin-Ciocalteu":[111],"method,":[112,120],"aluminum-chloride":[114],"colorimetric":[115],"assay,":[116],"DPPH":[119],"respectively.":[121,167],"cytotoxic":[123],"determined":[126,139,171,224],"by":[127,140],"MTT":[128],"assay":[129],"effect":[132],"vitro":[135],"healing":[137,237],"scratch":[141],"assay.":[142],"Findings:":[143],"Total":[144],"content,":[146,149],"extract":[155],"calculated":[157],"681\u00b146":[159],"\u00b5g":[160,163],"GAE/g,":[161],"442.35\u00b113":[162],"CE/g,":[164],"13.06%,":[166],"IC50":[168],"values":[169],"2972\u00b1179":[173],"\u00b5g/mL":[174,177],"2657\u00b1128":[176],"for":[178],"dermal":[179],"fibroblast":[180],"(BJ":[182],"cell":[183,189],"line)":[184,190],"melanoma":[186],"(SK-MEL-30":[188],"72":[192],"hours.":[193],"In":[194],"comparison":[195],"control":[198],"group,":[199],"it":[200],"found":[202],"studied":[208],"doses":[209],"do":[210],"not":[211],"have":[212,230],"effective":[213],"closure":[215],"rates":[216],"BJ":[218],"cells.":[219],"Conclusion:":[220],"It":[221],"has":[222],"been":[223],"will":[229],"promising":[231],"results":[232],"studies":[238],"thanks":[239],"their":[241],"potentially":[242],"active":[243],"biomolecules.":[244]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-01-24T00:00:00"}
