{"id":"https://openalex.org/W7125406080","doi":"https://doi.org/10.1097/fpc.0000000000000592","title":"Association between SLCO1B1, apolipoprotein E and ABCG2 genes and lipid response to rosuvastatin: a meta-analysis","display_name":"Association between SLCO1B1, apolipoprotein E and ABCG2 genes and lipid response to rosuvastatin: a meta-analysis","publication_year":2026,"publication_date":"2026-01-21","ids":{"openalex":"https://openalex.org/W7125406080","doi":"https://doi.org/10.1097/fpc.0000000000000592","pmid":"https://pubmed.ncbi.nlm.nih.gov/41564165"},"language":"en","primary_location":{"id":"doi:10.1097/fpc.0000000000000592","doi":"https://doi.org/10.1097/fpc.0000000000000592","is_oa":true,"landing_page_url":"https://doi.org/10.1097/fpc.0000000000000592","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/fpc.0000000000000592","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jianhai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]},{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianhai Li","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","Department of Pharmacy, College of Pharmacy, Dali University, Dali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]},{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Dali University, Dali","institution_ids":["https://openalex.org/I6593398"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongkun Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongkun Deng","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123544728","display_name":"Yong Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6593398","display_name":"Dali University","ror":"https://ror.org/02y7rck89","country_code":"CN","type":"education","lineage":["https://openalex.org/I6593398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Lai","raw_affiliation_strings":["Department of Pharmacy, College of Pharmacy, Dali University, Dali","National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, Yunnan Province, China","Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Dali University, Dali","institution_ids":["https://openalex.org/I6593398"]},{"raw_affiliation_string":"National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, Yunnan Province, China","institution_ids":["https://openalex.org/I6593398"]},{"raw_affiliation_string":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123622399","display_name":"Lei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123563352","display_name":"Limei Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Limei Yu","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huiyou Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiyou Li","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123565271","display_name":"Zhaohen Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaohen Yin","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123592605","display_name":"Lingyan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyan Liu","raw_affiliation_strings":["Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Protection Center, The 926th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army, Kaiyuan","institution_ids":["https://openalex.org/I4210160531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5123563352","https://openalex.org/A5123622399"],"corresponding_institution_ids":["https://openalex.org/I4210160531","https://openalex.org/I6593398"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03214286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"3","first_page":"88","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.4584999978542328,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/slco1b1","display_name":"SLCO1B1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9269999861717224},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.996999979019165},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9259999990463257},{"id":"https://openalex.org/keywords/statin-response","display_name":"statin response","score":0.6579999923706055},{"id":"https://openalex.org/keywords/lipid-lowering-efficacy","display_name":"lipid-lowering efficacy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7540000081062317},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.7279999852180481},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-response-variability","display_name":"drug response variability","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.8817999958992004},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7175999879837036},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.607699990272522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5371999740600586},{"id":"https://openalex.org/C512196","wikidata":"https://www.wikidata.org/wiki/Q4650095","display_name":"Abcg2","level":5,"score":0.49720001220703125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4887000024318695},{"id":"https://openalex.org/C2780499067","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41260001063346863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41200000047683716},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.3882000148296356},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3544999957084656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3513000011444092},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33889999985694885},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3359000086784363},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.321399986743927},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.30140000581741333},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.30059999227523804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29179999232292175},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.27950000762939453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2705000042915344},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.2660999894142151},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2628999948501587}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/fpc.0000000000000592","doi":"https://doi.org/10.1097/fpc.0000000000000592","is_oa":true,"landing_page_url":"https://doi.org/10.1097/fpc.0000000000000592","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},{"id":"pmid:41564165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41564165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13007914","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13007914/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacogenet Genomics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/fpc.0000000000000592","doi":"https://doi.org/10.1097/fpc.0000000000000592","is_oa":true,"landing_page_url":"https://doi.org/10.1097/fpc.0000000000000592","pdf_url":null,"source":{"id":"https://openalex.org/S192301155","display_name":"Pharmacogenetics and Genomics","issn_l":"1744-6872","issn":["1744-6872","1744-6880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,15,48,57,206,215],"effects":[4],"of":[5,18,31,60,75,203,208,217],"SLCO1B1,":[6,51],"apolipoprotein":[7],"E":[8],"(APOE)":[9],"and":[10,36,56,64,90,132,182,223],"ABCG2":[11,53,91,133,161,224],"gene":[12,54],"polymorphisms":[13,55,216],"on":[14,47],"lipid-modulating":[16,58],"efficacy":[17,59,202],"rosuvastatin.":[19],"METHODS:":[20],"Systematic":[21],"searches":[22],"were":[23,62,81],"conducted":[24],"in":[25,168],"PubMed,":[26],"Cochrane":[27],"Library,":[28],"Embase,":[29],"Web":[30],"Science,":[32],"PharmGKB,":[33],"CNKI,":[34],"VIP,":[35],"Wanfang":[37],"databases":[38],"(from":[39],"database":[40],"establishment":[41],"to":[42,111,127,144,180,193],"1":[43],"March":[44],"2025).":[45],"Studies":[46],"correlation":[49],"between":[50],"APOE,":[52],"rosuvastatin":[61,204],"collected,":[63],"meta-analysis":[65],"was":[66],"performed":[67],"using":[68],"RevMan":[69],"5.4":[70],"software.":[71],"RESULTS:":[72],"A":[73],"total":[74,169],"16":[76],"studies":[77],"involving":[78],"6167":[79],"patients":[80,159],"included,":[82],"covering":[83],"APOE":[84,116],"(p.C130R/rs429358,":[85],"p.R176C/rs741),":[86],"SLCO1B1":[87,98,218],"(p.V174A/rs4149056,":[88],"p.N130D/rs2306283),":[89],"(p.Q141K/rs2231142)":[92],"genes.":[93,226],"The":[94,200],"results":[95],"showed":[96],"that":[97],"[AG+GG":[99],"vs.":[100,118,135],"AA,":[101],"mean":[102,120,137],"difference":[103,121,138,174,187],"=":[104,114,122,139,175,188],"-4.36,":[105],"95%":[106,124,141,177,190],"confidence":[107],"interval":[108],"(CI):":[109],"-7.92":[110],"-0.80,":[112],"P":[113,129,146,196],"0.02],":[115],"(E2":[117],"E3,":[119],"-5.58,":[123],"CI:":[125,142,178,191],"-8.04":[126],"-2.51,":[128],"<":[130,147,197],"0.00001]":[131],"(CA+AA":[134],"CC,":[136],"-7.07,":[140],"-9.47":[143],"-4.68,":[145],"0.00001)":[148],"genotypes":[149],"all":[150],"significantly":[151,212],"affected":[152,213],"statin-induced":[153],"low-density":[154],"lipoprotein":[155],"cholesterol":[156,170],"(LDL-C)":[157],"reduction;":[158],"with":[160],"CA+AA":[162],"genotype":[163],"had":[164],"statistically":[165],"significant":[166],"differences":[167],"level":[171,184],"changes":[172,185],"(mean":[173,186],"-7.15,":[176],"-8.78":[179],"-5.53)":[181],"triglyceride":[183],"-7.37,":[189],"-10.91":[192],"-3.83)":[194],"(both":[195],"0.05).":[198],"CONCLUSION:":[199],"lipid-lowering":[201],"(especially":[205],"reduction":[207],"LDL-C":[209],"level)":[210],"is":[211],"by":[214],"(c.388A>G),":[219],"ApoE":[220],"(c.388T>C,":[221],"c.526C>T)":[222],"(c.421C>A)":[225]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-23T00:00:00"}