{"id":"https://openalex.org/W7125390980","doi":"https://doi.org/10.1016/j.jacadv.2025.102552","title":"Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023","display_name":"Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023","publication_year":2026,"publication_date":"2026-01-21","ids":{"openalex":"https://openalex.org/W7125390980","doi":"https://doi.org/10.1016/j.jacadv.2025.102552","pmid":"https://pubmed.ncbi.nlm.nih.gov/41570793"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacadv.2025.102552","doi":"https://doi.org/10.1016/j.jacadv.2025.102552","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacadv.2025.102552","pdf_url":null,"source":{"id":"https://openalex.org/S4220651314","display_name":"JACC Advances","issn_l":"2772-963X","issn":["2772-963X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jacadv.2025.102552","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065006726","display_name":"Michael Butzner","orcid":"https://orcid.org/0000-0002-6015-7910","observed_orcids":["https://orcid.org/0000-0002-6015-7910"]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Butzner","raw_affiliation_strings":["Cytokinetics, Incorporated, South San Francisco, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-6015-7910","affiliations":[{"raw_affiliation_string":"Cytokinetics, Incorporated, South San Francisco, California, USA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023461274","display_name":"Andrew K. ElHabr","orcid":"https://orcid.org/0000-0003-3778-5350","observed_orcids":["https://orcid.org/0000-0003-3778-5350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew K. ElHabr","raw_affiliation_strings":["Value Analytics Labs, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Value Analytics Labs, Boston, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120588478","display_name":"Kian Farajkhah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kian Farajkhah","raw_affiliation_strings":["Value Analytics Labs, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Value Analytics Labs, Boston, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038177258","display_name":"Jagpreet Chhatwal","orcid":"https://orcid.org/0000-0001-8741-4430","observed_orcids":["https://orcid.org/0000-0001-8741-4430"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jagpreet Chhatwal","raw_affiliation_strings":["Value Analytics Labs, Boston, Massachusetts, USA; Massachusetts General Hospital Institute for Technology Assessment, Harvard Medical University, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Value Analytics Labs, Boston, Massachusetts, USA; Massachusetts General Hospital Institute for Technology Assessment, Harvard Medical University, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040123651","display_name":"Turgay Ayer","orcid":"https://orcid.org/0000-0001-8720-0280","observed_orcids":["https://orcid.org/0000-0001-8720-0280"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Turgay Ayer","raw_affiliation_strings":["Value Analytics Labs, Boston, Massachusetts, USA; Department of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA; Emory School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Value Analytics Labs, Boston, Massachusetts, USA; Department of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA; Emory School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084278566","display_name":"Paulos Gebrehiwet","orcid":"https://orcid.org/0000-0002-7692-2189","observed_orcids":["https://orcid.org/0000-0002-7692-2189"]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paulos Gebrehiwet","raw_affiliation_strings":["Cytokinetics, Incorporated, South San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokinetics, Incorporated, South San Francisco, California, USA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047917814","display_name":"Sanatan Shreay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanatan Shreay","raw_affiliation_strings":["Cytokinetics, Incorporated, South San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytokinetics, Incorporated, South San Francisco, California, USA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037411450","display_name":"Ralph J. Riello","orcid":"https://orcid.org/0000-0003-1884-6269","observed_orcids":["https://orcid.org/0000-0003-1884-6269"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph J. Riello","raw_affiliation_strings":["Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Clinical and Translational Research Accelerator, Yale School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Clinical and Translational Research Accelerator, Yale School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055382903","display_name":"Nihar R. Desai","orcid":"https://orcid.org/0000-0003-2384-2545","observed_orcids":["https://orcid.org/0000-0003-2384-2545"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nihar R. Desai","raw_affiliation_strings":["Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038914998","display_name":"ANJALI TIKU OWENS","orcid":"https://orcid.org/0000-0002-9669-8495","observed_orcids":["https://orcid.org/0000-0002-9669-8495"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjali T. Owens","raw_affiliation_strings":["Hypertrophic Cardiomyopathy Clinic, Penn Center for Inherited Cardiovascular Disease, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertrophic Cardiomyopathy Clinic, Penn Center for Inherited Cardiovascular Disease, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002406935","display_name":"Theodore P. Abraham","orcid":"https://orcid.org/0000-0001-8966-6906","observed_orcids":["https://orcid.org/0000-0001-8966-6906","https://orcid.org/0000-0003-3411-1334"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Abraham","raw_affiliation_strings":["Department of Medicine, University of California-San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California-San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065594480","display_name":"Ahmad Masri","orcid":"https://orcid.org/0000-0002-6390-6526","observed_orcids":["https://orcid.org/0000-0002-6390-6526"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmad Masri","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: masria@ohsu.edu"],"raw_orcid":"https://orcid.org/0000-0002-6390-6526","affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: masria@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5065594480"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":2936,"currency":"USD","value_usd":2936},"apc_paid":{"value":2936,"currency":"USD","value_usd":2936},"fwci":27.7782,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.99569855,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"5","issue":"2","first_page":"102552","last_page":"102552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.9259999990463257},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-obstructive-hypertrophic-cardiomyopathy","display_name":"non-obstructive hypertrophic cardiomyopathy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hypertrophic-obstructive-cardiomyopathy","display_name":"hypertrophic obstructive cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/age-and-sex-differences","display_name":"age and sex differences","score":0.6359999775886536},{"id":"https://openalex.org/keywords/administrative-claims-data","display_name":"administrative claims data","score":0.6539999842643738},{"id":"https://openalex.org/keywords/united-states","display_name":"United States","score":0.6909999847412109},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.42800000309944153},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.4320000112056732},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.39899998903274536},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4480000138282776},{"id":"https://openalex.org/keywords/economic-burden","display_name":"economic burden","score":0.3869999945163727},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.382999986410141},{"id":"https://openalex.org/keywords/socioeconomic-inequality","display_name":"socioeconomic disparities","score":0.421999990940094},{"id":"https://openalex.org/keywords/insurance-status","display_name":"insurance status","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.8242999911308289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8202999830245972},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.695900022983551},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4902999997138977},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.46860000491142273},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.3610000014305115},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3188999891281128},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3046000003814697},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.2727000117301941}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jacadv.2025.102552","doi":"https://doi.org/10.1016/j.jacadv.2025.102552","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacadv.2025.102552","pdf_url":null,"source":{"id":"https://openalex.org/S4220651314","display_name":"JACC Advances","issn_l":"2772-963X","issn":["2772-963X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Advances","raw_type":"journal-article"},{"id":"pmid:41570793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41570793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Advances","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11667133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12859511","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c3ec0386868049f49c030e5e772b0f9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c3ec0386868049f49c030e5e772b0f9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Advances, Vol 5, Iss 2, Pp 102552- (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12859511","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12859511/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jacadv.2025.102552","doi":"https://doi.org/10.1016/j.jacadv.2025.102552","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacadv.2025.102552","pdf_url":null,"source":{"id":"https://openalex.org/S4220651314","display_name":"JACC Advances","issn_l":"2772-963X","issn":["2772-963X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7452993392944336,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315432","display_name":"Cytokinetics","ror":"https://ror.org/03tx9ss94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1159113625","https://openalex.org/W1987736934","https://openalex.org/W2016543066","https://openalex.org/W2020666677","https://openalex.org/W2029205619","https://openalex.org/W2097618980","https://openalex.org/W2149422196","https://openalex.org/W2290839120","https://openalex.org/W2743283875","https://openalex.org/W2887210220","https://openalex.org/W3081778241","https://openalex.org/W3196383445","https://openalex.org/W3198120200","https://openalex.org/W4318218141","https://openalex.org/W4391303934","https://openalex.org/W4396750647","https://openalex.org/W4396871808","https://openalex.org/W4398166332","https://openalex.org/W4401483963","https://openalex.org/W4401794465","https://openalex.org/W4403605500"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Data":[1],"on":[2,18],"the":[3,11,19,35,42,70,84,106,116,169,218,227,237,257],"contemporary":[4],"prevalence":[5,36,124,238],"of":[6,39,108,119,126,134,214,239],"hypertrophic":[7],"cardiomyopathy":[8],"(HCM)":[9],"in":[10,41,115,141,149,153,171,195,198,226,256],"United":[12,43,258],"States":[13,44],"are":[14],"limited,":[15],"and":[16,24,37,50,98,143,155,162,173,181,192,212,222,229],"information":[17],"epidemiology":[20],"by":[21,52],"disease":[22],"characteristics":[23],"patient":[25,53],"demographics":[26],"is":[27],"lacking.":[28],"OBJECTIVES:":[29],"This":[30],"study":[31,85],"aimed":[32],"to":[33,47,65,243,250],"estimate":[34],"incidence":[38,133,170],"HCM":[40,80,93,96,100,113,135,175,240,254],"from":[45,63,69,241],"2016":[46,64,242],"2023":[48,66,244],"overall":[49],"stratified":[51],"subgroups.":[54],"METHODS:":[55],"In":[56,232],"this":[57,233],"observational":[58],"study,":[59,236],"patient-level":[60],"administrative":[61,234],"claims":[62],"were":[67,76,88,111,157,225],"collected":[68],"Symphony":[71],"Integrated":[72],"Dataverse.":[73],"Selected":[74],"patients":[75,121],"those":[77],"with":[78,190,217],"\u22651":[79],"diagnosis":[81,102],"code":[82],"during":[83],"period.":[86],"Patients":[87],"designated":[89],"as":[90],"having":[91],"nonobstructive":[92],"(nHCM),":[94],"obstructive":[95],"(oHCM),":[97],"symptomatic":[99,174],"using":[101],"codes.":[103],"RESULTS:":[104],"During":[105],"period":[107],"2016-2023,":[109],"there":[110],"431,457":[112],"cases":[114,255],"total":[117],"population":[118],"141,003,247":[120],"for":[122],"a":[123],"rate":[125],"1/327":[127,246],"individuals":[128],"(95%":[129,138,146,159,164,178,183],"CI:":[130,139,147,160,165,179,184,202,207],"1/326-328).":[131],"The":[132,151,210],"was":[136,144,176,193,245],"50/100,000":[137],"50-51/100,000)":[140],"2017":[142],"56/100,000":[145],"56-57/100,000)":[148],"2023.":[150],"rates":[152,224],"nHCM":[154,223],"oHCM":[156],"188/100,000":[158],"187-189/100,000)":[161],"117/100,000":[163],"117-118/100,000),":[166],"respectively.":[167,186],"Similarly,":[168],"asymptomatic":[172],"171/100,000":[177],"171-172/100,000)":[180],"135/100,000":[182],"134-135/100,000),":[185],"Prevalence":[187],"generally":[188],"increased":[189],"age":[191],"higher":[194],"males":[196],"than":[197],"females":[199],"(341/100,000":[200],"[95%":[201,206],"339-342/100,000]":[203],"vs":[204],"277/100,000":[205],"275-278/100,000],":[208],"respectively).":[209],"regions":[211],"locations":[213],"individual":[215],"states":[216],"highest":[219],"HCM,":[220],"oHCM,":[221],"Northeast":[228],"Midwest.":[230],"CONCLUSIONS:":[231],"claims-based":[235],"individuals,":[247],"which":[248],"translates":[249],"an":[251],"estimated":[252],"832,956":[253],"States.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":6}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-23T00:00:00"}