{"id":"https://openalex.org/W7125375293","doi":"https://doi.org/10.1093/ejhf/xuag002","title":"Cardiogenic shock complicating peripartum cardiomyopathy benefits from combination therapy with levosimendan and bromocriptine","display_name":"Cardiogenic shock complicating peripartum cardiomyopathy benefits from combination therapy with levosimendan and bromocriptine","publication_year":2026,"publication_date":"2026-01-08","ids":{"openalex":"https://openalex.org/W7125375293","doi":"https://doi.org/10.1093/ejhf/xuag002","pmid":"https://pubmed.ncbi.nlm.nih.gov/41771115"},"language":"en","primary_location":{"id":"doi:10.1093/ejhf/xuag002","doi":"https://doi.org/10.1093/ejhf/xuag002","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ejhf/xuag002","pdf_url":null,"source":{"id":"https://openalex.org/S87609158","display_name":"European Journal of Heart Failure","issn_l":"1388-9842","issn":["1388-9842","1879-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Heart Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/ejhf/xuag002","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036014290","display_name":"Tobias Jonathan Pfeffer","orcid":"https://orcid.org/0000-0002-9130-9470","observed_orcids":["https://orcid.org/0000-0002-9130-9470"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias J Pfeffer","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0002-9130-9470","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091588637","display_name":"Faramarz Matinmehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Faramarz Matinmehr","raw_affiliation_strings":["Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063088713","display_name":"Ante Radocaj","orcid":"https://orcid.org/0000-0003-4518-6323","observed_orcids":["https://orcid.org/0000-0003-4518-6323"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ante Radocaj","raw_affiliation_strings":["Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0003-4518-6323","affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040610860","display_name":"Susanna Haidari","orcid":"https://orcid.org/0000-0002-8506-8578","observed_orcids":["https://orcid.org/0000-0002-8506-8578"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanna Haidari","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0002-8506-8578","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123625542","display_name":"Lukas Eisen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lukas Eisen","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007920088","display_name":"Manuel List","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuel List","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084381587","display_name":"Sergej Erschow","orcid":"https://orcid.org/0009-0004-9586-0202","observed_orcids":["https://orcid.org/0009-0004-9586-0202"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sergej Erschow","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0009-0004-9586-0202","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068815512","display_name":"Martina Kasten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Kasten","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011474469","display_name":"Birgit Piep","orcid":"https://orcid.org/0000-0001-5505-9737","observed_orcids":["https://orcid.org/0000-0001-5505-9737"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Piep","raw_affiliation_strings":["Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086468297","display_name":"Natalie Weber","orcid":"https://orcid.org/0000-0002-2302-1045","observed_orcids":["https://orcid.org/0000-0002-2302-1045"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Natalie Weber","raw_affiliation_strings":["Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,","Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0002-2302-1045","affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123620200","display_name":"Marian Stojanovski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marian Stojanovski","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061885364","display_name":"Jan\u2010Thorben Sieweke","orcid":"https://orcid.org/0000-0003-3215-7734","observed_orcids":["https://orcid.org/0000-0003-3215-7734"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan-Thorben Sieweke","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0003-3215-7734","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079775440","display_name":"Dominik Berliner","orcid":"https://orcid.org/0000-0002-5710-3540","observed_orcids":["https://orcid.org/0000-0002-5710-3540"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Berliner","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0002-5710-3540","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114177000","display_name":"Andreas Sch\u00e4fer","orcid":"https://orcid.org/0000-0003-3206-6162","observed_orcids":["https://orcid.org/0000-0003-3206-6162"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Sch\u00e4fer","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0003-3206-6162","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053529402","display_name":"Theresia Kraft","orcid":"https://orcid.org/0000-0002-8386-8088","observed_orcids":["https://orcid.org/0000-0002-8386-8088"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theresia Kraft","raw_affiliation_strings":["Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0002-8386-8088","affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Physiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066349732","display_name":"Denise Hilfiker\u2010Kleiner","orcid":"https://orcid.org/0000-0001-6065-9649","observed_orcids":["https://orcid.org/0000-0001-6065-9649"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Denise Hilfiker-Kleiner","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","President, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0001-6065-9649","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"President, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016118935","display_name":"Johann K Bauersachs","orcid":"https://orcid.org/0000-0002-9341-117X","observed_orcids":["https://orcid.org/0000-0002-9341-117X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johann Bauersachs","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0002-9341-117X","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022378009","display_name":"Melanie Ricke\u2010Hoch","orcid":"https://orcid.org/0000-0001-5479-2275","observed_orcids":["https://orcid.org/0000-0001-5479-2275"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Melanie Ricke-Hoch","raw_affiliation_strings":["Department of Cardiology and Angiology, Hannover Medical School , Hannover ,"],"raw_orcid":"https://orcid.org/0000-0001-5479-2275","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Angiology, Hannover Medical School , Hannover ,","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022378009"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":{"value":5300,"currency":"USD","value_usd":5300},"fwci":9.6475,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.96705313,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"28","issue":"2","first_page":"326","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12230","display_name":"Cardiovascular Issues in Pregnancy","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripartum-cardiomyopathy","display_name":"peripartum cardiomyopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiogenic-shock","display_name":"cardiogenic shock","score":1.0},{"id":"https://openalex.org/keywords/levosimendan","display_name":"levosimendan","score":1.0},{"id":"https://openalex.org/keywords/bromocriptine","display_name":"bromocriptine","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.6850000023841858},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8009999990463257},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.828000009059906},{"id":"https://openalex.org/keywords/left-ventricular-systolic-dysfunction","display_name":"left ventricular systolic dysfunction","score":0.8560000061988831},{"id":"https://openalex.org/keywords/postpartum-heart-failure","display_name":"postpartum heart failure","score":0.8610000014305115},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cardiac-recovery","display_name":"cardiac function recovery","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9700000286102295},{"id":"https://openalex.org/C2778490853","wikidata":"https://www.wikidata.org/wiki/Q2938089","display_name":"Peripartum cardiomyopathy","level":4,"score":0.883400022983551},{"id":"https://openalex.org/C2777335384","wikidata":"https://www.wikidata.org/wiki/Q162541","display_name":"Levosimendan","level":3,"score":0.7906000018119812},{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.708299994468689},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6636000275611877},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6353999972343445},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.633899986743927},{"id":"https://openalex.org/C2776856834","wikidata":"https://www.wikidata.org/wiki/Q413581","display_name":"Bromocriptine","level":4,"score":0.6111999750137329},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5666000247001648},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.46540001034736633},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.40149998664855957},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C2993376042","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricular function","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2644999921321869}],"mesh":[{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077464","descriptor_name":"Simendan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000099088","descriptor_name":"Peripartum Cardiomyopathy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099088","descriptor_name":"Peripartum Cardiomyopathy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099088","descriptor_name":"Peripartum Cardiomyopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000099088","descriptor_name":"Peripartum Cardiomyopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000099088","descriptor_name":"Peripartum Cardiomyopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000099088","descriptor_name":"Peripartum Cardiomyopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011249","descriptor_name":"Pregnancy Complications, Cardiovascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011249","descriptor_name":"Pregnancy Complications, Cardiovascular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011644","descriptor_name":"Puerperal Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011644","descriptor_name":"Puerperal Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012770","descriptor_name":"Shock, Cardiogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058725","descriptor_name":"Peripartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058725","descriptor_name":"Peripartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ejhf/xuag002","doi":"https://doi.org/10.1093/ejhf/xuag002","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ejhf/xuag002","pdf_url":null,"source":{"id":"https://openalex.org/S87609158","display_name":"European Journal of Heart Failure","issn_l":"1388-9842","issn":["1388-9842","1879-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Heart Failure","raw_type":"journal-article"},{"id":"pmid:41771115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41771115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of heart failure","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/ejhf/xuag002","doi":"https://doi.org/10.1093/ejhf/xuag002","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ejhf/xuag002","pdf_url":null,"source":{"id":"https://openalex.org/S87609158","display_name":"European Journal of Heart Failure","issn_l":"1388-9842","issn":["1388-9842","1879-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Heart Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7800570130348206}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2382586017","display_name":null,"funder_award_id":"RI 2531/2-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3174647780","display_name":"Targeted Approaches for Prevention and Treatment of Anthracycline-Induced Cardiotoxicity","funder_award_id":"19CVD02","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G4029092977","display_name":null,"funder_award_id":"HI 842/10\u20102","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4355980590","display_name":null,"funder_award_id":"RI 2531/4-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7650823930","display_name":null,"funder_award_id":"PF 1061/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8333890725","display_name":null,"funder_award_id":"ZN3452","funder_id":"https://openalex.org/F4320326725","funder_display_name":"Ministeriums f\u00fcr Wissenschaft, Weiterbildung und Kultur, Rheinland-Pfalz"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320326725","display_name":"Ministeriums f\u00fcr Wissenschaft, Weiterbildung und Kultur, Rheinland-Pfalz","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1484146179","https://openalex.org/W1970613354","https://openalex.org/W1978469147","https://openalex.org/W1999531750","https://openalex.org/W2021870008","https://openalex.org/W2029792039","https://openalex.org/W2058581105","https://openalex.org/W2058822152","https://openalex.org/W2059322719","https://openalex.org/W2098656972","https://openalex.org/W2120512747","https://openalex.org/W2125075201","https://openalex.org/W2137081126","https://openalex.org/W2161340566","https://openalex.org/W2161679538","https://openalex.org/W2167089178","https://openalex.org/W2310900891","https://openalex.org/W2491970284","https://openalex.org/W2739987363","https://openalex.org/W2954764069","https://openalex.org/W2985634617","https://openalex.org/W3002743065","https://openalex.org/W3006385921","https://openalex.org/W3081149527","https://openalex.org/W3110662356","https://openalex.org/W3193598686","https://openalex.org/W4238584751","https://openalex.org/W4307363596","https://openalex.org/W4377232871","https://openalex.org/W4402135081"],"related_works":[],"abstract_inverted_index":{"AIMS:":[0],"Peripartum":[1],"cardiomyopathy":[2],"(PPCM)":[3],"is":[4,28,35],"characterized":[5],"by":[6,141,243,258],"left-ventricular":[7],"systolic":[8],"dysfunction.":[9],"Plasminogen-activator-inhibitor":[10],"1":[11],"(PAI-1)":[12],"and":[13,51,64,79,106,133,159,173,203,210],"16K-prolactin":[14],"(PRL)":[15],"are":[16,44],"known":[17],"drivers":[18],"of":[19,22,53,66,74,130,135,164,183,218,231,249],"PPCM.":[20,56],"Treatment":[21],"cardiogenic":[23],"shock":[24],"(CS)":[25],"complicating":[26],"PPCM":[27,70,85,92,148,151,219,225,232,252],"challenging.":[29],"The":[30],"calcium":[31],"sensitizer":[32],"levosimendan":[33],"(LS)":[34],"considered":[36],"as":[37],"a":[38,208],"beneficial":[39,212],"therapy":[40,200],"in":[41,55,68,80,179,234,251],"CS.":[42,222],"There":[43],"only":[45],"sparse":[46],"data":[47,227],"regarding":[48],"the":[49,61,69,83,91,113,128,146,162,170,180,184,198,216,245],"safety":[50,65],"efficacy":[52],"LS-treatment":[54,67,95,110],"We":[57],"aimed":[58],"to":[59,206],"investigate":[60],"molecular":[62],"effects":[63],"mouse":[71,93,226],"model":[72],"(cardiomyocyte-specific-knockout":[73],"signal-transducer-and-activator-of-transcription":[75],"3":[76],"(STAT3),":[77],"CKO)":[78],"patients":[81,152,168,175,220,233,253],"from":[82],"German":[84,147],"registry.":[86],"METHODS":[87],"AND":[88],"RESULTS:":[89],"In":[90,120,145],"model,":[94],"aggravated":[96],"postpartum":[97],"heart":[98],"failure":[99],"associated":[100],"with":[101,112,143,153,157,201,221,236],"fibrosis,":[102],"reduced":[103],"capillary":[104],"density,":[105],"enhanced":[107],"mortality,":[108],"whereas":[109],"together":[111],"PRL-inhibitor":[114],"bromocriptine":[115],"(BR)":[116],"preserved":[117],"cardiac":[118,177,241],"function.":[119],"CKO":[121],"hearts,":[122],"LS":[123,158,202,237,250],"induced":[124],"PAI-1":[125],"expression":[126],"via":[127],"upregulation":[129],"thrombospondin-1/-4,":[131],"transforming-growth-factor-\u03b2,":[132],"activation":[134],"SMAD2":[136],"that":[137,229],"could":[138],"be":[139,207,256],"prevented":[140],"combination":[142,199],"BR.":[144,160],"registry,":[149],"17":[150],"CS":[154,235],"were":[155],"treated":[156],"Despite":[161],"severity":[163],"CS,":[165],"all":[166],"these":[167],"survived":[169],"acute":[171],"phase,":[172],"most":[174],"showed":[176],"recovery":[178],"ensuing":[181],"course":[182],"disease":[185],"(left":[186],"ventricular":[187],"ejection":[188],"fraction":[189],"at":[190],"3-month":[191],"follow-up:":[192],"40":[193],"\u00b1":[194],"19%).":[195],"CONCLUSION:":[196],"Thus,":[197],"BR":[204,259],"seems":[205],"safe":[209],"potentially":[211],"therapeutic":[213],"concept":[214],"for":[215],"treatment":[217,230,248],"As":[223],"experimental":[224],"suggest":[228],"alone":[238],"may":[239],"worsen":[240],"function":[242],"enhancing":[244],"PRL/PAI-1-dependent":[246],"pathomechanism,":[247],"should":[254],"always":[255],"accompanied":[257],"treatment.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2026-01-23T00:00:00"}