{"id":"https://openalex.org/W7125328126","doi":"https://doi.org/10.1016/j.biopha.2026.119013","title":"Plasma metabolomic profiling of patients with acute coronary syndrome treated with potent platelet inhibitors","display_name":"Plasma metabolomic profiling of patients with acute coronary syndrome treated with potent platelet inhibitors","publication_year":2026,"publication_date":"2026-01-20","ids":{"openalex":"https://openalex.org/W7125328126","doi":"https://doi.org/10.1016/j.biopha.2026.119013","pmid":"https://pubmed.ncbi.nlm.nih.gov/41564597"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2026.119013","doi":"https://doi.org/10.1016/j.biopha.2026.119013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119013","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2026.119013","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104603271","display_name":"Jovan Rogozarski","orcid":"https://orcid.org/0009-0004-6103-9643","observed_orcids":["https://orcid.org/0009-0004-6103-9643"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Jovan Rogozarski","raw_affiliation_strings":["Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria"],"raw_orcid":"https://orcid.org/0009-0004-6103-9643","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067318812","display_name":"Gloria M. Gager","orcid":"https://orcid.org/0000-0002-0232-4311","observed_orcids":["https://orcid.org/0000-0002-0232-4311"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gloria M. Steiner-Gager","raw_affiliation_strings":["Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072687265","display_name":"Karin Preindl","orcid":"https://orcid.org/0000-0002-9834-499X","observed_orcids":["https://orcid.org/0000-0002-9834-499X"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Karin Preindl","raw_affiliation_strings":["Department of Laboratory Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria; Joint Metabolome Facility, University of Vienna and Medical University Vienna, Waehringer Str. 38, Vienna 1090, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria; Joint Metabolome Facility, University of Vienna and Medical University Vienna, Waehringer Str. 38, Vienna 1090, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033660245","display_name":"Zofia Wicik","orcid":"https://orcid.org/0000-0002-2857-1986","observed_orcids":["https://orcid.org/0000-0002-2857-1986"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zofia Wicik","raw_affiliation_strings":["Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, \u017bwirki i Wigury 61, Warsaw 02-097, Poland; Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9 Street, Warsaw 02-957, Poland"],"raw_orcid":"https://orcid.org/0000-0002-2857-1986","affiliations":[{"raw_affiliation_string":"Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, \u017bwirki i Wigury 61, Warsaw 02-097, Poland; Department of Neurochemistry, Institute of Psychiatry and Neurology, Sobieskiego 9 Street, Warsaw 02-957, Poland","institution_ids":["https://openalex.org/I268303160","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050576957","display_name":"Ceren Eyileten","orcid":"https://orcid.org/0000-0002-3324-9625","observed_orcids":["https://orcid.org/0000-0002-3324-9625"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ceren Eyileten","raw_affiliation_strings":["Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, \u017bwirki i Wigury 61, Warsaw 02-097, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, \u017bwirki i Wigury 61, Warsaw 02-097, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120799312","display_name":"Christof Skos","orcid":"https://orcid.org/0009-0006-7880-0800","observed_orcids":["https://orcid.org/0009-0006-7880-0800"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christof Skos","raw_affiliation_strings":["Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035889786","display_name":"Christopher Gerner","orcid":"https://orcid.org/0000-0003-4964-0642","observed_orcids":["https://orcid.org/0000-0003-4964-0642"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christopher Gerner","raw_affiliation_strings":["Joint Metabolome Facility, University of Vienna and Medical University Vienna, Waehringer Str. 38, Vienna 1090, Austria; Faculty of Chemistry, Department of Analytical Chemistry, University of Vienna, Waehringer Str. 38, Vienna 1090, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Metabolome Facility, University of Vienna and Medical University Vienna, Waehringer Str. 38, Vienna 1090, Austria; Faculty of Chemistry, Department of Analytical Chemistry, University of Vienna, Waehringer Str. 38, Vienna 1090, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077425005","display_name":"Al Medina Dizdarevic","orcid":"https://orcid.org/0009-0004-2163-8449","observed_orcids":["https://orcid.org/0009-0004-2163-8449"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Almedina Dizdarevic","raw_affiliation_strings":["Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018345279","display_name":"Marek A Postula","orcid":"https://orcid.org/0000-0002-7826-4458","observed_orcids":["https://orcid.org/0000-0002-7826-4458"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marek Postula","raw_affiliation_strings":["Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, \u017bwirki i Wigury 61, Warsaw 02-097, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, \u017bwirki i Wigury 61, Warsaw 02-097, Poland","institution_ids":["https://openalex.org/I268303160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006655365","display_name":"Samuel M. Meier","orcid":"https://orcid.org/0000-0002-8930-4574","observed_orcids":["https://orcid.org/0000-0002-8930-4574"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Samuel M. Meier-Menches","raw_affiliation_strings":["Joint Metabolome Facility, University of Vienna and Medical University Vienna, Waehringer Str. 38, Vienna 1090, Austria; Faculty of Chemistry, Department of Analytical Chemistry, University of Vienna, Waehringer Str. 38, Vienna 1090, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Metabolome Facility, University of Vienna and Medical University Vienna, Waehringer Str. 38, Vienna 1090, Austria; Faculty of Chemistry, Department of Analytical Chemistry, University of Vienna, Waehringer Str. 38, Vienna 1090, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030107346","display_name":"Jolanta Maria Siller-Matula","orcid":"https://orcid.org/0000-0001-6041-1635","observed_orcids":["https://orcid.org/0000-0001-6041-1635"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Jolanta M. Siller-Matula","raw_affiliation_strings":["Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria. Electronic address: jolanta.siller-matula@meduniwien.ac.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria. Electronic address: jolanta.siller-matula@meduniwien.ac.at","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030107346"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":{"value":3610,"currency":"USD","value_usd":3610},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04040696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"195","issue":null,"first_page":"119013","last_page":"119013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ticagrelor","display_name":"ticagrelor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prasugrel","display_name":"prasugrel","score":1.0},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.8149999976158142},{"id":"https://openalex.org/keywords/plasma-metabolomics","display_name":"plasma metabolomics","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.8629999756813049},{"id":"https://openalex.org/keywords/3-methylhistidine","display_name":"3-methylhistidine","score":0.8939999938011169},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.8289999961853027},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.8040000200271606},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.7260000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7889999747276306},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6769999861717224},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9440000057220459},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.8500000238418579},{"id":"https://openalex.org/keywords/metabolomic-biomarkers","display_name":"metabolomic biomarkers","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2780890252","wikidata":"https://www.wikidata.org/wiki/Q420542","display_name":"Ticagrelor","level":4,"score":0.9355999827384949},{"id":"https://openalex.org/C2777028646","wikidata":"https://www.wikidata.org/wiki/Q416232","display_name":"Prasugrel","level":4,"score":0.8912000060081482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8511999845504761},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.828499972820282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5497999787330627},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.5450000166893005},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.48510000109672546},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4544000029563904},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4343000054359436},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3767000138759613},{"id":"https://openalex.org/C2909112448","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Platelet aggregation inhibitor","level":3,"score":0.37040001153945923},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3303999900817871},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C49059817","wikidata":"https://www.wikidata.org/wiki/Q14916330","display_name":"P2Y12","level":4,"score":0.259799987077713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25699999928474426}],"mesh":[{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000068799","descriptor_name":"Prasugrel Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077486","descriptor_name":"Ticagrelor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062645","descriptor_name":"Percutaneous Coronary Intervention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2026.119013","doi":"https://doi.org/10.1016/j.biopha.2026.119013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119013","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:41564597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41564597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2026.119013","doi":"https://doi.org/10.1016/j.biopha.2026.119013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2026.119013","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6387688517570496,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1957913826","https://openalex.org/W1967251766","https://openalex.org/W1967792461","https://openalex.org/W1988724735","https://openalex.org/W1992609620","https://openalex.org/W1993292496","https://openalex.org/W1995195447","https://openalex.org/W2012273576","https://openalex.org/W2015048883","https://openalex.org/W2016693012","https://openalex.org/W2021832011","https://openalex.org/W2022537971","https://openalex.org/W2027265691","https://openalex.org/W2035745440","https://openalex.org/W2037116841","https://openalex.org/W2037182281","https://openalex.org/W2038005259","https://openalex.org/W2044638285","https://openalex.org/W2045402270","https://openalex.org/W2052348281","https://openalex.org/W2060011496","https://openalex.org/W2065231082","https://openalex.org/W2066556630","https://openalex.org/W2080578796","https://openalex.org/W2083488580","https://openalex.org/W2092453096","https://openalex.org/W2115699947","https://openalex.org/W2118567486","https://openalex.org/W2122500634","https://openalex.org/W2123294877","https://openalex.org/W2126980526","https://openalex.org/W2128228188","https://openalex.org/W2140501627","https://openalex.org/W2160205454","https://openalex.org/W2165201727","https://openalex.org/W2167283250","https://openalex.org/W2174940789","https://openalex.org/W2462113069","https://openalex.org/W2520590970","https://openalex.org/W2780711651","https://openalex.org/W2904529981","https://openalex.org/W2971464712","https://openalex.org/W3016741459","https://openalex.org/W3022789786","https://openalex.org/W3043853585","https://openalex.org/W3074657795","https://openalex.org/W3113178943","https://openalex.org/W3140355758","https://openalex.org/W3141220996","https://openalex.org/W3160985962","https://openalex.org/W3170692918","https://openalex.org/W3196643373","https://openalex.org/W4200140201","https://openalex.org/W4248872138","https://openalex.org/W4322720015","https://openalex.org/W4323318796","https://openalex.org/W4360813683","https://openalex.org/W4386153206","https://openalex.org/W4390942257","https://openalex.org/W4394692256","https://openalex.org/W4396583448","https://openalex.org/W4402089707","https://openalex.org/W4407044441"],"related_works":[],"abstract_inverted_index":{"Ticagrelor":[0],"and":[1,58,112,129,147,149,163,183],"prasugrel":[2,59,72],"are":[3],"key":[4],"antiplatelet":[5,22],"agents":[6],"used":[7],"in":[8,42,104,160],"patients":[9,68,139,193],"with":[10,40,70,201],"acute":[11],"coronary":[12,17],"syndrome":[13],"(ACS)":[14],"undergoing":[15],"percutaneous":[16],"intervention":[18],"(PCI).":[19],"Beyond":[20],"their":[21],"effects,":[23],"both":[24],"drugs":[25],"exhibit":[26],"pleiotropic":[27],"actions":[28],"that":[29,137,171],"may":[30,174],"contribute":[31],"to":[32,48,53,85,154,177],"side":[33],"effects.":[34],"Notably,":[35],"ticagrelor":[36,57,77],"has":[37],"been":[38],"associated":[39,200],"dyspnea":[41,173],"clinical":[43],"trials.":[44],"This":[45],"study":[46],"aimed":[47],"identify":[49],"metabolomic":[50],"markers":[51],"linked":[52,176],"the":[54,93],"effects":[55],"of":[56],"using":[60],"targeted":[61],"metabolomics.":[62],"Plasma":[63],"samples":[64],"from":[65],"207":[66],"ACS":[67],"treated":[69],"either":[71],"(n":[73,78],"=":[74,79,107,110,115,118],"106)":[75],"or":[76],"101)":[80],"were":[81,102,158],"analyzed":[82],"for":[83,122],"up":[84],"631":[86],"metabolites.":[87],"Several":[88],"metabolites":[89],"differed":[90],"significantly":[91,132],"between":[92],"groups":[94],"(p":[95,106,114],"<":[96],"0.05).":[97],"The":[98,165],"most":[99],"notable":[100],"changes":[101,157],"found":[103],"DHEAS":[105,130,179],"0.0004,":[108],"FC":[109,117],"-1.66)":[111],"3-Met-His":[113],"0.0024,":[116],"1.75).":[119],"After":[120],"adjusting":[121],"risk":[123],"factors,":[124],"lysoPC":[125],"a":[126,168,195,202],"C17:0,":[127],"3-Met-His,":[128],"remained":[131],"altered.":[133],"Subgroup":[134],"analysis":[135],"revealed":[136],"diabetic":[138,192],"had":[140],"distinct":[141],"metabolic":[142,198],"profiles,":[143],"including":[144],"elevated":[145],"TMAO":[146],"choline":[148],"reduced":[150],"GUDCA":[151],"levels,":[152],"compared":[153],"non-diabetics.":[155],"Additional":[156],"observed":[159],"hexoses,":[161],"Met-SO,":[162],"TCDCA.":[164],"findings":[166],"support":[167],"novel":[169],"hypothesis":[170],"ticagrelor-induced":[172],"be":[175],"low":[178],"levels.":[180],"Reduced":[181],"methionine":[182],"Met-SO":[184],"levels":[185],"could":[186],"suggest":[187],"lower":[188],"oxidative":[189],"stress.":[190],"Moreover,":[191],"showed":[194],"gut":[196],"microbiome-related":[197],"shift":[199],"more":[203],"ischemic":[204],"profile.":[205]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-01-22T00:00:00"}