{"id":"https://openalex.org/W7125277652","doi":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","title":"DOP108 Randomised controlled trial of withdrawal of thiopurines in patients with IBD switching from intravenous to subcutaneous infliximab: Results of the MINIMISE study","display_name":"DOP108 Randomised controlled trial of withdrawal of thiopurines in patients with IBD switching from intravenous to subcutaneous infliximab: Results of the MINIMISE study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7125277652","doi":"https://doi.org/10.1093/ecco-jcc/jjaf231.145"},"language":"en","primary_location":{"id":"doi:10.1093/ecco-jcc/jjaf231.145","doi":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/Supplement_1/jjaf231.145/66498443/jjaf231.145.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn\u2019s and Colitis","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/Supplement_1/jjaf231.145/66498443/jjaf231.145.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031136418","display_name":"Peter Miles Irving","orcid":"https://orcid.org/0000-0003-0972-8148","observed_orcids":["https://orcid.org/0000-0003-0972-8148"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P M Irving","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","King\u2019s College London, School of Immunology and Microbial Science , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]},{"raw_affiliation_string":"King\u2019s College London, School of Immunology and Microbial Science , London,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034891419","display_name":"Andrea Centritto","orcid":"https://orcid.org/0009-0007-6682-2700","observed_orcids":["https://orcid.org/0009-0007-6682-2700"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Centritto","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040435782","display_name":"Xin Yi Choon","orcid":"https://orcid.org/0009-0007-1978-4430","observed_orcids":["https://orcid.org/0009-0007-1978-4430"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"X Y Choon","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123477568","display_name":"J H Yeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J H Yeo","raw_affiliation_strings":["University College London Hospitals NHS Foundation Trust , Gastroenterology, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London Hospitals NHS Foundation Trust , Gastroenterology, London,","institution_ids":["https://openalex.org/I1340918713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022462399","display_name":"William Blad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W Blad","raw_affiliation_strings":["University College London Hospitals NHS Foundation Trust , Gastroenterology, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London Hospitals NHS Foundation Trust , Gastroenterology, London,","institution_ids":["https://openalex.org/I1340918713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108295962","display_name":"Alison Talbot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Talbot","raw_affiliation_strings":["Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"A L Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Fitzgerald","raw_affiliation_strings":["Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112734820","display_name":"E Whitehead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Whitehead","raw_affiliation_strings":["Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123489381","display_name":"A Elford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Elford","raw_affiliation_strings":["Western General Hospital- NHS Lothian, Edinburgh IBD Unit , Edinburgh,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western General Hospital- NHS Lothian, Edinburgh IBD Unit , Edinburgh,","institution_ids":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015303619","display_name":"Michael Colwill","orcid":"https://orcid.org/0000-0001-6925-8358","observed_orcids":["https://orcid.org/0000-0001-6925-8358"]},"institutions":[{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Colwill","raw_affiliation_strings":["St George\u2019s University Hospital NHS Foundation Trust , Gastroenterology, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St George\u2019s University Hospital NHS Foundation Trust , Gastroenterology, London,","institution_ids":["https://openalex.org/I2801196673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000730948","display_name":"Samantha Baillie","orcid":"https://orcid.org/0000-0003-3280-0347","observed_orcids":["https://orcid.org/0000-0003-3280-0347"]},"institutions":[{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Baillie","raw_affiliation_strings":["St George\u2019s University Hospital NHS Foundation Trust , Gastroenterology, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St George\u2019s University Hospital NHS Foundation Trust , Gastroenterology, London,","institution_ids":["https://openalex.org/I2801196673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113505680","display_name":"Rashida Pramanik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Pramanik","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, Research and Development , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, Research and Development , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077153912","display_name":"Salma A. Ayis","orcid":"https://orcid.org/0000-0002-0449-869X","observed_orcids":["https://orcid.org/0000-0002-0449-869X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Ayis","raw_affiliation_strings":["King\u2019s College London, School of Population Health & Environmental Sciences , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, School of Population Health & Environmental Sciences , London,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066110533","display_name":"A\u00efcha Goubar","orcid":"https://orcid.org/0009-0003-0458-5317","observed_orcids":["https://orcid.org/0009-0003-0458-5317"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Goubar","raw_affiliation_strings":["King\u2019s College London, School of Population Health & Environmental Sciences , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King\u2019s College London, School of Population Health & Environmental Sciences , London,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017926690","display_name":"Monica Arenas-Hernandez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Arenas Hernandez","raw_affiliation_strings":["Synnovis LLP, Purine Research Lab , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synnovis LLP, Purine Research Lab , London,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073374320","display_name":"Jessica Cordle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Cordle","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078976339","display_name":"Charlie W. Lees","orcid":"https://orcid.org/0000-0002-0732-8215","observed_orcids":["https://orcid.org/0000-0002-0732-8215"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Lees","raw_affiliation_strings":["University of Edinburgh, Institute of Genetics and Cancer , Edinburgh,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh, Institute of Genetics and Cancer , Edinburgh,","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033416622","display_name":"Richard Charles G Pollok","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801196673","display_name":"St George\u2019s University Hospitals NHS Foundation Trust","ror":"https://ror.org/039zedc16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801196673"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Pollok","raw_affiliation_strings":["St George\u2019s University Hospital NHS Foundation Trust , Gastroenterology, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St George\u2019s University Hospital NHS Foundation Trust , Gastroenterology, London,","institution_ids":["https://openalex.org/I2801196673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123527334","display_name":"Shaji Sebastian","orcid":"https://orcid.org/0000-0002-3670-6545","observed_orcids":["https://orcid.org/0000-0002-3670-6545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sebastian","raw_affiliation_strings":["Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hull University Teaching Hospitals NHS Trust, IBD Unit , Hull,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036405798","display_name":"Robin Dart","orcid":"https://orcid.org/0000-0003-3470-8210","observed_orcids":["https://orcid.org/0000-0003-3470-8210"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Dart","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","King\u2019s College London, School of Immunology and Microbial Science , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]},{"raw_affiliation_string":"King\u2019s College London, School of Immunology and Microbial Science , London,","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039933427","display_name":"Mark Samaan","orcid":"https://orcid.org/0000-0002-4057-9200","observed_orcids":["https://orcid.org/0000-0002-4057-9200"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Samaan","raw_affiliation_strings":["Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guy\u2019s and St Thomas\u2019 Hospital, IBD Unit , London,","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037225457","display_name":"Paul Harrow","orcid":"https://orcid.org/0000-0002-6819-6623","observed_orcids":["https://orcid.org/0000-0002-6819-6623"]},"institutions":[{"id":"https://openalex.org/I1340918713","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P Harrow","raw_affiliation_strings":["University College London Hospitals NHS Foundation Trust , Gastroenterology, London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London Hospitals NHS Foundation Trust , Gastroenterology, London,","institution_ids":["https://openalex.org/I1340918713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4238,"currency":"EUR","value_usd":4790},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9848999977111816},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.71670001745224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5424000024795532},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.49900001287460327},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3555000126361847},{"id":"https://openalex.org/C2778363899","wikidata":"https://www.wikidata.org/wiki/Q23900955","display_name":"Window of opportunity","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29670000076293945},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.28540000319480896},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.27559998631477356},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.26980000734329224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ecco-jcc/jjaf231.145","doi":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/Supplement_1/jjaf231.145/66498443/jjaf231.145.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn\u2019s and Colitis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ecco-jcc/jjaf231.145","doi":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjaf231.145","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/Supplement_1/jjaf231.145/66498443/jjaf231.145.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn\u2019s and Colitis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7125277652.pdf","grobid_xml":"https://content.openalex.org/works/W7125277652.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165623562","https://openalex.org/W4391162087","https://openalex.org/W7160155818","https://openalex.org/W4391162554","https://openalex.org/W4283167678","https://openalex.org/W4318539799","https://openalex.org/W7125238586","https://openalex.org/W4406697889","https://openalex.org/W4381113218","https://openalex.org/W7125130246"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Combining":[2],"thiopurines":[3],"(TP)":[4],"with":[5,27,83,116,266,350,437],"intravenous":[6],"(IV)":[7],"infliximab":[8],"(IFX)":[9],"decreases":[10],"the":[11,50,125,146,163,183,203,259,269,276,279,284,302,334,343,355,450,455],"rate":[12],"of":[13,16,31,52,71,107,148,165,185,207,294,348,454,461,514,521,528,534,540,546,552,558,585,591,597,603,610,616,746],"immunogenicity.":[14],"Subanalyses":[15],"registration":[17],"studies":[18],"show":[19],"that":[20],"subcutaneous":[21],"(SC)":[22],"IFX":[23,98,130,310,319,408,439,448],"may":[24],"be":[25,443],"associated":[26],"a":[28,68,117,169,174,272,421],"decreased":[29],"chance":[30],"developing":[32],"anti-drug":[33],"antibodies":[34,154,161],"(ADAb)":[35,155],"compared":[36,265],"to":[37,48,54,63,79,109,121,172,181,244,251,406,446,457],"IV":[38,62,78,97,407,438],"IFX.":[39,81],"However,":[40],"there":[41],"are":[42],"no":[43,373],"randomised":[44,120,199],"controlled":[45],"trials":[46],"(RCT)":[47],"inform":[49],"decision":[51],"whether":[53],"continue":[55,122,270,335,426],"or":[56,90,112,123,314,391,395,567],"discontinue":[57,124],"TP":[58,72,118,239,441],"when":[59],"switching":[60,76],"from":[61,77,278,570],"SC.":[64],"Methods":[65],"We":[66],"conducted":[67],"multicentre,":[69],"RCT":[70],"withdrawal":[73,240,281],"in":[74,85,162,258,268,333,342,378,431],"patients":[75,149,178,188,194,213,217,221,232,257,282,285,349,430],"SC":[80,447],"Patients":[82,127],"IBD":[84,429],"stable":[86,105,432],"remission":[87,433],"(HBI":[88,382],"\u22644":[89],"SCCAI":[91],"\u22642)":[92],"who":[93,150,286],"had":[94,128],"been":[95],"receiving":[96],"for":[99,227,415,452],"at":[100,104,134,156,189,210,290,322,354,375],"least":[101],"22":[102],"weeks":[103,323],"doses":[106],"up":[108],"5mg/kg":[110],"q4w":[111],"10mg/kg":[113],"q8w":[114],"along":[115],"were":[119,137,179,198,214,328],"TP.":[126],"therapeutic":[129],"drug":[131],"levels":[132,320],"(DL)":[133],"screening":[135],"and":[136,283,326,331,340,362,365,368,398,417,440,579,621],"stratified":[138],"by":[139],"HLA":[140,304],"DQA1*05":[141,305],"status.":[142],"Primary":[143],"outcome":[144],"was":[145,241,359,372],"proportion":[147,347],"developed":[151,262,296,420],"free":[152,208,263,297,313],"antidrug":[153],"week":[157,190,225,228,236,291,376],"24":[158,229,237,327,377],"(ie":[159],"detectable":[160,166],"absence":[164],"drug).":[167],"Using":[168],"non-inferiority":[170],"design":[171],"detect":[173],"15%":[175,367],"difference,":[176],"102":[177,193],"required":[180,413],"meet":[182],"target":[184],"88":[186,212],"evaluable":[187,215],"24.":[191],"Results":[192],"(63=CD,":[195],"39=UC,":[196],"5=IBD-U)":[197],"(Table":[200],"1).":[201,402],"For":[202],"primary":[204],"outcome,":[205],"detection":[206],"ADAb":[209,264,316,353,459],"24W,":[211],"(2":[216],"withdrew":[218],"early,":[219],"8":[220],"attended":[222],"outside":[223],"1":[224],"window":[226],"assessment,":[230],"4":[231],"did":[233,299,307],"not":[234,300,308],"provide":[235],"samples).":[238],"non":[242],"inferior":[243],"continuation":[245,453],"(difference":[246],"-2.4":[247],"(95%":[248],"CI:":[249],"-12.3":[250],"5.4)":[252],"P":[253],"=":[254],"0.46).":[255],"1/41":[256],"stop":[260,344],"group":[261],"0/47":[267],"group;":[271],"sensitivity":[273],"analysis":[274],"including":[275],"samples":[277,289],"early":[280],"provided":[287],"late":[288],"24,":[292],"none":[293],"whom":[295],"ADAb,":[298],"change":[301],"outcome.":[303],"status":[306],"affect":[309],"DL,":[311],"nor":[312],"total":[315,351],"formation.":[317],"Median":[318],"(ug/ml)":[321],"8,":[324],"16":[325],"15.5,":[329],"17.7":[330],"18.4":[332],"arm":[336],"vs":[337],"17.0,":[338],"15.5":[339],"15.1":[341],"arm.":[345],"The":[346],"positive":[352],"same":[356],"time":[357],"points":[358],"21%,":[360],"22%":[361],"20%":[363],"(continue)":[364],"12%,":[366],"18%":[369],"(stop).":[370],"There":[371],"difference":[374],"clinically":[379],"active":[380],"disease":[381],">4,":[383],"SCCAI>2),":[384],"biomarker":[385,399],"activity":[386,400],"(FC":[387],">":[388],"250":[389],"ug/g":[390],"CRP":[392],">5":[393],"mg/L)":[394],"combined":[396],"clinical":[397],"(Figure":[401],"One":[403],"patient":[404,412,419],"reverted":[405],"(stop":[409],"group),":[410],"one":[411,418],"admission":[414],"pneumonia":[416],"basal":[422],"cell":[423],"carcinoma":[424],"(both":[425],"group).":[427],"Conclusion":[428],"on":[434],"combination":[435],"therapy":[436],"can":[442],"safely":[444],"switched":[445],"without":[449],"need":[451],"thiopurine":[456],"prevent":[458],"Conflict":[460],"interest:":[462],"Irving,":[463],"Peter":[464],"Miles:":[465],"Grant:":[466,650,698],"MSD,":[467,490,726,736],"Pfizer,":[468,491,572,628,655,722],"Takeda,":[469,502,575,629,651,673,685,706,716,735],"Celltrion,":[470,480,571,687],"Galapagos":[471,646],"Personal":[472,663,700],"Fees:":[473,664],"AbbVie,":[474,672,686,721,738],"Arena,":[475],"BMS,":[476,679],"Boomerang":[477],"Medical,":[478,499],"Celgene,":[479],"Falk":[481],"Pharma,":[482,507],"Ferring,":[483],"Galapagos,":[484,637,709,720,739],"Genentech,":[485],"Gilead,":[486,627],"Hospira,":[487],"Janssen,":[488,630,715,734],"Lilly,":[489,678,692,740],"Pharmacosmos,":[492,675],"Prometheus,":[493],"Roche,":[494],"Sandoz,":[495,500,717],"Samsung":[496,632,718],"Bioepis,":[497,633,719],"Sapphire":[498],"Shire,":[501,631],"Tillotts,":[503,703,728],"Topivert,":[504],"VH2,":[505],"Vifor":[506],"Warner":[508],"Chilcott":[509],"Centritto,":[510],"Andrea:":[511],"No":[512,519,526,532,538,544,550,556,583,589,595,601,608,614,744],"conflict":[513,520,527,533,539,545,551,557,584,590,596,602,609,615,745],"interest":[515,522,529,535,541,547,553,559,586,592,598,604,611,617,747],"Choon,":[516],"Xin":[517],"Yi:":[518],"Yeo,":[523],"Jie":[524],"Han:":[525],"Blad,":[530],"William:":[531],"Talbot,":[536],"Alison:":[537],"Fitzgerald,":[542],"Abbie-Lei:":[543],"Whitehead,":[548],"Emma:":[549],"Elford,":[554],"Alexander:":[555],"Colwill,":[560],"Michael:":[561],"I":[562],"have":[563],"received":[564],"speaker":[565],"fees":[566],"travel":[568],"grants":[569],"Dr":[573,634],"Falk,":[574,635,737],"Johnson":[576,578,657,666,688],"&":[577,658,667,689],"Ferring.":[580],"Baillie,":[581],"Samantha:":[582],"Pramanik,":[587],"Rashida:":[588],"Ayis,":[593],"Salma:":[594],"Goubar,":[599],"Aicha:":[600],"Arenas":[605],"Hernandez,":[606],"Monica:":[607],"Cordle,":[612],"Jessica:":[613],"Lees,":[618],"Charlie:":[619],"Consultancy":[620],"lecture":[622],"fees:":[623,701,705,714,731],"Abbvie,":[624,656],"Oshi":[625],"Health,":[626,639],"GSK,":[636],"Trellus":[638],"Iterative":[640],"Scopes,":[641],"Fresnius":[642],"Kabi":[643],"Pollok,":[644],"Richard:":[645],"consulting":[647],"Sebastian,":[648],"Shaji:":[649],"Tillots":[652],"pharma,":[653],"Biogen,":[654],"Johnson,":[659,668,690],"Olympus":[660,669],"-Odin":[661],"Vision":[662,681],"Tillots,":[665,684],"Odin":[670,680],"Vision,":[671],"Merck,":[674],"Amgen,":[676],"Eli":[677,691],"Non-financial":[682],"Support:":[683],"Alphasigma,":[693],"Ferring":[694],"Pharma":[695],"Dart,":[696],"Robin:":[697],"Takeda":[699,710],"N/A\u00bconsulting:":[702],"UCBSpeaker":[704],"UCB\u0beducational":[707],"sponsorship:":[708],"Samaan,":[711],"Mark:":[712],"Advisory":[713],"STADA,":[723],"Bristol-Myers":[724,732],"Squibb,":[725,733],"Sanofi,":[727],"MSD":[729],"Lecture":[730],"Advanz":[741],"Harrow,":[742],"Paul:":[743]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-01-22T00:00:00"}