{"id":"https://openalex.org/W7124872004","doi":"https://doi.org/10.1016/j.drudis.2026.104606","title":"Unfairly forgotten deconvolution methods of combinatorial libraries","display_name":"Unfairly forgotten deconvolution methods of combinatorial libraries","publication_year":2026,"publication_date":"2026-01-20","ids":{"openalex":"https://openalex.org/W7124872004","doi":"https://doi.org/10.1016/j.drudis.2026.104606","pmid":"https://pubmed.ncbi.nlm.nih.gov/41565151"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2026.104606","doi":"https://doi.org/10.1016/j.drudis.2026.104606","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drudis.2026.104606","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.drudis.2026.104606","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000155284","display_name":"\u00c1rp\u00e1d Furka","orcid":"https://orcid.org/0000-0002-0399-2709","observed_orcids":["https://orcid.org/0000-0002-0399-2709"]},"institutions":[{"id":"https://openalex.org/I106118109","display_name":"E\u00f6tv\u00f6s Lor\u00e1nd University","ror":"https://ror.org/01jsq2704","country_code":"HU","type":"education","lineage":["https://openalex.org/I106118109"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"\u00c1rp\u00e1d Furka","raw_affiliation_strings":["E\u00f6tv\u00f6s Lor\u00e1nd University, Rozsa u. 23-25, 1077 Budapest, Hungary. Electronic address: afurka2@yahoo.com"],"raw_orcid":"https://orcid.org/0000-0002-0399-2709","affiliations":[{"raw_affiliation_string":"E\u00f6tv\u00f6s Lor\u00e1nd University, Rozsa u. 23-25, 1077 Budapest, Hungary. Electronic address: afurka2@yahoo.com","institution_ids":["https://openalex.org/I106118109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000155284"],"corresponding_institution_ids":["https://openalex.org/I106118109"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":{"value":4720,"currency":"USD","value_usd":4720},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03278388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"2","first_page":"104606","last_page":"104606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/one-bead-one-compound-library","display_name":"one-bead-one-compound libraries","score":0.890999972820282},{"id":"https://openalex.org/keywords/dna-encoded-libraries","display_name":"DNA-encoded libraries","score":0.875},{"id":"https://openalex.org/keywords/positional-scanning","display_name":"positional scanning","score":0.9810000061988831},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.8849999904632568},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.8989999890327454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6444000005722046},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3968000113964081},{"id":"https://openalex.org/C30044814","wikidata":"https://www.wikidata.org/wiki/Q11334452","display_name":"Blind deconvolution","level":3,"score":0.38429999351501465},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3837999999523163},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.33980000019073486},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3357999920845032},{"id":"https://openalex.org/C203208320","wikidata":"https://www.wikidata.org/wiki/Q5150830","display_name":"Combinatorial search","level":4,"score":0.2874000072479248},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.2831999957561493},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.27790001034736633},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2614000141620636},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.25949999690055847},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2581000030040741}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.drudis.2026.104606","doi":"https://doi.org/10.1016/j.drudis.2026.104606","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drudis.2026.104606","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:41565151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41565151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.drudis.2026.104606","doi":"https://doi.org/10.1016/j.drudis.2026.104606","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drudis.2026.104606","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1988764306","https://openalex.org/W2017423606","https://openalex.org/W2049219263","https://openalex.org/W2080262597","https://openalex.org/W2089139581","https://openalex.org/W2089949578","https://openalex.org/W2094850820","https://openalex.org/W2105670555","https://openalex.org/W2136870717","https://openalex.org/W2140535155","https://openalex.org/W2270090559","https://openalex.org/W2921000810","https://openalex.org/W4410231688"],"related_works":[],"abstract_inverted_index":{"\u2022":[0,23,48],"Deconvolution":[1],"of":[2,10,17,27,45,60,71,131,138],"OBOC":[3],"libraries":[4,115],"leads":[5],"to":[6,79],"a":[7],"high":[8],"number":[9],"false":[11,37],"positives,":[12],"and":[13,39,73,96,106,116,129],"the":[14,18,25,31,42,46,58,61,69,92,97,107,111,117,127,132,136,144],"biological":[15,43,54],"effects":[16,44],"molecules":[19,64,142],"are":[20],"partially":[21,40],"shaded.":[22],"In":[24],"deconvolution":[26,86],"DNA":[28,33],"encoded":[29],"libraries,":[30,84],"encoding":[32],"oligomer":[34],"may":[35],"yield":[36],"positives":[38],"shadows":[41],"molecules.":[47],"The":[49,100],"Backsearch":[50],"method":[51],"uses":[52],"different":[53],"assays":[55],"in":[56,143],"which":[57],"effect":[59],"free":[62,140],"dissolved":[63,141],"is":[65],"fully":[66],"exerted.":[67],"Since":[68],"introduction":[70],"split":[72],"pool":[74],"synthesis,":[75],"making":[76],"it":[77],"possible":[78],"create":[80],"even":[81],"billion-member":[82],"combinatorial":[83],"two":[85],"possibilities":[87,108],"have":[88,120],"been":[89,122],"extensively":[90],"used:":[91],"one-bead":[93],"one-compound":[94],"(OBOC)":[95],"DNA-encoded":[98],"methods.":[99],"originally":[101],"available":[102],"back":[103,145],"search":[104,146],"screening":[105,139],"offered":[109],"by":[110],"later-developed":[112],"omission":[113],"peptide":[114],"positional":[118],"scanning":[119],"long":[121],"forgotten.":[123],"Here,":[124],"I":[125],"compared":[126],"advantages":[128],"disadvantages":[130],"above-mentioned":[133],"methods,":[134],"emphasizing":[135],"advantage":[137],"method.":[147]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-21T00:00:00"}