{"id":"https://openalex.org/W7124868639","doi":"https://doi.org/10.1158/0008-5472.can-25-2630","title":"KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment","display_name":"KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment","publication_year":2026,"publication_date":"2026-01-13","ids":{"openalex":"https://openalex.org/W7124868639","doi":"https://doi.org/10.1158/0008-5472.can-25-2630","pmid":"https://pubmed.ncbi.nlm.nih.gov/41556816","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13080325"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-25-2630","doi":"https://doi.org/10.1158/0008-5472.can-25-2630","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-2630","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-25-2630/3727213/can-25-2630.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-25-2630/3727213/can-25-2630.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067719739","display_name":"Rachel A. Burge","orcid":"https://orcid.org/0000-0001-9363-4333","observed_orcids":["https://orcid.org/0000-0001-9363-4333"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Burge","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0001-9363-4333","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065695313","display_name":"\u00d6zg\u00fcn Le Roux","orcid":"https://orcid.org/0000-0002-9885-6872","observed_orcids":["https://orcid.org/0000-0002-9885-6872"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ozgun Le Roux","raw_affiliation_strings":["Duke University Medical Center 2 Department of Pharmacology & Cancer Biology, , Durham, North Carolina"],"raw_orcid":"https://orcid.org/0000-0002-9885-6872","affiliations":[{"raw_affiliation_string":"Duke University Medical Center 2 Department of Pharmacology & Cancer Biology, , Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067060084","display_name":"Olesja Popow","orcid":"https://orcid.org/0000-0002-9683-5971","observed_orcids":["https://orcid.org/0000-0002-9683-5971"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olesja Popow","raw_affiliation_strings":["4Department of Medicine, Brigham & Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts","Dana-Farber Cancer Institute 3 Department of Cancer Biology, , Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-9683-5971","affiliations":[{"raw_affiliation_string":"4Department of Medicine, Brigham & Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute 3 Department of Cancer Biology, , Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094585099","display_name":"Victoria K. Spadafora","orcid":"https://orcid.org/0000-0001-9440-0467","observed_orcids":["https://orcid.org/0000-0001-9440-0467"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria K. Spadafora","raw_affiliation_strings":["Medical University of South Carolina 5 Department of Pediatrics, Darby Children\u2019s Research Institute, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0001-9440-0467","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 5 Department of Pediatrics, Darby Children\u2019s Research Institute, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065508915","display_name":"Christabelle Rajesh","orcid":"https://orcid.org/0000-0001-5211-4454","observed_orcids":["https://orcid.org/0000-0001-5211-4454"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christabelle Rajesh","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0001-5211-4454","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058477334","display_name":"Sara J. Adair","orcid":"https://orcid.org/0000-0002-9973-4252","observed_orcids":["https://orcid.org/0000-0002-9973-4252"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara J. Adair","raw_affiliation_strings":["University of Virginia 6 Department of Surgery, , Charlottesville, Virginia"],"raw_orcid":"https://orcid.org/0000-0002-9973-4252","affiliations":[{"raw_affiliation_string":"University of Virginia 6 Department of Surgery, , Charlottesville, Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064385057","display_name":"Lucas Bialousow","orcid":"https://orcid.org/0000-0003-1126-8670","observed_orcids":["https://orcid.org/0000-0003-1126-8670"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas Bialousow","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0003-1126-8670","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123445330","display_name":"Cailey Murphy","orcid":"https://orcid.org/0009-0008-8203-3733","observed_orcids":["https://orcid.org/0009-0008-8203-3733"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cailey Murphy","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0009-0008-8203-3733","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065292871","display_name":"Samaneh Saberi","orcid":"https://orcid.org/0000-0002-5246-9092","observed_orcids":["https://orcid.org/0000-0002-5246-9092"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samaneh Saberi","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0002-5246-9092","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012936662","display_name":"Silvia G. Vaena","orcid":"https://orcid.org/0009-0004-5811-1659","observed_orcids":["https://orcid.org/0009-0004-5811-1659"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia G. Vaena","raw_affiliation_strings":["Medical University of South Carolina 7 Bioinformatics Core, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0009-0004-5811-1659","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 7 Bioinformatics Core, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119727593","display_name":"Margaret C Taquey","orcid":"https://orcid.org/0009-0001-4181-7610","observed_orcids":["https://orcid.org/0009-0001-4181-7610"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret C. Taquey","raw_affiliation_strings":["Medical University of South Carolina 8 College of Graduate Studies, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0009-0001-4181-7610","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 8 College of Graduate Studies, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101575415","display_name":"Sarah Allen","orcid":"https://orcid.org/0009-0007-1079-400X","observed_orcids":["https://orcid.org/0009-0007-1079-400X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Allen","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0009-0007-1079-400X","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611077","display_name":"Lu Han","orcid":"https://orcid.org/0000-0002-9842-2636","observed_orcids":["https://orcid.org/0000-0002-9842-2636"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lu Han","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0002-9842-2636","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019011382","display_name":"Kristi L. Helke","orcid":"https://orcid.org/0000-0001-9746-0764","observed_orcids":["https://orcid.org/0000-0001-9746-0764"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristi L. Helke","raw_affiliation_strings":["Medical University of South Carolina 10 Department of Comparative Medicine, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0001-9746-0764","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 10 Department of Comparative Medicine, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046734660","display_name":"Sudarshana M. Sharma","orcid":"https://orcid.org/0000-0002-9745-0061","observed_orcids":["https://orcid.org/0000-0002-9745-0061"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudarshana Sharma","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0002-9745-0061","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040645408","display_name":"Michael C. Ostrowski","orcid":"https://orcid.org/0000-0003-2948-6297","observed_orcids":["https://orcid.org/0000-0003-2948-6297"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Ostrowski","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0003-2948-6297","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088452270","display_name":"Denis C. Guttridge D","orcid":"https://orcid.org/0000-0002-7276-6609","observed_orcids":["https://orcid.org/0000-0002-7276-6609"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denis C. Guttridge","raw_affiliation_strings":["Medical University of South Carolina 5 Department of Pediatrics, Darby Children\u2019s Research Institute, , Charleston, South Carolina","Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0002-7276-6609","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 5 Department of Pediatrics, Darby Children\u2019s Research Institute, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055367239","display_name":"Toros A. Dincman","orcid":"https://orcid.org/0000-0002-4449-0510","observed_orcids":["https://orcid.org/0000-0002-4449-0510"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toros A. Dincman","raw_affiliation_strings":["Medical University of South Carolina 11 Division of Hematology and Oncology, Department of Medicine, , Charleston, South Carolina","Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0002-4449-0510","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 11 Division of Hematology and Oncology, Department of Medicine, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105367259","display_name":"Todd W. Bauer","orcid":"https://orcid.org/0000-0002-9516-1848","observed_orcids":["https://orcid.org/0000-0002-9516-1848"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd W. Bauer","raw_affiliation_strings":["University of Virginia 6 Department of Surgery, , Charlottesville, Virginia"],"raw_orcid":"https://orcid.org/0000-0002-9516-1848","affiliations":[{"raw_affiliation_string":"University of Virginia 6 Department of Surgery, , Charlottesville, Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040920182","display_name":"David F. Kashatus","orcid":"https://orcid.org/0000-0001-8007-0612","observed_orcids":["https://orcid.org/0000-0001-8007-0612"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Kashatus","raw_affiliation_strings":["University of Virginia Health System 12 Department Microbiology, Immunology, and Cancer Biology, , Charlottesville, Virginia"],"raw_orcid":"https://orcid.org/0000-0001-8007-0612","affiliations":[{"raw_affiliation_string":"University of Virginia Health System 12 Department Microbiology, Immunology, and Cancer Biology, , Charlottesville, Virginia","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066121818","display_name":"Thomas B. McFall","orcid":"https://orcid.org/0000-0002-5284-6994","observed_orcids":["https://orcid.org/0000-0002-5284-6994"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4392738256","display_name":"Medical College of Wisconsin Cancer Center","ror":"https://ror.org/0115fxs14","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I204308271","https://openalex.org/I4392738256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas McFall","raw_affiliation_strings":["Medical College of Wisconsin 13 Department of Biochemistry and MCW Cancer Center, , Milwaukee, Wisconsin"],"raw_orcid":"https://orcid.org/0000-0002-5284-6994","affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin 13 Department of Biochemistry and MCW Cancer Center, , Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I204308271","https://openalex.org/I4392738256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040397780","display_name":"Kevin M. Haigis","orcid":"https://orcid.org/0000-0003-1922-4509","observed_orcids":["https://orcid.org/0000-0003-1922-4509"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M. Haigis","raw_affiliation_strings":["4Department of Medicine, Brigham & Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts","Dana-Farber Cancer Institute 3 Department of Cancer Biology, , Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-1922-4509","affiliations":[{"raw_affiliation_string":"4Department of Medicine, Brigham & Women\u2019s Hospital, and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute 3 Department of Cancer Biology, , Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026061991","display_name":"Michael Anthony Hollingsworth","orcid":"https://orcid.org/0000-0002-5255-8888","observed_orcids":["https://orcid.org/0000-0002-5255-8888"]},"institutions":[{"id":"https://openalex.org/I4390039344","display_name":"Fred and Pamela Buffett Cancer Center","ror":"https://ror.org/03n63wv08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695","https://openalex.org/I4390039344"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Hollingsworth","raw_affiliation_strings":["University of Nebraska Medical Center 14 Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, , Omaha, Nebraska"],"raw_orcid":"https://orcid.org/0000-0002-5255-8888","affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center 14 Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, , Omaha, Nebraska","institution_ids":["https://openalex.org/I4390039344","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087099776","display_name":"Christopher M. Counter","orcid":"https://orcid.org/0000-0003-0748-3079","observed_orcids":["https://orcid.org/0000-0003-0748-3079"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Counter","raw_affiliation_strings":["Duke University Medical Center 2 Department of Pharmacology & Cancer Biology, , Durham, North Carolina"],"raw_orcid":"https://orcid.org/0000-0003-0748-3079","affiliations":[{"raw_affiliation_string":"Duke University Medical Center 2 Department of Pharmacology & Cancer Biology, , Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Channing J. Der","raw_affiliation_strings":["University of North Carolina at Chapel Hill 15 Lineberger Comprehensive Cancer Center, , Chapel Hill, North Carolina","University of North Carolina at Chapel Hill 16 Department of Pharmacology, , Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0002-7751-2747","affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill 15 Lineberger Comprehensive Cancer Center, , Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill 16 Department of Pharmacology, , Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068312423","display_name":"G. Aaron Hobbs","orcid":"https://orcid.org/0000-0002-4751-9681","observed_orcids":["https://orcid.org/0000-0002-4751-9681"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210095449","display_name":"MUSC Hollings Cancer Center","ror":"https://ror.org/00w52vt71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095449"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Aaron Hobbs","raw_affiliation_strings":["Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina"],"raw_orcid":"https://orcid.org/0000-0002-4751-9681","affiliations":[{"raw_affiliation_string":"Medical University of South Carolina 1 Department of Biochemistry & Molecular Biology, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Medical University of South Carolina 9 Hollings Cancer Center, , Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5100611077"],"corresponding_institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210095449"],"apc_list":null,"apc_paid":null,"fwci":14.6427,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.98851577,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"86","issue":"8","first_page":"1868","last_page":"1882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/kras-g12d-mutation","display_name":"KRAS G12D mutation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pi3k-activation","display_name":"PI3K activation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.871999979019165},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7799999713897705},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/kras-mutation-status","display_name":"KRAS mutation status","score":0.4309999942779541},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8528000116348267},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7394999861717224},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6938999891281128},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.592199981212616},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.555400013923645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5245000123977661},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4740999937057495},{"id":"https://openalex.org/C2777996000","wikidata":"https://www.wikidata.org/wiki/Q7130412","display_name":"Pancreatic tumor","level":4,"score":0.39800000190734863},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.34929999709129333},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3312999904155731},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3019999861717224},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3019999861717224},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2897999882698059},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.2874000072479248},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.27219998836517334},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.257099986076355}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1158/0008-5472.can-25-2630","doi":"https://doi.org/10.1158/0008-5472.can-25-2630","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-2630","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-25-2630/3727213/can-25-2630.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:41556816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41556816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13080325","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41556816/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Res","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:r207v456v","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/2wpk-gd21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer research, 86(8)","raw_type":"Article"},{"id":"doi:10.17615/2wpk-gd21","doi":"https://doi.org/10.17615/2wpk-gd21","is_oa":true,"landing_page_url":"https://doi.org/10.17615/2wpk-gd21","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-25-2630","doi":"https://doi.org/10.1158/0008-5472.can-25-2630","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-25-2630","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/doi/10.1158/0008-5472.CAN-25-2630/3727213/can-25-2630.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1319661684","display_name":null,"funder_award_id":"22-WG-DERB","funder_id":"https://openalex.org/F4320306791","funder_display_name":"Pancreatic Cancer Action Network"},{"id":"https://openalex.org/G1410469566","display_name":null,"funder_award_id":"P30-CA138313","funder_id":"https://openalex.org/F4320332464","funder_display_name":"Hollings Cancer Center, Medical University of South Carolina"},{"id":"https://openalex.org/G2221353213","display_name":null,"funder_award_id":"R01CA42978","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2949882231","display_name":null,"funder_award_id":"P30 CA138313","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G297978257","display_name":null,"funder_award_id":"CA044579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2986049845","display_name":"Biological Activity of Ras Oncogenes","funder_award_id":"5r01ca042978-30","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3052603789","display_name":"Defining RAS isoform- and mutation-specific roles in oncogenesis","funder_award_id":"P01CA203657","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3594737752","display_name":null,"funder_award_id":"1R01CA276771","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4126989831","display_name":"Targeting undruggable RAS for cancer treatment","funder_award_id":"R35CA232113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4223979924","display_name":null,"funder_award_id":"P30 CA138313","funder_id":"https://openalex.org/F4320309383","funder_display_name":"Medical University of South Carolina"},{"id":"https://openalex.org/G4868467492","display_name":"Washington University SPORE in Pancreatic Cancer","funder_award_id":"P50CA196510","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5089944154","display_name":"Redefining indications of EGFR inhibitors in cancers that harbor mutant RAS","funder_award_id":"1r01ca276771-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G579175649","display_name":"Origin, diversification and function of pancreatic cancer associated fibroblasts","funder_award_id":"4r00ca263005-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6224975242","display_name":null,"funder_award_id":"GM130457","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6397191437","display_name":null,"funder_award_id":"P01CA203657 and R35CA232113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G64548576","display_name":null,"funder_award_id":"IRG #19-138-34","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G704522546","display_name":null,"funder_award_id":"P30 CA014236","funder_id":"https://openalex.org/F4320337798","funder_display_name":"Duke Cancer Institute"},{"id":"https://openalex.org/G7816896342","display_name":"Identification of synthetic lethal interactors in pancreatic cancer","funder_award_id":"U01CA199235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8439975161","display_name":null,"funder_award_id":"22-20-HOBB","funder_id":"https://openalex.org/F4320306791","funder_display_name":"Pancreatic Cancer Action Network"},{"id":"https://openalex.org/G8442482983","display_name":null,"funder_award_id":"CA138313","funder_id":"https://openalex.org/F4320309383","funder_display_name":"Medical University of South Carolina"},{"id":"https://openalex.org/G8998430635","display_name":"TARGETING KRAS-DYSREGULATED METABOLISM FOR NOVEL THERAPEUTIC APPROACHES","funder_award_id":"W81XWH2110692","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000865340","display_name":"Genetic dissection of oncogenic RAS-driven tumor initiation in vivo","funder_award_id":"R01CA269272","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000884466","display_name":"Selective Targeting of Pancreatic Cancer SPORE","funder_award_id":"P50CA257911","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000884671","display_name":"The role of the macroenvironment in pancreatic cancer-induced cachexia","funder_award_id":"P01CA236778","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000892278","display_name":"COBRE in Digestive and Liver Disease","funder_award_id":"P20GM130457","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000895176","display_name":"Pancreatic Cancer Detection Consortium","funder_award_id":"U01CA210240","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000901327","display_name":"University of Virginia Cancer Center Support Grant","funder_award_id":"P30CA044579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000911897","display_name":"Medical University of South Carolina - Cancer Center Support Grant","funder_award_id":"P30CA138313","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000914840","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014236","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G974618274","display_name":null,"funder_award_id":"CA138313","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306582","display_name":"Abney Foundation","ror":"https://ror.org/01m1se903"},{"id":"https://openalex.org/F4320306659","display_name":"Concern Foundation","ror":"https://ror.org/01hwjc346"},{"id":"https://openalex.org/F4320306791","display_name":"Pancreatic Cancer Action Network","ror":"https://ror.org/03t5n9b81"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320309383","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78"},{"id":"https://openalex.org/F4320315143","display_name":"Mark Foundation For Cancer Research","ror":"https://ror.org/00v7th354"},{"id":"https://openalex.org/F4320316262","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098"},{"id":"https://openalex.org/F4320317007","display_name":"Mirati Therapeutics","ror":"https://ror.org/01by01460"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332464","display_name":"Hollings Cancer Center, Medical University of South Carolina","ror":"https://ror.org/00w52vt71"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337798","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124868639.pdf","grobid_xml":"https://content.openalex.org/works/W7124868639.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1980520251","https://openalex.org/W1981362835","https://openalex.org/W1992995822","https://openalex.org/W1994634031","https://openalex.org/W2046468101","https://openalex.org/W2066135299","https://openalex.org/W2071087808","https://openalex.org/W2081681778","https://openalex.org/W2084239507","https://openalex.org/W2085736853","https://openalex.org/W2086756946","https://openalex.org/W2095630332","https://openalex.org/W2096491402","https://openalex.org/W2113609800","https://openalex.org/W2130410032","https://openalex.org/W2138155367","https://openalex.org/W2154799239","https://openalex.org/W2182290275","https://openalex.org/W2211890826","https://openalex.org/W2226712470","https://openalex.org/W2288522328","https://openalex.org/W2973514814","https://openalex.org/W2981746321","https://openalex.org/W3048519021","https://openalex.org/W3127912383","https://openalex.org/W3138323180","https://openalex.org/W3197559541","https://openalex.org/W3205053075","https://openalex.org/W4200368865","https://openalex.org/W4210389718","https://openalex.org/W4220717021","https://openalex.org/W4223603119","https://openalex.org/W4290780040","https://openalex.org/W4294916416","https://openalex.org/W4296782025","https://openalex.org/W4360858162","https://openalex.org/W4378901135","https://openalex.org/W4392683754","https://openalex.org/W4399380870","https://openalex.org/W4399394643","https://openalex.org/W4401993684","https://openalex.org/W4404165890","https://openalex.org/W4406034704","https://openalex.org/W4415522464"],"related_works":["https://openalex.org/W7154478591","https://openalex.org/W4390915456","https://openalex.org/W7133995099","https://openalex.org/W4409629655","https://openalex.org/W4401993684","https://openalex.org/W4410930165","https://openalex.org/W7160498025","https://openalex.org/W2981746321","https://openalex.org/W4379282617","https://openalex.org/W4317862682"],"abstract_inverted_index":{"Patients":[0],"with":[1,16,49,168,257],"pancreatic":[2,53,160,236],"ductal":[3],"adenocarcinoma":[4],"(PDAC)":[5],"harboring":[6,35,60],"KRASG12R":[7,135,145,158,181,224,258],"mutations":[8,39,259],"have":[9],"increased":[10],"overall":[11],"survival":[12],"relative":[13],"to":[14,152,260],"patients":[15,256],"KRASG12D/V":[17],"mutations.":[18],"To":[19],"investigate":[20],"the":[21,117,188,208,214,218],"mechanisms":[22],"underlying":[23],"this":[24,177],"differential":[25,209],"outcome,":[26],"we":[27],"developed":[28,74],"a":[29,139,228,252],"genetically":[30],"engineered":[31],"mouse":[32,97],"model":[33],"(GEMM)":[34],"KrasG12R":[36,44,64],"and":[37,83,87,93,128,136,172,193,199,213,245,272],"Trp53R172H":[38],"(KrasLSL-G12R/+;Trp53LSL-R172H/+;p48Cre-ERTM).":[40],"Unlike":[41],"KrasG12D":[42,72],"models,":[43,130],"GEMMs":[45],"exhibited":[46],"limited":[47,153],"tumorigenesis,":[48],"only":[50],"10%":[51],"developing":[52],"tumors":[54,161,201],"after":[55],"1":[56,69],"year.":[57],"Additionally,":[58],"mice":[59,73],"whole-body":[61],"expression":[62],"of":[63,79,120,132,184],"remained":[65],"healthy":[66],"for":[67,107,222,231,255],"over":[68],"year,":[70],"whereas":[71],"rapid":[75],"multifocal":[76],"disease.":[77],"Comparison":[78],"KRAS":[80,114,133],"mutant-selective":[81],"transcription":[82],"signaling":[84,211],"in":[85,111,123,205],"murine":[86],"human":[88,124,159,197],"PDAC":[89,125],"cell":[90,126],"lines,":[91],"GEMMs,":[92],"patient-derived":[94],"xenograft":[95],"(PDX)":[96],"models":[98],"revealed":[99],"that":[100,180],"direct":[101],"KRAS-mediated":[102],"PI3K":[103,121,206],"activation":[104],"is":[105,182,238],"necessary":[106],"robust":[108],"tumor":[109,165],"initiation":[110],"GEMMs.":[112],"Unexpectedly,":[113],"was":[115],"not":[116],"primary":[118],"driver":[119],"activity":[122,212],"lines":[127],"PDX":[129],"regardless":[131],"mutation.":[134],"KRASG12D":[137],"activated":[138],"similar":[140],"pancreas-specific":[141],"transcriptional":[142,194,246],"network,":[143],"but":[144],"promoted":[146],"these":[147],"pathways":[148],"less":[149],"robustly":[150],"due":[151],"ERK/MAPK":[154,190,210,242],"nuclear":[155,191,243],"translocation.":[156],"Finally,":[157],"had":[162],"an":[163],"altered":[164],"microenvironment":[166],"(TME)":[167],"reduced":[169,189],"collagen":[170],"deposition":[171],"metastatic":[173],"liver":[174],"invasion.":[175],"Together,":[176],"study":[178],"demonstrated":[179],"capable":[183],"driving":[185],"tumorigenesis":[186],"despite":[187],"translocation":[192,244],"output.":[195],"Although":[196],"KRASG12D-":[198],"KRASG12R-mutant":[200,235],"display":[202],"unexpected":[203],"similarities":[204],"activity,":[207],"extrinsic":[215],"consequences":[216],"on":[217],"TME":[219],"provide":[220],"support":[221],"using":[223],"mutation":[225],"status":[226],"as":[227],"prognostic":[229],"biomarker":[230],"therapeutic":[232],"strategies.":[233],"SIGNIFICANCE:":[234],"cancer":[237],"characterized":[239],"by":[240,270,279,288],"lower":[241],"output":[247],"than":[248],"KRASG12D-mutant":[249],"tumors,":[250],"offering":[251],"potential":[253],"window":[254],"derive":[261],"additional":[262],"benefit":[263],"from":[264],"neoadjuvant":[265],"therapy.":[266],"See":[267,276,285],"related":[268,277,286],"commentary":[269],"Tiriac":[271],"Engle,":[273],"p.":[274,283,292],"1817":[275],"article":[278,287],"Burge":[280],"et":[281,290],"al.,":[282,291],"1854":[284],"Kamgar":[289],"2042.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-01-21T00:00:00"}