{"id":"https://openalex.org/W7124861674","doi":"https://doi.org/10.4103/iju.iju_188_25","title":"Magnetic resonance imaging/ultrasound fusion-guided targeted biopsy and ultrasound-guided systematic biopsy for prior negative prostate biopsy: A meta-analysis","display_name":"Magnetic resonance imaging/ultrasound fusion-guided targeted biopsy and ultrasound-guided systematic biopsy for prior negative prostate biopsy: A meta-analysis","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7124861674","doi":"https://doi.org/10.4103/iju.iju_188_25","pmid":"https://pubmed.ncbi.nlm.nih.gov/42099853"},"language":"en","primary_location":{"id":"doi:10.4103/iju.iju_188_25","doi":"https://doi.org/10.4103/iju.iju_188_25","is_oa":true,"landing_page_url":"https://doi.org/10.4103/iju.iju_188_25","pdf_url":null,"source":{"id":"https://openalex.org/S178791478","display_name":"Indian Journal of Urology","issn_l":"0970-1591","issn":["0970-1591","1998-3824"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/iju.iju_188_25","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123410362","display_name":"Chaoyang Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaoyang Du","raw_affiliation_strings":["Department of Function, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Function, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102738231","display_name":"Xinyue Du","orcid":"https://orcid.org/0000-0003-4005-9050","observed_orcids":["https://orcid.org/0000-0003-4005-9050"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Du","raw_affiliation_strings":["Nanchang University, Nanchang, Jiangxi, 330006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanchang University, Nanchang, Jiangxi, 330006, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123404985","display_name":"Lisha Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisha Zhu","raw_affiliation_strings":["Department of Function, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Function, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066191094","display_name":"Qingsheng Chen","orcid":"https://orcid.org/0000-0002-4441-3769","observed_orcids":["https://orcid.org/0000-0002-4441-3769"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qingsheng Chen","raw_affiliation_strings":["Department of Urology, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Yichun People\u2019s Hospital, Yichun, Jiangxi, 336028, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066191094"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.402,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.80775774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"42","issue":"2","first_page":"99","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9139999747276306},{"id":"https://openalex.org/keywords/targeted-biopsy","display_name":"targeted biopsy","score":0.734000027179718},{"id":"https://openalex.org/keywords/transrectal-ultrasound-guided-biopsy","display_name":"transrectal ultrasound-guided biopsy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cancer-detection-rate","display_name":"cancer detection rate","score":0.7319999933242798},{"id":"https://openalex.org/keywords/clinically-significant-prostate-cancer","display_name":"clinically significant prostate cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/indolent-prostate-cancer","display_name":"indolent prostate cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9632999897003174},{"id":"https://openalex.org/C2779377019","wikidata":"https://www.wikidata.org/wiki/Q956131","display_name":"Overdiagnosis","level":2,"score":0.8385000228881836},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.7243000268936157},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6500999927520752},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5965999960899353},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5960999727249146},{"id":"https://openalex.org/C2781217009","wikidata":"https://www.wikidata.org/wiki/Q4086927","display_name":"Prostate biopsy","level":4,"score":0.489300012588501},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4740000069141388},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4551999866962433},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.45190000534057617},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.3889000117778778},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C2909814700","wikidata":"https://www.wikidata.org/wiki/Q18207010","display_name":"False Negative Reactions","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.33000001311302185},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2578999996185303},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.2572000026702881},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25450000166893005}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/iju.iju_188_25","doi":"https://doi.org/10.4103/iju.iju_188_25","is_oa":true,"landing_page_url":"https://doi.org/10.4103/iju.iju_188_25","pdf_url":null,"source":{"id":"https://openalex.org/S178791478","display_name":"Indian Journal of Urology","issn_l":"0970-1591","issn":["0970-1591","1998-3824"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Urology","raw_type":"journal-article"},{"id":"pmid:42099853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42099853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of urology : IJU : journal of the Urological Society of India","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13148844","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13148844/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13148844/pdf/IJU-42-99.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian J Urol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6edfed62f8eb4cf29791c090c7797848","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6edfed62f8eb4cf29791c090c7797848","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Urology, Vol 42, Iss 2, Pp 99-105 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/iju.iju_188_25","doi":"https://doi.org/10.4103/iju.iju_188_25","is_oa":true,"landing_page_url":"https://doi.org/10.4103/iju.iju_188_25","pdf_url":null,"source":{"id":"https://openalex.org/S178791478","display_name":"Indian Journal of Urology","issn_l":"0970-1591","issn":["0970-1591","1998-3824"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W2010198364","https://openalex.org/W2030094892","https://openalex.org/W2038185901","https://openalex.org/W2048714893","https://openalex.org/W2080725537","https://openalex.org/W2147236349","https://openalex.org/W2608889733","https://openalex.org/W2942893059","https://openalex.org/W3004841319","https://openalex.org/W3014844876","https://openalex.org/W3132228611","https://openalex.org/W4281391805","https://openalex.org/W4291002607","https://openalex.org/W4294215472","https://openalex.org/W4313544735","https://openalex.org/W4385715807","https://openalex.org/W4387930910","https://openalex.org/W4389080726","https://openalex.org/W4389455392","https://openalex.org/W4396608677","https://openalex.org/W4399500132","https://openalex.org/W4399694061","https://openalex.org/W4399948866","https://openalex.org/W4400301288","https://openalex.org/W4400469413","https://openalex.org/W4401352411","https://openalex.org/W4401496976","https://openalex.org/W4402643328"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Introduction:":[1],"The":[2],"comparative":[3],"efficacy":[4],"of":[5,22,48,84,132,146,157,177,184],"magnetic":[6],"resonance":[7],"imaging":[8],"(MRI)/ultrasound":[9],"fusion-guided":[10],"targeted":[11],"biopsy":[12,17,64],"(MRI-TBx)":[13],"versus":[14,111],"systematic":[15],"ultrasound-guided":[16],"(TRUS-Bx)":[18],"for":[19,40,56],"the":[20,100,144],"detection":[21,103,156,164],"prostate":[23,159],"cancer":[24,102,148],"(PCa)":[25],"in":[26,62],"men":[27],"with":[28,70,94,109,114],"prior":[29,95],"negative":[30,96],"biopsies":[31,97],"remains":[32],"clinically":[33,133],"undefined.":[34],"Methods:":[35],"This":[36],"Preferred":[37],"Reporting":[38],"Items":[39],"Systematic":[41],"Reviews":[42],"and":[43,51,60,142,169],"Meta-Analyses-adherent":[44],"meta-analysis":[45],"searched":[46],"Web":[47],"Science,":[49],"PubMed,":[50],"EMBASE":[52],"(through":[53],"December":[54],"2024)":[55],"studies":[57,86],"comparing":[58],"MRI-TBx":[59,110,127,168,174],"TRUS-Bx":[61,115,153,170,181],"repeat":[63],"cohorts.":[65],"Pooled":[66,82],"relative":[67],"risks":[68],"(RRs)":[69],"95%":[71,119],"confidence":[72],"intervals":[73],"(CIs)":[74],"were":[75,105],"calculated":[76],"using":[77],"a":[78,129],"fixed-effects":[79],"model.":[80],"Results:":[81],"analysis":[83],"seven":[85],"(including":[87],"two":[88],"randomized":[89],"trials)":[90],"involving":[91],"459":[92],"patients":[93],"showed":[98,154],"that":[99],"overall":[101],"rates":[104,165],"comparable:":[106],"73%":[107],"(172/235)":[108],"77%":[112],"(181/235)":[113],"(RR":[116],"=":[117,121,124],"0.97,":[118],"CI":[120],"0.82\u20131.14,":[122],"P":[123],"0.232).":[125],"However,":[126],"detected":[128],"higher":[130],"proportion":[131],"significant":[134],"PCa":[135],"(Gleason":[136,149],"score":[137,150],"s7)":[138],"(84.4%":[139],"vs.":[140],"65.1%)":[141],"reduced":[143],"diagnosis":[145],"indolent":[147,178],"<7),":[151],"whereas":[152,180],"superior":[155],"anterior":[158,185],"tumors.":[160,186],"Conclusions:":[161],"Although":[162],"aggregate":[163],"are":[166],"comparable,":[167],"exhibit":[171],"complementary":[172],"strengths:":[173],"reduces":[175],"overdiagnosis":[176],"cancer,":[179],"ensures":[182],"sampling":[183]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-21T00:00:00"}