{"id":"https://openalex.org/W7124587985","doi":"https://doi.org/10.1002/cbdv.202502843","title":"Molecular Hybridization Strategy for Developing Lipid\u2010Lowering Compounds: Design and Synthesis of Vanillin\u2010Based Fibrate Derivatives","display_name":"Molecular Hybridization Strategy for Developing Lipid\u2010Lowering Compounds: Design and Synthesis of Vanillin\u2010Based Fibrate Derivatives","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7124587985","doi":"https://doi.org/10.1002/cbdv.202502843","pmid":"https://pubmed.ncbi.nlm.nih.gov/41548057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13420738"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.202502843","doi":"https://doi.org/10.1002/cbdv.202502843","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202502843","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13420738/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100314869","display_name":"Kexin Xu","orcid":"https://orcid.org/0009-0008-1387-6665","observed_orcids":["https://orcid.org/0009-0008-1387-6665","https://orcid.org/0009-0007-7676-9632"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kexin Xu","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0008-1387-6665","affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125564330","display_name":"Wenjing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Li","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036804809","display_name":"Boling Zhou","orcid":"https://orcid.org/0000-0001-5600-1123","observed_orcids":["https://orcid.org/0000-0001-5600-1123"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boling Zhou","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086000157","display_name":"Yunbi Zhang","orcid":"https://orcid.org/0009-0003-4416-0065","observed_orcids":["https://orcid.org/0009-0003-4416-0065"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunbi Zhang","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083929861","display_name":"Huanxian Shi","orcid":"https://orcid.org/0000-0002-3792-7913","observed_orcids":["https://orcid.org/0000-0002-3792-7913"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanxian Shi","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071202758","display_name":"Ling Ding","orcid":"https://orcid.org/0000-0002-6518-1768","observed_orcids":["https://orcid.org/0000-0002-6518-1768"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Ding","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115061373","display_name":"Huizi Shangguan","orcid":"https://orcid.org/0009-0001-5940-2392","observed_orcids":["https://orcid.org/0009-0001-5940-2392"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huizi Shangguan","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123270736","display_name":"Jiping Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271309","display_name":"Shaanxi Administration of Traditional Chinese Medicine","ror":"https://ror.org/027hagy81","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405271309"]},{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiping Liu","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine Shaanxi Administration of Traditional Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]},{"raw_affiliation_string":"Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine Shaanxi Administration of Traditional Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I4405271309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016141225","display_name":"Yongheng Shi","orcid":"https://orcid.org/0000-0002-4290-2593","observed_orcids":["https://orcid.org/0000-0002-4290-2593"]},"institutions":[{"id":"https://openalex.org/I4405271309","display_name":"Shaanxi Administration of Traditional Chinese Medicine","ror":"https://ror.org/027hagy81","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405271309"]},{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongheng Shi","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine Shaanxi Administration of Traditional Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]},{"raw_affiliation_string":"Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine Shaanxi Administration of Traditional Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I4405271309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068177321","display_name":"Yundong Xie","orcid":"https://orcid.org/0009-0008-9358-4864","observed_orcids":["https://orcid.org/0009-0008-9358-4864"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yundong Xie","raw_affiliation_strings":["College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0008-9358-4864","affiliations":[{"raw_affiliation_string":"College of Pharmacy Shaanxi University of Chinese Medicine  Xianyang People's Republic of China","institution_ids":["https://openalex.org/I75920027"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068177321"],"corresponding_institution_ids":["https://openalex.org/I75920027"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.6048,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.85766352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"23","issue":"1","first_page":"e02843","last_page":"e02843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanillin","display_name":"vanillin","score":0.75},{"id":"https://openalex.org/keywords/molecular-hybridization","display_name":"molecular hybridization","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.7519999742507935},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6309999823570251},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.5130000114440918},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.4440000057220459},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2776933373","wikidata":"https://www.wikidata.org/wiki/Q424744","display_name":"Fibrate","level":3,"score":0.920799970626831},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8783000111579895},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.7560999989509583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5534999966621399},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5311999917030334},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5236999988555908},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49399998784065247},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.4805000126361847},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.46320000290870667},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41589999198913574},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3806999921798706},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.33489999175071716},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.30820000171661377},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27619999647140503}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001547","descriptor_name":"Benzaldehydes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058607","descriptor_name":"Fibric Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D058607","descriptor_name":"Fibric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D058607","descriptor_name":"Fibric Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbdv.202502843","doi":"https://doi.org/10.1002/cbdv.202502843","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202502843","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:41548057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41548057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13420738","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13420738/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chem Biodivers","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13420738","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13420738/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chem Biodivers","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W15180894","https://openalex.org/W63790420","https://openalex.org/W1695322171","https://openalex.org/W1968505581","https://openalex.org/W1973860866","https://openalex.org/W2000197810","https://openalex.org/W2006566461","https://openalex.org/W2016716965","https://openalex.org/W2020915011","https://openalex.org/W2032303688","https://openalex.org/W2055966049","https://openalex.org/W2075293275","https://openalex.org/W2076152331","https://openalex.org/W2100106197","https://openalex.org/W2224900308","https://openalex.org/W2256742438","https://openalex.org/W2311878352","https://openalex.org/W2580928085","https://openalex.org/W2592440173","https://openalex.org/W2726817416","https://openalex.org/W2771532173","https://openalex.org/W2805754149","https://openalex.org/W2881801033","https://openalex.org/W2895314500","https://openalex.org/W2895319213","https://openalex.org/W2897402281","https://openalex.org/W2899494981","https://openalex.org/W2901309888","https://openalex.org/W2911199225","https://openalex.org/W2921135840","https://openalex.org/W2940323454","https://openalex.org/W3119201707","https://openalex.org/W3134189711","https://openalex.org/W3158167405","https://openalex.org/W4210421703","https://openalex.org/W4210760317","https://openalex.org/W4213213155","https://openalex.org/W4283072690","https://openalex.org/W4293072690","https://openalex.org/W4307945755","https://openalex.org/W4316690577","https://openalex.org/W4362583528","https://openalex.org/W4385811149","https://openalex.org/W4387296925","https://openalex.org/W4394875384","https://openalex.org/W4400343972","https://openalex.org/W4401039615","https://openalex.org/W4402087639","https://openalex.org/W4403334828","https://openalex.org/W4411299554"],"related_works":["https://openalex.org/W4415600007","https://openalex.org/W4416852987","https://openalex.org/W4396672075","https://openalex.org/W4410699149","https://openalex.org/W4415555967","https://openalex.org/W7143813385","https://openalex.org/W4399768400","https://openalex.org/W4392250660","https://openalex.org/W7128530911","https://openalex.org/W4411299554"],"abstract_inverted_index":{"In":[0,169],"this":[1],"research,":[2],"we":[3],"developed":[4],"and":[5,44,87,94,114,136,143,176,187],"synthesized":[6],"a":[7,74,98,116,163,184],"range":[8],"of":[9,22,51,107,124,139,157],"fibrate":[10],"derivatives":[11],"based":[12],"on":[13,27],"vanilla":[14],"using":[15],"molecular":[16],"hybridization":[17],"techniques.":[18],"The":[19,48],"lipid-lowering":[20,189],"effects":[21,131],"target":[23],"compounds":[24],"was":[25,59],"performed":[26],"Triton":[28],"WR-1339-induced":[29],"hyperlipidemic":[30],"mouse":[31],"model,":[32],"where":[33],"T2":[34,52,58,102,128,151,171,180],"showed":[35,54],"the":[36,55,105,121,125,155,160],"best":[37],"anti-hyperlipidemia":[38],"activity,":[39],"reducing":[40],"total":[41],"cholesterol":[42],"(TC)":[43],"triglycerides":[45],"(TG)":[46],"significantly.":[47],"hypolipidemic":[49],"activity":[50],"also":[53,172],"dose-dependent":[56],"action.":[57],"shown":[60,149],"to":[61],"notably":[62],"enhance":[63],"lipid":[64,81],"metabolism":[65],"issues":[66],"in":[67,159],"mice":[68],"that":[69,150],"had":[70],"hyperlipidemia":[71],"caused":[72],"by":[73,92,132],"high-fat":[75],"diet":[76],"(HFD).":[77],"Among":[78],"them,":[79],"blood":[80],"indicators":[82],"such":[83],"as":[84,183],"TG,":[85],"TC,":[86],"LDL-C":[88],"were":[89],"significantly":[90,103],"regulated":[91],"T2,":[93],"their":[95],"levels":[96,138],"show":[97],"significant":[99,174],"downward":[100],"trend.":[101],"upregulates":[104],"expression":[106],"peroxisome":[108],"proliferator-activated":[109],"receptor":[110],"alpha":[111],"(PPAR-\u03b1)":[112],"protein":[113],"shows":[115],"strong":[117],"binding":[118],"affinity":[119],"for":[120],"active":[122],"site":[123],"PPAR-\u03b1":[126],"receptor.":[127],"exhibits":[129,173],"hepatoprotective":[130,192],"markedly":[133],"lowering":[134],"serum":[135],"hepatic":[137],"aspartate":[140],"aminotransferase":[141,145],"(AST)":[142],"alanine":[144],"(ALT).":[146],"Studies":[147],"have":[148],"administration":[152],"can":[153],"lessen":[154],"buildup":[156],"lipids":[158],"liver,":[161],"offering":[162],"protective":[164],"benefit":[165],"against":[166],"liver":[167],"damage.":[168],"addition,":[170],"anti-inflammatory":[175],"antioxidant":[177],"effects.":[178],"Therefore,":[179],"may":[181],"serve":[182],"potential":[185],"novel":[186],"effective":[188],"compound":[190],"with":[191],"properties.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-01-19T00:00:00"}