{"id":"https://openalex.org/W7124572011","doi":"https://doi.org/10.60713/pist-198748","title":"Classification mol\u00e9culaire des Tumeurs Gliales, identification des virus associ\u00e9s et analyse du statut de m\u00e9thylation des miARN et de son implication dans le diagnostic et pronostic","display_name":"Classification mol\u00e9culaire des Tumeurs Gliales, identification des virus associ\u00e9s et analyse du statut de m\u00e9thylation des miARN et de son implication dans le diagnostic et pronostic","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W7124572011","doi":"https://doi.org/10.60713/pist-198748"},"language":"fr","primary_location":{"id":"doi:10.60713/pist-198748","doi":"https://doi.org/10.60713/pist-198748","is_oa":true,"landing_page_url":"https://doi.org/10.60713/pist-198748","pdf_url":null,"source":{"id":"https://openalex.org/S7407051441","display_name":"Tunisian Scientific and Technical Information Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4392738169","host_organization_name":"University National Center of Scientific and Technical Documentation","host_organization_lineage":["https://openalex.org/I4392738169"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.60713/pist-198748","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113891789","display_name":"Sarra Limam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Limam, Sarra","raw_affiliation_strings":["Institut Sup\u00e9rieur de Biotechnologie de Monastir"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Sup\u00e9rieur de Biotechnologie de Monastir","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029076105","display_name":"Boulbaba Selmi","orcid":"https://orcid.org/0000-0001-6854-5339","observed_orcids":["https://orcid.org/0000-0001-6854-5339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selmi, Boulbaba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.765999972820282},{"id":"https://openalex.org/keywords/molecular-classification","display_name":"molecular classification","score":0.6380000114440918},{"id":"https://openalex.org/keywords/polyomavirus","display_name":"polyomavirus","score":0.8019999861717224},{"id":"https://openalex.org/keywords/simian-virus-40","display_name":"simian virus 40","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bk-polyomavirus","display_name":"BK virus","score":0.8230000138282776},{"id":"https://openalex.org/keywords/merkel-cell-polyomavirus","display_name":"Merkel cell polyomavirus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/herpesviruses","display_name":"herpesvirus","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ebv","display_name":"EBV","score":0.6819999814033508},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.796999990940094},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dnmt3b","display_name":"DNMT3B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pediatric-glioma","display_name":"pediatric glioma","score":0.6520000100135803},{"id":"https://openalex.org/keywords/adult-glioma","display_name":"adult glioma","score":0.6269999742507935},{"id":"https://openalex.org/keywords/microrna-mimics","display_name":"miRNA mimics","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5889000296592712},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4948999881744385},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.47200000286102295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28529998660087585},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C2777580203","wikidata":"https://www.wikidata.org/wiki/Q3237100","display_name":"Leucosis","level":3,"score":0.24169999361038208},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23579999804496765},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.22679999470710754},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.22619999945163727},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.22540000081062317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.60713/pist-198748","doi":"https://doi.org/10.60713/pist-198748","is_oa":true,"landing_page_url":"https://doi.org/10.60713/pist-198748","pdf_url":null,"source":{"id":"https://openalex.org/S7407051441","display_name":"Tunisian Scientific and Technical Information Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4392738169","host_organization_name":"University National Center of Scientific and Technical Documentation","host_organization_lineage":["https://openalex.org/I4392738169"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":{"id":"doi:10.60713/pist-198748","doi":"https://doi.org/10.60713/pist-198748","is_oa":true,"landing_page_url":"https://doi.org/10.60713/pist-198748","pdf_url":null,"source":{"id":"https://openalex.org/S7407051441","display_name":"Tunisian Scientific and Technical Information Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4392738169","host_organization_name":"University National Center of Scientific and Technical Documentation","host_organization_lineage":["https://openalex.org/I4392738169"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109030142","https://openalex.org/W1988744291","https://openalex.org/W238769601","https://openalex.org/W7199127702","https://openalex.org/W4393370089","https://openalex.org/W59095301","https://openalex.org/W2070390277","https://openalex.org/W425947012","https://openalex.org/W4388750667","https://openalex.org/W2040036522"],"abstract_inverted_index":{"Les":[0],"gliomes":[1,84,88,98,240,252,271,280,286,291,348,374,393,404,504],"sont":[2,33,90],"les":[3,6,50,185,296,347,373,417,420,424,453,506],"tumeurs":[4,32,312],"primaires":[5],"plus":[7,79,421],"fr\u00e9quentes":[8],"du":[9],"syst\u00e8me":[10],"nerveux":[11],"central":[12],"chez":[13,22,28,184,505],"l\u2019enfant":[14],"et":[15,24,53,86,100,120,124,126,168,179,188,218,230,237,243,249,259,267,274,278,288,343,369,380,390,395,401,430,447,469,487,509],"l\u2019adulte.":[16],"Ils":[17],"repr\u00e9sentent":[18],"2%":[19],"des":[20,26,67,77,97,113,141,143,162,196,205,212,270,301,319,326,354,377,409,463,477,503],"cancers":[21,27],"l'adulte":[23],"23%":[25],"l\u2019enfant.":[29],"Auparavant,":[30],"ces":[31,131,182,491],"class\u00e9es":[34],"selon":[35,102],"la":[36,42,71,103,146,176,225,299,445,449,472,485,488,500],"classification":[37,61,72,105],"de":[38,41,56,75,106,139,148,153,157,181,227,257,315,317,407,440,442,444,448,457,490],"l\u2019Organisation":[39],"Mondiale":[40],"Sant\u00e9":[43],"(OMS)":[44],"2007":[45],"en":[46,65,203],"se":[47],"basant":[48],"sur":[49,208],"caract\u00e9ristiques":[51],"histologiques":[52],"le":[54,137,414],"degr\u00e9":[55],"malignit\u00e9.":[57],"R\u00e9cemment,":[58],"une":[59],"nouvelle":[60,104],"a":[62,261,321,382,411],"\u00e9t\u00e9":[63,262,383],"\u00e9merg\u00e9e":[64],"incorporant":[66],"param\u00e8tres":[68],"mol\u00e9culaires":[69],"dans":[70,92,130,232,244,264,275,346,372,385,396,423,452,471,484],"histologique":[73],"permettant":[74],"caract\u00e9riser":[76],"entit\u00e9s":[78],"homog\u00e8nes.":[80],"Au":[81,455],"total":[82],"112":[83],"adultes":[85,99,187,287,394,508],"74":[87,397],"p\u00e9diatriques":[89,101,292],"inclus":[91],"cette":[93,458],"\u00e9tude.":[94],"Apr\u00e8s":[95],"reclassification":[96],"l\u2019OMS":[107],"2016,":[108],"nous":[109,134,173,191,460],"avons":[110,135,174,192],"analys\u00e9":[111],"l\u2019implication":[112,462],"polyomvirus":[114],"(SV40,":[115],"JCPyV,":[116,465],"BKPyV,":[117],"MCPyV,":[118,466],"KIPyV":[119],"WUPyV),":[121],"herpesvirus":[122],"(EBV":[123],"HCMV)":[125],"papillomavirus":[127],"humains":[128],"(HPV)":[129],"tumeurs.":[132,492],"Ensuite,":[133,172],"\u00e9tudi\u00e9":[136],"profil":[138,316],"m\u00e9thylation":[140,318],"promoteurs":[142],"miARNs":[144,197,206,320,410,478],"par":[145,170,200,309],"technique":[147],"PCR-m\u00e9thylation":[149],"sp\u00e9cifique":[150],"apr\u00e8s":[151],"modification":[152],"l\u2019ADN":[154],"au":[155],"bisulfite":[156],"sodium":[158],"ainsi":[159,350],"que":[160,413],"l\u2019expression":[161],"enzymes":[163],"ADN":[164],"m\u00e9thyltransf\u00e9rases":[165],"(DNMT1,":[166],"DNMT3a":[167,379],"DNMT3b)":[169],"immunohistochimie.":[171],"\u00e9valu\u00e9":[175],"signification":[177],"clinico-pathologique":[178],"pronostique":[180,308],"r\u00e9sultats":[183,222],"patients":[186,297,507],"p\u00e9diatriques.":[189,281,375,405,510],"Enfin,":[190],"examin\u00e9":[193],"l\u2019effet":[194],"cytotoxique":[195],"trouv\u00e9":[198],"hyperm\u00e9thyl\u00e9s":[199],"transfection":[201],"invers\u00e9e":[202],"utilisant":[204],"mimiques":[207],"deux":[209,425],"lign\u00e9es":[210,426],"cellulaires":[211,427],"glioblastome":[213],"multiforme":[214],"(GBM)":[215],"adulte":[216],"(U251)":[217],"p\u00e9diatrique":[219],"(KNS42).":[220],"Nos":[221],"ont":[223],"montr\u00e9":[224,322],"pr\u00e9sence":[226,256,300],"SV40,":[228,464],"JCPyV":[229],"MCPyV":[231],"12":[233],"(10,7%),":[234],"5":[235],"(4,5%)":[236],"30":[238],"(26,8%)":[239],"adultes,":[241,272,298,349],"respectivement,":[242,273],"1":[245],"(1,4%),":[246],"3":[247,276],"(4,1%)":[248,277],"8":[250,391],"(10,8%)":[251],"p\u00e9diatriques,":[253],"respectivement.":[254],"La":[255],"l\u2019EBV":[258],"HCMV":[260,468],"identifi\u00e9e":[263],"24":[265,388],"(21,4%)":[266,389],"55":[268],"(49,1%)":[269],"8(10,8%)":[279],"De":[282,474],"plus,":[283,475],"44":[284],"(39,3%)":[285],"7":[289,402],"(9,6%)":[290],"\u00e9taient":[293],"HPV-positifs.":[294],"Chez":[295],"EBV":[302],"\u00e9tait":[303],"associ\u00e9e":[304],"\u00e0":[305],"un":[306,323,437,480,496],"mauvais":[307],"comparaison":[310],"aux":[311],"EBV-n\u00e9gatives.":[313],"L\u2019analyse":[314,406],"taux":[324,352],"d\u2019hyperm\u00e9thylation":[325,353],"miR-9":[327,355],"(41,1%),":[328],"miR-34":[329,357,415,435,494],"(42,9%),":[330],"miR-124":[331,359],"(27,7%),":[332],"miR-107":[333,361],"(16,1%),":[334],"miR-127":[335,363],"(33,9%),":[336,340],"miR-137":[337,365],"(34,8%),":[338],"miR-148":[339],"miR-193":[341,367],"(31,3%)":[342],"miR-203":[344,370],"(15,2%)":[345],"qu\u2019un":[351],"(17,6%),":[356],"(31,1%),":[358],"(33,8%),":[360],"(6,8%),":[362],"(27,0%),":[364],"(9,5%),":[366],"(23,0%)":[368],"(8,1%)":[371],"L\u2019expression":[376],"DNMT1,":[378],"DNMT3b":[381],"d\u00e9tect\u00e9e":[384],"51":[386],"(45,5%),":[387],"(7,1%)":[392],"(100%),":[398],"16":[399],"(21,6%)":[400],"(9,5%)":[403],"cytotoxicit\u00e9":[408],"r\u00e9v\u00e9l\u00e9":[412],"pr\u00e9sentait":[416],"Z":[418],"scores":[419],"\u00e9lev\u00e9s":[422],"U251":[428],"(-3,10)":[429],"KNS42":[431],"(-3,89).":[432],"Par":[433],"cons\u00e9quent,":[434],"serait":[436],"candidat":[438,497],"potentiel":[439],"l\u2019induction":[441],"l'arr\u00eat":[443],"prolif\u00e9ration":[446],"mort":[450],"cellulaire":[451],"gliomes.":[454],"terme":[456],"\u00e9tude,":[459],"sugg\u00e9rons":[461],"EBV,":[467],"HPV":[470],"gliomagen\u00e8se.":[473],"l\u2019hyperm\u00e9thylation":[476],"constitue":[479],"\u00e9v\u00e8nement":[481],"\u00e9pig\u00e9n\u00e9tique":[482],"impliqu\u00e9":[483],"gen\u00e8se":[486],"progression":[489],"Le":[493],"semble":[495],"prometteur":[498],"pour":[499],"th\u00e9rapie":[501],"cibl\u00e9e":[502]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-19T00:00:00"}