{"id":"https://openalex.org/W7124508321","doi":"https://doi.org/10.1038/s41531-025-01199-2","title":"Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson\u2019s and inflammatory bowel disease","display_name":"Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson\u2019s and inflammatory bowel disease","publication_year":2026,"publication_date":"2026-01-16","ids":{"openalex":"https://openalex.org/W7124508321","doi":"https://doi.org/10.1038/s41531-025-01199-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/40661410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12258910"},"language":"en","primary_location":{"id":"doi:10.1038/s41531-025-01199-2","doi":"https://doi.org/10.1038/s41531-025-01199-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-025-01199-2","pdf_url":"https://www.nature.com/articles/s41531-025-01199-2_reference.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41531-025-01199-2_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035859489","display_name":"MacKenzie L. Bolen","orcid":"https://orcid.org/0000-0003-1973-3784","observed_orcids":["https://orcid.org/0000-0003-1973-3784"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MacKenzie L. Bolen","raw_affiliation_strings":["Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA","Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA","McKnight Brain Institute, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-1973-3784","affiliations":[{"raw_affiliation_string":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I4387154804"]},{"raw_affiliation_string":"Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"McKnight Brain Institute, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114299851","display_name":"Marc Buendia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marc Buendia","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain","Inflammatory Bowel Disease Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, CIBER-EHD, Barcelona, Spain","University of Barcelona, Gran Via de les Corts, 08007, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, CIBER-EHD, Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]},{"raw_affiliation_string":"University of Barcelona, Gran Via de les Corts, 08007, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059897100","display_name":"Ji Shi","orcid":"https://orcid.org/0009-0001-9696-8627","observed_orcids":["https://orcid.org/0009-0001-9696-8627"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji Shi","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103108690","display_name":"Hannah A. Staley","orcid":"https://orcid.org/0009-0001-8284-6178","observed_orcids":["https://orcid.org/0009-0001-8284-6178"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Staley","raw_affiliation_strings":["Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA","McKnight Brain Institute, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"McKnight Brain Institute, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072734589","display_name":"Jennifer M. Kachergus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Kachergus","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031214939","display_name":"Philip Alexander Efron","orcid":"https://orcid.org/0000-0002-3931-650X","observed_orcids":["https://orcid.org/0000-0002-3931-650X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip A. Efron","raw_affiliation_strings":["Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066600769","display_name":"Gwoncheol Park","orcid":"https://orcid.org/0000-0003-3778-5895","observed_orcids":["https://orcid.org/0000-0003-3778-5895"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwoncheol Park","raw_affiliation_strings":["The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035364158","display_name":"Ravinder Nagpal","orcid":"https://orcid.org/0000-0002-4250-1749","observed_orcids":["https://orcid.org/0000-0002-4250-1749"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravinder Nagpal","raw_affiliation_strings":["The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gut Biome Lab, Department of Health, Nutrition, and Food Sciences, College of Education, Health, and Human Sciences, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102656629","display_name":"Stephan D. Alvarez","orcid":"https://orcid.org/0009-0000-4420-7394","observed_orcids":["https://orcid.org/0009-0000-4420-7394"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan D. Alvarez","raw_affiliation_strings":["Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102163207","display_name":"Qing\u2010Shan Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing-Shan Xue","raw_affiliation_strings":["Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045713119","display_name":"Nikolaus R. McFarland","orcid":"https://orcid.org/0000-0002-8699-8857","observed_orcids":["https://orcid.org/0000-0002-8699-8857"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolaus R. McFarland","raw_affiliation_strings":["Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA","Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110316456","display_name":"Ellen M. Zimmermann","orcid":"https://orcid.org/0000-0002-7966-2837","observed_orcids":["https://orcid.org/0000-0002-7966-2837"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen M. Zimmermann","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030058343","display_name":"Christopher E. Forsmark","orcid":"https://orcid.org/0000-0002-2508-1543","observed_orcids":["https://orcid.org/0000-0002-2508-1543"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher E. Forsmark","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077448441","display_name":"Kelly B. Menees","orcid":"https://orcid.org/0000-0003-4282-8546","observed_orcids":["https://orcid.org/0000-0003-4282-8546"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly B. Menees","raw_affiliation_strings":["Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA","Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","Department of Neurology, Stark Neuroscience Research Institute, School of Medicine, Indiana University, Indianapolis, IN, USA","Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA","McKnight Brain Institute, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-4282-8546","affiliations":[{"raw_affiliation_string":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I4387154804"]},{"raw_affiliation_string":"Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Neurology, Stark Neuroscience Research Institute, School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"McKnight Brain Institute, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112709607","display_name":"Azucena Salas","orcid":"https://orcid.org/0000-0003-4572-2907","observed_orcids":["https://orcid.org/0000-0003-4572-2907"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Azucena Salas","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain","Inflammatory Bowel Disease Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, CIBER-EHD, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Inflammatory Bowel Disease Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, CIBER-EHD, Barcelona, Spain","institution_ids":["https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123184006","display_name":"E. Aubrey Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Aubrey Thompson","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008036209","display_name":"Mal\u00fa G. Tansey","orcid":"https://orcid.org/0000-0002-1719-4708","observed_orcids":["https://orcid.org/0000-0002-1719-4708"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4387154804","display_name":"Aligning Science Across Parkinson's","ror":"https://ror.org/03zj4c476","country_code":"US","type":"other","lineage":["https://openalex.org/I4387154804"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mal\u00fa G\u00e1mez Tansey","raw_affiliation_strings":["Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. mgtansey@iu.edu","Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu","Department of Neurology, Stark Neuroscience Research Institute, School of Medicine, Indiana University, Indianapolis, IN, USA. mgtansey@iu.edu","Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu","McKnight Brain Institute, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu"],"raw_orcid":"https://orcid.org/0000-0002-1719-4708","affiliations":[{"raw_affiliation_string":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. mgtansey@iu.edu","institution_ids":["https://openalex.org/I4387154804"]},{"raw_affiliation_string":"Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Neurology, Stark Neuroscience Research Institute, School of Medicine, Indiana University, Indianapolis, IN, USA. mgtansey@iu.edu","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"McKnight Brain Institute, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5008036209"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4387154804","https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":8.4379,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.95665614,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":1.0},{"id":"https://openalex.org/keywords/colonic-epithelium","display_name":"colonic epithelium","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ccl22","display_name":"CCL22","score":0.7440000176429749},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.6370000243186951},{"id":"https://openalex.org/keywords/gastrointestinal-dysfunction","display_name":"gastrointestinal dysfunction","score":0.5070000290870667},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.8087000250816345},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6563000082969666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6330999732017517},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6309000253677368},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6116999983787537},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.532800018787384},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.4043999910354614},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.39100000262260437},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.35030001401901245},{"id":"https://openalex.org/C2910239545","wikidata":"https://www.wikidata.org/wiki/Q3843811","display_name":"Immune Dysfunction","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C2909243047","wikidata":"https://www.wikidata.org/wiki/Q13208902","display_name":"Motor dysfunction","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.2685999870300293},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25450000166893005}],"mesh":[],"locations_count":11,"locations":[{"id":"doi:10.1038/s41531-025-01199-2","doi":"https://doi.org/10.1038/s41531-025-01199-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-025-01199-2","pdf_url":"https://www.nature.com/articles/s41531-025-01199-2_reference.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},{"id":"doi:10.1101/2025.04.29.651228","doi":"https://doi.org/10.1101/2025.04.29.651228","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.29.651228","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/02/2025.04.29.651228.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-7115293/v1","doi":"https://doi.org/10.21203/rs.3.rs-7115293/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7115293/v1","pdf_url":"https://www.researchsquare.com/article/rs-7115293/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11657134","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12847817","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40661410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40661410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41545356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41545356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Parkinson's disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12847817","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12847817/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Parkinsons Dis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11064054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12258910","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12258910","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12258910","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ca6cd72c7fab4d8ba64e794baa671d67","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ca6cd72c7fab4d8ba64e794baa671d67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Parkinson's Disease, Vol 12, Iss 1, Pp 1-14 (2026)","raw_type":"article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/53901","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/53901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41531-025-01199-2","doi":"https://doi.org/10.1038/s41531-025-01199-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-025-01199-2","pdf_url":"https://www.nature.com/articles/s41531-025-01199-2_reference.pdf","source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2025142915","display_name":null,"funder_award_id":"PRE2022-102617","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2369866016","display_name":"Role of central and peripheral immune crosstalk in FTD-Grn neurodegeneration","funder_award_id":"RF1NS128800","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G315848923","display_name":null,"funder_award_id":"ASAP-020527","funder_id":"https://openalex.org/F4320306136","funder_display_name":"Michael J. Fox Foundation for Parkinson's Research"},{"id":"https://openalex.org/G3364844421","display_name":"Role of Gut Inflammation and Immunity on Proteostasis, Noradrenergic Degeneration and AD risk","funder_award_id":"RF1AG057247","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5821074941","display_name":null,"funder_award_id":"PF-VSA 1293721","funder_id":"https://openalex.org/F4320314164","funder_display_name":"Parkinson's Foundation"},{"id":"https://openalex.org/G6892736131","display_name":null,"funder_award_id":"ASAP-020527","funder_id":"https://openalex.org/F4320318016","funder_display_name":"Aligning Science Across Parkinson\u2019s"},{"id":"https://openalex.org/G9000890856","display_name":"Pathological Myeloid Activation After Sepsis and Trauma","funder_award_id":"R35GM140806","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000892498","display_name":"Role of central and peripheral immune crosstalk in FTD-Grn neurodegeneration","funder_award_id":"4r01ns128800-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320314164","display_name":"Parkinson's Foundation","ror":"https://ror.org/005aa3k38"},{"id":"https://openalex.org/F4320318016","display_name":"Aligning Science Across Parkinson\u2019s","ror":"https://ror.org/03zj4c476"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124508321.pdf","grobid_xml":"https://content.openalex.org/works/W7124508321.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1574681462","https://openalex.org/W1614021468","https://openalex.org/W1637013412","https://openalex.org/W1930034014","https://openalex.org/W1971599063","https://openalex.org/W1972755311","https://openalex.org/W1973491977","https://openalex.org/W1985842394","https://openalex.org/W1987783497","https://openalex.org/W1993790483","https://openalex.org/W1997848360","https://openalex.org/W2018677712","https://openalex.org/W2047512700","https://openalex.org/W2058927078","https://openalex.org/W2063160102","https://openalex.org/W2075337306","https://openalex.org/W2076588832","https://openalex.org/W2077604810","https://openalex.org/W2084357246","https://openalex.org/W2115207445","https://openalex.org/W2123913108","https://openalex.org/W2126030177","https://openalex.org/W2141337211","https://openalex.org/W2156272127","https://openalex.org/W2326309657","https://openalex.org/W2341917228","https://openalex.org/W2555006703","https://openalex.org/W2556775258","https://openalex.org/W2558041282","https://openalex.org/W2575605891","https://openalex.org/W2594538593","https://openalex.org/W2626849072","https://openalex.org/W2744280559","https://openalex.org/W2753871615","https://openalex.org/W2790100459","https://openalex.org/W2804298260","https://openalex.org/W2892510782","https://openalex.org/W2899178785","https://openalex.org/W2900171085","https://openalex.org/W2904404980","https://openalex.org/W2967652511","https://openalex.org/W2969327149","https://openalex.org/W2971640672","https://openalex.org/W2991203943","https://openalex.org/W2995437528","https://openalex.org/W3035602929","https://openalex.org/W3037194075","https://openalex.org/W3081307311","https://openalex.org/W3114491174","https://openalex.org/W3127379712","https://openalex.org/W3132551180","https://openalex.org/W3133861441","https://openalex.org/W3157419554","https://openalex.org/W3205142056","https://openalex.org/W3208114579","https://openalex.org/W4200374506","https://openalex.org/W4206360051","https://openalex.org/W4210278145","https://openalex.org/W4214833982","https://openalex.org/W4220875195","https://openalex.org/W4282922318","https://openalex.org/W4302362633","https://openalex.org/W4309109636","https://openalex.org/W4311280294","https://openalex.org/W4311710727","https://openalex.org/W4313527680","https://openalex.org/W4317830385","https://openalex.org/W4318620386","https://openalex.org/W4323037248","https://openalex.org/W4366599022","https://openalex.org/W4367317462","https://openalex.org/W4382396988","https://openalex.org/W4385295765","https://openalex.org/W4385382046","https://openalex.org/W4385950368","https://openalex.org/W4386499153","https://openalex.org/W4390741459","https://openalex.org/W4391071064","https://openalex.org/W4392858331","https://openalex.org/W4401965117","https://openalex.org/W4402893334","https://openalex.org/W4403020137","https://openalex.org/W4403929147","https://openalex.org/W4408510409","https://openalex.org/W4408605848","https://openalex.org/W4408705583"],"related_works":["https://openalex.org/W4406272803","https://openalex.org/W6889741501","https://openalex.org/W7141318981","https://openalex.org/W4410607995","https://openalex.org/W4413282860","https://openalex.org/W7160412421","https://openalex.org/W2911938169","https://openalex.org/W7116391229","https://openalex.org/W3114686193","https://openalex.org/W4409535142"],"abstract_inverted_index":{"Abstract":[0],"Parkinson\u2019s":[1],"disease":[2,8,81],"(PD)":[3,117],"is":[4],"the":[5,10,44,90,102,131],"fastest-growing":[6],"neurodegenerative":[7],"in":[9,24,77,101,105],"world":[11],"1":[12],".":[13,34],"Gastrointestinal":[14],"(GI)":[15],"dysfunction":[16],"can":[17],"occur":[18],"decades":[19],"before":[20],"motor":[21],"impairments":[22],"and":[23,62,83,95,108,118],"up":[25],"to":[26,49,71,136,149],"80%":[27],"of":[28,58,93,123],"individuals":[29],"living":[30],"with":[31,74],"PD":[32,50,84,109,151],"2\u20134":[33],"We":[35,86],"investigated":[36],"peripheral":[37],"relationships":[38],"that":[39,47,69,88,144],"may":[40,140],"underlie":[41],"mechanisms":[42],"along":[43,130],"gut\u2013blood":[45],"axis":[46],"contribute":[48],"progression.":[51,152],"Single-cell":[52],"multiomic":[53],"spatial":[54],"molecular":[55],"imaging":[56],"(SMI)":[57],"colonic":[59],"tissue":[60],"localized":[61],"identified":[63],"inflammatory":[64,79],"injury":[65],"within":[66],"epithelial":[67],"cells":[68,148],"appear":[70],"be":[72,141],"associated":[73],"iron":[75,128],"mishandling":[76,129],"both":[78,89,106],"bowel":[80],"(IBD)":[82,120],"biosamples.":[85,110],"found":[87],"single-cell":[91],"SMI":[92],"RNA":[94],"protein":[96,121],"revealed":[97],"parallel":[98],"cross-modal":[99],"dysregulation":[100],"gut":[103,132],"epithelium,":[104],"IBD":[107],"These":[111],"data":[112],"are":[113],"accompanied":[114],"by":[115],"plasma":[116],"stool":[119],"depletion":[122],"CCL22.":[124],"Our":[125],"findings":[126],"suggest":[127],"barrier":[133],"likely":[134],"contributes":[135],"systemic":[137],"inflammation,":[138],"which":[139],"one":[142],"catalyst":[143],"primes":[145],"circulating":[146],"immune":[147],"body-first":[150]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-01-17T00:00:00"}