{"id":"https://openalex.org/W71244933","doi":null,"title":"The role of perioperative antiplatelet therapy and platelet reactivity testing in carotid revascularization: overview of the evidence.","display_name":"The role of perioperative antiplatelet therapy and platelet reactivity testing in carotid revascularization: overview of the evidence.","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W71244933","mag":"71244933","pmid":"https://pubmed.ncbi.nlm.nih.gov/25600432"},"language":"en","primary_location":{"id":"pmid:25600432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25600432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cardiovascular surgery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069412011","display_name":"Tesse C. Leunissen","orcid":"https://orcid.org/0000-0003-2963-1888","observed_orcids":["https://orcid.org/0000-0003-2963-1888"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T C Leunissen","raw_affiliation_strings":["Department of Vascular Surgery,University Medical Centre Utrecht, Utrecht, The Netherlands - jurtenberg@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery,University Medical Centre Utrecht, Utrecht, The Netherlands - jurtenberg@gmail.com","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020097116","display_name":"Gert Jan de Borst","orcid":"https://orcid.org/0000-0002-1389-4141","observed_orcids":["https://orcid.org/0000-0002-1389-4141","https://orcid.org/0000-0002-4454-9244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G J De Borst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044824813","display_name":"Paul W.A. Janssen","orcid":"https://orcid.org/0000-0003-1976-1515","observed_orcids":["https://orcid.org/0000-0003-1976-1515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P W Janssen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007123733","display_name":"Jurri\u00ebn M. ten Berg","orcid":"https://orcid.org/0000-0001-5192-886X","observed_orcids":["https://orcid.org/0000-0001-5192-886X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M ten Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5886,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.83898792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"56","issue":"2","first_page":"165","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/carotid-revascularization","display_name":"carotid revascularization","score":0.9890000224113464},{"id":"https://openalex.org/keywords/p2y12-inhibitors","display_name":"P2Y12 inhibitors","score":0.8349999785423279},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":1.0},{"id":"https://openalex.org/keywords/prasugrel","display_name":"prasugrel","score":1.0},{"id":"https://openalex.org/keywords/platelet-function-testing","display_name":"platelet function testing","score":0.8220000267028809},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.796999990940094},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.9860000014305115},{"id":"https://openalex.org/keywords/individualized-antiplatelet-therapy","display_name":"individualized antiplatelet therapy","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.930530309677124},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.9117270708084106},{"id":"https://openalex.org/C2777028646","wikidata":"https://www.wikidata.org/wiki/Q416232","display_name":"Prasugrel","level":4,"score":0.8855795860290527},{"id":"https://openalex.org/C49059817","wikidata":"https://www.wikidata.org/wiki/Q14916330","display_name":"P2Y12","level":4,"score":0.8186396956443787},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.7689177989959717},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6574432849884033},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.5547481775283813},{"id":"https://openalex.org/C2779464278","wikidata":"https://www.wikidata.org/wiki/Q7317735","display_name":"Revascularization","level":3,"score":0.5447365641593933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5268524885177612},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4497883915901184},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2925611734390259},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.07307654619216919}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010979","descriptor_name":"Platelet Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015607","descriptor_name":"Stents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016894","descriptor_name":"Endarterectomy, Carotid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017130","descriptor_name":"Angioplasty","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017130","descriptor_name":"Angioplasty","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058921","descriptor_name":"Purinergic P2Y Receptor Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D058921","descriptor_name":"Purinergic P2Y Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058925","descriptor_name":"Receptors, Purinergic P2Y12","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058925","descriptor_name":"Receptors, Purinergic P2Y12","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25600432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25600432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cardiovascular surgery","raw_type":"Journal Article"},{"id":"mag:71244933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25600432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W115569928","https://openalex.org/W144700851","https://openalex.org/W242280210","https://openalex.org/W1409766979","https://openalex.org/W1535785785","https://openalex.org/W1972372351","https://openalex.org/W1991745019","https://openalex.org/W1993464453","https://openalex.org/W1995480977","https://openalex.org/W2001759058","https://openalex.org/W2007242643","https://openalex.org/W2008000663","https://openalex.org/W2010831619","https://openalex.org/W2015479343","https://openalex.org/W2028479091","https://openalex.org/W2028732571","https://openalex.org/W2042869268","https://openalex.org/W2045410214","https://openalex.org/W2070321224","https://openalex.org/W2077069572","https://openalex.org/W2078050788","https://openalex.org/W2085447892","https://openalex.org/W2088724639","https://openalex.org/W2097090338","https://openalex.org/W2101414888","https://openalex.org/W2105489963","https://openalex.org/W2110119498","https://openalex.org/W2112883703","https://openalex.org/W2130557334","https://openalex.org/W2133064830","https://openalex.org/W2141883929","https://openalex.org/W2144381249","https://openalex.org/W2145323902","https://openalex.org/W2157833432","https://openalex.org/W2166950143","https://openalex.org/W2329490408","https://openalex.org/W2382476361"],"related_works":["https://openalex.org/W2077069572","https://openalex.org/W2987399071","https://openalex.org/W1982945137","https://openalex.org/W2317599702","https://openalex.org/W2020194511","https://openalex.org/W1594417447","https://openalex.org/W2073995431","https://openalex.org/W7128470085","https://openalex.org/W2002368574","https://openalex.org/W1966234147"],"abstract_inverted_index":{"Antiplatelet":[0],"therapy":[1,103,133],"has":[2],"reduced":[3],"the":[4,15,23,60,79,106,116,126],"incidence":[5,61],"of":[6,19,62,81,87,131],"thromboembolic":[7,49],"events":[8,50],"for":[9,48,91,100,129],"patients":[10,135],"undergoing":[11,136],"carotid":[12,54,137],"revascularization.":[13,55,138],"However,":[14,75],"platelet":[16,37,64,92,94,120,122],"inhibitory":[17],"effect":[18],"aspirin":[20,40],"and":[21,52,109,125],"clopidogrel,":[22],"most":[24,117],"commonly":[25,118],"used":[26,119],"P2Y12":[27,68],"receptor":[28,69],"inhibitors,":[29,121],"is":[30,85],"variable":[31],"among":[32],"patients.":[33],"Patients":[34],"displaying":[35],"high":[36,63],"reactivity":[38],"despite":[39],"or":[41],"clopidogrel":[42],"treatment":[43],"are":[44,73],"at":[45],"higher":[46],"risk":[47,80],"during":[51],"after":[53],"In":[56],"order":[57],"to":[58,134],"reduce":[59],"reactivity,":[65],"more":[66],"potent":[67],"inhibitors":[70],"as":[71],"prasugrel":[72],"used.":[74],"this":[76],"strategy":[77],"increases":[78],"bleeding.":[82],"As":[83],"there":[84],"evidence":[86,113,128],"a":[88],"therapeutic":[89],"window":[90],"inhibition,":[93],"function":[95,123],"tests":[96,124],"could":[97],"be":[98],"helpful":[99],"tailoring":[101,130],"antiplatelet":[102,132],"based":[104],"on":[105],"patient's":[107],"thrombotic":[108],"bleeding":[110],"risk.":[111],"This":[112],"overview":[114],"describes":[115],"current":[127]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}