{"id":"https://openalex.org/W7124461237","doi":"https://doi.org/10.1016/j.orcp.2026.01.002","title":"Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials","display_name":"Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7124461237","doi":"https://doi.org/10.1016/j.orcp.2026.01.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/41545261"},"language":"en","primary_location":{"id":"doi:10.1016/j.orcp.2026.01.002","doi":"https://doi.org/10.1016/j.orcp.2026.01.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.orcp.2026.01.002","pdf_url":null,"source":{"id":"https://openalex.org/S67314508","display_name":"Obesity Research & Clinical Practice","issn_l":"1871-403X","issn":["1871-403X","1878-0318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research & Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030040551","display_name":"A Badran","orcid":"https://orcid.org/0009-0002-8445-778X","observed_orcids":["https://orcid.org/0009-0002-8445-778X"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed Samy Badran","raw_affiliation_strings":["Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: ahmedsamybadran23178@gmail.com"],"raw_orcid":"https://orcid.org/0009-0002-8445-778X","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: ahmedsamybadran23178@gmail.com","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114229010","display_name":"Abdulrhman Helal","orcid":"https://orcid.org/0009-0009-1192-7892","observed_orcids":["https://orcid.org/0009-0009-1192-7892"]},"institutions":[{"id":"https://openalex.org/I207547235","display_name":"Benha University","ror":"https://ror.org/03tn5ee41","country_code":"EG","type":"education","lineage":["https://openalex.org/I207547235"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdulrhman Helal","raw_affiliation_strings":["Faculty of Medicine, Benha University, Benha, Egypt. Electronic address: r.abdoo.h2015@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Benha University, Benha, Egypt. Electronic address: r.abdoo.h2015@gmail.com","institution_ids":["https://openalex.org/I207547235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116041891","display_name":"Karim Samir Shata","orcid":"https://orcid.org/0009-0003-8069-9180","observed_orcids":["https://orcid.org/0009-0003-8069-9180"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Karim Samir Shata","raw_affiliation_strings":["Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: karim_sam_kamel@students.kasralainy.edu.eg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: karim_sam_kamel@students.kasralainy.edu.eg","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054115891","display_name":"Hazem Ayesh","orcid":"https://orcid.org/0000-0001-8231-705X","observed_orcids":["https://orcid.org/0000-0001-8231-705X"]},"institutions":[{"id":"https://openalex.org/I4210165087","display_name":"Deaconess Hospital","ror":"https://ror.org/05vczwc13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210165087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hazem Ayesh","raw_affiliation_strings":["Deaconess Health System, Evansville, IN, USA. Electronic address: hazimayesh@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deaconess Health System, Evansville, IN, USA. Electronic address: hazimayesh@gmail.com","institution_ids":["https://openalex.org/I4210165087"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030040551"],"corresponding_institution_ids":["https://openalex.org/I107720978"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.9463,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.80104167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"20","issue":"1","first_page":"2","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tesamorelin","display_name":"tesamorelin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hiv-associated-lipodystrophy","display_name":"HIV-associated lipodystrophy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/visceral-adipose-tissue","display_name":"visceral adipose tissue","score":0.9120000004768372},{"id":"https://openalex.org/keywords/liver-fat-content","display_name":"liver fat","score":0.8460000157356262},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.9800000190734863},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8820000290870667},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6859999895095825},{"id":"https://openalex.org/keywords/injection-site-reactions","display_name":"injection site reactions","score":0.6740000247955322},{"id":"https://openalex.org/keywords/metabolic-outcomes","display_name":"metabolic outcomes","score":0.44699999690055847},{"id":"https://openalex.org/keywords/safety-outcomes","display_name":"safety outcomes","score":0.5590000152587891},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.492000013589859},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.8059999942779541},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.4129999876022339},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8715000152587891},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.629800021648407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5990999937057495},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.4293000102043152},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.313400000333786},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2800000011920929},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.1956000030040741},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.18629999458789825},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17299999296665192}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050152","descriptor_name":"Intra-Abdominal Fat","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.orcp.2026.01.002","doi":"https://doi.org/10.1016/j.orcp.2026.01.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.orcp.2026.01.002","pdf_url":null,"source":{"id":"https://openalex.org/S67314508","display_name":"Obesity Research & Clinical Practice","issn_l":"1871-403X","issn":["1871-403X","1878-0318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity Research & Clinical Practice","raw_type":"journal-article"},{"id":"pmid:41545261","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41545261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity research & clinical practice","raw_type":"Meta-Analysis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1537972189","https://openalex.org/W1562295238","https://openalex.org/W1973235296","https://openalex.org/W1975244513","https://openalex.org/W1988903540","https://openalex.org/W2010149513","https://openalex.org/W2042344118","https://openalex.org/W2045141517","https://openalex.org/W2046894504","https://openalex.org/W2048331100","https://openalex.org/W2049813983","https://openalex.org/W2059373752","https://openalex.org/W2061478685","https://openalex.org/W2077909287","https://openalex.org/W2084608105","https://openalex.org/W2091239171","https://openalex.org/W2118840057","https://openalex.org/W2125435699","https://openalex.org/W2135400982","https://openalex.org/W2157823046","https://openalex.org/W2163300881","https://openalex.org/W2170892587","https://openalex.org/W2560438049","https://openalex.org/W2580679685","https://openalex.org/W2891685206","https://openalex.org/W2970684805","https://openalex.org/W2979687596","https://openalex.org/W2981465062","https://openalex.org/W3118615836","https://openalex.org/W4211262958","https://openalex.org/W4232245631","https://openalex.org/W4387637304","https://openalex.org/W4406420214"],"related_works":["https://openalex.org/W7171946082","https://openalex.org/W1993515264","https://openalex.org/W2037486981","https://openalex.org/W2146022521","https://openalex.org/W130985735","https://openalex.org/W2010315307","https://openalex.org/W2061478685","https://openalex.org/W2045141517","https://openalex.org/W2408613644","https://openalex.org/W7095784048"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-17T00:00:00"}