{"id":"https://openalex.org/W7124426833","doi":"https://doi.org/10.3390/bioengineering13010110","title":"bFGF-Loaded PDA Microparticles Enhance Vascularization of Engineered Skin with a Concomitant Increase in Leukocyte Recruitment","display_name":"bFGF-Loaded PDA Microparticles Enhance Vascularization of Engineered Skin with a Concomitant Increase in Leukocyte Recruitment","publication_year":2026,"publication_date":"2026-01-16","ids":{"openalex":"https://openalex.org/W7124426833","doi":"https://doi.org/10.3390/bioengineering13010110","pmid":"https://pubmed.ncbi.nlm.nih.gov/41596041"},"language":"en","primary_location":{"id":"doi:10.3390/bioengineering13010110","doi":"https://doi.org/10.3390/bioengineering13010110","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering13010110","pdf_url":null,"source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/bioengineering13010110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042133535","display_name":"Britani N. Blackstone","orcid":"https://orcid.org/0000-0002-2884-8324","observed_orcids":["https://orcid.org/0000-0002-2884-8324"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britani N. Blackstone","raw_affiliation_strings":["Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0002-2884-8324","affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095772687","display_name":"Zachary Everett","orcid":"https://orcid.org/0009-0008-7733-2907","observed_orcids":["https://orcid.org/0009-0008-7733-2907"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary W. Everett","raw_affiliation_strings":["Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0009-0008-7733-2907","affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073023706","display_name":"Syed Baseeruddin Alvi","orcid":"https://orcid.org/0000-0003-3533-840X","observed_orcids":["https://orcid.org/0000-0003-3533-840X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed B. Alvi","raw_affiliation_strings":["Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","Division of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0003-3533-840X","affiliations":[{"raw_affiliation_string":"Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031847318","display_name":"Autumn Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Autumn C. Campbell","raw_affiliation_strings":["Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123248287","display_name":"Emilio Alvalle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilio Alvalle","raw_affiliation_strings":["Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123245623","display_name":"Olivia Borowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Borowski","raw_affiliation_strings":["Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024741532","display_name":"Jennifer M. Hahn","orcid":"https://orcid.org/0009-0007-9017-4053","observed_orcids":["https://orcid.org/0009-0007-9017-4053"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Hahn","raw_affiliation_strings":["Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA","Shriners Children\u2019s Ohio, Dayton, OH 45404, USA"],"raw_orcid":"https://orcid.org/0009-0007-9017-4053","affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Shriners Children\u2019s Ohio, Dayton, OH 45404, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021657967","display_name":"Divya Sridharan","orcid":"https://orcid.org/0000-0003-1931-6470","observed_orcids":["https://orcid.org/0000-0003-1931-6470"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Sridharan","raw_affiliation_strings":["Division of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0003-1931-6470","affiliations":[{"raw_affiliation_string":"Division of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019178531","display_name":"Dorothy M. Supp","orcid":"https://orcid.org/0000-0002-2429-6630","observed_orcids":["https://orcid.org/0000-0002-2429-6630"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy M. Supp","raw_affiliation_strings":["Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA","Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA","Shriners Children\u2019s Ohio, Dayton, OH 45404, USA"],"raw_orcid":"https://orcid.org/0000-0002-2429-6630","affiliations":[{"raw_affiliation_string":"Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Shriners Children\u2019s Ohio, Dayton, OH 45404, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112804936","display_name":"M Martin- Khan","orcid":"https://orcid.org/0000-0003-3430-374X","observed_orcids":["https://orcid.org/0000-0003-3430-374X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmood Khan","raw_affiliation_strings":["Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","Division of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0003-3430-374X","affiliations":[{"raw_affiliation_string":"Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Basic and Translational Research, Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090112496","display_name":"Heather M. Powell","orcid":"https://orcid.org/0000-0002-6845-8101","observed_orcids":["https://orcid.org/0000-0002-6845-8101"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heather M. Powell","raw_affiliation_strings":["Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA","Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA","Shriners Children\u2019s Ohio, Dayton, OH 45404, USA"],"raw_orcid":"https://orcid.org/0000-0002-6845-8101","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Shriners Children\u2019s Ohio, Dayton, OH 45404, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090112496"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02664965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"1","first_page":"110","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.6880000233650208},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/growth-factor-delivery","display_name":"growth factor delivery","score":0.8640000224113464},{"id":"https://openalex.org/keywords/collagen-scaffolds","display_name":"collagen scaffolds","score":0.9330000281333923},{"id":"https://openalex.org/keywords/full-thickness-wounds","display_name":"full-thickness wounds","score":0.7799999713897705},{"id":"https://openalex.org/keywords/leukocyte-recruitment","display_name":"leukocyte recruitment","score":0.859000027179718},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.847000002861023},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.515999972820282},{"id":"https://openalex.org/keywords/skin-grafting","display_name":"skin grafting","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.661899983882904},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5141000151634216},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47940000891685486},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.4765999913215637},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.46880000829696655},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44200000166893005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39579999446868896},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.39089998602867126},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35839998722076416},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3529999852180481},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.34850001335144043},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32339999079704285},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.31630000472068787},{"id":"https://openalex.org/C2778615670","wikidata":"https://www.wikidata.org/wiki/Q3811988","display_name":"Keratinocyte growth factor","level":4,"score":0.3125},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29919999837875366},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2628999948501587},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/bioengineering13010110","doi":"https://doi.org/10.3390/bioengineering13010110","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering13010110","pdf_url":null,"source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},{"id":"pmid:41596041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41596041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:16dc38a9182e4ffc88121dd945edcb64","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/16dc38a9182e4ffc88121dd945edcb64","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering, Vol 13, Iss 1, p 110 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12837753","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12837753/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/bioengineering13010110","doi":"https://doi.org/10.3390/bioengineering13010110","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering13010110","pdf_url":null,"source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.7224197387695312,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2461673218","display_name":null,"funder_award_id":"1R01AR080946-01A1","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4115186004","display_name":"TISSUE ENGINEERING FOR CUTANEOUS AND SYSTEMIC EPIDERMOLYSIS BULLOSA GENE THERAPY","funder_award_id":"HT94252310592","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G412685997","display_name":null,"funder_award_id":"71003-OHI-22","funder_id":"https://openalex.org/F4320313002","funder_display_name":"Shriners Hospitals for Children"},{"id":"https://openalex.org/G8713168295","display_name":null,"funder_award_id":"HL157453","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G882885486","display_name":"Mesoporous nanoparticles for enhancing myocardial repair","funder_award_id":"25TPA1481526","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320313002","display_name":"Shriners Hospitals for Children","ror":"https://ror.org/03e8tm275"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W1525205194","https://openalex.org/W1723227640","https://openalex.org/W1949335843","https://openalex.org/W1966016852","https://openalex.org/W1968996211","https://openalex.org/W1970209371","https://openalex.org/W1975250411","https://openalex.org/W1976450624","https://openalex.org/W1979797716","https://openalex.org/W1981330012","https://openalex.org/W1982568227","https://openalex.org/W1983079870","https://openalex.org/W1984276938","https://openalex.org/W1987433586","https://openalex.org/W1989726643","https://openalex.org/W1996958121","https://openalex.org/W2001868884","https://openalex.org/W2010067741","https://openalex.org/W2014146468","https://openalex.org/W2015943594","https://openalex.org/W2016387108","https://openalex.org/W2017608924","https://openalex.org/W2020295736","https://openalex.org/W2021489532","https://openalex.org/W2021689192","https://openalex.org/W2028283357","https://openalex.org/W2030008253","https://openalex.org/W2031847166","https://openalex.org/W2042864468","https://openalex.org/W2045461459","https://openalex.org/W2054259755","https://openalex.org/W2058340155","https://openalex.org/W2059973095","https://openalex.org/W2062962443","https://openalex.org/W2063907039","https://openalex.org/W2074029723","https://openalex.org/W2076896175","https://openalex.org/W2079924835","https://openalex.org/W2092042046","https://openalex.org/W2093656216","https://openalex.org/W2097151723","https://openalex.org/W2098799479","https://openalex.org/W2116715149","https://openalex.org/W2129087118","https://openalex.org/W2129437774","https://openalex.org/W2132422721","https://openalex.org/W2134569259","https://openalex.org/W2138178479","https://openalex.org/W2139324418","https://openalex.org/W2141642398","https://openalex.org/W2144060214","https://openalex.org/W2151186872","https://openalex.org/W2155212884","https://openalex.org/W2168857275","https://openalex.org/W2171762116","https://openalex.org/W2226812673","https://openalex.org/W2318866146","https://openalex.org/W2323310581","https://openalex.org/W2328606545","https://openalex.org/W2344310603","https://openalex.org/W2396063206","https://openalex.org/W2486463840","https://openalex.org/W2529013366","https://openalex.org/W2546870527","https://openalex.org/W2546877416","https://openalex.org/W2748891890","https://openalex.org/W2763564461","https://openalex.org/W2771166770","https://openalex.org/W2776496710","https://openalex.org/W2793510327","https://openalex.org/W2806520535","https://openalex.org/W2883552344","https://openalex.org/W2899262837","https://openalex.org/W2938035349","https://openalex.org/W2955650461","https://openalex.org/W2962961071","https://openalex.org/W2969153115","https://openalex.org/W2982816240","https://openalex.org/W2993011074","https://openalex.org/W2998634182","https://openalex.org/W3033333700","https://openalex.org/W3034055358","https://openalex.org/W3048197814","https://openalex.org/W3048967465","https://openalex.org/W3087181499","https://openalex.org/W3087731201","https://openalex.org/W3096126679","https://openalex.org/W3127949652","https://openalex.org/W3130785559","https://openalex.org/W3161256277","https://openalex.org/W3198044621","https://openalex.org/W3198645026","https://openalex.org/W3208128360","https://openalex.org/W3209034184","https://openalex.org/W3214171206","https://openalex.org/W3215083175","https://openalex.org/W3216408632","https://openalex.org/W4205928078","https://openalex.org/W4206546582","https://openalex.org/W4220661628","https://openalex.org/W4220724103","https://openalex.org/W4225261174","https://openalex.org/W4226126879","https://openalex.org/W4284883112","https://openalex.org/W4287960612","https://openalex.org/W4308485570","https://openalex.org/W4312314934","https://openalex.org/W4318694064","https://openalex.org/W4319767881","https://openalex.org/W4323534313","https://openalex.org/W4328053556","https://openalex.org/W4387160366","https://openalex.org/W4389178618","https://openalex.org/W4390106612","https://openalex.org/W4399361977","https://openalex.org/W4399821792","https://openalex.org/W4401247093","https://openalex.org/W4401406635","https://openalex.org/W4417483700"],"related_works":[],"abstract_inverted_index":{"Engineered":[0],"skin":[1,151],"(ES)":[2],"can":[3,18],"serve":[4],"as":[5],"an":[6,142],"advanced":[7],"therapy":[8],"for":[9,193],"treatment":[10],"of":[11,33,41,88,195,203,208],"large":[12],"full-thickness":[13,79],"wounds,":[14],"but":[15],"delayed":[16],"vascularization":[17,217],"cause":[19],"ischemia,":[20],"necrosis,":[21],"and":[22,62,69,75,152,221],"graft":[23],"failure.":[24],"To":[25],"accelerate":[26],"ES":[27,70,109,137],"vascularization,":[28],"this":[29,95],"study":[30],"assessed":[31],"incorporation":[32],"polydopamine":[34],"(PDA)":[35],"microparticles":[36,113,140,188],"loaded":[37],"with":[38,54,92,102,110,167],"different":[39],"concentrations":[40],"basic":[42],"fibroblast":[43],"growth":[44,196,210],"factor":[45],"(bFGF)":[46],"into":[47],"collagen":[48],"scaffolds,":[49],"which":[50],"were":[51,71],"subsequently":[52],"seeded":[53],"human":[55],"fibroblasts":[56],"to":[57,65,78,104,215],"create":[58,66],"dermal":[59],"templates":[60],"(DTs),":[61],"then":[63],"keratinocytes":[64,103],"ES.":[67,106,199],"DTs":[68,89],"evaluated":[72],"in":[73,81,117,146,178,198],"vitro":[74],"following":[76,100],"grafting":[77],"wounds":[80],"immunodeficient":[82],"mice.":[83],"In":[84],"vitro,":[85],"metabolic":[86],"activity":[87],"was":[90,97,165],"enhanced":[91],"PDA+bFGF,":[93],"though":[94],"increase":[96,145],"not":[98],"observed":[99],"seeding":[101],"generate":[105],"After":[107],"grafting,":[108],"bFGF-loaded":[111],"PDA":[112,187],"displayed":[114],"dose-dependent":[115],"increases":[116],"CD31-positive":[118],"vessel":[119],"formation":[120],"vs.":[121,162,173],"PDA-only":[122],"controls":[123,174],"(p":[124,180],"<":[125,131,181],"0.001":[126],"at":[127,133,158,175],"day":[128,134,159,176],"7;":[129],"p":[130],"0.05":[132],"14).":[135],"Interestingly,":[136],"containing":[138],"PDA+bFGF":[139],"exhibited":[141],"almost":[143],"3-fold":[144],"water":[147],"loss":[148],"through":[149],"the":[150],"a":[153,190],"less-organized":[154],"basal":[155],"keratinocyte":[156],"layer":[157],"14":[160],"post-grafting":[161],"controls.":[163],"This":[164],"associated":[166],"significantly":[168],"increased":[169],"inflammatory":[170],"cell":[171],"infiltrate":[172],"7":[177],"vivo":[179],"0.001).":[182],"The":[183],"results":[184],"demonstrate":[185],"that":[186],"are":[189],"viable":[191],"method":[192],"delivery":[194],"factors":[197],"However,":[200],"further":[201],"investigation":[202,207],"bFGF":[204],"concentrations,":[205],"and/or":[206],"alternative":[209],"factors,":[211],"will":[212],"be":[213],"required":[214],"promote":[216],"while":[218],"reducing":[219],"inflammation":[220],"maintaining":[222],"epidermal":[223],"health.":[224]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2026-01-17T00:00:00"}